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Showing 3001 to 3050 of 3807 results for treatment

  1. Risk factors for and clinical indicators of early-onset infection: What is the risk of early-onset neonatal infection with maternal obesity and how does this change with increasing body mass index?

    from guidance Neonatal infection: antibiotics for prevention and treatment Number NG195 Date issued April 2021 Other details

    Research recommendation
    Published
    6 August 2021

  2. Endovascular stent insertion for intracranial atherosclerotic disease should only be used in the context of research. Research should clearly define patient selection and be designed to provide outcome data based on follow-up of at least 2 years.

    no substantial differences in clinical outcomes compared with medical treatment after 1–2 years. Evidence on its safety shows that there...

    Research recommendation
    Published
    9 June 2015

  3. Impact of drug-related adverse effects on cost effectiveness and quality of life:- What is the impact of drug-related adverse effects on health economics and quality of life in neuropathic pain?

    about how this affects cost of the quality of life of patients receiving treatment. Further research should be conducted as described...

    Research recommendation
    Published
    9 June 2015

  4. Intravascular catheters for reducing the risk of late-onset neonatal infection: What is the effectiveness of catheters impregnated with silver zeolite for preventing late-onset catheter-related bloodstream infections in newborn babies?

    from guidance Neonatal infection: antibiotics for prevention and treatment Number NG195 Date issued April 2021 Other details

    Research recommendation
    Published
    6 August 2021

  5. Endometriosis now has its own fertility pathway in NICE guidance

    The updated fertility guideline includes a brand-new section specifically for those with endometriosis who are struggling to conceive.

    News
    Last updated
    1 April 2026

  6. Cataracts in adults: management (NG77)

    This guideline covers managing cataracts in adults aged 18 and over. It aims to improve care before, during and after cataract surgery by optimising service organisation, referral and surgical management, and reducing complications. It further aims to improve the availability of information for people with cataracts before, during and after cataract surgery.

    NICE guideline
    Published
    26 October 2017
    View recommendations

    Sections for NG77

  7. Medication choice in people with no previous medication for ADHD:- What is the clinical and cost effectiveness of ADHD medications in people with ADHD with noprevious medication for the condition?

    diagnosed ADHD.There may be differing levels of efficacy of the various treatment options in people who have received no previous...

    Research recommendation
    Published
    14 November 2018

  8. Specialist investigation:- What specialist investigations should be conducted to exclude a diagnosis of functional dyspepsia in people with uninvestigated dyspepsia that does not respond to PPIs or H2 receptor antagonists (H2RAs) despite optimum primary care?

    correct diagnosis or to correct misdiagnosis, so that the most appropriate treatment can be offered. Source guidance details Comes from...

    Research recommendation
    Published
    9 June 2015

  9. Intravascular catheters for reducing the risk of late-onset neonatal infection: What is the effectiveness of antimicrobial-impregnated catheters other than those impregnated with rifampicin and miconazole for preventing late-onset catheter-related bloodstream infections in newborn babies?

    from guidance Neonatal infection: antibiotics for prevention and treatment Number NG195 Date issued April 2021 Other details

    Research recommendation
    Published
    6 August 2021

  10. Risk factors for and clinical indicators of early-onset infection: What is the accuracy of clinical prediction models for early-onset neonatal infection in the UK and what is their effectiveness in guiding management in the baby?

    from guidance Neonatal infection: antibiotics for prevention and treatment Number NG195 Date issued April 2021 Other details

    Research recommendation
    Published
    6 August 2021

  11. During this appraisal it was noted that there is a need for additional research on the management of bleeds that occur while people are receiving apixaban, rivaroxaban or dabigatran etexilate, as there are no antidotes or established treatments to stop active bleeding for these agents.

    rivaroxaban or dabigatran etexilate, as there are no antidotes or established treatments to stop active bleeding for these agents. Any...

    Research recommendation
    Published
    10 August 2021

  12. Pipeline Flex embolisation device with Shield Technology for the treatment of complex intracranial aneurysms (MTG10)

    We have moved medical technologies guidance 10 to become HealthTech guidance 287. This is to better reflect the NICE HealthTech programme which combines the former NICE Diagnostics Assessment programme, Interventional Procedures programme and Medical Technologies Evaluation programme and to help you find relevant content more quickly. The guidance itself has not changed.

    Withdrawn guidance

  13. Cetuximab for the treatment of metastatic colorectal cancer following failure of oxaliplatin-containing chemotherapy (TA150)

    This appraisal has been updated and replaced by NICE technology appraisal guidance 242.

    Withdrawn guidance

  14. Docetaxel, paclitaxel, gemcitabine and vinorelbine for the treatment of non-small cell lung cancer (TA26)

    This guidance has been replaced by NICE guideline CG24 [Replaced by NICE guideline CG121].

    Withdrawn guidance

  15. For people with generalised anxiety disorder (GAD) who are ready to start a low-intensity intervention, what is the clinical effectiveness of physical activity compared with waiting-list control?

    of this study will have important implications in widening the range of treatment options available in the NHS. Source guidance details...

    Research recommendation
    Published
    9 June 2015

  16. Interventions to improve CPAP adherence: Which interventions, including behavioural interventions, are most clinically and cost effective to improve adherence to CPAP in people with OSAHS, obesity hypoventilation syndrome (OHS) and COPD–OSAHS (chronic obstructive pulmonary disease–OSAHS) overlap syndrome who have difficulty using CPAP?

    recommendation for research, see the rationale section on supporting adherence to treatment for OSAHS. Full details of the evidence and...

    Research recommendation
    Published
    30 September 2021

  17. Psychotic symptoms (hallucinations and delusions):- What is the effectiveness of rivastigmine compared with atypical antipsychotic drugs for treating psychotic symptoms (particularly hallucinations and delusions) associated with Parkinson's disease?

    to undertake primary research in this area to determine the most effective treatment options formanaging Parkinson's disease psychosis....

    Research recommendation
    Published
    15 October 2018

  18. Risk factors for and clinical indicators of late-onset infection: What is the accuracy of new or existing clinical prediction models for late-onset neonatal infection in the UK and what is their effectiveness in guiding management: - for babies already on a neonatal unit? - for babies admitted from home?

    from guidance Neonatal infection: antibiotics for prevention and treatment Number NG195 Date issued April 2021 Other details

    Research recommendation
    Published
    6 August 2021

  19. What specialist investigations should be conducted to exclude a diagnosis of functional dyspepsia in people with uninvestigated dyspepsia that does not respond to PPIs or H 2   receptor antagonists (H 2 RAs) despite optimum primary care?

    correct diagnosis or to correct misdiagnosis, so that the most appropriate treatment can be offered. Source guidance details Comes from...

    Research recommendation
    Published
    15 November 2019

  20. Bladder management strategies:- What are the long-term risks and effects on quality of life of different bladder management strategies for lower urinary tract dysfunction in people with neurological disease?

    other neurological diseases. Bladder management strategies are a long-term treatment with implications for maintaining health and...

    Research recommendation
    Published
    9 June 2015

  21. Interventions to manage cystoid macular oedema:- What is the most effective postoperative medical management for cystoid macular oedema?

    lead to the formulation offuture recommendations for the postoperative treatment cystoid macular oedema. Source guidance details Comes...

    Research recommendation
    Published
    18 October 2018

  22. Core outcome set for studies of management of Lyme disease:- Can a core outcome set be developed for clinical trials of management of Lyme disease?

    explanatory notes(if applicable) Why this is important:- Antibiotic treatment is the mainstay of management for Lyme disease. The...

    Research recommendation
    Published
    21 November 2018

  23. Dietitian contribution to patient management:- How can the role of the dietitian contribute most effectively within a coeliac disease team?

    applicable) Why this is important:- As a gluten-free diet is the primary treatment option for people with coeliac disease, it is...

    Research recommendation
    Published
    13 October 2015

  24. Changes to NICE's cost-effectiveness thresholds confirmed

    The government has today (1 December 2025) announced that it will increase the thresholds NICE uses in evaluations of new medicines to decide which are cost-effective for use in the NHS.

    News
    Last updated
    21 April 2026

  25. Autologous blood injection for plantar fasciitis (HTG298)

    Evidence-based recommendations on autologous blood injection for plantar fasciitis. This involves supplying the connective tissue with growth factors that promote the healing process.

    HealthTech guidance
    Published
    23 January 2013
    View recommendations

    Sections for HTG298

  26. What is the clinical and cost effectiveness of cognitive behavioural therapy (CBT) for adults with tinnitus delivered by appropriately trained healthcare professionals other than psychologists (for example, audiologists)?

    intervention. This intervention would allow people with tinnitus to receive their treatment faster and help to reduce waiting lists. It...

    Research recommendation
    Published
    17 March 2020

  27. What is the clinical and cost effectiveness of psychological therapies for children and young people who have tinnitus-related distress?

    intervention. This intervention would allow people with tinnitus to receive their treatment faster and help to reduce waiting lists. It...

    Research recommendation
    Published
    17 March 2020

  28. Embryo selection for single embryo transfer:- Further research is needed to improve embryo selection to facilitate single embryo transfers.

    details Comes from guidance Fertility problems: assessment and treatment Number CG156 Date issued February 2013 Other

    Research recommendation
    Published
    9 June 2015

  29. Dedicated transfer service:- Is it clinically and cost effective to provide a dedicated service to transfer patients with major trauma from the emergency department for ongoing care?

    transfer them without delay but may not be able to provide specialist treatment during the transfer. A specialist team sent by the...

    Research recommendation
    Published
    4 April 2016

  30. Evidence on the safety and efficacy of daytime intraoral neuromuscular electrical tongue stimulation using a removable device for obstructive sleep apnoea is inadequate in quality and quantity. So, this procedure should be used only in research. Find out what only in research means on the NICE interventional procedures guidance page.

    adherence. Research should report details of patient selection, duration of treatment and effect, effect on snoring and sleep apnoea,...

    Research recommendation
    Published
    5 May 2023

  31. In patients hospitalised with moderate- to high-severity community-acquired pneumonia, does using C-reactive protein monitoring in addition to clinical observation to guide antibiotic duration safely reduce the total duration of antibiotic therapy compared with a fixed empirical antibiotic course?

    by NICE. The burden of community-acquired pneumonia is large, and its treatment accounts for a high proportion of antibiotic use in...

    Research recommendation
    Published
    9 June 2015

  32. Is intravenous methylprednisolone more clinically and cost effective than oral methylprednisolone in people with relapsing–remitting Multiple Sclerosis (MS) and people with secondary progressive MS with continued relapses?

    which place a burden on individual patients and the NHS. The primary treatment of acute relapses is with corticosteroids, using a...

    Research recommendation
    Published
    9 June 2015

  33. The use of autologous chondrocyte implantation for the treatment of cartilage defects in the knee joints (TA89)

    This guidance has been updated and replaced by NICE technology appraisal guidance 477. 

    Withdrawn guidance

  34. Guidance on the use of capecitabine for the treatment of locally advanced or metastatic breast cancer (TA62)

    This appraisal has been updated and replaced by NICE guideline CG81.

    Withdrawn guidance

  35. Collection and publication of data on the outcomes of percutaneous cryotherapy for renal cancer in the long term is encouraged. Further research should compare the long-term outcomes of cryotherapy with those of other treatments for renal cancer.

    should compare the long-term outcomes of cryotherapy with those of other treatments for renal cancer. Any explanatory notes(if...

    Research recommendation
    Published
    9 June 2015

  36. The evidence on transvaginal laser therapy for urogenital atrophy does not show any short-term safety concerns. Evidence on long-term safety and efficacy is inadequate in quality and quantity. Therefore, this procedure should only be used in the context of research. Find out what only in research means on the NICE interventional procedures guidance page.

    randomised controlled trials and report details of patient selection, treatment protocols, and long-term safety and efficacy including...

    Research recommendation
    Published
    10 August 2021

  37. Care and support of people growing older with learning disabilities (NG96)

    This guideline covers care and support for adults with learning disabilities as they grow older. It covers identifying changing needs, planning for the future, and delivering services including health, social care and housing. It aims to support people to access the services they need as they get older.

    NICE guideline
    Published
    11 April 2018
    View recommendations

    Sections for NG96

  38. Pharmacological therapies:- What is the clinical and cost effectiveness of codeine with and without paracetamol for the acute management of low back pain?

    using paracetamol and codeine together has a synergistic effect in the treatment of back pain. Source guidance details Comes from...

    Research recommendation
    Published
    13 February 2017

  39. Monitoring for cystic-fibrosis-related diabetes:- What is the most effective strategy to detect diabetes in people with cystic fibrosis?

    identification of cystic-fibrosis-related diabetes would help teams start prompt treatment and prevent the clinical decline associated...

    Research recommendation
    Published
    18 October 2018

  40. The evidence on transvaginal laser therapy for stress urinary incontinence does not show any short-term safety concerns. Evidence on long-term safety andefficacy is inadequate in quality and quantity. Therefore, this procedure should only be used in the context of research. Find out what only in research means onthe NICE interventional procedures guidance page.

    long-term safety and efficacy outcomes, the type of laser and energy used, treatment protocols, and patient selection including age,...

    Research recommendation
    Published
    10 August 2021

  41. Intrauterine laser ablation of placental vessels for the treatment of twin-to-twin transfusion syndrome (IPG198)

    We have moved interventional procedures guidance 198 to become HealthTech guidance 126. This is to better reflect the NICE HealthTech programme which combines the former NICE Diagnostics Assessment programme, Interventional Procedures programme and Medical Technologies Evaluation programme and to help you find relevant content more quickly. The guidance itself has not changed.

    Withdrawn guidance

  42. What is the clinical effectiveness of double-dose PPIs in people with severe erosive reflux disease (Los Angeles classification grade C/D or Savary–Miller grade 3/4): to reduce severe oesophagitis to control symptoms as maintenance therapy?

    It would substantially improve people's quality of life if an optimal treatment regimen could be identified. Currently, there is a lack...

    Research recommendation
    Published
    15 November 2019

  43. What are the risks that predict the development of blood-borne virus infections in people with complex psychosis in the UK?

    in the UK? Any explanatory notes(if applicable) Care and treatment for physical health conditions (recommendations 1.10.18 and 1.10.19)...

    Research recommendation
    Published
    26 October 2020

  44. Clinical epidemiology of Lyme disease in the UK:- What are the incidence, presenting features, management and outcome of Lyme disease in the UK?

    stics. These statistics would enable interventions such as antibiotic treatment and service improvements to be assessed properly and for...

    Research recommendation
    Published
    21 November 2018

  45. What specialist management is effective for people whose symptoms do not respond to PPIs despite optimum primary care, or for people whose symptoms return after surgery?

    tricyclic antidepressants versus standard or full-dose PPI. The purpose of any treatment should focus on improving quality of life....

    Research recommendation
    Published
    15 November 2019

  46. HPV testing:- What is the comparative effectiveness of single-step laboratory diagnostic tests to identify human papillomavirus (HPV) against current diagnostic test algorithms and reference standards in people with cancer of the oropharynx?

    Current methods use a 2-step procedure that is not widely available in all treatment centres. A single-step test is likely to be more...

    Research recommendation
    Published
    6 April 2016

  47. Bisphosphonates for the prevention of bone disease:- What is the effectiveness of monthly zoledronic acid given indefinitely compared with zoledronic acid given for a fixed duration in patients with myeloma?

    in people with myeloma. However, the optimal frequency and duration of treatment is not clearly defined and needs further research,...

    Research recommendation
    Published
    5 April 2016

  48. NICE encourages further research into the use of innovative technologies for the management of severe acute respiratory failure, and may review this guidance on publication of further evidence.

    hospitals in the control group and a single centre was used for the ECMO treatment group. Therefore this procedure should only be used...

    Research recommendation
    Published
    9 June 2015

  49. Effective proton pump inhibitor dosage for severe erosive reflux disease:- What is the clinical effectiveness of double-dose PPIs in people with severe erosive reflux disease (Los Angeles classification grade C/D or Savary–Miller grade 3/4): - to reduce severe oesophagitis - to control symptoms - as maintenance therapy?

    It would substantially improve people's quality of life if an optimal treatment regimen could be identified. Currently, there is a lack...

    Research recommendation
    Published
    9 June 2015

  50. Other specialist management:- What specialist management is effective for people whose symptoms do not respond to PPIs despite optimum primary care, or for people whose symptoms return after surgery?

    tricyclic antidepressants versus standard or full-dose PPI. The purpose of any treatment should focus on improving quality of life....

    Research recommendation
    Published
    9 June 2015