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Showing 3101 to 3150 of 3807 results for treatment

  1. In people with suspected TB, what is the relative clinical and cost effectiveness of universal andrisk-based use of rapid nucleic acid amplification tests?

    avoiding a large number of falsepositives, which leads to unnecessary treatment. This trade-off may lead to differences in the...

    Research recommendation
    Published
    8 November 2019

  2. Pilon fractures:- In adults with closed pilon fractures, what method of fixation provides the best clinical and cost effectiveness outcomes as assessed by function and incidence of major complications at 2 years (stratified for timing of definitive surgery early [under 36 hours] versus later [over 36 hours])?

    potential for life-changing adverse consequences of both the injury and its treatment is known, but the best management strategy to...

    Research recommendation
    Published
    21 March 2016

  3. Pregnancy and complex social factors: a model for service provision for pregnant women with complex social factors (CG110)

    This guideline covers antenatal care for all pregnant women with complex social factors (particularly alcohol or drug misuse, recent migrant or asylum seeker status, difficulty reading or speaking English, aged under 20, domestic abuse). It offers advice on improving access to care, maintaining contact with antenatal carers, and additional information and support for these women.

    Clinical guideline
    Published
    22 September 2010
    View recommendations

    Sections for CG110

  4. Hybrid closed loop systems for managing blood glucose levels in type 1 diabetes (TA943)

    Evidence-based recommendations on hybrid closed loop systems for managing blood glucose levels in type 1 diabetes.

    Technology appraisal guidance
    Published
    19 December 2023
    View recommendations

    Sections for TA943

  5. Techniques for confirming a diagnosis in people with suspected atypical Spitzoid melanocytic lesions: In people with reported atypical Spitzoid lesions, how effective are fluorescence in situ hybridization (FISH), comparative genomic hybridization (CGH) and tests to detect driver mutations compared with histopathological examination alone in predicting disease specific survival? This should be investigated ina prospective diagnostic study. Secondary outcomes should include sensitivity, specificity, accuracy, positive predictive value, disease specific survival and progression free survival.

    changes in molecular pathways could predict outcome and inform individual treatment planning. Source guidance details Comes from...

    Research recommendation
    Published
    4 August 2022

  6. Evaluation of extensively used interventions:- Evaluate currently unevaluated but extensively used interventions for attachment difficulties.

    psychotherapy, and attachment aware schools program with an evidence-based treatment for attachment difficulties. The interventions...

    Research recommendation
    Published
    11 December 2015

  7. Compression as a management option:- What is the clinical and cost effectiveness of compression hosiery versus no compression for the management of symptomatic varicose veins?

    Why this is important:- Compression hosiery is widely used as first-line treatment for symptomatic varicose veins. In some areas of the...

    Research recommendation
    Published
    9 June 2015

  8. Denosumab for the treatment of therapy-induced bone loss in non-metastatic prostate cancer (terminated appraisal) (TA194)

    This guidance has been updated and replaced by NICE guideline CG175.

    Withdrawn guidance

  9. Inhaler devices for routine treatment of chronic asthma in older children (aged 5 to 15 years) (TA38)

    This guidance has been updated and replaced by the NICE guideline on asthma: diagnosis, monitoring and chronic asthma management (BTS, NICE, SIGN).

    Withdrawn guidance

  10. Ipilimumab for the adjuvant treatment of completely resected stage IV or high risk stage III melanoma [ID721]

    Discontinued Reference number: GID-TAG479

    Technology appraisal guidance
    Discontinued

  11. Technology appraisal data: appraisal recommendations

    Data on the recommendations made by our technology appraisal programme. Includes information on the number of positive recommendations we've made.

  12. Can rapid microbiological diagnosis of hospital-acquired pneumonia reduce the use of xtendedspectrum antibiotic therapy, without adversely affecting outcomes?

    Hospital-acquired infections can be caused by highly resistant pathogens that need treatment with extended-spectrum antibiotics (for...

    Research recommendation
    Published
    9 June 2015

  13. 1.1 Evidence on the safety of electrical stimulation to improve muscle strength in chronic respiratory conditions, chronic heart failure and chronic kidney disease shows no major safety concerns. For people who are having an acute exacerbation of their chronic condition and are unable to exercise, evidence of efficacy is adequate to support the use of this procedure provided that standard arrangements are in place for clinical governance, consent and audit.   Find out  what standard arrangements mean on the NICE website . For people who are able to exercise, evidence on efficacy is inadequate in quality. Therefore, this procedure should only be used in the context of research. Find out  what only in research means on the NICE website .

    These should report details of patient selection, and type and duration of treatment. Outcomes should include quality of life, social...

    Research recommendation
    Published
    10 August 2020

  14. Signs and symptoms that predict neutropenic sepsis in the community:- A prospective study should be carried out to determine which signs and symptoms experienced by patients in the community predict neutropenic sepsis and the outcomes of these episodes.

    service. Referral criteria that are too narrow will delay the emergency treatment of infection and may lead to death, increased need for...

    Research recommendation
    Published
    9 June 2015

  15. Topical therapy:- In people of all ages with psoriasis: 1. How should topical therapies be used to maintain disease control i) safely; ii) effectively and iii) what are the health economic implications? 2. What are the risks of 'real life' long term corticosteroid use, are there particular people at risk and what strategies can be used to modify or avoid risks?

    prescribed to virtually everyone with psoriasis, often as first line psoriasis treatment and they are also frequently used adjunctively...

    Research recommendation
    Published
    9 June 2015

  16. What is the clinical effectiveness and rate of adverse events of statin therapy using atorvastatin 20 mg per day compared with atorvastatin 40 mg per day and atorvastatin 80 mg per day in people without established CVD?

    QRISK2 calculator. However, this analysis looked at the effectiveness of treatment shown by 'high-intensity' statins as a group, as it...

    Research recommendation
    Published
    9 June 2015

  17. Lymphovenous anastomosis during axillary or inguinal node dissection for preventing secondary lymphoedema (HTG717)

    Evidence-based recommendations on lymphovenous anastomosis during axillary or inguinal node dissection for preventing secondary lymphoedema in adults. This involves diverting some of the lymphatic vessels around where lymph nodes have been removed to nearby veins.

    HealthTech guidance
    Published
    16 April 2024
    View recommendations

    Sections for HTG717

  18. PeritX peritoneal catheter drainage system for vacuum-assisted drainage of treatment-resistant, recurrent malignant ascites (MTG9)

    We have moved medical technologies guidance 9 to become HealthTech guidance 282. This is to better reflect the NICE HealthTech programme which combines the former NICE Diagnostics Assessment programme, Interventional Procedures programme and Medical Technologies Evaluation programme and to help you find relevant content more quickly. The guidance itself has not changed.

    Withdrawn guidance

  19. Gilteritinib for maintenance treatment of FLT3-mutation-positive acute myeloid leukaemia after stem cell transplant [ID6243]

    Discontinued Reference number: GID-TA11255

    Technology appraisal guidance
    Discontinued

  20. Preferred place of care and place of death:- When planning and managing end of life care, what factors help children and young people with life-limiting conditions and their parents or carers to decide where they would like end of life care to be provided and where they prefer to die?

    children and young people as well as their parents and carers (in particular, treatment of distressing symptoms) that may affect their...

    Research recommendation
    Published
    15 February 2017

  21. What is the safety and efficacy of botulinum toxin compared with (a) usual care, (b) antimuscarinics and (c) augmentation cystoplasty in people with primary cerebral conditions with lower urinary tract dysfunction?

    include heterogeneous groups of patients. Potential benefits of successful treatment in cerebral disease may include the avoidance of...

    Research recommendation
    Published
    9 June 2015

  22. Delirium in long-term care: How common is delirium and what are its adverse outcomes in people in long-term care?

    study would also inform cost-effectiveness analyses for the prevention and treatment of delirium. Source guidance details Comes from...

    Research recommendation
    Published
    3 February 2023

  23. Further research in superior rectal artery embolisation for haemorrhoids should report details of patient selection, and follow-up efficacy (including symptom relief), need for subsequent treatments, quality of life and safety outcomes for at least 1 year.

    and follow-up efficacy (including symptom relief), need for subsequent treatments, quality of life and safety outcomes for at least 1...

    Research recommendation
    Published
    12 December 2018

  24. Have your say on NICE's adoption of the new EQ-5D-5L value set

    We have launched a public consultation on the proposed adoption of the new EQ-5D-5L value set which will help us to make more accurate assessments of how treatments improve health-related quality of life.

    News
    Last updated
    22 April 2026

  25. Inhaled corticosteroids for the treatment of chronic asthma in adults and in children aged 12 years and over (TA138)

    This guidance has been updated and replaced by the NICE guideline on asthma: diagnosis, monitoring and chronic asthma management (BTS, NICE, SIGN).

    Withdrawn guidance

  26. Tests to help assess risk of acute kidney injury for people being considered for critical care admission (ARCHITECT and Alinity i Urine NGAL assays, BioPorto NGAL test and NephroCheck test) (HTG544)

    Evidence-based recommendations on tests to help assess risk of acute kidney injury for people being considered for critical care admission. The tests are the ARCHITECT and ALINITY i Urine NGAL assays, BioPorto NGAL test and NephroCheck test.

    HealthTech guidance
    Published
    17 June 2020
    View recommendations

    Sections for HTG544

  27. Are psychological interventions effective for treating moderate to severe anxiety disorders (including obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder and social anxiety disorder) in pregnancy?

    interventions (for example, mode of delivery, duration, content, and intensity of treatment) that are needed for use in pregnancy - the...

    Research recommendation
    Published
    9 June 2015

  28. Changes to NICE's cost-effectiveness thresholds take effect

    NICE has implemented new measures to evaluate the cost-effectiveness of medicines, following a policy change that aims to give patients improved access to treatments.

    News
    Last updated
    21 April 2026

  29. Drug allergy (QS97)

    This quality standard covers diagnosing and managing drug allergy in adults, young people and children. It describes high-quality care in priority areas for improvement.

    Quality standard
    Published
    30 July 2015
    View quality statements

    Sections for QS97

  30. Abatacept for the treatment of rheumatoid arthritis after the failure of conventional disease-modifying anti-rheumatic drugs (TA234)

    This guidance has been updated and replaced by NICE technology appraisal guidance 280.

    Withdrawn guidance

  31. Atezolizumab as neoadjuvant (with chemotherapy) and adjuvant (as monotherapy) treatment for resectable non-small-cell lung cancer [ID3894]

    In development Reference number: GID-TA10777 Expected publication date: TBC

    Technology appraisal guidance
    In development

  32. Is structured clinical management for moderate to severe personality disorders in pregnancy and the postnatal period effective at improving outcomes for women and their babies?

    disorder may present problems for engagement even in those motivated to seek treatment. Structured clinical management is a...

    Research recommendation
    Published
    9 June 2015

  33. Radiofrequency denervation:- What is the clinical and cost effectiveness of radiofrequency denervation for chronic low back pain in the long term?

    the outcomes and duration of these outcomes are similar to the initial treatment. If repeated radiofrequency denervation is to be...

    Research recommendation
    Published
    13 February 2017

  34. SecurAcath for securing percutaneous catheters (HTG440)

    Evidence-based recommendations on SecurAcath for securing percutaneous catheters.

    HealthTech guidance
    Last updated
    10 August 2022
    View recommendations

    Sections for HTG440

  35. Interventions for coordination and delivery of care to improve access and uptake:- What models for the coordination and delivery of care for people in contact with the criminal justice system provide for the most effective and efficient coordination of care and improve access and uptake of services?

    However, there is clear evidence of poor engagement, uptake and retention in treatment for people with mental health problems in contact...

    Research recommendation
    Published
    16 May 2017

  36. Seroprevalence of Lyme disease-specific antibodies and other tick-borne infections in the UK population:- What is the current seroprevalence of Lyme disease-specific antibodies and other tick-borne infections in people in the UK?

    to confirm or refute this. Better evidence may improve diagnostic and treatment decisions. Source guidance details Comes from guidance

    Research recommendation
    Published
    27 November 2018

  37. Flu vaccination: increasing uptake (NG103)

    This guideline covers how to increase uptake of the free flu vaccination among people who are eligible. It describes ways to increase awareness and how to use all opportunities in primary and secondary care to identify people who should be encouraged to have the vaccination.

    NICE guideline
    Published
    22 August 2018
    View recommendations

    Sections for NG103

  38. Sacral nerve stimulation for urge incontinence and urgency-frequency (HTG37)

    Evidence-based recommendations on sacral nerve stimulation for urge incontinence and urgency-frequency. This involves placing electrodes and connecting them to an implantable pulse generator.

    HealthTech guidance
    Published
    23 June 2004
    View recommendations

    Sections for HTG37

  39. Transaxial interbody lumbosacral fusion for severe chronic low back pain (HTG478)

    Evidence-based recommendations on transaxial interbody lumbosacral fusion for low back pain in adults. This involves removing a damaged disc through a small cut at the base of the spine, and replacing it with an artificial implant.

    HealthTech guidance
    Published
    25 July 2018
    View recommendations

    Sections for HTG478

  40. Servo-n with Neurally Adjusted Ventilatory Assist (NAVA) for babies and children (MIB163)

    NICE has developed a medtech innovation briefing (MIB) on Serve-n with Neurally Adjusted Ventilatory Assist (NAVA) for babies and children .

    Medtech innovation briefing
    Published
    26 October 2018

  41. Total prosthetic replacement of the temporomandibular joint (HTG352)

    Evidence-based recommendations on total prosthetic replacement of the temporomandibular joint. This involves replacing the joint with an artificial one.

    HealthTech guidance
    Published
    27 August 2014
    View recommendations

    Sections for HTG352

  42. Predictors of acute physical risk:- What clinical and biochemical markers are the best predictors of acute physical risk for people with eating disorders?

    details Comes from guidance Eating disorders: recognition and treatment Number NG69 Date issued May 2017 Other details

    Research recommendation
    Published
    12 October 2018

  43. Premature ovarian insufficiency:- What are the main clinical manifestations of premature ovarian insufficiency and the short- and long-term impact of the most common therapeutic interventions?

    oral contraceptives are often prescribed when this might not be the best treatment in terms of quality of life and preservation of bone...

    Research recommendation
    Published
    11 December 2015

  44. Hearing loss prevalence in people who under-present for hearing loss:- What is the prevalence of hearing loss among populations who under-present for possible hearingloss?

    identified and addressed at an early stage, yet people often delay seeking treatment for up to 10 years. There are certain groups who...

    Research recommendation
    Published
    10 December 2018

  45. Pharmacological prevention: In people in hospital who are at high risk of delirium, which medication (atypical antipsychotics, typical antipsychotics, benzodiazepines or acetylcholinesterase inhibitors), compared with placebo or each other, is more clinically and cost effective in preventing the development of delirium?

    methods of prevention. Pharmacological agents may be a simple preventive treatment for delirium, but there is uncertainty about...

    Research recommendation
    Published
    3 February 2023

  46. What is the comparative clinical and cost effectiveness of pharmacological and psychosocial interventions for anxiety disorders in autistic children and young people?

    autistic children and young people and an anxiety disorder. Pharmacological treatment should be with a selective serotonin reuptake...

    Research recommendation
    Published
    10 August 2021

  47. Modes of provision of support to healthcare professionals:- What would be the impact of dietetic telephone support to healthcare professionals to aid in the diagnosis and assessment of babies showing non-IgE-mediated food allergy symptoms in primary care and community settings?

    surgeries and health clinics, reduced need for unnecessary medications and treatment, improved health for the whole family and improved...

    Research recommendation
    Published
    9 June 2015

  48. Erlotinib in combination with bevacizumab for the maintenance treatment of advanced or metastatic non-small cell lung cancer [ID44]

    Discontinued Reference number: GID-TA11206

    Technology appraisal guidance
    Discontinued

  49. Nivolumab–relatlimab for adjuvant treatment of resected stage 3 or 4 melanoma in people 12 years and over [ID6475]

    In development Reference number: GID-TA11586 Expected publication date: TBC

    Technology appraisal guidance
    In development

  50. The physical health benefits of discontinuing antipsychotic medication:- What are the short- and long-term benefits to physical health of guided medication discontinuation and/or reduction in first episode psychosis and can this be achieved without major risks?

    reducing the long-term physical health risks associated with antipsychotic treatment and improving outcomes. The programme of research...

    Research recommendation
    Published
    9 June 2015