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Showing 3401 to 3450 of 4138 results for patient

  1. Assessment and monitoring:- What is the incidence of complications during, and as a consequence of, IV fluid therapy?

    certainly under-reported in the ward setting with significant implications for patients, predominantly morbidity through to mortality....

  2. Motivating dental practice teams to take a preventive approach:- What would motivate dental practice teams to take a preventive approach to oral health – especially with high risk groups – and how does this fit into the dental practice business model?

    services. This is particularly the case in low socioeconomic areas, where patients attend irregularly (or cannot afford to attend) or do...

  3. Interventions to prevent endophthalmitis:- What is the effectiveness of postoperative antibiotic drops to reduce rates of endophthalmitis after cataract surgery?

    standard good clinical practice in the UK. In addition, it is recognised that patients are invariably receiving other drops (for...

  4. Imaging of ankle fractures:- Is CT scanning in addition to initial plain film X-ray clinically effective and cost effective for planning surgical treatment of unstable/displaced ankle fractures compared with plain film X-ray alone?

    number of people every year. Outcomes following surgery are important for patients' long-term function and quality of life, and may also...

  5. Is intravenous methylprednisolone more clinically and cost effective than oral methylprednisolone in people with relapsing–remitting Multiple Sclerosis (MS) and people with secondary progressive MS with continued relapses?

    relapses will occur each year in the UK, which place a burden on individual patients and the NHS. The primary treatment of acute...

  6. Monitoring adherence to treatment:- What is the clinical and cost effectiveness of using electronic alert systems designed to monitor and improve adherence with regular inhaled maintenance therapy in people with asthma?

    achieve control of asthma and prevent asthma attacks. Published evidence in patients with severe asthma suggests that at least 30% of...

  7. Audit:- What is the clinical and cost effectiveness of collecting long-term outcomes in a national trauma audit system?

    collected on clinical observations, timing and staffing in the acute phase in patients who are treated at a major trauma centre. Data on...

  8. The frequency and effects of biphasic reactions:- What are the frequency, timing, severity and predictors of biphasic reactions in people who have received emergency treatment for anaphylaxis?

    recommended that a UK-based prospective cohort study be conducted that follows patients up after emergency treatment for anaphylaxis....

  9. Safety and efficacy of carotid stenting: What is the safety and efficacy of carotid stenting compared with carotid endarterectomy when these procedures are carried out within 2 weeks of TIA or recovered stroke?

    invasive than carotid endarterectomy and might be safer, particularly for patients very soon after a TIA or stroke, for whom the risks...

  10. What is the effectiveness and safety of a treatment dose with a low molecular weight heparin (LMWHs) compared with a standard prophylactic dose for venous thromboembolism (VTE) prophylaxis in young people under 18 years with COVID-19?

    Suggested PICO (Population, Intervention, Comparator, Outcome) P: patients 18 years and under who have COVID-19 pneumonia I:...

  11. What are the frequency, timing, severity and predictors of biphasic reactions in people who have received emergency treatment for anaphylaxis?

    recommended that a UK-based prospective cohort study be conducted that follows patients up after emergency treatment for anaphylaxis....

  12. Monitoring inhaler technique:- What is the current frequency and the current method being used to check the inhaler technique of people with asthma? What is the optimal frequency and the best method of checking inhaler technique to improve clinical outcomes for people with asthma?

    on their own and in a combination of 2 drugs. It is therefore vital for patients to learn the proper inhaler technique for their device...

  13. What is the effectiveness and safety of extended pharmacological venous thromboembolism (VTE) prophylaxis for people who have been discharged after treatment for COVID-19?

    Suggested PICO (Population, Intervention, Comparator, Outcome) P: patients 16 years and over who have been discharged after treatment...

  14. Intra-aortic balloon counter‑pulsation: In people with acute heart failure and hypoperfusion syndrome, is the use of intra‑aortic balloon counter‑pulsation pump (IABP) better than the use of intravenous inotropes?

    uncertain whether it can provide clinical benefit in the critically unwell patients with acute heart failure due to left ventricular...

  15. Long-term effects of IVF with or without intracytoplasmic sperm injection in children:- What are the long-term (over 20 years) effects of IVF with or without intracytoplasmic sperm injection (ICSI) in children in the UK?

    applicable) Why this is important:- This topic is important in informing patients, service providers and society at large about the...

  16. Technology appraisal committee D members

    Find out more about NICE technology appraisals advisory committee D members

  17. Compression as a management option:- What is the clinical and cost effectiveness of compression hosiery versus no compression for the management of symptomatic varicose veins?

    multicentre trial randomising compression hosiery versus no compression in patients with symptomatic varicose veins is needed. The trial...

  18. Using GP practice lists to identify people at high risk:- What is the clinical and cost effectiveness of using GP practice lists to identify people at high risk of fracture, leading to formal risk assessment and possible treatment?

    computerised and contain information that may be useful in identifying patients at high risk of fracture (for example, age, record of...

  19. Oral health promotion advice:- For groups at high risk of poor oral health, how effective and cost effective is it to extend an existing appointment by a few minutes, or to offer separate sessions on oral health advice?

    general dental practices already give some advice about self-care during a patient's dental check-up or treatment. The economic...

  20. Access to medicines:- Does the use of directly observed supply of named high-risk medicines (that is, not supplying the medicines to people to hold in-possession), reduce diversion, abuse and non-adherence?

    observed administration is reserved for high-risk medicines and vulnerable patients. But different medicines are categorised as high...

  21. Managing glioma: early detection of recurrence after treatment:- Does early detection of recurrence after treatment improve overall survival/outcomes inmolecularly stratified glioma?

    identifying recurrence early is outweighed by the harms of increasing burden to patients.To find out why the committee made the research...

  22. What is the effectiveness and safety of standard-dose compared with intermediate-dose pharmacological venous thromboembolism (VTE) prophylaxis for people with COVID-19, with or without additional risk factors for VTE?

    Suggested PICO (Population, Intervention, Comparator, Outcome) P: patients 16 years and over being treated for COVID-19 pneumonia in...

  23. What are the appropriate indications, effectiveness and safety of LDL apheresis in people with heterozygous FH?

    there is limited published evidence on the cardiovascular outcome of such patients treated with LDL apheresis. Evidence on the value of...

  24. Negative pressure wound therapy:- Does negative pressure wound therapy (with appropriate dressing) improve the healing of pressure ulcers, compared with the use of dressing alone in adults with pressure ulcers?

    hired negative pressure wound therapy pumps. There would be benefits to patients and the NHS in establishing whether negative pressure...

  25. Percutaneous laser therapy for fetal tumours (IPG180)

    Evidence-based recommendations on percutaneous laser therapy for fetal tumours. This involves inserting a needle through the mother's abdomen to the tumour and using laser energy to shrink it.

  26. Fetal cystoscopy for the diagnosis and treatment of lower urinary outflow tract obstruction (IPG205)

    Evidence-based recommendations on fetal cystoscopy for the diagnosis and treatment of lower urinary outflow tract obstruction. This involves inserting a tube with a flexible camera through small cuts in the mother's abdomen to identify and open any blockage.

  27. Avoidance of aspiration pneumonia: Does the withdrawal of oral liquids or the use of modified (thickened) oral fluids prevent the development of aspiration pneumonia after an acute stroke?

    litres/day) may be infected as a result. Medications are not given orally, and patients may be distressed by the withholding of oral...

  28. Seroprevalence of Lyme disease-specific antibodies and other tick-borne infections in the UK population:- What is the current seroprevalence of Lyme disease-specific antibodies and other tick-borne infections in people in the UK?

    disease is spreading and becoming more common. This will be of benefit to patients affected by Lyme disease and healthcare workers...

  29. Infantile spasms: Does treatment response relate to cause in infantile spasms? Does early treatment success in seizure control and resolution of the hypsarrhythmic EEG influence the long-term developmental and cognitive outcomes more than the underlying cause of the spasms?

    based on both cause and treatment lag; this would require large numbers of patients and would need to be multicentre, possibly involving...

  30. Point-of-care coagulation testing:- What is the clinical and cost effectiveness of point-of-care coagulation testing using rotational thromboelastometry (ROTEM) or thromboelastography (TEG) to target treatment, compared with standard laboratory coagulation testing?

    reduce mortality from haemorrhage, which is the main cause of death in patients with major trauma. Point-of-care ROTEM and TEG are...

  31. Mental health interventions to support discharge from general inpatient hospital settings:- What interventions are cost effective in supporting people with mental health difficulties on discharge from general hospital inpatient settings?

    the cost of assessment while in hospital is particularly important for patients with dementia or delirium because early identification...

  32. NICE's backing of the prostate cancer drug abiraterone could help thousands and save the NHS millions

    Our landmark review demonstrates a new approach to keeping NHS care up-to-date and could benefit thousands of adults with metastatic prostate cancer.

  33. Antimicrobials evaluation panel members

    Read the biographies for all members of the NICE antimicrobial evaluation committee.

  34. 5-aminosalicylate (5-ASA) treatment:- Following successful medical induction of remission of Crohn's disease of the colon, is mesalazine more clinically and cost effective than no treatment?

    to induce remission in a first presentation of colonic Crohn's disease. Patients would be recruited once in remission and...

  35. Anti-reflux therapy as a treatment for idiopathic pulmonary fibrosis:- Is anti-reflux therapy an effective treatment for idiopathic pulmonary fibrosis?

    life (ideally employing a tool validated in idiopathic pulmonary fibrosis patients). Phase III trials should include a health economic...

  36. Dopamine: In people with acute heart failure, congestion and worsening renal function, does the addition of low‑dose dopamine to standard therapy lead to greater diuresis and renal protection compared with adding placebo to standard therapy?

    water excretion. Clinical trials have not yet resolved whether in some patients, the use of low‑dose dopamine actually results in...

  37. Fluid balance charts:- For children and young people receiving IV fluids, does the use of a standardised national fluid balance chart reduce the rate of complications arising as a result of prescription and/or administration errors?

    Deaths reports in 1999 and 2009 identified problems in fluid management in patients in the UK. A lack of consistency in prescribing and...

  38. Specialised units for older people:- What is the most clinically and cost effective way to configure services to assess frail older people who present to hospital with a medical emergency?

    people. Hospital services have adapted to the growing population of older patients by introducing liaison services such as Frail Older...

  39. Jejunostomy support after radical surgery:- What is the effectiveness of long-term jejunostomy support compared to intensive dietary counselling and support along with symptom management for people having radical surgery for oesophago-gastric cancer?

    It is well recognised that they have a poor quality of life (QoL). Most patients have adjuvant treatment, however their nutritional...

  40. Intensive rehabilitation therapies after hip fracture: What is the clinical and cost effectiveness of additional intensive physiotherapy and/or occupational therapy (for example, progressive resistance training) after hip fracture?

    and cost effectiveness. The ideal sample size will be around 400 to 500 patients, and the primary outcome should be physical function...

  41. Chemical sympathectomy for managing critical limb ischaemic pain:- What is the clinical and cost effectiveness of chemical sympathectomy in comparison with other methods of pain control for managing critical limb ischaemic pain?

    reduce pain and improve wound healing, and may prevent amputation in some patients. Initially achieved surgically, it is now most...