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Showing 4701 to 4750 of 8238 results

  1. Evidence on the safety of focal therapy using high-intensity focused ultrasound for localised prostate cancer is adequate, but evidence on its efficacy is limited. Therefore, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Find out what special arrangements mean on the NICE interventional procedures guidance page.

    Recommendation ID IPG756/1 Question Evidence on the safety of focal therapy using high-intensity focused ultrasound for localised prostate

    Research recommendation
    Published
    5 May 2023

  2. Evidence on the safety of genicular artery embolisation for pain from knee osteoarthritis shows no major safety concerns in the short term. Evidence on its efficacy and long-term safety is inadequate in quality and quantity. Therefore, this procedure should only be used in the context of research. Find out what only in research means on the NICE interventional procedures guidance page. Research should preferably be randomised controlled trials against sham and current best practice. It should report details of patient selection and identify those who would most benefit from this procedure. It should also report details of the technique used, long-term safety, and patient-reported outcomes. The procedure should only be done by interventional radiologists with specific training in this technique.

    Recommendation ID IPG708/01 Question Evidence on the safety of genicular artery embolisation for pain from knee osteoarthritis shows no

    Research recommendation
    Published
    5 November 2021

  3. Evidence on the safety of laparoscopic removal of uterine fibroids with power morcellation shows potentially serious complications. In particular there is a risk of spreading undiagnosed malignant tissue, which has higher prevalence in people who are postmenopausal or over 50. Evidence on the procedure's efficacy is limited in quantity. Therefore, further research should report details of patient selection, surgical technique (including any containment system used) and long-term outcomes.

    Recommendation ID IPG703/1 Question Evidence on the safety of laparoscopic removal of uterine fibroids with power morcellation shows potentially

    Research recommendation
    Published
    30 September 2021

  4. Evidence on the safety of long-term tunnelled peritoneal drainage catheter insertion for refractory ascites in cirrhosis is limited but shows well-recognised complications. Evidence on the efficacy is limited in quantity and quality. Therefore, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Find out what special arrangements mean on the NICE interventional procedures guidance page.

    Recommendation ID IPG746/01 Question Evidence on the safety of long-term tunnelled peritoneal drainage catheter insertion for refractory

    Research recommendation
    Published
    12 December 2022

  5. Evidence on the safety of magnetic resonance therapy for knee osteoarthritis shows no major safety concerns. Evidence on efficacy is inadequate in quality and quantity and shows no benefit over placebo. Therefore, this procedure should not be used unless it is part of a research study. Further research should be in the form of appropriately powered randomised  controlled trials comparing the procedure with placebo. It should report patient  selection and treatment protocols, including the number of sessions and  magnetic field strength.

    Recommendation ID IPG702/1 Question Evidence on the safety of magnetic resonance therapy for knee osteoarthritis shows no major safety

    Research recommendation
    Published
    30 September 2021

  6. Evidence on the safety of microwave ablation for treating primary lung cancer and metastases in the lung is adequate but shows it can cause infrequent serious complications. Evidence on its efficacy shows it reduces tumour size. But the evidence on improvement in survival, long-term outcomes and quality of life is limited in quantity and quality. Therefore, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Find out what special arrangements mean on the NICE interventional procedures guidance page. Further research should be randomised controlled trials or disease registry studies. It should report patient selection, disease progression and quality of life, and take account of the effectiveness of managing oligometastatic disease in patients.

    Recommendation ID IPG716/01 Question Evidence on the safety of microwave ablation for treating primary lung cancer and metastases in the

    Research recommendation
    Published
    24 March 2022

  7. Evidence on the safety of repetitive short-pulse transscleral cyclophotocoagulation for glaucoma shows no major safety concerns. Evidence on efficacy is inadequate in quality. Therefore, this procedure should only be used in the context of research. Find out what only in research means on the NICE website.

    Recommendation ID IPG692/1 Question Evidence on the safety of repetitive short-pulse transscleral cyclophotocoagulation for glaucoma shows

    Research recommendation
    Published
    16 August 2021

  8. Evidence on the safety of transcutaneous electrical neuromuscular stimulation for urinary incontinence raises no major safety concerns. Evidence on its efficacy is limited in quantity and quality. Therefore, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Find out what special arrangements mean on the NICE interventional procedures guidance page.

    Recommendation ID IPG735/01 Question Evidence on the safety of transcutaneous electrical neuromuscular stimulation for urinary incontinence

    Research recommendation
    Published
    7 September 2022

  9. Expectant management before IVF:- What is the optimum period of expectant management for women of different age groups before invasive treatment such as IVF is considered?

    Recommendation ID CG156/1 Question Expectant management before IVF:- What is the optimum period of expectant management for women of different

    Research recommendation
    Published
    9 June 2015

  10. Exposure to air pollution using different modes of transport How does altering a person's mode of transport and route affect their personal exposure to air pollution?

    Recommendation ID NG70/6 Question Exposure to air pollution using different modes of transport How does altering a person's mode of transport

    Research recommendation
    Published
    12 October 2018

  11. For women who are having medical abortion between 10 +1   and 12 +0  weeks, what is the efficacy and acceptability of expulsion at home compared with expulsion in a clinical setting?

    Recommendation ID NG140/4 Question For women who are having medical abortion between 10 +1 and 12 +0 weeks, what is the efficacy and

    Research recommendation
    Published
    8 November 2019

  12. Facilitators and barriers to carrying out daily mouth care and oral health assessments for adults in care homes:- What are the facilitators and barriers to delivering daily oral care and conducting oral health assessments in residential and nursing care homes?

    Recommendation ID NG48/6 Question Facilitators and barriers to carrying out daily mouth care and oral health assessments for adults in

    Research recommendation
    Published
    24 August 2016

  13. Duration and intensity of home-based intermediate care:- How effective and cost effective are different approaches, in terms of duration and intensity, to providing home-based intermediate care for adults?

    Recommendation ID NG74/7 Question Duration and intensity of home-based intermediate care:- How effective and cost effective are different

    Research recommendation
    Published
    15 October 2018

  14. Duration and intensity of psychological treatment:- What is the effectiveness of treating eating disorders with psychological treatments of reduced duration and reduced intensity, compared with standard treatment?

    Recommendation ID NG69/2 Question Duration and intensity of psychological treatment:- What is the effectiveness of treating eating disorders

    Research recommendation
    Published
    12 October 2018

  15. During this appraisal it was noted that there is a need for additional research on the management of bleeds that occur while people are receiving apixaban, rivaroxaban or dabigatran etexilate, as there are no antidotes or established treatments to stop active bleeding for these agents.

    Recommendation ID TA275/1 Question During this appraisal it was noted that there is a need for additional research on the management of

    Research recommendation
    Published
    10 August 2021

  16. Early help home visiting:- What are the components of effective home visiting programmes for preventing child abuse and neglect in families of children and young people at risk of child abuse and neglect in the UK?

    Recommendation ID NG76/4 Question Early help home visiting:- What are the components of effective home visiting programmes for preventing

    Research recommendation
    Published
    18 October 2018

  17. Early interventions to prevent problems escalating:- What interventions are effective in diverting children and young people away from further harmful sexual behaviour before a legal response is needed?

    Recommendation ID NG55/4 Question Early interventions to prevent problems escalating:- What interventions are effective in diverting children

    Research recommendation
    Published
    17 October 2016

  18. Early revascularisation strategy for people with angina and multivessel disease:- In people with stable angina and multivessel disease (including left main stem disease) whose symptoms are controlled with optimal drug treatment, would an initial treatment strategy of revascularisation be clinically and cost effective compared with continued drug treatment?

    Recommendation ID CG126/3 Question Early revascularisation strategy for people with angina and multivessel disease:- In people with stable

    Research recommendation
    Published
    9 June 2015

  19. Does early review of service provision and referral to additional specialist palliative care services improve outcomes for adults with progressive non-cancer disease thought to be approaching the end of their life?

    Recommendation ID NG142/1 Question Does early review of service provision and referral to additional specialist palliative care services

    Research recommendation
    Published
    18 November 2019

  20. E-cigarettes and established future smoking: Is e‑cigarette use in children, young people and young adults who do not smoke associated with future established smoking?

    Recommendation ID NG209/09 Question E-cigarettes and established future smoking: Is e‑cigarette use in children, young people and young

    Research recommendation
    Published
    17 December 2021

  21. What is the role of educational models and psycho-behavioural interventions in prevention of diabetic foot complications?

    Recommendation ID NG19/3 Question What is the role of educational models and psycho-behavioural interventions in prevention of diabetic

    Research recommendation
    Published
    15 November 2019

  22. When and with what criteria should people with diabetes be referred to the foot protection service or the multidisciplinary foot care service?

    Recommendation ID NG19/2 Question When and with what criteria should people with diabetes be referred to the foot protection service or

    Research recommendation
    Published
    15 November 2019

  23. Education and psycho-behavioural interventions for prevention:- What is the role of educational models and psycho-behavioural interventions in prevention of diabetic foot complications?

    Recommendation ID NG19/3 Question Education and psycho-behavioural interventions for prevention:- What is the role of educational models

    Research recommendation
    Published
    12 October 2015

  24. Effective interventions for children and young people who have experienced online-facilitated abuse, including online grooming:- What interventions are effective and cost effective in improving the wellbeing of children and young people who have experienced online-facilitated abuse, including grooming online?

    Recommendation ID NG76/8 Question Effective interventions for children and young people who have experienced online-facilitated abuse,

    Research recommendation
    Published
    18 October 2018

  25. What  components   and  characteristics   of digital and mobile health behaviour change interventions are most effective, separately and in combination, to achieve behaviour change?

    Recommendation ID NG183/2 Question What components and characteristics of digital and mobile health behaviour change interventions

    Research recommendation
    Published
    26 October 2020

  26. Effective interventions for parents or carers with substance misuse problems:- What interventions, including family behaviour therapy, are effective and cost effective inimproving parenting and preventing recurrence of neglect by parents or carers with substance misuse problems and whose children are on a child protection plan under the category of neglect in the UK?

    Recommendation ID NG76/13 Question Effective interventions for parents or carers with substance misuse problems:- What interventions, including

    Research recommendation
    Published
    18 October 2018

  27. Effective interventions for addressing child abuse and neglect in the UK:- What interventions, approaches and methodologies provided by social care and voluntary sectorservices are effective and cost effective in the UK to prevent the recurrence of child abuse and neglect, and to improve the wellbeing of children, young people and families?

    Recommendation ID NG76/9 Question Effective interventions for addressing child abuse and neglect in the UK:- What interventions, approaches

    Research recommendation
    Published
    18 October 2018

  28. Chemoprevention to reduce incidence of breast cancer:- A randomised controlled trial is recommended to compare the clinical and cost effectiveness of aromatase inhibitors and tamoxifen for reducing the incidence of breast cancer in women with a family history of breast or ovarian cancer. [new 2013]

    Recommendation ID CG164/4 Question Chemoprevention to reduce incidence of breast cancer:- A randomised controlled trial is recommended

    Research recommendation
    Published
    9 June 2015

  29. What is the clinical and cost effectiveness of cannabis-based medicinal products as an add-on treatment in babies, children and young people with chemotherapy-induced nausea or vomiting which persists with optimised conventional antiemetics?

    Recommendation ID NG144/7 Question What is the clinical and cost effectiveness of cannabis-based medicinal products as an add-on treatment

    Research recommendation
    Published
    10 February 2020

  30. What is the clinical and cost effectiveness of cannabis-based medicinal products as an add-on treatment for adults with chemotherapy-induced nausea and vomiting which persists with optimised conventional antiemetics?

    Recommendation ID NG144/6 Question What is the clinical and cost effectiveness of cannabis-based medicinal products as an add-on treatment

    Research recommendation
    Published
    10 February 2020

  31. Children and young people aged 5 to 18 years – brief, group-based, ADHDfocused, parent-training intervention What is the clinical and cost effectiveness, and optimum length, of a brief parent-training intervention for parents and carers of children and young people with attention deficit hyperactivity disorder (ADHD) aged 5 to 18 years?

    Recommendation ID NG87/1 Question Children and young people aged 5 to 18 years – brief, group-based, ADHDfocused, parent-training intervention What

    Research recommendation
    Published
    14 November 2018

  32. Children and young people in transition between settings:- What is the effect of specific interventions to support children and young people during transition between inpatient mental health settings and community or care home settings? Is there any particular benefit for black, Asian and minority ethnic communities?

    Recommendation ID NG53/3 Question Children and young people in transition between settings:- What is the effect of specific interventions

    Research recommendation
    Published
    17 October 2016

  33. Chronic conditions:- What is the prevalence of disease in the UK prison population?

    Recommendation ID NG57/2 Question Chronic conditions:- What is the prevalence of disease in the UK prison population? Any explanatory

    Research recommendation
    Published
    16 November 2017

  34. For children and young people with intractable cancer-related pain and pain associated with specific diseases (such as epidermolysis bullosa), what is the clinical and cost effectiveness of cannabis-based medicinal products as an add-on to standard treatment to improve symptoms compared with treatment with standard care?

    Recommendation ID NG144/2 Question For children and young people with intractable cancer-related pain and pain associated with specific

    Research recommendation
    Published
    10 February 2020

  35. Clean air zones:- How do different elements of a clean air zone interact to improve air quality and what is the overall effect on people's health?

    Recommendation ID NG70/3 Question Clean air zones:- How do different elements of a clean air zone interact to improve air quality and what

    Research recommendation
    Published
    12 October 2018

  36. Clinical predictors of non-IgE-mediated food allergy:- Which features in the clinical history best predict the presence of non-IgEmediated food allergy in children and young people in primary care and community settings?

    Recommendation ID CG116/2 Question Clinical predictors of non-IgE-mediated food allergy:- Which features in the clinical history best predict

    Research recommendation
    Published
    9 June 2015

  37. Clinical trials should be conducted comparing ticagrelor with prasugrel in people with acute coronary syndromes (ACS).

    Recommendation ID TA236/1 Question Clinical trials should be conducted comparing ticagrelor with prasugrel in people with acute coronary

    Research recommendation
    Published
    9 June 2015

  38. Clinicians are encouraged to collect long-term data on clinical outcomes and patient-reported quality-of-life outcomes using validated scales. NICE may update the guidance on publication of further evidence.

    Recommendation ID IPG581/1 Question Clinicians are encouraged to collect long-term data on clinical outcomes and patient-reported quality-of-life

    Research recommendation
    Published
    12 October 2018

  39. Clinicians are encouraged to collect long-term data on clinical outcomes and patient-reported quality-of-life outcomes using validated scales. NICE may update the guidance on publication of further evidence into infracoccygeal sacropexy using mesh to repair uterine prolapse.

    Recommendation ID IPG582/1 Question Clinicians are encouraged to collect long-term data on clinical outcomes and patient-reported quality-of-life

    Research recommendation
    Published
    12 October 2018

  40. Individual circumstances and the risk of dependence: Do individual circumstances such as social distress, low income or limited access to alternative sources of support lead to an increased risk of problems associated with dependence on prescribed medicines?

    Recommendation ID NG215/04 Question Individual circumstances and the risk of dependence: Do individual circumstances such as social distress

    Research recommendation
    Published
    11 May 2022

  41. Do needle and syringe programmes have any unintended consequences: Do they increase the uptake, frequency and length of injecting drug use? Does the provision of disposal facilities (for example, drop-boxes) affect the amount of drug-related litter in an area? Do they have a negative impact on the local community, for example, in terms of crime rates or the fear of crime?

    Recommendation ID PH52/5 Question Do needle and syringe programmes have any unintended consequences: Do they increase the uptake, frequency

    Research recommendation
    Published
    9 June 2015

  42. Follow-up care after bariatric surgery: Do post-operative lifestyle intervention programmes (exercise, behavioural or dietary) improve weight loss and weight-loss maintenance following bariatric surgery?

    Recommendation ID CG189/03 Question Follow-up care after bariatric surgery: Do post-operative lifestyle intervention programmes (exercise

    Research recommendation
    Published
    30 September 2022

  43. Do primary care practitioners use NICE guidance when encouraging people to be physically active?

    Recommendation ID PH44/6 Question Do primary care practitioners use NICE guidance when encouraging people to be physically active?

    Research recommendation
    Published
    9 June 2015

  44. What is the clinical and cost effectiveness of dosimetry-guided radioactive iodine strategies for hyperthyroidism?

    Recommendation ID NG145/5 Question What is the clinical and cost effectiveness of dosimetry-guided radioactive iodine strategies for hyperthyroidism

    Research recommendation
    Published
    10 February 2020

  45. System-level factors and the risk of dependence: Do system-level factors, such as training received by prescribers alter the risk of developing problems associated with dependence on prescribed medicines?

    Recommendation ID NG215/06 Question System-level factors and the risk of dependence: Do system-level factors, such as training received

    Research recommendation
    Published
    11 May 2022

  46. E-cigarette flavours: Do the flavours used in nicotine-containing e‑cigarettes have an impact on their effectiveness as an aid to stopping smoking, and are there any adverse effects associated with them?

    Recommendation ID NG209/08 Question E-cigarette flavours: Do the flavours used in nicotine-containing e‑cigarettes have an impact on their

    Research recommendation
    Published
    17 December 2021

  47. Symptoms and signs of recurrent UTI:  Do the symptoms and signs of UTI in babies, children and young people aged under 16 years differ in those with a history of recurrent UTIs compared with those without a history of recurrent UTI?

    Recommendation ID NG224/03 Question Symptoms and signs of recurrent UTI: Do the symptoms and signs of UTI in babies, children and young

    Research recommendation
    Published
    4 August 2022

  48. Drainage, irrigation and fibrinolytic therapy (DRIFT) for post-haemorrhagic hydrocephalus in preterm infants should only be used in the context of research. Research should aim to establish the risk of secondary haemorrhage and its consequences, and the need for shunt insertion. Outcomes should include death and disability in the long-term: these should be reported separately.

    Recommendation ID IPG412/1 Question Drainage, irrigation and fibrinolytic therapy (DRIFT) for post-haemorrhagic hydrocephalus in preterm

    Research recommendation
    Published
    9 June 2015

  49. What is the most clinically and cost-effective dual antiplatelet therapy for people aged 75 and over with an acute coronary syndrome, who are having percutaneous coronary intervention (PCI)?

    Recommendation ID NG185/1 Question What is the most clinically and cost-effective dual antiplatelet therapy for people aged 75 and over

    Research recommendation
    Published
    22 January 2021

  50. In patients with negative MRI (Likert score 1 or 2), what is the next best diagnostic investigation to rule out clinically significant prostate cancer? What is the diagnostic accuracy of transperineal mapping biopsy compared with transperineal non-mapping biopsy in the diagnosis of clinically significant prostate cancer?

    Recommendation ID NG131/7 Question In patients with negative MRI (Likert score 1 or 2), what is the next best diagnostic investigation

    Research recommendation
    Published
    25 October 2019