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Showing 4851 to 4900 of 8238 results

  1. Public transport provision and ticketing:- How effective and cost effective are changes to public transport provision and ticketing in creating and sustaining an increase in physical activity at a population level?

    Recommendation ID NG90/1 Question Public transport provision and ticketing:- How effective and cost effective are changes to public transport

    Research recommendation
    Published
    15 November 2018

  2. How effective and cost effective are different types of exercise referral scheme? Compare the relative effects of different models in controlled studies. Include health-related quality of life as an outcome. Compare exercise referral schemes that vary by: - setting – for example, home-based, gym-based, community-based or outdoors - intensity and duration – for example, a 12-week scheme involving 1 session a week, or a 6-week scheme involving 4 1-hour sessions per week - the techniques used, for example, some use additional 'supportive' techniques such as 'motivational interviewing' and education sessions - the target group, for example, people who are overweight and obese, people with raised blood pressure or cholesterol levels or those experiencing mild depression, anxiety or stress; or by age, gender, race or socioeconomic status - other scheme characteristics including: design, content and delivery; referral mechanisms; choice of activity; cost and qualifications of instructors; and whether it is commissioned and delivered by an NHS, non-NHS or community-based organisation.

    Recommendation ID PH54/1 Question How effective and cost effective are different types of exercise referral scheme? Compare the relative

    Research recommendation
    Published
    9 June 2015

  3. How effective and cost effective are different types of intervention to prevent a range of cold-related illnesses and death? How do these vary with groups in different circumstances?

    Recommendation ID NG6/3 Question How effective and cost effective are different types of intervention to prevent a range of cold-related

    Research recommendation
    Published
    9 June 2015

  4. Effectiveness of digital technologies:- How effective and cost effective are digital technologies, such as web-based interventions, online self-assessment or targeted new media, for drug misuse prevention among groups at risk in the UK?

    Recommendation ID NG64/5 Question Effectiveness of digital technologies:- How effective and cost effective are digital technologies, such

    Research recommendation
    Published
    4 May 2017

  5. People with limited mobility:- How effective and cost effective are environmental changes to increase physical activity among people with limited mobility because of either enduring or life-stage specific factors (for example, small children, parents with prams or buggies, disabled people including those with sensoryimpairments and learning disabilities, older people, people with dementia and their carers)? Are effects maintained over time?

    Recommendation ID NG90/4 Question People with limited mobility:- How effective and cost effective are environmental changes to increase

    Research recommendation
    Published
    15 November 2018

  6. NICE encourages the peer-reviewed publication of all further research for percutaneous balloon valvuloplasty for fetal critical aortic stenosis. Further research could be in the form of controlled trials, analysis of registry data or other observational studies. It should address patient selection, timing of the intervention and the natural history of the disease.

    Recommendation ID IPG613/1 Question NICE encourages the peer-reviewed publication of all further research for percutaneous balloon valvuloplasty

    Research recommendation
    Published
    10 December 2018

  7. NICE highlighted the importance of collecting further data within registries of patients receiving biological treatments for psoriatic arthritis to obtain information on long-term outcomes, including adverse events.

    Recommendation ID TA220/1 Question NICE highlighted the importance of collecting further data within registries of patients receiving biological

    Research recommendation
    Published
    9 June 2015

  8. NICE noted that the cost effectiveness of lenalidomide compared with standard care for people with low- or intermediate-1-risk MDS associated with an isolated deletion 5q cytogenetic abnormality when other therapeutic options are insufficient or inadequate, was sensitive to whether the patient access scheme would be realised in clinical practice. The Committee agreed that it would be critical to generate evidence to support the following: - The proportion of people who become eligible for the patient access scheme, that is, that they remain on treatment beyond 26 cycles. - The benefit of lenalidomide after 26 cycles, that is the associated overall survival and health related quality of life for those who remain on treatment beyond 26 cycles.

    Recommendation ID TA322/1 Question NICE noted that the cost effectiveness of lenalidomide compared with standard care for people with low-

    Research recommendation
    Published
    9 June 2015

  9. NICE proposes that a clinical trial is needed to establish the relative effectiveness of mannitol compared with hypertonic saline.

    Recommendation ID TA266/1 Question NICE proposes that a clinical trial is needed to establish the relative effectiveness of mannitol compared

    Research recommendation
    Published
    9 June 2015

  10. NICE recognised the importance of further clinical trials comparing the effectiveness of the tyrosine kinase inhibitors (afatinib, erlotinib and gefitinib) in EGFR mutation-positive locally advanced or metastatic NSCLC.

    Recommendation ID TA310/1 Question NICE recognised the importance of further clinical trials comparing the effectiveness of the tyrosine

    Research recommendation
    Published
    9 June 2015

  11. NICE recommended that clinical data, including genotype and sustained virological response at 12 weeks, are collected for all people having treatment with simeprevir in the NHS.

    Recommendation ID TA333/1 Question NICE recommended that clinical data, including genotype and sustained virological response at 12 weeks

    Research recommendation
    Published
    9 June 2015

  12. NICE recommended that clinical data, including genotype and sustained virological response at 12 weeks, is collected for all people treated with sofosbuvir in the NHS.

    Recommendation ID TA330/1 Question NICE recommended that clinical data, including genotype and sustained virological response at 12 weeks

    Research recommendation
    Published
    9 June 2015

  13. NICE recommended that further research should be designed to generate robust evidence of the clinical- and cost-effectiveness of Holoclar for treating both eyes in people with bilateral limbal stem cell deficiency after eye burns if they do not have enough tissue for a conjunctival limbal autograft. The study should recruit people with bilateral disease and evaluate the effectiveness of treatment in both eyes. Outcomes should include transplant success and assessments of health-related quality of life using a generic preference-based measure.

    Recommendation ID TA467/2 Question NICE recommended that further research should be designed to generate robust evidence of the clinical-

    Research recommendation
    Published
    15 October 2018

  14. NICE recommended that research should be carried out to determine the relationship between activity and prosthesis failure.

    Recommendation ID TA304/1 Question NICE recommended that research should be carried out to determine the relationship between activity

    Research recommendation
    Published
    9 June 2015

  15. NICE recommended the collection of data on prosthesis failure or on the prevalence of people living with a failed hip but for whom revision surgery is not suitable or who choose not to have revision surgery. NICE further recommended that nomenclature for hip replacement failure needs to be established to allow demarcation of prosthesis-dependent and prosthesisindependent hip replacement failure. Furthermore, patient reported outcome measures collected as part of the National Joint Registry should allow for reporting of hip replacement failure in people who cannot or choose not to have revision surgery.

    Recommendation ID TA304/2 Question NICE recommended the collection of data on prosthesis failure or on the prevalence of people living

    Research recommendation
    Published
    9 June 2015

  16. NICE recommends further research to better inform future cost-effectiveness models of relapsing-remitting multiple sclerosis. In particular, this research should include a more comprehensive synthesis of available evidence on the underlying disease progression of multiple sclerosis in the UK context, the impact of disability and relapses on preference-based measures of quality of life, and associated resource use and costs.

    Recommendation ID TA320/1 Question NICE recommends further research to better inform future cost-effectiveness models of relapsing-remitting

    Research recommendation
    Published
    9 June 2015

  17. Morphine compared with ketamine for first-line management of pain:- Is morphine clinically and cost effective compared with ketamine for first-line pharmacological pain management (in both pre-hospital and hospital settings) in patients with major trauma?

    Recommendation ID NG39/3 Question Morphine compared with ketamine for first-line management of pain:- Is morphine clinically and cost effective

    Research recommendation
    Published
    21 March 2016

  18. Motivating dental practice teams to take a preventive approach:- What would motivate dental practice teams to take a preventive approach to oral health – especially with high risk groups – and how does this fit into the dental practice business model?

    Recommendation ID NG30/5 Question Motivating dental practice teams to take a preventive approach:- What would motivate dental practice

    Research recommendation
    Published
    28 January 2016

  19. MRI-guided laser interstitial thermal therapy for drug-resistant epilepsy Interventional procedures guidance

    Recommendation ID IPG671/1 Question MRI-guided laser interstitial thermal therapy for drug-resistant epilepsy Interventional procedures

    Research recommendation
    Published
    17 March 2020

  20. Mucoactive agents:- What is the most clinically and cost-effective dose of rhDNase (dornase alfa; recombinant human deoxyribonuclease) for people with cystic fibrosis?

    Recommendation ID NG78/6 Question Mucoactive agents:- What is the most clinically and cost-effective dose of rhDNase (dornase alfa; recombinant

    Research recommendation
    Published
    18 October 2018

  21. Multidimensional assessment of outcomes- How can the individual factors associated with COPD prognosis (collected from a range of sources including primary care, imaging and pulmonary rehabilitation results) be combined into a multidimensional analysis that provides accurate and useful information on prognosis?

    Recommendation ID NG115/2 Question Multidimensional assessment of outcomes- How can the individual factors associated with COPD prognosis

    Research recommendation
    Published
    6 February 2019

  22. Is the use of chlorhexidine body wash associated with increased antimicrobial resistance?

    Recommendation ID NG125/2 Question Is the use of chlorhexidine body wash associated with increased antimicrobial resistance? Any

    Research recommendation
    Published
    16 August 2019

  23. What is the clinical effectiveness of preoperative nasal decolonisation using mupirocin in combination with a chlorhexidine body wash in the whole population?

    Recommendation ID NG125/1 Question What is the clinical effectiveness of preoperative nasal decolonisation using mupirocin in combination

    Research recommendation
    Published
    16 August 2019

  24. What is the contribution to clinical effectiveness of the timing of nasal decolonisation and body wash for the prevention of surgical site infection?

    Recommendation ID NG125/6 Question What is the contribution to clinical effectiveness of the timing of nasal decolonisation and body wash

    Research recommendation
    Published
    26 October 2020

  25. Nasal suction:- What is the clinical and cost effectiveness of suction to remove secretions from the upper respiratory tract compared with minimal handling?

    Recommendation ID NG9/5 Question Nasal suction:- What is the clinical and cost effectiveness of suction to remove secretions from the upper

    Research recommendation
    Published
    6 October 2015

  26. National pre-hospital triage tool:- A national pre-hospital triage tool for major trauma should be developed and validated.

    Recommendation ID NG40/4 Question National pre-hospital triage tool:- A national pre-hospital triage tool for major trauma should be developed

    Research recommendation
    Published
    4 April 2016

  27. What is the natural history of post-COVID-19 syndrome?

    Recommendation ID NG188/5 Question What is the natural history of post-COVID-19 syndrome? Any explanatory notes(if applicable)

    Research recommendation
    Published
    12 November 2021

  28. Natural history of progression to colorectal cancer in people at increased risk:- What is the natural history of progression to colorectal cancer in people with inflammatory bowel disease (IBD) or adenomas?

    Recommendation ID CG118/2 Question Natural history of progression to colorectal cancer in people at increased risk:- What is the natural

    Research recommendation
    Published
    9 June 2015

  29. What is the natural history of people with a Likert score on MRI of less than 3 without biopsy at long-term follow‑up?

    Recommendation ID NG131/5 Question What is the natural history of people with a Likert score on MRI of less than 3 without biopsy at long-term

    Research recommendation
    Published
    25 October 2019

  30. NICE concluded that further research directly comparing the clinical and cost effectiveness of ranibizumab and bevacizumab in people with macular oedema secondary to retinal vein occlusion should be conducted.

    Recommendation ID TA283/1 Question NICE concluded that further research directly comparing the clinical and cost effectiveness of ranibizumab

    Research recommendation
    Published
    9 June 2015

  31. NICE considered that if enzalutamide is used in routine clinical practice for treating hormone relapsed metastatic prostate cancer that has been previously treated with abiraterone, data should be collected on resource use and overall survival.

    Recommendation ID TA316/2 Question NICE considered that if enzalutamide is used in routine clinical practice for treating hormone relapsed

    Research recommendation
    Published
    9 June 2015

  32. NICE considered that more research is needed to establish the treatment sequence for vemurafenib and ipilimumab in patients who have BRAF V600 mutation-positive melanoma.

    Recommendation ID TA319/1 Question NICE considered that more research is needed to establish the treatment sequence for vemurafenib and

    Research recommendation
    Published
    9 June 2015

  33. NICE considered that there is an important need for head-to-head comparisons between biological treatments for psoriatic arthritis, particularly in people for whom treatment with tumour necrosis factor (TNF) alpha inhibitors has been unsuccessful.

    Recommendation ID TA340/1 Question NICE considered that there is an important need for head-to-head comparisons between biological treatments

    Research recommendation
    Published
    5 October 2015

  34. NICE encourages clinicians to enter patients into research studies with the particular aims of guiding selection of patients and of defining the place of percutaneous balloon cryoablation in relation to other procedures for treating atrial fibrillation. Further research should define patient selection criteria clearly and should document adverse events and long-term control of atrial fibrillation.

    Recommendation ID IPG427/1 Question NICE encourages clinicians to enter patients into research studies with the particular aims of guiding

    Research recommendation
    Published
    9 June 2015

  35. NICE encourages further data collection, including randomised controlled trials on microstructural scaffold insertion without autologous cell implantation for repairing symptomatic chondral knee defects. Studies should clearly describe patient selection, clinical indications and adjunctive treatments. Outcome measures should include symptom relief, functional ability, long-term outcomes measured by appropriate imaging techniques and patient-reported outcomes.

    Recommendation ID IPG560/1 Question NICE encourages further data collection, including randomised controlled trials on microstructural

    Research recommendation
    Published
    9 August 2016

  36. NICE encourages further research and data collection on endoscopic full thickness removal of non-lifting colonic polyps and may update the guidance on publication of further evidence. This should include safety and efficacy outcomes such as perforation, bleeding, the need for immediate re-intervention, inadequate resection and longer-term follow-up of patients found to have malignant disease.

    Recommendation ID IPG580/1 Question NICE encourages further research and data collection on endoscopic full thickness removal of non-lifting

    Research recommendation
    Published
    12 October 2018

  37. NICE encourages further research and data collection on partial replacement of the meniscus of the knee using a biodegradable scaffold. This should include clear descriptions of patient selection and adjunctive treatments. Outcome measures should include symptom relief and functional ability in the short term and the need for further treatment in the longer term.

    Recommendation ID IPG430/1 Question NICE encourages further research and data collection on partial replacement of the meniscus of the

    Research recommendation
    Published
    9 June 2015

  38. NICE encourages further research and publication of results from consecutive case series of patients having this procedure. Details of patient selection should be clearly documented. Reported outcomes should include the effects of the procedure on symptoms and quality of life, the duration of benefits, and the need for further procedures. All complications should be reported. NICE may review this procedure in the light of longer-term outcomes.

    Recommendation ID IPG475/1 Question NICE encourages further research and publication of results from consecutive case series of patients

    Research recommendation
    Published
    9 June 2015

  39. NICE encourages further research and publication on efficacy of miniature lens system implantation for advanced age-related macular degeneration (AMD) which patients may benefit and on safety and efficacy outcomes, particularly longer-term results. NICE may update the guidance on publication of further evidence.

    Recommendation ID IPG565/1 Question NICE encourages further research and publication on efficacy of miniature lens system implantation

    Research recommendation
    Published
    17 October 2016

  40. NICE encourages further research comparing autologous blood injections (with or without techniques to produce platelet-rich plasma) against established nonsurgical methods for managing tendinopathy. Trials should clearly describe patient selection (including the site of tendinopathy, duration of symptoms and any prior treatments) and document whether a 'dry needling' technique is used. Outcomes should include specific measures of pain, quality of life and function, and whether subsequent surgical intervention is needed.

    Recommendation ID IPG438/1 Question NICE encourages further research comparing autologous blood injections (with or without techniques

    Research recommendation
    Published
    9 June 2015

  41. NICE encourages further research into faecal microbiota transplant for C. difficile infection, specifically to investigate optimal dosage, mode of administration and choice of donor.

    Recommendation ID IPG485/1 Question NICE encourages further research into faecal microbiota transplant for C. difficile infection, specifically

    Research recommendation
    Published
    9 June 2015

  42. NICE encourages further research into focal cryoablation for localised prostate cancer. This should take the form of controlled studies comparing the procedure against other forms of management. Studies should clearly define patient selection criteria and should report outcomes including local recurrence in the long term.

    Recommendation ID IPG423/1 Question NICE encourages further research into focal cryoablation for localised prostate cancer. This should

    Research recommendation
    Published
    9 June 2015

  43. NICE encourages further research into the efficacy of MRI-guided transcutaneous focused ultrasound for uterine fibroids. Research studies should report long-term outcomes, including the need for further treatment. Data on the incidence and outcomes of subsequent pregnancy in patients who choose this procedure because they wish to maintain or improve their fertility are particularly important.

    Recommendation ID IPG413/1 Question NICE encourages further research into the efficacy of MRI-guided transcutaneous focused ultrasound

    Research recommendation
    Published
    9 June 2015

  44. NICE encourages further research into the role of negative pressure wound therapy (NPWT) for the open abdomen. Patient selection should be documented and research should report on efficacy outcomes such as impact on wound care and healing rates, and duration of hospital stay.

    Recommendation ID IPG467/1 Question NICE encourages further research into the role of negative pressure wound therapy (NPWT) for the open

    Research recommendation
    Published
    9 June 2015

  45. NICE encourages further research into the use of a wireless capsule to assess motility of the gastrointestinal tract. Studies should include clear details of patient selection. They should report on the diagnostic accuracy of the procedure in different parts of the gastrointestinal tract, and should provide data on the clinical benefits of the procedure for patients.

    Recommendation ID IPG502/1 Question NICE encourages further research into the use of a wireless capsule to assess motility of the gastrointestinal

    Research recommendation
    Published
    9 June 2015

  46. NICE encourages further research into the use of innovative technologies for the management of severe acute respiratory failure, and may review this guidance on publication of further evidence.

    Recommendation ID IPG391/1 Question NICE encourages further research into the use of innovative technologies for the management of severe

    Research recommendation
    Published
    9 June 2015

  47. NICE encourages further research into total artificial heart implantation as a bridge to transplantation for end-stage refractory biventricular heart failure, including well matched comparative studies. NICE may update the guidance on publication of further evidence.

    Recommendation ID IPG602/1 Question NICE encourages further research into total artificial heart implantation as a bridge to transplantation

    Research recommendation
    Published
    19 October 2018

  48. NICE encourages further research into transapical transcatheter mitral valvein-ring implantation after failed annuloplasty for mitral valve repair. Studies should include details on patient selection, type and size of valve used, functional outcomes (New York Heart Association functional class, mitral valve regurgitation), quality of life, patient-reported outcome measures, survival and complications. Studies should report long-term follow up of clinical outcomes and valve durability. NICE may update this guidance on publication of further evidence.

    Recommendation ID IPG707/1 Question NICE encourages further research into transapical transcatheter mitral valvein-ring implantation after

    Research recommendation
    Published
    30 September 2021

  49. NICE encourages further research into transapical transcatheter mitral valvein-valve implantation for a failed surgically implanted mitral valve bioprosthesis. Studies should include details on patient selection, type and size of valve used, functional outcomes (New York Heart Association functional class, mitral valve regurgitation), quality of life, patient-reported outcome measures, survival and complications. Studies should report long-term follow up of clinical outcomes and valve durability. NICE may update this guidance on publication of further evidence.

    Recommendation ID IPG706/1 Question NICE encourages further research into transapical transcatheter mitral valvein-valve implantation for

    Research recommendation
    Published
    30 September 2021

  50. NICE encourages further research into transcranial direct current stimulation (tDCS) for depression, which should document how patients were selected and any other treatments they were having. It should describe the precise method and regime used for administering tDCS. Outcome measures should include the duration of effect. NICE may update the guidance on publication of further evidence.

    Recommendation ID IPG530/1 Question NICE encourages further research into transcranial direct current stimulation (tDCS) for depression

    Research recommendation
    Published
    12 October 2015