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Showing 4901 to 4950 of 8238 results

  1. NICE encourages further research into ultrasound-enhanced, catheter-directedthrombolysis for pulmonary embolism. Ideally this should include comparative studies against catheter-directed thrombolysis alone. Patient selection should be  documented. The dose of thrombolytic agent used and the duration of thrombolysis should be reported, together with all complications. Outcome measures should include the success of thrombolysis (complete, partial or failed) and long-term sequelae. NICE may update the guidance on publication of further evidence.

    Recommendation ID IPG524/1 Question NICE encourages further research into ultrasound-enhanced, catheter-directedthrombolysis for pulmonary

    Research recommendation
    Published
    6 October 2015

  2. NICE encourages further research on corticosteroid-eluting bioabsorbable stent or spacer insertion during endoscopic sinus surgery and, specifically, controlled studies designed for between-patient (rather than within-patient) comparisons. Outcomes should include symptom scores, quality of life and the need for retreatment in the long term. All complications should be reported. NICE may update this guidance on publication of further evidence.

    Recommendation ID IPG551/1 Question NICE encourages further research on corticosteroid-eluting bioabsorbable stent or spacer insertion

    Research recommendation
    Published
    6 April 2016

  3. NICE encourages further research on endovascular aneurysm sealing for abdominal aortic aneurysmthis procedure in the form of controlled clinical trials, observational studies and analysis of registry data. Details about patient selection, including anatomical details, should be clearly documented.Research should compare the procedure with conventional stent graft endovascular aneurysm repair. All complications should be reported. Long-term outcomes should be described as data become available. NICE may update the guidance on publication of further evidence.

    Recommendation ID IPG547/1 Question NICE encourages further research on endovascular aneurysm sealing for abdominal aortic aneurysmthis

    Research recommendation
    Published
    21 March 2016

  4. NICE encourages further research on insertion of an annular disc implant at lumbar discectomy, particularly comparative trials. All studies should report details of patient selection and recurrence rates.

    Recommendation ID IPG506/1 Question NICE encourages further research on insertion of an annular disc implant at lumbar discectomy, particularly

    Research recommendation
    Published
    9 June 2015

  5. NICE encourages further research on insertion of an epiretinal prosthesis for retinitis pigmentosa. Outcomes should include the impact on quality of life and activities of day-to-day living, and durability of implants. NICE may update the guidance on publication of further evidence.

    Recommendation ID IPG519/1 Question NICE encourages further research on insertion of an epiretinal prosthesis for retinitis pigmentosa

    Research recommendation
    Published
    5 October 2015

  6. NICE encourages further research on laparoscopic gastric plication for severe obesity, which should include information about long-term efficacy and safety, and specifically how the procedure influences further gastric surgery. Comparison with alternative procedures would be useful.

    Recommendation ID IPG432/1 Question NICE encourages further research on laparoscopic gastric plication for severe obesity, which should

    Research recommendation
    Published
    9 June 2015

  7. NICE encourages further research on sphenopalatine ganglion stimulation for chronic cluster headache. Reported outcomes should include long-term efficacy and device durability.

    Recommendation ID IPG527/1 Question NICE encourages further research on sphenopalatine ganglion stimulation for chronic cluster headache

    Research recommendation
    Published
    6 October 2015

  8. NICE encourages further research on subretinal prosthesis system for retinitis pigmentosa. Outcomes should include the impact on quality of life and activities of day-to-day living, and durability of implants. NICE may update the guidance on publication of further evidence.

    Recommendation ID IPG537/1 Question NICE encourages further research on subretinal prosthesis system for retinitis pigmentosa. Outcomes

    Research recommendation
    Published
    25 January 2016

  9. NICE encourages further research on transcranial magnetic stimulation (TMS) for treating and preventing migraine. Data should be collected for all patients not entered into controlled trials. Studies should describe clearly whether its use is for treatment or prevention. They should report details of patient selection and the dose and frequency of use. Outcome measures should include the number and severity of migraine episodes, and quality of life in both the short and long term. The development of any neurological disorders (such as epilepsy) in the short or longer term after starting treatment should be documented.

    Recommendation ID IPG477/1 Question NICE encourages further research on transcranial magnetic stimulation (TMS) for treating and preventing

    Research recommendation
    Published
    9 June 2015

  10. NICE encourages further research on transcutaneous stimulation of the cervical branch of the vagus nerve for cluster headache and migraine. Studies should describe whether the procedure is used for treatment or prevention, and whether it is used for cluster headache or migraine. Clinicians should clearly document details of patient selection and the treatment regimen. Outcome measures should include changes in the number and severity of cluster headache or migraine episodes, medication use, quality of life in the short and long term, side effects, acceptability, and device  durability. NICE may update this guidance on publication of further evidence.

    Recommendation ID IPG552/1 Question NICE encourages further research on transcutaneous stimulation of the cervical branch of the vagus

    Research recommendation
    Published
    6 April 2016

  11. NICE encourages further research, preferably randomised controlled trials, into percutaneous endovascular forearm arteriovenous fistula creation for haemodialysis access. This should report details of patient selection, particularly about vascular anatomy, technique used, need for training, patency of the fistula and its subsequent ease of use, and quality of life.

    Recommendation ID IPG710/01 Question NICE encourages further research, preferably randomised controlled trials, into percutaneous endovascular

    Research recommendation
    Published
    5 November 2021

  12. NICE encourages research into endovascular stentgrafting of popliteal aneurysms and may review this procedure on publication of further evidence.

    Recommendation ID IPG390/1 Question NICE encourages research into endovascular stentgrafting of popliteal aneurysms and may review this

    Research recommendation
    Published
    9 June 2015

  13. NICE encourages the company, NHS England and treatment centres to collect more evidence, particularly on the longer-term benefits and costs of eliglustat and enzyme replacement therapy for treating type 1 Gaucher disease.

    Recommendation ID HST5/1 Question NICE encourages the company, NHS England and treatment centres to collect more evidence, particularly

    Research recommendation
    Published
    12 October 2018

  14. What is the effectiveness and safety of regimens using mifepristone and misoprostol for women who are having medical abortion after 23 +6  weeks' gestation, particularly for those who have had a previous caesarean section or uterine surgery?

    Recommendation ID NG140/6 Question What is the effectiveness and safety of regimens using mifepristone and misoprostol for women who are

    Research recommendation
    Published
    8 November 2019

  15. Medication choice in people with coexisting conditions:- What is the clinical and cost effectiveness of ADHD medications in people with ADHD and tic disorders, a history of psychosis or mania, or personality disorder?

    Recommendation ID NG87/2 Question Medication choice in people with coexisting conditions:- What is the clinical and cost effectiveness

    Research recommendation
    Published
    14 November 2018

  16. Medication choice in people with no previous medication for ADHD:- What is the clinical and cost effectiveness of ADHD medications in people with ADHD with noprevious medication for the condition?

    Recommendation ID NG87/3 Question Medication choice in people with no previous medication for ADHD:- What is the clinical and cost effectiveness

    Research recommendation
    Published
    14 November 2018

  17. Medication for promoting de-escalation:- Which medication is effective in promoting de-escalation in people who are identified as likely to demonstrate significant  violence?

    Recommendation ID NG10/1 Question Medication for promoting de-escalation:- Which medication is effective in promoting de-escalation in

    Research recommendation
    Published
    5 October 2015

  18. What interventions are effective to support medicines adherence for people with complex psychosis in supported accommodation?

    Recommendation ID NG181/9 Question What interventions are effective to support medicines adherence for people with complex psychosis in

    Research recommendation
    Published
    26 October 2020

  19. For which service users who are moderately and severely dependent on alcohol is an assertive community treatment model a clinically and cost-effective intervention compared with standard care?

    Recommendation ID CG115/4 Question For which service users who are moderately and severely dependent on alcohol is an assertive community

    Research recommendation
    Published
    9 June 2015

  20. FRAX and QFracture in adults living in residential care:- What is the utility of FRAX and QFracture in detecting risk of fragility fracture in adults living in residential care?

    Recommendation ID CG146/5 Question FRAX and QFracture in adults living in residential care:- What is the utility of FRAX and QFracture

    Research recommendation
    Published
    9 June 2015

  21. FRAX and QFracture in adults receiving bone protective therapy:- What is the utility of FRAX and QFracture in adults receiving bone protective therapy?

    Recommendation ID CG146/2 Question FRAX and QFracture in adults receiving bone protective therapy:- What is the utility of FRAX and QFracture

    Research recommendation
    Published
    9 June 2015

  22. FRAX and QFracture in adults with secondary causes of osteoporosis:- What is the utility of FRAX and QFracture in detecting risk of fragility fracture in adults with secondary causes of osteoporosis?

    Recommendation ID CG146/3 Question FRAX and QFracture in adults with secondary causes of osteoporosis:- What is the utility of FRAX and

    Research recommendation
    Published
    9 June 2015

  23. What are the benefits of planned, regular community-based reviews compared with as-required review of non-cancer patients approaching the end of their life?

    Recommendation ID NG142/3 Question What are the benefits of planned, regular community-based reviews compared with as-required review of

    Research recommendation
    Published
    18 November 2019

  24. Frequency of monitoring: For adults, children and young people with CKD, what is the optimal monitoring frequency for albumin:creatinine ratio?

    Recommendation ID NG203/9 Question Frequency of monitoring: For adults, children and young people with CKD, what is the optimal monitoring

    Research recommendation
    Published
    30 September 2021

  25. Frequency of monitoring:- How frequently should children be measured to identify faltering growth?

    Recommendation ID NG75/4 Question Frequency of monitoring:- How frequently should children be measured to identify faltering growth?

    Research recommendation
    Published
    15 October 2018

  26. Frequency of monitoring:- What is the effectiveness of more frequent monitoring compared with monitoring at 12 months after diagnosis in people with newly diagnosed coeliac disease?

    Recommendation ID NG20/5 Question Frequency of monitoring:- What is the effectiveness of more frequent monitoring compared with monitoring

    Research recommendation
    Published
    13 October 2015

  27. Frequency of monitoring:- What is the long-term cost effectiveness, in terms of patient-relevant outcomes including bestcorrected visual acuity and quality of life, of different review frequencies/strategies for people at risk of progression to late AMD (wet active)?

    Recommendation ID NG82/4 Question Frequency of monitoring:- What is the long-term cost effectiveness, in terms of patient-relevant outcomes

    Research recommendation
    Published
    13 November 2018

  28. Frequency of review: What is the most clinical and cost-effective frequency of review for children and young people with CKD?

    Recommendation ID NG203/12 Question Frequency of review: What is the most clinical and cost-effective frequency of review for children

    Research recommendation
    Published
    30 September 2021

  29. Fresh frozen plasma for patients with abnormal haemostasis who are having invasive procedures or surgery:- What dose of fresh frozen plasma is most clinically effective at preventing bleeding in patients with abnormal haemostasis who are having invasive procedures or surgery?

    Recommendation ID NG24/4 Question Fresh frozen plasma for patients with abnormal haemostasis who are having invasive procedures or surgery:-

    Research recommendation
    Published
    11 December 2015

  30. Needs assessment: From the perspective of everyone involved, what is the acceptability of strengths and rights-based approaches to social work assessment and what are the barriers and facilitators to delivering these?

    Recommendation ID NG216/01 Question Needs assessment: From the perspective of everyone involved, what is the acceptability of strengths

    Research recommendation
    Published
    1 June 2022

  31. Risk assessment: From the perspective of everyone involved, what works well and could be improved about the use of tools and checklists to support social work risk assessment for people with complex needs?

    Recommendation ID NG216/02 Question Risk assessment: From the perspective of everyone involved, what works well and could be improved about

    Research recommendation
    Published
    1 June 2022

  32. In infants, children and young people with overt or occult reflux, is fundoplication effective in reducing acid reflux as determined by oesophageal pH monitoring?

    Recommendation ID NG1/3 Question In infants, children and young people with overt or occult reflux, is fundoplication effective in reducing

    Research recommendation
    Published
    15 November 2019

  33. Further collection of quality of life data from people who are cured and who have experience of amputation and chemotherapy are also needed. Additional data on the health effects on parents, siblings and others with life-threatening illness would also be of value.

    Recommendation ID TA235/2 Question Further collection of quality of life data from people who are cured and who have experience of amputation

    Research recommendation
    Published
    9 June 2015

  34. For people with alcohol dependence, which medication is most likely to improve adherence and thereby promote abstinence and prevent relapse?

    Recommendation ID CG115/6 Question For people with alcohol dependence, which medication is most likely to improve adherence and thereby

    Research recommendation
    Published
    9 June 2015

  35. Antiplatelet therapy: For people with CKD at the highest risk of cardiovascular disease, what is the clinical effectiveness of low-dose aspirin compared with placebo for primary prevention of cardiovascular disease?

    Recommendation ID NG203/19 Question Antiplatelet therapy: For people with CKD at the highest risk of cardiovascular disease, what is the

    Research recommendation
    Published
    30 September 2021

  36. Duration of thyroid stimulating hormone suppression: For people with differentiated thyroid cancer who have had surgery and radioactive iodine (RAI), what is the optimal duration of thyroid stimulating hormone suppression?

    Recommendation ID NG230/04 Question Duration of thyroid stimulating hormone suppression: For people with differentiated thyroid cancer

    Research recommendation
    Published
    6 January 2023

  37. Imaging for further staging: For people with differentiated thyroid cancer who have initial ultrasound evidence of extensive local spread (T2N1), what is the clinical and cost effectiveness of CT, MRI or F-18 FDG PET-CT scanning, with or without ultrasound, as part of a further staging strategy?

    Recommendation ID NG230/07 Question Imaging for further staging: For people with differentiated thyroid cancer who have initial ultrasound

    Research recommendation
    Published
    6 January 2023

  38. For people with favourable aneurysm morphology needing an EVAR as a primary procedure, evidence on the safety of using endoanchoring systems is adequate. However, evidence on efficacy is inadequate in quantity and quality. Therefore, for these people, this procedure should only be used in the context of research. Find out what only in research means on the NICE interventional procedures guidance page.

    Recommendation ID IPG725/02 Question For people with favourable aneurysm morphology needing an EVAR as a primary procedure, evidence on

    Research recommendation
    Published
    1 June 2022

  39. For people with generalised anxiety disorder (GAD) who are ready to start a low-intensity intervention, what is the clinical effectiveness of physical activity compared with waiting-list control?

    Recommendation ID CG113/3 Question For people with generalised anxiety disorder (GAD) who are ready to start a low-intensity intervention

    Research recommendation
    Published
    9 June 2015

  40. Thyroid peroxidase antibody testing: For people with indeterminate cytopathology, what is the clinical and cost effectiveness of thyroid peroxidase antibody testing?

    Recommendation ID NG230/06 Question Thyroid peroxidase antibody testing: For people with indeterminate cytopathology, what is the clinical

    Research recommendation
    Published
    6 January 2023

  41. Surgical excision for people with lentigo maligna: For people with lentigo maligna (stage 0 in sun damaged skin, usually on the face) how effective is Mohs micrographic surgery, compared with excision with a 0.5 cm clinical margin, in preventing biopsy proven local recurrence at 5 years? This should be investigated in a randomised controlled trial. Secondary outcomes should include cosmetic and functional outcomes.

    Recommendation ID NG14/08 Question Surgical excision for people with lentigo maligna: For people with lentigo maligna (stage 0 in sun damaged

    Research recommendation
    Published
    4 August 2022

  42. For people with mild or moderate tricuspid regurgitation, evidence on the safety and efficacy of transcatheter tricuspid valve annuloplasty is inadequate in quantity and quality. Therefore, for these people, this procedure should only be used in the context of research. Find out what only in research means on the NICE interventional procedures guidance page.

    Recommendation ID IPG730/02 Question For people with mild or moderate tricuspid regurgitation, evidence on the safety and efficacy of transcatheter

    Research recommendation
    Published
    4 August 2022

  43. For people with mild or moderate tricuspid regurgitation, evidence on the safety and efficacy of transcatheter tricuspid valve leaflet repair is inadequate in quantity and quality. Therefore, for these people, this procedure should only be used in the context of research. Find out what only in research means on the NICE interventional procedures guidance page.

    Recommendation ID IPG731/02 Question For people with mild or moderate tricuspid regurgitation, evidence on the safety and efficacy of transcatheter

    Research recommendation
    Published
    5 August 2022

  44. For people with moderate and severe alcohol dependence who have significant comorbid problems, is an intensive residential rehabilitation programme clinically and cost effective when compared with intensive community-based care?

    Recommendation ID CG115/5 Question For people with moderate and severe alcohol dependence who have significant comorbid problems, is an

    Research recommendation
    Published
    9 June 2015

  45. For people with severe and symptomatic tricuspid regurgitation, evidence on the efficacy of transcatheter tricuspid valve annuloplasty is limited in quantity and quality. Evidence on its safety shows there are serious but well-recognised complications. Therefore, for these people, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Find out what special arrangements mean on the NICE interventional procedures guidance page.

    Recommendation ID IPG730/01 Question For people with severe and symptomatic tricuspid regurgitation, evidence on the efficacy of transcatheter

    Research recommendation
    Published
    4 August 2022

  46. For people with severe and symptomatic tricuspid regurgitation, evidence on the efficacy of transcatheter tricuspid valve leaflet repair is limited in quantity and quality. Evidence on its safety shows there are serious but well-recognised complications. Therefore, for these people, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Find out what special arrangements mean on the NICE interventional procedures guidance page.

    Recommendation ID IPG731/01 Question For people with severe and symptomatic tricuspid regurgitation, evidence on the efficacy of transcatheter

    Research recommendation
    Published
    5 August 2022

  47. Active surveillance compared with surgery: For people with stage 1 differentiated thyroid cancer, what is the clinical and cost effectiveness of active surveillance compared with surgery?

    Recommendation ID NG230/03 Question Active surveillance compared with surgery: For people with stage 1 differentiated thyroid cancer, what

    Research recommendation
    Published
    6 January 2023

  48. Undisplaced intracapsular hip fractures: For people with undisplaced (or non-displaced) intracapsular hip fracture, what features should be used to characterise the injury and what are the optimal clinical and cost-effective management strategies?

    Recommendation ID CG124/03 Question Undisplaced intracapsular hip fractures: For people with undisplaced (or non-displaced) intracapsular

    Research recommendation
    Published
    3 February 2023

  49. For people with unfavourable aneurysm morphology needing an endovascular aortic aneurysm repair (EVAR) as a primary procedure, or for people with an existing EVAR who need a secondary procedure, evidence on the safety of using endoanchoring systems is adequate. Evidence on efficacy is limited in quantity and quality. Therefore, for these people, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Find out what special arrangements mean on the NICE interventional procedures guidance page.

    Recommendation ID IPG725/01 Question For people with unfavourable aneurysm morphology needing an endovascular aortic aneurysm repair (EVAR)

    Research recommendation
    Published
    1 June 2022

  50. Are relaxation strategies clinically and cost effective for the management of tinnitus for children, young people and adults?

    Recommendation ID NG155/9 Question Are relaxation strategies clinically and cost effective for the management of tinnitus for children

    Research recommendation
    Published
    17 March 2020