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Evidence-based recommendations on tucatinib (TUKYSA) for HER2-positive locally advanced or metastatic breast cancer in adults after 2 or more anti-HER2 treatment therapies.
Is obesity an independent risk factor for perinatal morbidity and mortality?
the woman's preference and obstetric indications in line with the NICE guideline on intrapartum care for health women and babies . There...
Any explanatory notes(if applicable) Why this is important:- The guideline committee felt that primary care was well suited to managing...
and cost effectiveness. The cost-effectiveness model developed for this guideline combined evidence of clinical effectiveness, costs and...
as encouraging shared decision making, are covered in the NICE clinical guideline on patient experience in adult NHS services. Given...
Sapropterin for treating hyperphenylalaninaemia in phenylketonuria (TA729)
Evidence-based recommendations on sapropterin for treating hyperphenylalaninaemia in phenylketonuria.
Summary of the evidence on cangrelor for coronary revascularisation to inform local NHS planning and decision-making
What training, support or interventions help to reduce caring-related accidents or incidents?
are included in the psychological and emotional support section of this guideline.By consensus, the committee also agreed to add some...
Ixekizumab for treating active psoriatic arthritis after inadequate response to DMARDs (TA537)
Evidence-based recommendations on ixekizumab (Taltz) for treating active psoriatic arthritis in adults.
Ustekinumab for treating moderate to severe plaque psoriasis (TA180)
Evidence-based recommendations on ustekinumab (Stelara) for treating psoriasis in adults.
committee agreed that the 2‑year follow‑up recommended in the previous guideline was conservative, and based on their expertise, people...
Ultrasound‑enhanced, catheter‑directed thrombolysis for deep vein thrombosis (HTG375)
Evidence-based recommendations on ultrasound enhanced catheter-directed thrombolysis for deep vein thrombosis. This involves using ultrasound waves and a drug to break up the clot.
NICE has developed a medtech innovation briefing (MIB) on Optilume for anterior urethral strictures .
NICE has developed a medtech innovation briefing (MIB) on AI technologies for detecting diabetic retinopathy .
November 2025: We have withdrawn this quality standard following the launch of new NICE guidelines on suspected sepsis in people aged 16 or over, suspected sepsis in under 16s and suspected sepsis in pregnant or recently pregnant people. This quality standard is now partially replaced by NICE's quality standard on suspected sepsis in over 16s. Quality standards for sepsis in people under 16 and for people who are or have recently been pregnant will publish when paediatric and maternity early warning score tools are reviewed for the next update to the NICE guidelines in 2026. For any queries, please contact qualitystandards@nice.org.uk.