Read the committee members' biographies and registered interests.

Dr Charles Crawley 

Chair

Consultant haematologist

More about Charles

Biography

Charles is a consultant haematologist in Cambridge. After graduating, he trained in oncology and then haematology at St Bartholomew’s and the Hammersmith Hospitals in London and the Fred Hutchinson Cancer Research Centre in Seattle.

He has subspecialty interests in myeloma, leukaemia, stem cell transplantation and cellular therapy. He is the programme director for the bone marrow transplant (BMT) and cell therapy programme in Cambridge and the past president of the British Society for Blood and Marrow Transplant and Cellular Therapy. He was the lead for haemato-oncology in Cambridge until 2021 and is actively engaged in clinical research in myeloma and transplantation.

He is an experienced inspector for the Joint Accreditation committee of ISCT and EBMT (JACIE) and a member of the accreditation committee, which accredits BMT and cell therapy programs in the UK and internationally. He is also a member of the clinical standards writing group for Foundation for Accreditation of Cellular Therapy (FACT) - JACIE.

He has been chair of the Joint Drugs and Therapeutics committee in Cambridge since 2010 and and is a member of the regional prescribing group.


Baljit Singh

Vice chair

Consultant colorectal surgeon and honorary associate professor at the University Hospitals Leicester

More about Baljit

Biography

Baljit is a consultant colorectal surgeon and honorary Associate Professor at the University Hospitals Leicester with specialist interests in rectal cancer and early diagnosis of colorectal cancer using faecal immunochemical testing.

He trained in Oxford and is chair of the NHS England Specialised Colorectal Services CRG and East Midlands Colorectal ECAG.

Baljit has previously served on the executive committees of the ACPGBI and ASGBI and currently is a member of the ESCP executive.

Registered interests

None


Dr Carlo Berti (leave of absence until further notice)

Consultant psychiatrist and honorary lecturer, Kent and Medway Partnership Trust

More about Carlo

Biography

Biography to follow.

Registered interests

Non-financial professional and personal interest

Ministry of Defence, novel psychoactive substances expert, fee paying service.


Dr Laura Bojke

Reader in health economics, Centre for Health Economics, University of York

More about Laura

Biography

Laura has more than 20 years’ experience as a health economist. Over this time she has contributed to technology appraisals for NICE in her role as a member of one of the independent academic groups undertaking assessments and evidence reviews. She completed her PhD at the University of York in 2008, titled 'Characterising structural uncertainty within decision analytic models’. She has worked on a number of projects involving the use of expert elicited data within decision analytic models. Laura is particularly interested in this area and its application to issues of extrapolation uncertainty.

She has worked on a wide range of applied and methodological projects and has gained extensive experience of modelling the cost-effectiveness of arthritis and musculoskeletal diseases, especially psoriatic arthritis.

Laura currently co-leads the Applied Research and Collaborations (ARC) Yorkshire and Humber Health Economics theme. The program of work includes the use of economic evaluation across sectors, economic evaluation for local decision makers and the use of routine data for economic evaluation.


Maria Brezitski

Policy manager within Health Research Authority

More about Maria

Biography

Maria is an NMC registered professional and a member of the Royal College of Nursing. She has extensive acute clinical and research work experience coordinating hyperacute investigational medicinal product/device/interventional trials.

This experience is well-complemented by:

  • MSc in Clinical Drug Development providing thorough understanding of the drug development process.
  • NIHR Advanced Leadership Programme enabling to explore management and leadership in health research on an individual, team, institution and system level.
  • MSc in Psychology helping to negotiate problems and use de-escalation techniques when dealing with people.

Additional roles include:

  • Alternate vice chair/expert member for Research Ethics Committee (HRA) (temporarily paused).
  • Independent external NIHR research studies reviewer.
  • NIHR Advanced Leadership Programme Community of Practice (COP) boundary spanning team lead/COP steering group member.
  • Course mentor for Improving Healthcare Through Clinical Research Online Future Learn Courses, University of Leeds.
  • Member of the NICE Adoption and Impact Reference Panel.
  • COVID-19 vaccinator.

Denise Bryceland

More about Denise

Biography

Denise has been working in the health tech industry for 23 years, mainly for Terumo Aortic, a manufacturer of surgical and endovascular devices for the treatment of aortic disease. She works closely with, and supports clinicians in the South East.

Her clinical background is in critical care nursing within the NHS where she has helped to set up and run the first stand-alone high dependency unit.

Denise has always had a strong desire to help people where she can and has been a parent governor at school and currently volunteers for St John Ambulance on the COVID 19 national vaccination programme.

Registered interests

Professional and personal interests

Member of Association of British HealthTech Industries commercial committee and cardiovascular committee

Indirect interests

Husband also works for Terumo Aortic


Professor Iolo Doull

More about Iolo

Biography

Iolo is a consultant respiratory paediatrician and honorary professor at the Children’s Hospital of Wales in Cardiff, and interim medical director of the Welsh Health Specialised Services Committee.

He is a former president of the British Paediatric Respiratory Society Health and previously served as the officer for Wales of the Royal College of Paediatrics and Child Health, and as president of the Welsh Paediatric Society. He was an expert advisor on our cystic fibrosis guideline and was previously an expert advisor to the Commission on Human Medicines.

He has clinical and research interests in cystic fibrosis and respiratory diseases in children.

Registered interests

None


Professor Francis Drobniewski

More about Francis

Biography

Francis is Professor of Global Health and Tuberculosis at Imperial College, London (ICL), a clinical and public health microbiologist and physician (accredited in Microbiology, Virology, and Immunology) and Consultant Microbiologist at University Hospitals Dorset. He was Director of the UK National Mycobacterium Reference Laboratory (1996-2015) providing public health, clinical and has 25 years’ experience as PI/Co-I for complex respiratory disease research programmes focusing on TB/HIV infections, COVID19, biomarker discovery, molecular and genomic diagnostics, antimicrobial drug resistance detection, with integration of clinical, biological, and social themes. Much of his research and training programme activity is focused in low/middle income countries especially in Eastern Europe and Africa.

He was a Board Non-Executive Director for Kent Community Hospital Foundation Trust (2018-2022) including the COVID Clinical Reference Group, Vice Chair of the Quality Committee (with particular interest in medication errors, quality improvement and safety, End of Life issues, patients with learning disabilities and health inequalities), and a member of the Strategic Workforce, Remuneration and Audit/Risk Committees. He founded and remains a member of the ECDC TB Reference Lab Network (2009-onwards) and served on several clinical and public health ECDC committees. He has been a consultant for and had several roles with the World Health Organisation focusing on the diagnosis and treatment of drug resistant bacterial infections, and the management of multidrug resistant tuberculosis and HIV-TB including, Director WHO Supra-national Reference Laboratory, member of the WHO Strategic Advisory Group, Chair WHO European Laboratory Initiative on TB, HIV and viral hepatitis including supporting COVID diagnostic policy and activity. He was made a Fellow of the European Society of Clinical Microbiology and Infectious Diseases in 2017, is a Member of the Antimicrobial Research Collaborative (ARC) at ICL; co-founding member of the NIHR Health Protection Research Unit Respiratory Infections, ICL (Co-I 2014-2017); member of the International Advisory Board HPRU Antimicrobial Resistance, ICL (2014-20); a member of the Global CrypTIC molecular TB DST Consortium; a member of the MRC DPFS grant panel in 2021.

Registered interests

None


Dr James Fotheringham

More about James

Biography

James graduated from the University of Sheffield and following a PhD in performance measurement using routine healthcare data in renal services was funded by a National Institute of Health Research (NIHR) fellowship to improve outcomes for people on dialysis for kidney failure.

He works between the Sheffield Teaching Hospitals and the University of Sheffield. A consultant in renal medicine since 2015, James has published across a range of areas within kidney disease and co-authored guidelines. He has ongoing funded research by the NIHR evaluating the clinical and cost-effectiveness of kidney disease treatments.

Registered interests

Direct - financial

  • Health gains from improved kidney graft survival – review of economic model.
  • Chaired a meeting for the British Transplant Society Industry symposium.
  • Received speaker fees from Fresenius healthcare Germany.

Non-direct - financial

  • Received fees for providing consultancy to Novartis for an Iscalimab randomized trial.

Dr Mark Glover

MRC clinician scientist, associate professor and honorary consultant physician, University of Nottingham

More about Mark

Biography

Mark trained in pre-clinical pharmacology and clinical medicine at Gonville and Caius College, Cambridge. He is a clinical pharmacologist and general physician at the University of Nottingham and Nottingham University Hospitals NHS Trust. His clinical and research interests are in hypertension.

Mark leads the hypertension service in Nottingham and leads an MRC funded research group focused on the molecular pathophysiology of sodium reabsorption in the distal nephron in Thiazide Induced Hyponatraemia and Gordon syndrome.

Mark is a member of the Prescribing Safety Assessment Board for UK medical students, and a member of the NICE hypertension in adults guideline committee.

Registered interests

None.


Dr Nicholas Latimer

Reader in health economics, School of Health and Related Research, University of Sheffield

More about Nicholas

Biography

Nicholas is a health economist and a Yorkshire Cancer Research Senior Fellow. He studied economics at the University of Nottingham, health economics at the University of York, and has a PhD in health economics from the University of Sheffield.

Nicholas has worked as a health economist in academia and the pharmaceutical industry and has experience in the design and analysis of clinical trials and economic modelling. His main research interests are in survival analysis for economic evaluation, and the use of causal inference in health technology assessment.

Registered interests

Direct - financial

June 2017 to November 2017: BMS consultancy fee received on three occasions for attending advisory board meetings. June 2017 - nivolumab for metastatic microsatellite instability high colorectal cancer; November 2017 – nivolumab for first line non-small cell lung cancer and small cell lung cancer; November 2017 – nivolumab for adjuvant melanoma.

January 2017 to December 2017: Pfizer consultancy fees received. Member of Pfizer’s global modelling advisory committee. In 2017 discussed avelumab for ovarian, gastric, NSCLC and merkel cell carcinoma. In April 2017 provided advice to Pfizer on a statistical analysis plan relating to mylotarg for acute myeloid leukaemia.

May 2017: Merck consultancy fee received for providing a training course on treatment switching adjustment methods.

August 2017: fee received from a consultancy for work done on a Tesaro product. Reviewed survival analysis undertaken by FIECON on niraparib for maintenance treatment of adult patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in a complete or partial response to platinum-based chemotherapy. Note, contact and payment was solely with FIECON.

September 2017: Janssen consultancy fee received for providing a 0.5 day training course on survival analysis.

October 2017 to December 2017: Astra Zeneca consultancy fee received for giving advice on survival modelling for durvalumab as a monotherapy among patients with stage IIIB-IV NSCLC.

November 2017 to March 2018: Bluebirdbio consultancy fee received for attending an innovation panel meeting for the treatment of transfusion-dependent β-thalassemia (November 2017), and for attending an advisory board meeting on Lenti-D in Cerebral Adrenoleukodystrophy (March 2018).

May 2018: provided a training course to Pierre Fabre on treatment switching methods.

January 2019 to present: fee received from Pierre Fabre for advice on adjusting for treatment switching in the Beacon Study investigating Encorafenib + Cetuximab Plus or Minus Binimetinib in patients with BRAF V600E-mutant metastatic colorectal cancer.

May 2018 to present: provided modelling advice to Sirtex Medical UK for selective internal radiation therapy using microspheres (SIR-Spheres) for patients with locally advanced inoperable hepatocellular carcinoma.

November 2018 to March 2019: Bluebirdbio consultancy fee received for attending advisory board meetings on Lenti-globin for transfusion-dependent β-thalassemia and sickle cell disease and on Lenti-d for cerebral adrenoleukodystrophy.

January 2019: Sobi consultancy fee received for attending advisory board meeting on emapalumab for primary haemophagocytic lymphohistiocytosis.

March 2019: Atara Biotherapeutics consultancy fee received for attending advisory board meeting on tab-cel®, an allogeneic T-cell immunotherapy for patients with Epstein-Barr virus-positive post-transplant lymphoproliferative disorder.

April 2019: Merck Sharp & Dohme Limited consultancy fee received for providing a one-day training course on survival analysis.

Direct - non-financial

September 2017 to November 2017: advised on modelling for enzalutamide in non-metastatic prostate cancer. Also gave advice to Astellas through the NICE Scientific Advice programme on enfortumab vedotin for urothelial carcinoma. No payment received.

January 2017 to present: data sharing agreements with the following companies, to aid my post-doctoral research fellowship:

  • Roche - data from BRIM 3 trial (Vemurafenib for patients with unresectable stage IIIC or IV melanoma with V600 BRAF mutation) and data from the M77001 trial (trastuzumab for patients with HER2 positive metastatic breast cancer).
  • Amgen - data from Study 20020408 (panitumumab for patients with metastatic colorectal cancer).
  • Bohringher Ingelheim - data from LUX-Lung 1, LUX-Lung 3 and LUX-Lung 6. Afatinib for Stage IIIB/IV lung cancer.

No funding is involved in these agreements.

January 2017 to present: The University of Sheffield has received funding from BMS to conduct research into survival analysis methods, not product specific.

January 2017 to August 2017: The University of Sheffield received funding from Merck for analysing the pivotal trial of cladribine for Multiple Scelerosis. Work was completed in August 2017 although resulting papers are still being written.

Non-financial professional and personal

March 2019: currently on the project team for a project being carried out on the surrogate relationship between PFS and OS in cancer, funded by Takeda. The University of Sheffield receives the funding.


Dr Veline L'Esperance (leave of absence from May to October 2022)

NIHR doctoral research fellow/general practitioner, King's College London

More about Veline

Biography

Veline is an academic general practitioner in South London and an NIHR doctoral fellow at Kings College London. She holds a Master of Public Health and a Master of Science in Healthcare Policy and Management.

Her current research uses econometric methods to investigate the relationship between the allocation of resources and healthcare outcomes in general practice. Her ongoing interests are in primary care health economics and health service research.

She teaches on the Master of Public Health (MPH) programme at Kings College London. She was previously a National Medical Director's clinical fellow and prior to studying medicine she worked in the pharmaceutical industry.

Registered interests

None.


Prof David McAllister

Wellcome Trust intermediate clinical fellow and Beit fellow and professor of Clinical epidemiology and medical informatics, University of Glasgow, honorary consultant in public health medicine, Public Health Scotland.

More about David

Biography

David McAllister is a Wellcome Trust Intermediate Clinical Fellow and Beit Fellow and Professor of Clinical Epidemiology and Medical Informatics at the University of Glasgow and is an Honorary Consultant in Public Health Medicine at Public Health Scotland.

His interest is in chronic disease epidemiology – diabetes, cardiovascular disease and multimorbidity – as well as routine healthcare data research. He leads projects funded by Wellcome and the MRC where he uses Bayesian methods to analyse routine healthcare data alongside clinical trial data in order to both measure and improve trial representativeness/applicability.

He also has an interest in global health, and is currently leading work looking at vaccine efficacy in low versus high income settings.

During the COVID-19 pandemic – thanks to the agreement of the Wellcome Trust - he was able to divert much of his time to work for Public Health Scotland on COVID-19. He used his expertise in routine data research to lead work examining the effect of COVID-19 on healthcare workers, teachers and care home residents, and to examine the effect of vaccinating healthcare workers on their household members. Internationally, he works with the RECORD committee on improving research methods in routine data epidemiology.

Registered interests

None.


Dr Rhiannon Owen

Associate professor in biostatistics at Swansea University

More about Rhiannon

Biography

Rhiannon graduated with a BSc in Mathematics and Sports Science from Loughborough University. She completed an MSc in Medical Statistics from the University of Leicester, funded by the National Institute for Health Research (NIHR) Research Methods Fellowship. In 2013 she was awarded an NIHR Doctoral Research Fellowship to complete her PhD in biostatistics at the University of Leicester, titled ‘Bayesian methods in health technology assessment’.

Rhiannon is currently an associate professor in biostatistics at Swansea University Medical School. She has extensive experience of evidence synthesis methods for complex healthcare interventions and diagnostic tests. Rhiannon is a member of the Health Data Research (HDR) Community of Experts and associate member of the NICE Technology Support Unit.

Her main research interests include evidence synthesis methods for health technology assessment, network meta-analysis, Bayesian statistical methods in healthcare evaluation, analysis of large scale linked electronic health records, economic evaluation, and analysis of value of information. This work has been and is supported by HDR UK, the Medical Research Council, NIHR and the Academy of Medical Sciences.

Registered interests

Financial interests

From November 2019: paid consultant for Cogentia Healthcare Consulting Ltd and Daiichi Sankyo offering statistical advice and undertaking network meta-analysis of direct acting oral-anticoagulants for the prevention of stroke in atrial fibrillation.

September 2019 to January 2020: paid consultant for Cogentia Healthcare Consulting Ltd and Vifor Pharma offering statistical advice on evidence synthesis and undertaking network meta-analysis of iron therapy for iron deficiency without anaemia.

September 2019: paid tutor on the Indirect and Mixed Treatment Comparisons course at the University of Bristol.

May 2019 to June 2019: paid consultant and seminar speaker for F. Hoffmann-La Roche Ltd offering statistical advice on general methods in health technology assessment.


Ms Anna Pracz, MPharm PGDip

Senior medicines optimisation pharmacist, Greater Manchester Joint Commissioning Team

More about Anna

Biography

Anna is a senior medicines optimisation pharmacist at the Greater Manchester Joint Commissioning Team. She qualified from the Medical University of Warsaw and completed a postgraduate diploma (with merit) in clinical and health services pharmacy at the University of Manchester.

Anna has worked as a pharmacist across many settings including community, hospital, clinical trials and primary care. In her current role she supports the Greater Manchester Medicines Management Group and specialises in production of high quality evidence based guidance, particularly in the area of high cost medicines.

Anna has interest in managed entry of new medicines, guidance development processes and decision making.

Registered interests

None.


Mr Peter Wheatley Price

Director of market access and pricing, Takeda UK

More about Peter

Biography

Peter qualified as a nurse in Oxford and after 7 years working in the NHS, joined the pharmaceutical industry. He has held a wide variety of commercial and management roles with responsibility at UK, EU and global levels. For the past 11 years he has worked developing strategies and appraisals for submission to NICE, the Scottish Medicines Consortium, the All Wales Medicines Strategy Group and other similar bodies globally to get access for patients.

Peter currently works for Takeda in the UK leading a team focussed on access for patients. He was a trustee for the National Ankylosing Spondylitis Society, a national patient charity for 12 years.


Gabriel Rogers

Health economist at the Manchester Centre for Health Economics, University of Manchester

More about Gabriel

Biography

Gabriel's research interests include decision-making when there are many potential options and/or separate, interacting decision-points. He is also interested in how to communicate the methods and results of health economic models.

Gabriel has contributed to NICE for many years. Before taking up his current job, he was lead health economist for about 30 NICE clinical guidelines. He also used to work for one of the independent academic groups that review evidence for technology appraisals.


Dr Stephen Smith, BSc MPhil MB BChir PhD MRCP

MRC post-doctoral clinical research fellow, University of Cambridge

More about Stephen

Biography

Stephen is a clinical academic working at the University of Cambridge and EMBL-European Bioinformatics Institute. His clinical training is as a clinical pharmacologist and dermatologist at Addenbrookes in Cambridge.

Following a BSc in virology and PhD in Immuno-genomics from Edinburgh, he completed his medical degree in Cambridge, early clinical training at Addenbrookes and then MPhil from the Cambridge department of Applied Mathematics and Theoretical Physics. He went on to pursue an academic clinical career focused on applying bioinformatics to cancer biology.

Stephen has an ongoing interest in the application of computational modeling and machine learning techniques to healthcare datasets including to health economics and health technology.

Registered interests

None


Professor Toby Smith

More about Toby

Biography

Toby is an associate professor in physiotherapy at the University of East Anglia and senior trauma and orthopaedic physiotherapist at the Norfolk and Norwich University Hospital NHS Foundation Trust.

Toby’s clinical and research interests are predominantly based around the rehabilitation of people with lower limb (hip and knee) bone, joint and muscle diseases and following orthopaedic surgery

Registered interests

None


Mary Weatherstone

More about Mary

Biography

Mary has held several roles in her career as a clinical pharmacist and NHS manager, working as a commissioner head of medicines management, CSU head of secondary care services and individual funding requests, as an urgent care pharmacist, community pharmacist and senior clinical pharmacist manager in GP surgeries and primary care networks.

Mary was a clinical pharmacist ambassador for Health Education England (HEE), promoting clinical pharmacists in general practice and is also a NICE medicines and prescribing associate. She is an independent prescriber, with postgraduate qualifications in healthcare leadership and prescribing and therapeutics.

Registered interests

Financial interests

  • Was a pharmacist ambassador for HEE East of England.
  • Occasionally teaches GP trainees at University of East Anglia Norwich.

Indirect interests

  • Is an employee of Coastal Partnership GP practice and AGEM CSU.

Professor Nicky J Welton BSc MSc PhD

Professor of statistical and health economic modelling, University of Bristol

More about Nicky

Biography

Nicky graduated with a BSc in mathematics from Sheffield University, an MSc in statistics from University College London, and a PhD in mathematical biology from the University of Bristol. She is currently professor of statistical and health economic modelling in the department of population health sciences at the University of Bristol. Here she leads the Multi-Parameter Evidence Synthesis research group and is director of the NICE Guidelines Technical Support Unit.

Her research interests include methods for evidence synthesis in health technology assessment, network meta-analysis, extrapolating survival curves, bias adjustment in evidence synthesis, use of evidence in economic models, and value of information analysis.

Registered interests

Direct - financial

June 2015 to present: contributes a session (for which she receives payment) on evidence synthesis for an Association of British Pharmaceutical Industry master class entitled: 'What makes a good submission to NICE'.

February 2019: received fees from the Association of the British Pharmaceutical Industry (ABPI) for delivering masterclasses on evidence synthesis.

Indirect - financial

January 2015 to September 2018: principle investigator for an MRS Methodology Research grant, in collaboration with Pfizer Ltd. Pfizer part fund a junior researcher on the project. The project is purely methodological and uses historical date on pain relief.

Principal Investigator for a research project part funded by the MRC and Pfizer Ltd. Pfizer part-funded a junior researcher until Dec 2018. The project is purely methodological, concerned with synthesis of dose-response and time-course information. The project used historical data on pain relief.


Mr Nigel Westwood

Lay member

More about Nigel

Biography

Nigel left school and joined the Royal Navy as an officer in 1975. After initial training he served on a number of ships including appointments as a bridge watch-keeping officer, gunnery officer, navigating officer, specialist warfare officer, second-in-command and as captain. On moving ashore he joined the staff of the Commander-in-Chief Fleet with responsibility for controlling naval operations around the world before moving to a new NATO headquarters where he worked on NATO policy and negotiating allocation of forces with nations.

After completing the prestigious Joint Service Defence College course he took up an appointment in the Ministry of Defence in London working on future equipment requirements.

In 1997 he showed the first signs of what subsequently proved to be ulcerative colitis and despite an intensive drug regime, his condition deteriorated forcing him to undergo a pan-proctocolectomy and obliging him to leave the Royal Navy in the rank of commander after 25 years service. He now owns and runs an information technology business.

He has been an active volunteer with a number of charities and organisations particularly Crohn's and Colitis UK since his diagnosis serving as a trustee and vice-chairman for a number of years before stepping back for personal reasons in 2010.

Registered interests

None.


Dr Stuart Williams

Consultant radiologist, Norfolk and Norwich University Hospital

More about Stuart

Biography

Stuart qualified in medicine from Oxford University and worked in a variety of medical jobs in Oxford, Birmingham and London before returning to Oxford to train in radiology. Since 2001 he has been a consultant radiologist at Norwich and honorary senior lecturer at Norwich Medical School. He has variously been head of training, radiology clinical director, RCR regional chair and Trust lead for audit and improvement.

Between 2010 and 2013, Stuart was one of the first cohort of NICE clinical fellows and was subsequently a member of the guideline development group around recognition and referral of suspected cancer (NG12).

Registered interests

None.


Mr Tony Wootton

Lay member

More about Tony

Biography

Tony is a retired secondary school headteacher. After graduating from Newcastle University he started his working life as an accountant before embarking on a teaching career which spanned nearly 30 years, working in Leeds, London and North Yorkshire.

Since retiring Tony has served on a number of NICE guideline development groups covering topics ranging from ‘anti-social behaviour and conduct disorders’ through to ‘achieving better access to urgent and emergency mental health care for children and young people’ and most recently ‘Suspected Neurological Conditions Recognition and Referral’.

Tony has been a member of the Lymphoma Association for a number of years since his own diagnosis of Non-Hodgkin Lymphoma in 2009. In recent years Tony and his wife have provided short break respite care to children and young people with learning difficulties.

Registered interests

None.

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