Medicines optimisation: key therapeutic topics summarise the evidence-base on topics identified to support medicines optimisation, but are not formal NICE guidance.

These topics are selected and prioritised therapeutic areas where there are potential opportunities for maintaining or improving quality and improving value from our use of medicines. Releasing resources from one area of health care whilst maintaining or improving quality of care means those resources are available for use elsewhere, for example - the prescribing of innovative medicines.

NHS Digital lead on the development of comparators for the therapeutic topics included in the document. These are developed under a separate process by NHS Digital. Data on the comparators are available on the Information Services Portal, hosted by the NHS Business Services Authority.

The 2017 update of 'medicines optimisation: key therapeutic topics' has been published.

Individual therapeutic topics can be accessed via the ‘view the key therapeutic topics’ link on the right hand side of this page.

You can view the full document here:

  Medicines optimisation: key therapeutic topics (January 2017)   PDF

Consultation for the 2018 update

We are in the process of updating the medicines optimisation: key therapeutic topics document.

A consultation on the topics to be included in the update was carried out in June/July 2017, and the final list of key therapeutic topics for the update has been agreed. You can view the final list of topics as well as responses to comments received during the consultation in the following documents:

  Key therapeutic topics 2018 update: final list of topics (September 2017) PDF

  Responses to comments received during consultation for the 2018 update (September 2017) PDF

You can view a draft of the Medicines optimisation: key therapeutic topics document to be updated in February 2018 below. We would be pleased to receive any comments on this draft by 5pm on 3 January 2018 by emailing them to

  Draft Medicines optimisation: key therapeutic topics (December 2017) PDF


More information

Our integrated process statement sets out how we select topics and prepare the documents.

Past consultations