Find out more about the members of TAC C by reading their biographies.

Professor Stephen G O'Brien BSc (Hons) PhD MBChB FRCP MRCPath


Professor of haematology at Newcastle University and honorary consultant haematologist at Newcastle Hospitals NHS Foundation Trust

More about Stephen

Stephen is an academic clinician with an interest in leukaemia research. Following graduation and general medicine experience in Manchester he trained in haematology, completing a PhD in the molecular biology of leukaemia, at the Hammersmith Hospital in London.

He treated the first UK patients to receive imatinib and continues to be closely involved with ongoing trials of tyrosine kinase inhibitors in chronic myeloid leukaemia. As well as looking after NHS patients with haematological malignancies, Professor O’Brien is the Chief Investigator for the National Cancer Research Network’s SPIRIT trials in CML, involving over 1,000 patients in 150 UK hospitals and is a member of the NCRN Haem Onc Clinical Studies Group.

Dr Peter Selby

Vice Chair

Consultant physician, Central Manchester University Hospitals NHS Foundation Trust

More about Peter

Peter Selby is a consultant physician at the Manchester Royal Infirmary and honorary senior lecturer in medicine at the University of Manchester. After qualifying from Cambridge and Birmingham he undertook postgraduate training in endocrinology, diabetes and general medicine at Leeds and Newcastle before moving to Manchester in 1990. His main clinical and research field is endocrinology, especially disorders of calcium and bone metabolism.

He is currently chair of the Speciality Advisory Committee for training in Endocrinology and Diabetes and has previously been a trustee of the National Osteoporosis Society and the Paget's Association. In addition to his specialist work he remains active in general medicine and is clinical director for acute and rehabilitation medicine in the Manchester Royal Infirmary.

Dr Alex Cale

Mike Chambers

Director, MC Healthcare Evaluation

More about Mike

With degrees in mathematical philosophy (University of Cambridge), demography (LSE) and health economics (University of York), Mike Chambers is currently founder and director of MC Healthcare Evaluation. From 2006 to 2015 he worked for GlaxoSmithKline as director of health economics and latterly as head of reimbursement and value demonstration.

Previously he worked in the UK NHS (district information officer), at London Hospital Medical College (lecturer in department of epidemiology and medical statistics), MEDTAP International (contract research in economic evaluation) and as head of health economics at Amersham Health/GE Healthcare.

His main research interests have been in the development and application of principles of evidence-based medicine and in the methods and processes of health technology assessment, in particular the use of economic modelling and real world evidence to inform decision-making.

Dr Prithwiraj Das

Senior health economist, Boehringer Ingelheim Ltd

More about Prithwiraj

Prithwiraj trained and worked as a medical doctor (MBBS, Gold Medallist). He pursued a Masters degree in International Health Policy from the London School Economics (LSE).

He has worked for more than 11 years in getting patients access to health technologies while working in academia (LSE), consulting (i3 Innovus, LSE, PRMA Consulting), medical devices industry (Medtronic) and pharmaceutical industry (Boehringer Ingelheim Ltd, BI).

Prithwiraj currently works as the market access lead for speciality medicines at Boehringer Ingelheim UK and Ireland, covering multiple therapy areas and brands.

David Foreman


More about David

David is a consultant child and adolescent psychiatrist who has combined a clinical and academic career. Current interests include the impact of information within a public policy and public mental health framework. This includes their use within policy instruments and developing scalable approaches to psychopathology. These have derived from a long-standing interest in perinatal mental health and infant psychiatry, as well as measurement and detection of common psychiatric disorders especially ADHD. He also has a long-standing interest in biomedical ethics.

He is now demitting from the committees of the Perinatal and Child and Adolescent Faculties of the Royal College of Psychiatrists after 6 years. His roles there included data, early years and liaison between the two committees. He continues his academic connection to IoPPN, King's College. He has retired from full-time NHS work, but continues to see patients in private practice.

Rob Forsyth

Senior lecturer at Newcastle University and honorary consultant in paediatric neurology for Newcastle Hospitals NHS Foundation Trust

More about Rob

After qualifying from Cambridge and Oxford, Rob trained in Nottingham and Newcastle with subspecialty training in Vancouver. His research interests centre on translational research in paediatric acquired brain injury and rehabilitation and epilepsy.

Rob is an active acute paediatric neurologist. His clinical responsibilities include co-ordination of the inpatient acquired brain injury service. He was UK national training advisor in paediatric neurology 2003-9. He is editor of the Oxford Specialist Handbook in Paediatric Neurology (third edition 2017). He was on the editorial boards of Developmental Medicine and Child Neurology 2005-11 and European Journal of Paediatric Neurology 2013 to present. He is currently secretary of the European Paediatric Neurology Society.

Dr Natalie Hallas

Senior health economics and commissioning manager, Medtronic UK and Ireland

More about Natalie

Natalie is a senior health economics and commissioning manager with over 10 years' experience in the medical device industry. Natalie completed her PhD in cardiovascular physiology at Brunel University alongside providing exercise physiology support to athletes, before joining Medtronic in 2006 as a clinical research specialist. In this role she managed multi-centre clinical trials in various geographies including Australia and New Zealand.

Natalie holds a Postgraduate Diploma in Health Economics from the University of York, which she is now applying to her current role in relation to a range of medical technologies.

Mr John Hampson

Public health specialist, Cheshire West and Chester Council and lead for medicines management for the Cheshire and Merseyside Public Health Collaborative (Champs)

More about John

John has been a public health specialist since 2004 working in a Primary Care Trust (PCT) and latterly for the public health department of the local authority. He initially trained as a pharmacist and has over 20 years’ experience working in various hospitals in a variety of roles including formulary work, clinical pharmacy and in academia.

The main focus of his public health role is in evidence-based practice and involves critical appraisal of the literature for policy and strategy development at county and regional levels. As a registered pharmacist, he also provides medicines management advice to the public health departments in the local authorities of Cheshire and Merseyside.

Previous research interests have included antimicrobial therapy, diabetes and pharmacoepidemiology.

Dr Nigel Langford

Consultant acute physician and clinical pharmacologist

More about Nigel

Nigel Langford is a consultant acute physician and clinical pharmacologist at Leicester Royal Infirmary, graduating from the Leicester Medical School in 1995. Prior to qualifying he had also worked as a pharmacist and retains membership of the Royal Pharmaceutical Society. He was awarded an MD in clinical pharmacology in 2005 from the University of Birmingham.

He has a long-standing interest in medical education, medical error and adverse drug reactions. He was a member of the NICE Guidelines Development Group for two guidelines looking at the prevention, identification and management of venous thromboembolic diseases. He is an honorary senior lecturer to the Leicester Medical School.

Iain McGowan

Lecturer in education (mental health), Queens University, Belfast

More about Iain

Iain qualified as a mental health nurse in 1998 and has worked in nurse education since 2001. He is a former board member of the Northern Ireland Practice and Education Council for Nursing and Midwifery.

His research interests include health economics, post-traumatic stress disorder and heroin use. He is currently a member of the editorial board of the International Journal of Psychiatry and Mental Health, and former editor in chief of the editorial board of the International Journal of Clinical Psychiatry.

Iain was awarded a post-graduated diploma in Applied Health Economics from the University of Wales in 2018. From September 2019 he's studying for his PhD in Health Economics and Policy at the University of Lancaster.

Dr Andrea Manca

Senior health economist, Centre for Health Economics, University of York

More about Andrea

Andrea is a senior health economist in the Centre for Health Economics at the University of York. His research interests focus on the application of statistical methods for the analysis of cost effectiveness and health outcomes data, and the use of quantitative evidence synthesis techniques to support healthcare decision making.

Andrea holds an MSc in Health Economics (1998) and a PhD in Economics (2005), both awarded by the University of York. He completed a post-doctoral fellowship in Health Services Research in 2007, awarded by The Wellcome Trust, and he is currently holding a Career Development Fellowship titled “Developing economic evaluation methods for decision making: the value of access to individual patient data” funded by the National Institute for Health Research (NIHR).

Andrea has evaluated health technologies in several clinical areas including breast and advanced colorectal cancer, endovascular aneurysm repair, coronary revascularisation, diabetes, neck and chronic low back pain, surgical interventions for urinary stress incontinence, and hysterectomy. He is co-editor of the journal Value in Health and senior associate editor of Pharmacoeconomics Italian Research Articles.

Dr Mudasar Mushtaq

General practitioner

More about Mudasar

Mudasar graduated with honours in medicine and surgery (MBChB) from the University of Liverpool. He went on to train as a general practitioner in the North West. Currently he works in Greater Manchester providing primary care in a variety of settings.

Mudasar is passionate about delivering gold standard healthcare and has a strong interest in evidence-based medicine and health economics. He is currently undertaking a master’s in health economics, policy and management at the London School of Economics.

Richard Nicholas

Ugochinyere Nwulu

Stella O'Brien

Professor Andrew Renehan

Professor of cancer studies and surgery, University of Manchester and honorary consultant in colorectal and peritoneal surgery, Christie NHS Foundation Trust

Read more

Andrew holds honorary degrees in dentistry from Trinity College, Dublin and medicine from University of Manchester. He did his PhD in cancer sciences at the Paterson Cancer Research Institute, Manchester. His main clinical and research field is specialist colorectal surgery, especially cancers of the anus, rectum, and peritoneum.

He is currently chair of the European Association of the Study of Diabetes Cancer Study Group and previous member of the International Agency for Research in Cancer Weight Control and Cancer handbook group. He is a deputy theme lead within the Manchester NIHR Biomedical Research Centre and a member of various NIHR Research Collaboratives. He was previously a member the Cochrane Collaborative Colorectal Cancer Group and a member of our colorectal cancer diagnosis and management guideline development group.

Professor Matt Stevenson BSc, PhD

Professor of health technology assessment, School of Health and Related Research, University of Sheffield

More about Matt

Matt studied operational research at Lancaster University where he received his doctorate. Matt has worked for the University of Sheffield for over 20 years where he has conducted cost-effectiveness analyses primarily for the National Institute for Health Research.

He is director of the School of Health and Related Research Technology Assessment Group, an academic group undertaking modelling work to provide data for NICE technology and diagnostic appraisals, and is additionally a member of NICE's technology appraisal committee and also the NICE Decision Support Unit.

Dr Paul Tappenden

Reader in health economic modelling, ScHARR

More about Paul

Paul Tappenden is a reader in health economic modelling at the School of Health and Related Research (ScHARR) within the University of Sheffield. Paul is the deputy technical director of the ScHARR Technology Assessment Group. Paul is also a member of the NICE Decision Support Unit (DSU).

Paul has an MSc in Health Services Research and Technology Assessment and a PhD on the role and value of “Whole Disease Models”, both awarded by the University of Sheffield. He has over 10 years' experience in designing, developing and appraising models. His primary research interest relates to the development and use of health economic models to inform decision-making.

Dr Derek Ward

Clinical senior lecturer in public health at the University of Birmingham

More about Derek

Dr Derek Ward is a clinical senior lecturer in public health at the University of Birmingham and an honorary consultant in public health with Public Health England.

Derek originally qualified in medicine and was appointed consultant in communicable disease control for the Health Protection Agency West Midlands in 2005. Subsequently, he worked as co-director of the NIHR Horizon Scanning Research and Intelligence Centre, where he developed a particular interest in new and emerging pharmaceuticals. At the University of Birmingham, Derek is the academic lead for assessment on the MBChB course, he leads a popular MPH programme and teaches across a broad range of programmes relevant to public health.

More information

Find out more about the committee and read papers from previous meetings.

About the Technology Appraisal committee


Get involved

Find out when TAC meetings are held and register to attend.