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Guidance, NICE advice and quality standards in development
Title
Type
Expected publication date
Nivolumab for adjuvant treatment of resected non-small-cell lung cancer [ID4053]
Technology appraisal guidance
TBC
Nivolumab with BMS-986205 and chemotherapy for neoadjuvant treatment of muscle-invasive bladder cancer [ID6321]
Technology appraisal guidance
TBC
Nivolumab with chemotherapy for untreated unresectable or metastatic urothelial cancer [ID5102]
Technology appraisal guidance
TBC
Nivolumab with ipilimumab for untreated advanced hepatocellular carcinoma [ID6239]
Technology appraisal guidance
29 July 2026
Nivolumab with ipilimumab for untreated unresectable or metastatic urothelial cancer when cisplatin is unsuitable [ID3939]
Technology appraisal guidance
TBC
Nivolumab with ipilimumab for untreated unresectable stage 3 non-small-cell lung cancer [ID6248]
Technology appraisal guidance
TBC
Nivolumab–relatlimab for adjuvant treatment of resected stage 3 or 4 melanoma in people 12 years and over [ID6475]
Technology appraisal guidance
TBC
Nogapendekin alfa inbakicept with intravesical BCG for non-muscle-invasive bladder cancer with carcinoma in situ that is unresponsive to BCG [ID6582]
Technology appraisal guidance
TBC
Nusinersen and risdiplam for treating spinal muscular atrophy (review of TA588 and TA755) [ID6195]
Technology appraisal guidance
TBC
NY-ESO-1 T-cells for treating synovial sarcoma ID1286
Technology appraisal guidance
TBC
Obecabtagene autoleucel for treating relapsed or refractory B-cell acute lymphoblastic leukaemia [ID6347]
Technology appraisal guidance
11 December 2025
Obeticholic acid for treating liver fibrosis in people with steatohepatitis [ID1645]
Technology appraisal guidance
TBC
Obicetrapib and obicetrapib–ezetimibe for treating primary hypercholesterolaemia or mixed dyslipidaemia ID6519
Technology appraisal guidance
TBC
Obinutuzumab with immunosuppressive therapies for treating lupus nephritis [ID6420]
Technology appraisal guidance
11 March 2026
Odevixibat for treating cholestasis and pruritus in Alagille Syndrome [ID6181]
Technology appraisal guidance
TBC
Olezarsen for treating familial chylomicronaemia syndrome [ID6585]
Technology appraisal guidance
19 August 2026
Omburtamab for treating relapsed neuroblastoma [ID1664]
Technology appraisal guidance
TBC
Oral paclitaxel with encequidar for treating advanced breast cancer [ID5111]
Technology appraisal guidance
TBC
Orforglipron for managing overweight and obesity ID6516
Technology appraisal guidance
TBC
Osimertinib for maintenance treatment of EGFR mutation-positive locally advanced unresectable non-small-cell lung cancer after platinum-based chemoradiation [ID6223]
Technology appraisal guidance
28 January 2026
Osimertinib for neoadjuvant treatment of EGFR mutation-positive resectable non-small-cell lung cancer [ID6472]
Technology appraisal guidance
TBC
Oxybutynin hydrochloride for managing neurogenic detrusor overactivity in people 6 years and over with spinal cord injury or spina bifida [ID5089]
Technology appraisal guidance
TBC
Palbociclib with trastuzumab and endocrine therapy for maintenance treatment of hormone-receptor positive, HER2-positive metastatic breast cancer [ID6251]
Technology appraisal guidance
TBC
Palforzia for treating peanut allergy in children aged 1 to 3 [ID6144]
Technology appraisal guidance
TBC
Palopegteriparatide for treating chronic hypoparathyroidism [ID6380]
Technology appraisal guidance
23 July 2026
Patritumab deruxtecan for treating EGFR mutation-positive advanced non-small-cell lung cancer after 1 or 2 tyrosine kinase inhibitor treatment [ID6467]
Technology appraisal guidance
TBC
Pegcetacoplan for amyotrophic lateral sclerosis TS ID 10594
Technology appraisal guidance
TBC
Pegcetacoplan for treating geographic atrophy [ID4041]
Technology appraisal guidance
TBC
Pegcetacoplan for treating primary complement 3 glomerulopathy and primary immune-complex membranoproliferative glomerulonephritis in people 12 years and over [ID6489]
Technology appraisal guidance
18 June 2026
Pembrolizumab adjuvant for urothelial carcinoma and/or localised muscle invasive bladder cancer [TSID12021]
Technology appraisal guidance
TBC
Pembrolizumab before surgery (neoadjuvant) then with radiotherapy after surgery (adjuvant) for newly diagnosed, resectable, locally advanced, squamous cell head and neck cancer [ID6477]
Technology appraisal guidance
1 July 2026
Pembrolizumab for adjuvant treatment of hepatocellular carcinoma [ID3994]
Technology appraisal guidance
29 October 2026
Pembrolizumab for adjuvant treatment of locally advanced cutaneous squamous cell carcinoma after surgery and radiotherapy ID 6473
Technology appraisal guidance
TBC
Pembrolizumab with chemoradiation, then with or without olaparib, for untreated unresectable locally advanced non-small-cell lung cancer [ID6399]
Technology appraisal guidance
TBC
Pembrolizumab with chemotherapy for adjuvant treatment of newly diagnosed high-risk endometrial cancer after surgery with curative intent [ID6207]
Technology appraisal guidance
TBC
Pembrolizumab with chemotherapy for treating hormone receptor-positive HER2-negative locally recurrent inoperable or metastatic breast cancer [ID6285]
Technology appraisal guidance
TBC
Pembrolizumab with chemotherapy then olaparib maintenance for treating BRCA-negative advanced epithelial ovarian, fallopian tube or peritoneal cancer [ID3853]
Technology appraisal guidance
TBC
Pembrolizumab with chemotherapy with or without bevacizumab for treating platinum-resistant recurrent ovarian cancer after 1 or 2 treatments ID6363
Technology appraisal guidance
TBC
Pembrolizumab with ipilimumab for treating PD-L1-positive advanced non-small-cell lung cancer [ID3861]
Technology appraisal guidance
TBC
Pembrolizumab with lenvatinib and chemotherapy for untreated advanced gastro-oesophageal junction cancer [TSID11861]
Technology appraisal guidance
TBC
Pembrolizumab with lenvatinib and chemotherapy for untreated metastatic squamous cell oesophageal cancer [TSID12096]
Technology appraisal guidance
TBC
Pembrolizumab with olaparib and chemoradiation for previously untreated limited-stage small-cell lung cancer [ID6412]
Technology appraisal guidance
TBC
Pembrolizumab with olaparib for treating hormone-relapsed metastatic prostate cancer after abiraterone or enzalutamide and chemotherapy [ID3814]
Technology appraisal guidance
TBC
Pembrolizumab with pemetrexed and platinum-based chemotherapy for untreated unresectable advanced malignant pleural mesothelioma [ID4044]
Technology appraisal guidance
TBC
Pembrolizumab with stereotactic body radiotherapy for treating unresected stage 1 or 2 non-small-cell lung cancer [ID6149]
Technology appraisal guidance
TBC
Pembrolizumab–vibostolimab for untreated metastatic non-small-cell lung cancer [ID6365]
Technology appraisal guidance
TBC
Pembrolizumab–vibostolimab with etoposide and platinum-based chemotherapy for untreated extensive-stage small-cell lung cancer [ID6361]
Technology appraisal guidance
TBC
Pertuzumab–trastuzumab with chemotherapy for treating HER2-positive breast cancer [ID2724]
Technology appraisal guidance
TBC
Pharmalgen for the treatment of bee and wasp venom allergy
Technology appraisal guidance
TBC
Pirtobrutinib for treating chronic lymphocytic leukaemia or small lymphocytic lymphoma after 1 or more BTK inhibitors [ID6269]
Technology appraisal guidance
29 January 2026
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