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This manual explains how NICE develops and updates social care guidance. It provides advice on the technical aspects of guidance development and the methods used

International collaboration with NICE

Training and development opportunities at NICE

Training and development opportunities at NICE

This guide provides an overview of the principles and methods of health technology assessment and appraisal within the context of the NICE appraisal process

Evidence-based recommendations on crizotinib (Xalkori) for untreated anaplastic lymphoma kinase-positive advanced non-small-cell lung cancer in adults.

Result type

Technology appraisal guidance

Published

28 September 2016

Evidence-based recommendations on nintedanib (Vargatef) for treating locally advanced, metastatic or locally recurrent non-small-cell lung cancer in adults.

Result type

Technology appraisal guidance

Published

22 July 2015

Evidence-based recommendations on peginterferon alfa (Pegasys; ViraferonPeg) and ribavirin for treating chronic hepatitis C in adults.

Result type

Technology appraisal guidance

Published

22 September 2010

Evidence-based recommendations on extracorporeal whole liver perfusion for acute liver failure. This involves blood being diverted to a whole liver (perfusion) outside the body and returned to the patient.

Result type

HealthTech guidance

Published

31 March 2021

Evidence-based recommendations on free-functioning gracilis transfer to restore upper limb function in brachial plexus injury in adults. This involves taking a piece of hamstring muscle and its nerve and blood supply from the inner thigh, transferring it to the arm and joining it to the damaged nerve.

Result type

HealthTech guidance

Published

3 March 2021

Evidence-based recommendations on normothermic extracorporeal preservation of hearts for transplant after brainstem death. This technique is used to store a donor heart for longer before being transplanted.

Result type

HealthTech guidance

Published

24 February 2016

Evidence-based recommendations on balloon valvuloplasty for aortic valve stenosis in adults and children. This involves inflating a balloon inserted into the narrow valve to widen it so that blood can flow out more easily.

Result type

HealthTech guidance

Published

28 July 2004

NICE has developed a Medtech Innovation Briefing (MIB) on the AccuVein AV400 for vein visualisation

Result type

Medtech innovation briefing

Published

23 June 2014

Evidence-based recommendations on nivolumab (Opdivo) for treating advanced (unresectable or metastatic) melanoma in adults.

Result type

Technology appraisal guidance

Published

18 February 2016

People have the right to be able to make informed decisions about their care. Our guidance should be taken into account when making decisions with them.