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Showing 5801 to 5850 of 8236 results

  1. What is the effectiveness and cost effectiveness of endoscopic variceal band ligation plus a non-selective beta-blocker compared with either of these interventions alone for preventing variceal bleeding in adults with cirrhosis and medium or large oesophageal varices?

    Recommendation ID NG50/1 Question What is the effectiveness and cost effectiveness of endoscopic variceal band ligation plus a non-selective

    Research recommendation
    Published
    11 January 2024

  2. Case management:- What is the effectiveness and cost effectiveness of high-intensity case management compared with usual care on quality of life (for the person living with dementia and for their carers) and the timing of entry to long-term care?

    Recommendation ID NG97/1 Question Case management:- What is the effectiveness and cost effectiveness of high-intensity case management

    Research recommendation
    Published
    10 December 2018

  3. Effectiveness of intensive rehabilitation in adults: What is the effectiveness and cost effectiveness of intensive rehabilitation programmes in adults with complex rehabilitation needs after a traumatic injury?

    Recommendation ID NG211/01 Question Effectiveness of intensive rehabilitation in adults: What is the effectiveness and cost effectiveness

    Research recommendation
    Published
    1 February 2022

  4. Effectiveness of intensive rehabilitation in children and young people: What is the effectiveness and cost effectiveness of intensive rehabilitation programmes in children and young people with complex rehabilitation needs after a traumatic injury?

    Recommendation ID NG211/02 Question Effectiveness of intensive rehabilitation in children and young people: What is the effectiveness and

    Research recommendation
    Published
    1 February 2022

  5. Interaction between behavioural and environmental interventions:- What is the effectiveness and cost effectiveness of interventions to change the environment alone, compared with interventions to change the environment that are supported by interventions to change people's behaviour?

    Recommendation ID NG90/6 Question Interaction between behavioural and environmental interventions:- What is the effectiveness and cost

    Research recommendation
    Published
    15 November 2018

  6. What is the effectiveness and cost effectiveness of intravenous compared with oral antibiotics for preventing postnatal infections after birth with forceps or ventouse?

    Recommendation ID NG235/5 Question What is the effectiveness and cost effectiveness of intravenous compared with oral antibiotics for preventing

    Research recommendation
    Published
    11 January 2024

  7. Longer health and social care contacts: What is the effectiveness and cost effectiveness of longer health and social care contacts compared with usual care for people experiencing homelessness?

    Recommendation ID NG214/03 Question Longer health and social care contacts: What is the effectiveness and cost effectiveness of longer

    Research recommendation
    Published
    8 April 2022

  8. Models of supported living:- What is the effectiveness and cost effectiveness of models of shared, supported living, such as Shared Lives?What are the views and experiences of people sharing their home and people who live with themunder programmes such as Shared Lives?

    Recommendation ID NG93/3 Question Models of supported living:- What is the effectiveness and cost effectiveness of models of shared, supported

    Research recommendation
    Published
    15 November 2018

  9. Self-management materials: What is the effectiveness and cost effectiveness of rehabilitation programmes combined with self-management materials, compared with rehabilitation programmes alone, in people with complex rehabilitation needs after a traumatic injury?

    Recommendation ID NG211/04 Question Self-management materials: What is the effectiveness and cost effectiveness of rehabilitation programmes

    Research recommendation
    Published
    1 February 2022

  10. Length of bed rest after spinal cord injury: What is the effectiveness and cost effectiveness of short-term bed rest compared with long-term bed rest on functional outcomes in people with complex rehabilitation needs after traumatic injury that involves the spinal column or spinal cord injury?

    Recommendation ID NG211/05 Question Length of bed rest after spinal cord injury: What is the effectiveness and cost effectiveness of short-term

    Research recommendation
    Published
    1 February 2022

  11. Information and support: What is the clinical and cost effectiveness of information and support offered to parents and carers of babies who have received antibiotics for suspected or proven early-onset neonatal infection?

    Recommendation ID NG195/9 Question Information and support: What is the clinical and cost effectiveness of information and support offered

    Research recommendation
    Published
    6 August 2021

  12. Acute haemodialysis versus acute peritoneal dialysis:- What is the clinical and cost effectiveness of initial haemodialysis versus initial peritoneal dialysis for people who start dialysis in an unplanned way?

    Recommendation ID NG107/3 Question Acute haemodialysis versus acute peritoneal dialysis:- What is the clinical and cost effectiveness of

    Research recommendation
    Published
    18 December 2018

  13. Managing communication difficulties in children with cerebral palsy:- What is the clinical and cost effectiveness of interventions for managing communication difficulties in children with cerebral palsy?

    Recommendation ID NG62/2 Question Managing communication difficulties in children with cerebral palsy:- What is the clinical and cost effectiveness

    Research recommendation
    Published
    17 February 2017

  14. Complex PTSD:- What is the clinical and cost effectiveness of interventions to deliver stabilisation and reintegration for people with complex PTSD?

    Recommendation ID NG116/5 Question Complex PTSD:- What is the clinical and cost effectiveness of interventions to deliver stabilisation

    Research recommendation
    Published
    13 February 2019

  15. Intra-articular injections:- What is the clinical and cost effectiveness of intra-articular corticosteroids for managing osteoarthritis-affected joints other than the knee? - What is the clinical and cost effectiveness of intra-articular stem cells for managing osteoarthritis?

    Recommendation ID NG226/11 Question Intra-articular injections:- What is the clinical and cost effectiveness of intra-articular corticosteroids

    Research recommendation
    Published
    7 November 2022

  16. Intrapartum antibiotics: What is the clinical and cost effectiveness of intrapartum antibiotics for women with meconium-stained amniotic fluid?

    Recommendation ID NG195/10 Question Intrapartum antibiotics: What is the clinical and cost effectiveness of intrapartum antibiotics for

    Research recommendation
    Published
    6 August 2021

  17. Creatinine-based estimate of eGFR – improving accuracy of calculations: In adults, children and young people from black, Asian and other minority ethnic groups with CKD living in the UK, what biomarkers or factors, other than ethnicity, improve the diagnostic accuracy of eGFR calculations?

    Recommendation ID NG203/2 Question Creatinine-based estimate of eGFR – improving accuracy of calculations: In adults, children and young

    Research recommendation
    Published
    30 September 2021

  18. NICE encourages further research into implanted vagus nerve stimulation for treatment-resistant depression, in the form of randomised controlled trials with a placebo or sham stimulation arm. Studies should report details of patient selection. Outcomes should include validated depression rating scales, patient-reported quality of life, time to onset of effect and duration of effect, and any changes in concurrent treatments.

    Recommendation ID IPG679/1 Question NICE encourages further research into implanted vagus nerve stimulation for treatment-resistant depression

    Research recommendation
    Published
    26 October 2020

  19. Femoral component design: In adults undergoing hemiarthroplasty for displaced intracapsular hip fracture (including in different subgroups), which femoral component design has the best long-term outcomes?

    Recommendation ID CG124/07 Question Femoral component design: In adults undergoing hemiarthroplasty for displaced intracapsular hip fracture

    Research recommendation
    Published
    3 February 2023

  20. Indications for interventions – CT or MRI: In adults with aortic or mitral regurgitation in whom the need for intervention is unclear after echocardiography, what is the prognostic value and cost effectiveness of left ventricular ejection fraction (LVEF) measured on cardiac MRI to assess the need for intervention?

    Recommendation ID NG208/09 Question Indications for interventions – CT or MRI: In adults with aortic or mitral regurgitation in whom the

    Research recommendation
    Published
    16 December 2021

  21. Indications for interventions – CT or MRI: In adults with aortic or primary mitral regurgitation in whom the need for intervention is unclear after echocardiography, what is the prognostic value and cost effectiveness of cardiac MRI to assess the severity of valvular regurgitation?

    Recommendation ID NG208/08 Question Indications for interventions – CT or MRI: In adults with aortic or primary mitral regurgitation in

    Research recommendation
    Published
    16 December 2021

  22. Use of hearing aids and incidence of dementia:- In adults with hearing loss, does the use of hearing aids reduce the incidence of dementia?

    Recommendation ID NG98/3 Question Use of hearing aids and incidence of dementia:- In adults with hearing loss, does the use of hearing

    Research recommendation
    Published
    10 December 2018

  23. Indications for interventions – global longitudinal strain: In adults with asymptomatic, severe aortic regurgitation or mitral regurgitation what is the prognostic value and cost effectiveness of B‑type natriuretic peptide (BNP) to assess the need for intervention?

    Recommendation ID NG208/13 Question Indications for interventions – global longitudinal strain: In adults with asymptomatic, severe aortic

    Research recommendation
    Published
    16 December 2021

  24. Indications for interventions – CT or MRI: In adults with asymptomatic severe aortic stenosis what is the prognostic value and cost effectiveness of LVEF measured on cardiac MRI to assess the need for intervention?

    Recommendation ID NG208/10 Question Indications for interventions – CT or MRI: In adults with asymptomatic severe aortic stenosis what

    Research recommendation
    Published
    16 December 2021

  25. Indications for interventions – global longitudinal strain: In adults with severe heart valve disease what is the prognostic value and cost effectiveness of global longitudinal strain to assess the need for intervention?

    Recommendation ID NG208/12 Question Indications for interventions – global longitudinal strain: In adults with severe heart valve disease

    Research recommendation
    Published
    16 December 2021

  26. Phosphate binders: In adults with stage 4 or 5 CKD, including those on dialysis, what is the clinical and cost effectiveness and safety of long-term calcium acetate combined with magnesium carbonate for controlling serum phosphate?

    Recommendation ID NG203/17 Question Phosphate binders: In adults with stage 4 or 5 CKD, including those on dialysis, what is the clinical

    Research recommendation
    Published
    30 September 2021

  27. Indications for interventions – CT or MRI: In adults with asymptomatic severe tricuspid regurgitation what is the prognostic value and cost effectiveness of cardiac MRI for assessment of the right ventricle to assess the need for intervention?

    Recommendation ID NG208/11 Question Indications for interventions – CT or MRI: In adults with asymptomatic severe tricuspid regurgitation

    Research recommendation
    Published
    16 December 2021

  28. Anticoagulation and antiplatelet therapy: In adults with biological valve replacement, what effect does anticoagulation or antiplatelet therapy have on long-term valve function and outcomes?

    Recommendation ID NG208/23 Question Anticoagulation and antiplatelet therapy: In adults with biological valve replacement, what effect

    Research recommendation
    Published
    16 December 2021

  29. The effects of stopping and/or switching drug treatments to control blood glucose levels: In adults with type 2 diabetes, what are the effects of stopping and/or switching drug treatments to control blood glucose levels, and what criteria should inform the decision?

    Recommendation ID NG28/01 Question The effects of stopping and/or switching drug treatments to control blood glucose levels: In adults

    Research recommendation
    Published
    16 December 2021

  30. Long-term outcomes associated with blood glucose lowering agents: In adults with type 2 diabetes, what are the long‑term effects of blood glucose lowering therapies such as dipeptidyl peptidase‑4 (DPP‑4) inhibitors, sodium–glucose cotransporter‑2 (SGLT2) inhibitors and meglitinides?

    Recommendation ID NG28/04 Question Long-term outcomes associated with blood glucose lowering agents: In adults with type 2 diabetes, what

    Research recommendation
    Published
    16 December 2021

  31. Pilon fractures: In adults with closed pilon fractures, what method of fixation provides the best clinical and cost effectiveness outcomes as assessed by function and incidence of major complications at 2 years (stratified for timing of definitive surgery early [under 36 hours] versus later [over 36 hours])?

    Recommendation ID NG37/03 Question Pilon fractures: In adults with closed pilon fractures, what method of fixation provides the best clinical

    Research recommendation
    Published
    12 December 2022

  32. In adults with common bile duct stones, should laparoscopic cholecystectomy be performed early (within 2 weeks of bile duct clearance), or should it be delayed (until 6 weeks after bile duct clearance)?

    Recommendation ID CG188/4 Question In adults with common bile duct stones, should laparoscopic cholecystectomy be performed early (within

    Research recommendation
    Published
    9 June 2015

  33. Non-metformin-based drug treatment combinations to control blood glucose levels: In adults with type 2 diabetes, what treatment combinations (for example, glucagon‑like peptide‑1 [GLP‑1] mimetics and insulin combination therapy with meglitinides) are most effective when initial drug treatment with non‑metformin monotherapy fails to adequately control blood glucose levels?

    Recommendation ID NG28/02 Question Non-metformin-based drug treatment combinations to control blood glucose levels: In adults with type

    Research recommendation
    Published
    16 December 2021

  34. Indicators and thresholds for referral for cataract surgery:- What is the association between preoperative vision- and health-related quality of life, and postoperative vision-related quality of life, health-related quality of life, and self-reported postoperative improvement?

    Recommendation ID NG77/3 Question Indicators and thresholds for referral for cataract surgery:- What is the association between preoperative

    Research recommendation
    Published
    6 November 2018

  35. Individual versus group CBT for children and young people with social anxiety disorder:- What is the clinical and cost effectiveness of individual and group CBT for children and young people with social anxiety disorder?

    Recommendation ID CG159/4 Question Individual versus group CBT for children and young people with social anxiety disorder:- What is the

    Research recommendation
    Published
    9 June 2015

  36. What is the clinical and cost effectiveness of prednisolone compared with aminosalicylates for the induction of remission for people with moderate ulcerative colitis?

    Recommendation ID NG130/4 Question What is the clinical and cost effectiveness of prednisolone compared with aminosalicylates for the induction

    Research recommendation
    Published
    25 October 2019

  37. What is the clinical and cost effectiveness of prednisolone plus an aminosalicylate compared with beclometasone plus an aminosalicylate for induction of remission for people with moderate ulcerative colitis?

    Recommendation ID NG130/5 Question What is the clinical and cost effectiveness of prednisolone plus an aminosalicylate compared with beclometasone

    Research recommendation
    Published
    25 October 2019

  38. What are the benefits, risks and cost effectiveness of methotrexate, ciclosporin, tacrolimus, adalimumab and infliximab compared with each other and with placebo for induction of remission for people with subacute ulcerative colitis that is refractory to systemic corticosteroids?

    Recommendation ID NG130/6 Question What are the benefits, risks and cost effectiveness of methotrexate, ciclosporin, tacrolimus, adalimumab

    Research recommendation
    Published
    25 October 2019

  39. Further research is recommended to help address remaining clinical and cost-effectiveness uncertainties for esketamine, summarised in section 3.36 .

    Recommendation ID TA854/01 Question Further research is recommended to help address remaining clinical and cost-effectiveness uncertainties

    Research recommendation
    Published
    6 January 2023

  40. Further research is recommended to resolve the uncertainties about the long-term clinical effectiveness of darvadstrocel compared with standard care. In particular, estimates of long-term remission rates (minimum of 2 years' follow-up) in Crohn's disease with perianal fistulas are needed.

    Recommendation ID TA556/1 Question Further research is recommended to resolve the uncertainties about the long-term clinical effectiveness

    Research recommendation
    Published
    19 March 2019

  41. Further research is recommended to resolve uncertainties about the clinical effectiveness of degarelix compared with luteinising hormone-releasing hormone (LHRH) agonists such as leuprorelin, goserelin and triptorelin for treating advanced hormone-dependent prostate cancer, particularly in subgroups of people with preexisting cardiovascular disease, people with skeletal (including spinal) metastases and people with impending ureteric and urethral obstruction. Research should be planned as part of well-conducted randomised clinical trials.

    Recommendation ID TA404/1 Question Further research is recommended to resolve uncertainties about the clinical effectiveness of degarelix

    Research recommendation
    Published
    17 October 2016

  42. Pelvic floor muscle training for preventing pelvic floor dysfunction in young women: Is pelvic floor muscle training for young women (between 12 and 17 years) effective in preventing pelvic floor dysfunction?

    Recommendation ID NG210/02 Question Pelvic floor muscle training for preventing pelvic floor dysfunction in young women: Is pelvic floor

    Research recommendation
    Published
    7 January 2022

  43. Electroacupuncture: Is electroacupuncture a clinically and cost-effective treatment for any subgroup of people with osteoarthritis?

    Recommendation ID NG226/07 Question Electroacupuncture: Is electroacupuncture a clinically and cost-effective treatment for any subgroup

    Research recommendation
    Published
    7 November 2022

  44. Is primary radical cystectomy more effective than primary intravesical BCG (Bacille Calmette-Guérin) in high risk non-muscle-invasive bladder cancer, in terms of quality of life and cancer-specific outcomes?

    Recommendation ID NG2/2 Question Is primary radical cystectomy more effective than primary intravesical BCG (Bacille Calmette-Guérin) in

    Research recommendation
    Published
    9 June 2015

  45. Extended access to GP services:- Is extended access to GP services, for example during early mornings, evenings and weekends, more clinically and cost effective than standard access?

    Recommendation ID NG94/1 Question Extended access to GP services:- Is extended access to GP services, for example during early mornings

    Research recommendation
    Published
    15 November 2018

  46. Is providing treatment for psychosis and substance misuse services within staffed accommodation more cost-effective than a combination of hospital and home treatment?

    Recommendation ID CG120/3 Question Is providing treatment for psychosis and substance misuse services within staffed accommodation more

    Research recommendation
    Published
    9 June 2015

  47. Method of botulinum toxin type A injection in treating focal spasticity:- Is guided botulinum toxin type A injection using electrical localisation (electrostimulation orelectromyography) of muscles more clinically and cost effective than ultrasound-guided injections or clinical positioning for localisation of injections in treating focal spasticity in adults with cerebral palsy?

    Recommendation ID NG119/1 Question Method of botulinum toxin type A injection in treating focal spasticity:- Is guided botulinum toxin

    Research recommendation
    Published
    8 March 2019

  48. Referral within a formal care pathway:- Is referral from a community pharmacy within a formal local care pathway framework more effective and cost effective than signposting alone in improving access to, and uptake of, services by underserved groups and the general population?

    Recommendation ID NG102/1 Question Referral within a formal care pathway:- Is referral from a community pharmacy within a formal local

    Research recommendation
    Published
    12 December 2018

  49. Routine admission to hospital: Is routine or automatic admission effective for young people or older adults who have self-harmed?

    Recommendation ID NG225/03 Question Routine admission to hospital: Is routine or automatic admission effective for young people or older

    Research recommendation
    Published
    30 September 2022

  50. Is high-flow nasal oxygen effective in reducing breathlessness compared with standard care or conventional oxygen therapy for people in hospital with COVID-19 and respiratory failure when it is agreed that treatment will not be escalated beyond non-invasive respiratory support or palliative care is needed?

    Recommendation ID NG191/5 Question Is high-flow nasal oxygen effective in reducing breathlessness compared with standard care or conventional

    Research recommendation
    Published
    21 October 2021