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  1. Erythropoiesis‑stimulating agents (epoetin and darbepoetin) for treating anaemia in people with cancer having chemotherapy (TA323)

    Evidence-based recommendations on erythropoiesis-stimulating agents (epoetin alfa [Eprex], epoetin beta [NeoRecormon], epoetin theta, epoeitin zeta [Retacrit] and darbepoetin alfa [Aranesp]) for treating anaemia in adults with cancer having chemotherapy.

    Technology appraisal guidance
    Published
    26 November 2014
    View recommendations

    Sections for TA323

  2. Artificial intelligence (AI) technologies to aid contouring for radiotherapy treatment planning: early value assessment (HTG695)

    Early value assessment (EVA) guidance on artificial intelligence (AI) technologies to aid contouring for radiotherapy treatment planning in people having external beam radiotherapy.

    HealthTech guidance
    Published
    27 September 2023
    View recommendations

    Sections for HTG695

  3. Comprehensive assessment versus a brief assessment:- For people with a suspected common mental health disorder, what is the clinical and cost effectiveness of using a comprehensive assessment (conducted by mental health professional) versus a brief assessment (conducted by a paraprofessional)?

    answered using a randomised controlled design that reports short- and medium-term outcomes (including cost-effectiveness outcomes) of at...

    Research recommendation
    Published
    9 June 2015

  4. Evidence on the safety and efficacy of biodegradable spacer insertion to reduce rectal toxicity during radiotherapy for prostate cancer is limited in quality. Therefore, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Find out what special arrangements mean on the NICE interventional procedures guidance page.

    ofradiotherapy technique and device used, improvement in quality of life, and long-term efficacy and safety. It should also identify...

    Research recommendation
    Published
    9 March 2023

  5. Evidence on the progression of X-linked hypophosphataemia (XLH) over time and the long-term benefits of burosumab would also be valuable.

    the progression of X-linked hypophosphataemia (XLH) over time and the long-term benefits of burosumab would also be valuable. Any...

    Research recommendation
    Published
    22 March 2019

  6. Intrapartum care: existing medical conditions and obstetric complications (QS192)

    This quality standard covers care during labour and birth for women who need extra support because they have a medical condition or complications in their current or previous pregnancy. It also covers women who have had no antenatal care. It describes high-quality care in priority areas for improvement. It does not cover the antenatal and postnatal care of pregnant women with mental health conditions, hypertension in pregnancy, diabetes in pregnancy or the organisation of care for pregnant women with complex social factors.

    Quality standard
    Published
    28 February 2020
    View quality statements

    Sections for QS192

  7. Support needs of parents:- What are the experiences and concerns of parents of children with faltering growth?

    or unheard. Faltering growth happens when children are young so can have a long-term impact on the child–parent relationship. There are...

    Research recommendation
    Published
    15 October 2018

  8. Pharmacological therapies:- What is the clinical and cost effectiveness of benzodiazepines for the acute management of low back pain?

    extremely small. Benzodiazepines are not without risk of harm, even for short-term use. Because of this, there is a need to find out if...

    Research recommendation
    Published
    13 February 2017

  9. Electronic media:- How does the use of electronic media affect harmful sexual behaviour?

    behaviour of children and young people. Research is also needed on its long-term impact on children and young people's social and...

    Research recommendation
    Published
    17 October 2016

  10. What is the relative effectiveness of sertraline compared with cognitive behavioural therapy (CBT) in people with generalised anxiety disorder (GAD) that has not responded to guided self-help and psychoeducation in a stepped-care model?

    to particular therapies. Clarification of the relative short- and longer-term benefits of sertraline and CBT would be helpful in guiding...

    Research recommendation
    Published
    9 June 2015

  11. Percutaneous laser therapy for fetal tumours (IPG180)

    Evidence-based recommendations on percutaneous laser therapy for fetal tumours. This involves inserting a needle through the mother's abdomen to the tumour and using laser energy to shrink it.

    Interventional procedures guidance
    Published
    28 June 2006
    View recommendations

    Sections for IPG180

  12. Extracorporeal albumin dialysis for acute liver failure (IPG316)

    Evidence-based recommendations on extracorporeal albumin dialysis for acute liver failure. This involves using a dialysis machine to remove both water-soluble toxins and toxins that are attached to albumin and accumulate in liver failure.

    Interventional procedures guidance
    Published
    23 September 2009
    View recommendations

    Sections for IPG316

  13. Radiofrequency cold ablation for respiratory papillomatosis (IPG434)

    Evidence-based recommendations on radiofrequency cold ablation for respiratory papillomatosis. This involves using an electrical current to dissolve or shrink the papillomas (non-cancerous growths).

    Interventional procedures guidance
    Published
    27 November 2012
    View recommendations

    Sections for IPG434

  14. Percutaneous transforaminal endoscopic lumbar discectomy for sciatica (IPG556)

    Evidence-based recommendations on percutaneous transforaminal endoscopic lumbar discectomy for sciatica in adults. This involves removing part of the damaged spinal disc to relieve the symptoms of sciatica.

    Interventional procedures guidance
    Published
    27 April 2016
    View recommendations

    Sections for IPG556

  15. Fetal cystoscopy for the diagnosis and treatment of lower urinary outflow tract obstruction (IPG205)

    Evidence-based recommendations on fetal cystoscopy for the diagnosis and treatment of lower urinary outflow tract obstruction. This involves inserting a tube with a flexible camera through small cuts in the mother's abdomen to identify and open any blockage.

    Interventional procedures guidance
    Published
    24 January 2007
    View recommendations

    Sections for IPG205

  16. Hybrid procedure for interim management of hypoplastic left heart syndrome in neonates (IPG246)

    Evidence-based recommendations on hybrid procedure for interim management of hypoplastic left heart syndrome in neonates. This involves placing bands around the branches of the pulmonary artery and inserting stents to keep the ductus arteriosus open.

    Interventional procedures guidance
    Published
    12 December 2007
    View recommendations

    Sections for IPG246

  17. Intramedullary distraction for upper limb lengthening (IPG722)

    Evidence-based recommendations on intramedullary distraction for upper limb lengthening in children, young people and adults. This involves surgically inserting a metal lengthening device in the shorter arm.

    Interventional procedures guidance
    Published
    20 April 2022
    View recommendations

    Sections for IPG722

  18. What is the effectiveness and cost effectiveness of complex  endovascular aneurysm repair   (EVAR) versus open surgical repair in people for whom open surgical repair is suitable for: elective repair of an unruptured AAA  or emergency repair of a ruptured AAA?

    more expensive. Although standard EVAR has been shown to produce no long-term benefit over open surgical repair in people with an...

    Research recommendation
    Published
    10 August 2020

  19. Advance statements and decisions:- What forms of management of violence and aggression do service users prefer and do advance statements and decisions have an important role in management and prevention?

    guidance details Comes from guidance Violence and aggression: short-term management in mental health, health and community settings...

    Research recommendation
    Published
    1 October 2015

  20. Current evidence on the safety and efficacy of electrical stimulation of the lower oesophageal sphincter for treating gastro-oesophageal reflux disease (GORD) is limited in quantity and quality. Therefore, this procedure should only be used in the context of research.

    device durability, the need for surgical treatment for GORD in the longer term (at least 2 years) and all complications should be...

    Research recommendation
    Published
    25 January 2016

  21. Evidence on the safety and efficacy of inducing and maintaining normothermia using temperature modulation devices to improve outcomes after stroke or subarachnoid haemorrhage is inadequate in quality and quantity. Therefore, this procedure should only be used in the context of research. Find out what only in research means on the NICE interventional procedures guidance page.

    measures, and patient-reported outcomes (including quality of life) in the long term. Source guidance details Comes from guidance...

    Research recommendation
    Published
    13 August 2021

  22. Interaction between behavioural and environmental interventions:- What is the effectiveness and cost effectiveness of interventions to change the environment alone, compared with interventions to change the environment that are supported by interventions to change people's behaviour?

    currently little evidence on whether changes are sustained in the longer term. Source guidance details Comes from guidance Physical...

    Research recommendation
    Published
    15 November 2018

  23. PredictSURE IBD and IBDX to guide treatment of Crohn's disease (HTG610)

    Evidence-based recommendations on PredictSURE IBD and IBDX for guiding treatment of Crohn’s disease.

    HealthTech guidance
    Published
    23 February 2022
    View recommendations

    Sections for HTG610

  24. How can the design and reporting of the outcomes used in intervention studies be improved, so researchers can identify 'active ingredients'? Which validated tools are effective at consistently measuring success, especially in relation to health and wellbeing, performance, productivity and in economic terms?

    relation to health and wellbeing, performance, productivity and in economic terms? Any explanatory notes(if applicable) Research studies...

    Research recommendation
    Published
    5 October 2015

  25. GaitSmart rehabilitation exercise programme for gait and mobility issues (HTG716)

    Evidence-based recommendations on GaitSmart rehabilitation exercise programme for gait and mobility issues in adults.

    HealthTech guidance
    Published
    3 April 2024
    View recommendations

    Sections for HTG716

  26. Fever in under 5s (QS64)

    This quality standard covers the assessment and early management of fever with no obvious cause in babies and children (from birth to 5 years). It describes high-quality care in priority areas for improvement.

    Quality standard
    Last updated
    27 July 2022
    View quality statements

    Sections for QS64

  27. Pancreatic cancer (QS177)

    This quality standard covers diagnosis of pancreatic cancer and management of pancreatic ductal adenocarcinoma in adults aged over 18. This quality standard describes high-quality care in priority areas for improvement. It does not cover national initiatives, such as cancer screening or audit.

    Quality standard
    Published
    20 December 2018
    View quality statements

    Sections for QS177

  28. Fenfluramine for treating seizures associated with Lennox–Gastaut syndrome in people 2 years and over (TA1050)

    Evidence-based recommendations on fenfluramine (Fintepla) for treating seizures associated with Lennox–Gastaut syndrome in people 2 years and over.

    Technology appraisal guidance
    Published
    26 March 2025
    View recommendations

    Sections for TA1050

  29. Factors that influence older people's mental wellbeing:- In the UK, which factors or processes in an intervention influence older people's mental wellbeing?How do these factors interact with one another and does the importance differ for different groups?

    importance of these factors and processes varies according to ethnicity,long-term disability, level of social deprivation, gender,...

    Research recommendation
    Published
    25 January 2016

  30. Ultrasound in diagnosis:- What is the clinical and cost effectiveness of using ultrasound in addition to clinical assessment when there is uncertainty about the diagnosis in adults with suspected RA?

    enables earlier treatment, providing an opportunity to improve the longer term outcomes for people with RA. The use of ultrasound may...

    Research recommendation
    Published
    11 December 2018

  31. Violence related to drug or alcohol misuse:- What is the best environment in which to contain violence in people who have misused drugs or alcohol?

    guidance details Comes from guidance Violence and aggression: short-term management in mental health, health and community settings...

    Research recommendation
    Published
    5 October 2015

  32. What are the possible outcomes for people who are critically ill and have COVID-19-associated pulmonary aspergillosis (CAPA)?

    of hospital stay, admission to and length of stay in intensive care)• long-term morbidity outcomes, functional measures and patient...

    Research recommendation
    Published
    17 December 2021

  33. Medication for promoting de-escalation:- Which medication is effective in promoting de-escalation in people who are identified as likely to demonstrate significant  violence?

    guidance details Comes from guidance Violence and aggression: short-term management in mental health, health and community settings...

    Research recommendation
    Published
    5 October 2015

  34. Developing a 'risk positive' approach in care homes:- What is the effectiveness and acceptability of different strategies to enable positive risk-taking in care homes?

    from guidance Older people with social care needs and multiple long-term conditions Number NG22 Date issued November 2015

    Research recommendation
    Published
    11 December 2015

  35. Psychological assessment:- What is the most effective measure of psychological functioning to use as a test for thresholds of concern in people with cystic fibrosis?

    generic measures (for example for depression and anxiety). People with a long-term physical health condition are more likely to present...

    Research recommendation
    Published
    18 October 2018

  36. Predictive accuracy of the WPPSI-IV at age 4 years (uncorrected) for children born preterm:- What is the accuracy of a Wechsler Preschool and Primary Scale of Intelligence 4th Edition (WPPSI-IV) assessment at age 4 years (uncorrected) for predicting later educational difficulties in children of primary school age who were born before 28+0 weeks' gestation?

    that educational support can be provided in order to reduce the risk of long-term learning disability (intellectual disability). Source...

    Research recommendation
    Published
    15 October 2018

  37. Pilon fractures:- In adults with closed pilon fractures, what method of fixation provides the best clinical and cost effectiveness outcomes as assessed by function and incidence of major complications at 2 years (stratified for timing of definitive surgery early [under 36 hours] versus later [over 36 hours])?

    surface is vulnerable to degeneration. Therefore, the injury can lead to long-term disability, most commonly arthritis with pain and...

    Research recommendation
    Published
    21 March 2016

  38. Allogeneic stem cell transplantation:- What is the effectiveness of combined autologous–allogeneic stem cell transplantation compared with autologous stem cell transplantation, plus consolidation and maintenance treatment in chemosensitive patients at first response or first relapse?

    important:- There are conflicting data from a small number of studies on long-term survival following auto/allo stem cell...

    Research recommendation
    Published
    5 April 2016

  39. Stopping antiviral treatment in HBeAg-negative disease:- Further research should be undertaken to evaluate the clinical and cost effectiveness of hepatitis B surface antigen (HBsAg) quantitative assays in determining treatment duration in hepatitis B e antigen- (HBeAg) negative disease.

    HBeAg-negative disease would transform current treatment strategies. People on long-term nucleoside or nucleotide analogues could safely...

    Research recommendation
    Published
    9 June 2015

  40. What are the most clinically effective interventions (including social prescribing and structured community support) for managing post‑COVID‑19 syndrome? Does effectiveness vary for different population groups (for example sex, age, socioeconomic group, black, Asian and minority ethnic group communities or people with learning disabilities)? Do any symptoms of post‑COVID‑19 syndrome predict the need for specialist intervention? Are there clusters of symptoms that identify response to interventions in post‑COVID‑19 syndrome? What is the clinical effectiveness of different service models of multimodality/multidisciplinary post‑COVID‑19 syndrome rehabilitation in improving patient‑reported outcomes (such as quality of life)? What is the clinical effectiveness of exercise interventions for people with post‑COVID‑19 syndrome? Does effectiveness vary for different population groups (for example sex, age, socioeconomic group, black, Asian and minority ethnic group communities or people with learning disabilities)? Does early exercise rehabilitation assist in improving symptoms of post‑COVID‑19 syndrome?

    Comes from guidance COVID-19 rapid guideline: managing the long-term effects of COVID-19 Number NG188 Date issued December

    Research recommendation
    Published
    12 November 2021

  41. Predicting life expectancy:- Is it possible to analyse primary care data to identify characteristics that affect life expectancy and to develop algorithms and prediction tools for patients and healthcare providers to predict reduced life expectancy?

    information that could inform decisions about starting or continuing long-term preventive treatments. Conversely younger people with...

    Research recommendation
    Published
    18 October 2016

  42. What is the clinical effectiveness and safety of vitamin D for treating COVID-19 in children, young people and adults?

    admission to intensive care symptom alleviation adherence to therapy long-term effects of COVID-19 (at least 4 weeks from acute COVID-19...

    Research recommendation
    Published
    14 July 2022

  43. Minimally invasive pancreatectomy:- Prospective randomised trials should be undertaken to compare the effectiveness of minimally invasive pancreatectomy or pancreatoduodenectomy (laparoscopic or robotic) with open pancreatectomy or pancreatoduodenectomy in people with pancreatic cancer.

    hospital stay- time to return to normal activity- mortality of surgery- long-term survival after surgery- quality of life, patient...

    Research recommendation
    Published
    13 November 2018

  44. Fetal vesico–amniotic shunt for lower urinary tract outflow obstruction (IPG202)

    Evidence-based recommendations on fetal vesico–amniotic shunt for lower urinary tract outflow obstruction. This involves inserting a cannula through the mother's abdominal and uterine walls into the amniotic cavity and subsequently into the bladder of the fetus.

    Interventional procedures guidance
    Published
    13 December 2006
    View recommendations

    Sections for IPG202

  45. Percutaneous insertion of a closure device to repair a paravalvular leak around a replaced mitral or aortic valve (IPG700)

    Evidence-based recommendations on percutaneous insertion of a closure device to repair a paravalvular leak around a replaced mitral or aortic valve. This involves passing a closure device through a catheter to block the area that is leaking.

    Interventional procedures guidance
    Published
    23 June 2021
    View recommendations

    Sections for IPG700

  46. Laparoscopic removal of uterine fibroids with power morcellation (IPG703)

    Evidence-based recommendations on laparoscopic removal of uterine fibroids with power morcellation in adults. This involves cutting the fibroids into small pieces to remove them.

    Interventional procedures guidance
    Published
    25 August 2021
    View recommendations

    Sections for IPG703

  47. Lung cancer: diagnosis and management (NG122)

    This guideline covers diagnosing and managing non-small-cell and small-cell lung cancer. It aims to improve outcomes for patients by ensuring that the most effective tests and treatments are used, and that people have access to suitable palliative care and follow-up.

    NICE guideline
    Last updated
    8 March 2024

    Sections for NG122

  48. Endoscopic mastectomy and endoscopic wide local excision for breast cancer (IPG296)

    Evidence-based recommendations on endoscopic mastectomy and endoscopic wide local excision for breast cancer. This involves removing part or all of the breast using special instruments inserted through small cuts in the skin (keyhole surgery).

    Interventional procedures guidance
    Published
    22 April 2009
    View recommendations

    Sections for IPG296

  49. Photorefractive (laser) surgery for the correction of refractive errors (IPG164)

    Evidence-based recommendations on photorefractive (laser) surgery for the correction of refractive errors. This involves using a special laser to permanently change the shape of the cornea.

    Interventional procedures guidance
    Published
    22 March 2006
    View recommendations

    Sections for IPG164

  50. Airway clearance techniques:- How effective are daily airway clearance techniques in maintaining lung function in infants and children with cystic fibrosis?

    impact on the lives of parents, family members and carers, as well as long-term clinical outcomes for infants and children with cystic...

    Research recommendation
    Published
    6 November 2018