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Showing 2401 to 2450 of 4138 results for patient

  1. Evidence on the safety of irreversible electroporation for primary liver cancer shows serious but infrequent and well-recognised complications. Evidence on its efficacy is inadequate in quantity and quality. Therefore, this procedure should only be used in the context of research.

    of case series or registry-based research.It should include: details of patient selection; tumour position and size; longterm outcomes...

    Research recommendation
    Published
    10 February 2020

  2. Neoadjuvant therapy:- Prospective randomised trials should be undertaken to compare preoperative (neoadjuvant) therapy with standard postoperative therapy in people with resectable pancreatic cancer.

    feasibility of delivering neoadjuvant treatment- feasibility of randomising patients- objective response rate of neoadjuvant therapy- R0...

    Research recommendation
    Published
    13 November 2018

  3. The evidence on cardiac contractility modulation device implantation for heart failure raises no major safety concerns. However, the evidence on efficacy is inadequate in quantity and quality. Therefore, this procedure should only be used in the context of  research .

    the form of randomised controlled trials. These should report details of patient selection, duration and timing of stimulation, and...

    Research recommendation
    Published
    15 November 2019

  4. Evidence on the safety and efficacy of balloon cryoablation for Barrett's oesophagus is inadequate in quantity and quality. Therefore, this procedure should only be used in the context of research. This could be in the form of randomised controlled trials or published registry data.   Find out  what only in research means on the NICE interventional procedures guidance page .

    applicable) Patient selection should be done by clinicians experienced in managing Barrett's oesophagus. Further research should report...

    Research recommendation
    Published
    22 January 2021

  5. Evidence on the safety and efficacy of balloon cryoablation for squamous dysplasia of the oesophagus is inadequate in quantity and quality. Therefore, this procedure should only be used in the context of research. This could be in the form of randomised controlled trials or published registry data.   Find out  what only in research means on the NICE interventional procedures guidance page .

    procedures guidance page . Any explanatory notes(if applicable) Patient selection should be done by clinicians experienced in managing...

    Research recommendation
    Published
    22 January 2021

  6. Diabetic retinopathy: management and monitoring (NG242)

    This guideline covers managing and monitoring diabetic retinopathy in people under the care of hospital eye services. This includes non-proliferative and proliferative diabetic retinopathy, and diabetic macular oedema.

    NICE guideline
    Published
    13 August 2024
    View recommendations

    Sections for NG242

  7. Postnatal care (NG194)

    This guideline covers the routine postnatal care that women and their babies should receive in the first 8 weeks after the birth. It includes the organisation and delivery of postnatal care, identifying and managing common and serious health problems in women and their babies, how to help parents form strong relationships with their babies, and baby feeding. The recommendations on emotional attachment and baby feeding also cover the antenatal period.

    NICE guideline
    Published
    20 April 2021
    View recommendations

    Sections for NG194

  8. Minimally invasive fusionless posterior-approach surgery to correct idiopathic scoliosis in children and young people should be used only in research. Find out what only in research means on the NICE interventional procedures guidance page.

    explanatory notes(if applicable) Further research should include: • patient selection in terms of age, skeletal maturity, and site and...

    Research recommendation
    Published
    7 August 2023

  9. Core outcome set for studies of management of Lyme disease:- Can a core outcome set be developed for clinical trials of management of Lyme disease?

    meta-analysis to strengthen results. The methods used should be patient-focused and include patient input on priority...

    Research recommendation
    Published
    21 November 2018

  10. NICE recommended further research to explore the impact of having experiences of patients having continuous infusion 5-FU and take into account the impact on quality of life. The potential consequences of introducing pharmacokinetic dose adjustment should also be explored.

    recommended further research to explore the impact of having experiences of patients having continuous infusion 5-FU and take into...

    Research recommendation
    Published
    9 June 2015

  11. Laparoscopic uterine nerve ablation (LUNA) for chronic pelvic pain (IPG234)

    Evidence-based recommendations on laparoscopic uterine nerve ablation (LUNA) for chronic pelvic pain. This involves the destruction of a small segment of ligament that carries nerve fibres within the pelvis.

    Interventional procedures guidance
    Published
    30 October 2007
    View recommendations

    Sections for IPG234

  12. The evidence on transvaginal laser therapy for urogenital atrophy does not show any short-term safety concerns. Evidence on long-term safety and efficacy is inadequate in quality and quantity. Therefore, this procedure should only be used in the context of research. Find out what only in research means on the NICE interventional procedures guidance page.

    trials and report details of patient selection, treatment protocols, and long-term safety and efficacy including...

    Research recommendation
    Published
    10 August 2021

  13. What models of cross-organisational working improve clinical and cost effectiveness in relation to the suboptimal prescribing of medicines – for example, between NHS and social care, or primary and secondary care, or between NHS and commercial organisations?

    However, no published evidence was found to show whether or not it improves patient-reported outcomes in relation to suboptimal...

    Research recommendation
    Published
    10 August 2015

  14. What are the long-term benefits and harms, and cost effectiveness of endoscopic ultrasound (EUS) compared with magnetic resonance cholangiopancreatography (MRCP) in adults with suspected common bile duct stones?

    non-invasive and so carries negligible risks to the patient. However, EUS carries a small but significant risk of patient...

    Research recommendation
    Published
    9 June 2015

  15. Selective internal radiation therapy with QuiremSpheres for treating unresectable advanced hepatocellular carcinoma (TA985)

    This guidance has been withdrawn because the simple discount patient access scheme for QuiremSpheres has been withdrawn.

    Technology appraisal guidance
    Published
    3 July 2024

  16. Evidence on the safety and efficacy of inducing and maintaining normothermia using temperature modulation devices to improve outcomes after stroke or subarachnoid haemorrhage is inadequate in quality and quantity. Therefore, this procedure should only be used in the context of research. Find out what only in research means on the NICE interventional procedures guidance page.

    preferably be randomised controlled trials. It should report details of patient selection (including cause of fever, severity of stroke...

    Research recommendation
    Published
    13 August 2021

  17. Psychological support needs:- A qualitative study should be undertaken to evaluate information and support interventions to address psychological needs at different points in the care pathway for people with pancreatic cancer.

    psychological wellbeing- ability to carry out normal activities- patient experience and patient-reported outcome measures....

    Research recommendation
    Published
    14 November 2018

  18. Telemetric adjustable pulmonary artery banding for pulmonary hypertension in infants with congenital heart defects (IPG505)

    Evidence-based recommendations on telemetric adjustable pulmonary artery banding for reducing pulmonary hypertension in infants with congenital heart defects. This involves placing a remote-controlled band around the pulmonary artery that can be tightened or loosened to control blood flow.

    Interventional procedures guidance
    Published
    27 November 2014
    View recommendations

    Sections for IPG505

  19. Balloon catheter insertion for Bartholin's cyst or abscess (IPG323)

    Evidence-based recommendations on balloon catheter insertion for Bartholin's cyst or abscess. This involves making a passage from the cyst or abscess through which the gland can drain by inflating a small, specially designed balloon.

    Interventional procedures guidance
    Published
    16 December 2009
    View recommendations

    Sections for IPG323

  20. Extended access to GP services:- Is extended access to GP services, for example during early mornings, evenings and weekends, more clinically and cost effective than standard access?

    of care improves patient experience, aids clinical decision-making and could reduce hospital admissions. GPs' knowledge of...

    Research recommendation
    Published
    15 November 2018

  21. Long-term outcomes of pharmacological and uterine-sparing surgical treatments for HMB associated with adenomyosis:- What are the long-term clinical outcomes of pharmacological and uterine-sparing surgical treatments in women with HMB associated with adenomyosis?

    best treatment for this condition. Optimising treatment can lead to better patient satisfaction and the avoidance of unnecessary...

    Research recommendation
    Published
    14 November 2018

  22. Pouchitis: rifaximin (ESUOM30)

    Summary of the evidence on rifaximin for treating pouchitis to inform local NHS planning and decision-making

    Evidence summary
    Published
    25 March 2014

  23. Pain management:- A randomised trial should be undertaken comparing early endoscopic ultrasound-guided neurolytic coeliac plexus (EUS-guided NCP) interventions with on-demand EUS-guided NCP interventions in people with unresectable pancreatic cancer.

    to on-demand NCP intervention in terms of the important outcomes for the patient and duration of effect of the procedure. On-demand NCP...

    Research recommendation
    Published
    13 November 2018

  24. Evidence on the safety and efficacy of removal, preservation and subsequent reimplantation of ovarian tissue to prevent symptoms from the menopause is inadequate in quality and quantity. Therefore, this procedure should not be done unless it is part of a formal research study, with appropriate governance and ethics approval. Find out what only in research means on the NICE interventional procedures guidance page.

    should include randomised controlled trials and should report details of:• patient selection, including the age at which ovarian tissue...

    Research recommendation
    Published
    30 September 2022

  25. Clinicians are encouraged to collect long-term data on clinical outcomes and patient-reported quality-of-life outcomes using validated scales. NICE may update the guidance on publication of further evidence into infracoccygeal sacropexy using mesh to repair uterine prolapse.

    Clinicians are encouraged to collect long-term data on clinical outcomes and patient-reported quality-of-life outcomes using validated...

    Research recommendation
    Published
    12 October 2018

  26. More research is needed on the following key outcomes:

    with high confidence and the impact of this on work prioritisation and patient flow the technical failure and rejection rates of the...

    Research recommendation
    Published
    11 January 2024

  27. NICE encourages further research and publication on efficacy of miniature lens system implantation for advanced age-related macular degeneration (AMD) which patients may benefit and on safety and efficacy outcomes, particularly longer-term results. NICE may update the guidance on publication of further evidence.

    implantation for advanced age-related macular degeneration (AMD) which patients may benefit and on safety and efficacy outcomes,...

    Research recommendation
    Published
    17 October 2016

  28. Thyroid cancer: assessment and management (NG230)

    This guideline covers diagnosis and management of thyroid cancer in people aged 16 and over. It aims to reduce variation in practice and increase the quality of care and survival for people with thyroid cancer.

    NICE guideline
    Published
    19 December 2022
    View recommendations

    Sections for NG230

  29. Radiotherapy in first-line treatment of diffuse large B-cell lymphoma:- In people presenting with diffuse large B-cell lymphoma and sites of bulky disease, are outcomes improved by radiotherapy to those sites following a full course of chemotherapy?

    treatment-related morbidity, health-related quality of life, patient satisfaction, patient preference and overall response...

    Research recommendation
    Published
    25 August 2016

  30. Radiofrequency denervation for osteoarthritic knee pain (IPG767)

    Evidence-based recommendations on radiofrequency denervation for osteoarthritic knee pain. This involves applying heat (radiofrequency) energy to damage the nerves (denervation) that are causing pain in the knee.

    Interventional procedures guidance
    Published
    28 June 2023
    View recommendations

    Sections for IPG767

  31. Single‑incision laparoscopic cholecystectomy (IPG508)

    Evidence-based recommendations on single incision laparoscopic cholecystectomy. This involves removing the gallbladder through a small cut, most often below the bellly button.

    Interventional procedures guidance
    Published
    17 December 2014
    View recommendations

    Sections for IPG508

  32. TearLab osmolarity system for diagnosing dry eye disease (MIB47)

    NICE has developed a medtech innovation briefing (MIB) on TearLab osmolarity system for diagnosing dry eye disease .

    Medtech innovation briefing
    Published
    15 December 2015

  33. There is a need for further evidence on the long-term outcomes of treatment with eculizumab, and on the effect of treatment in children, adolescents and during pregnancy. The Committee supports enrolment of patients into the aHUS registry and the collection of high-quality information from these registries periodically to inform treatment decisions.

    adolescents and during pregnancy. The Committee supports enrolment of patients into the aHUS registry and the collection of...

    Research recommendation
    Published
    9 June 2015

  34. Risk of radiotherapy in people with cancer and COVID-19: Are patients with cancer and COVID-19 who are receiving/have recently received radiotherapy (that is, within the 4 weeks preceding a diagnosis of COVID-19) at increased risk of severe COVID-19 illness or death?

    Question Risk of radiotherapy in people with cancer and COVID-19: Are patients with cancer and COVID-19 who are receiving/have recently...

    Research recommendation
    Published
    21 October 2021

  35. Prostate-specific antigen testing: What is the diagnostic accuracy of using age-adjusted and fixed prostate-specific antigen thresholds for people with symptoms of prostate cancer, including those at high risk of developing prostate cancer (such as those with an African family background or a family history of prostate cancer)?

    treatment that might not benefit them. Therefore, the committee agreed that a patient-centred approach to referral is important, and...

    Research recommendation
    Published
    7 January 2022

  36. Lumella point-of-care test for assessing pre-eclampsia risk (MIB287)

    NICE has developed a medtech innovation briefing (MIB) on Lumella point-of-care test for assessing pre-eclampsia risk .

    Medtech innovation briefing
    Published
    1 March 2022

  37. What is the effectiveness and safety of sacral nerve stimulation and transanal irrigation compared to symptomatic treatment for people with major low anterior resection syndrome?

    using a validated tool, for example the LARS score, which is a validated patient-administered questionnaire.No comparative evidence on...

    Research recommendation
    Published
    10 February 2020

  38. Thoracoscopic aortopexy for severe primary tracheomalacia (IPG243)

    Evidence-based recommendations on thoracoscopic aortopexy for severe primary tracheomalacia. This involves attaching the aorta to the sternum with sutures, using special instruments through small cuts in the chest (keyhole surgery).

    Interventional procedures guidance
    Published
    12 December 2007
    View recommendations

    Sections for IPG243

  39. Use of a simple algorithm compared with a standard clinical assessment:- For people with a common mental health disorder, is the use of a simple algorithm (based on factors associated with treatment response), when compared with a standard clinical assessment, more clinically and cost effective?

    an indication of likely response to such treatments, thereby informing patient choice and leading to clinically and cost-effective...

    Research recommendation
    Published
    9 June 2015

  40. Coeliac disease: recognition, assessment and management (NG20)

    This guideline covers the recognition, assessment and management of coeliac disease in children, young people and adults.

    NICE guideline
    Published
    2 September 2015
    View recommendations

    Sections for NG20

  41. Gastro-oesophageal reflux disease and dyspepsia in adults: investigation and management (CG184)

    This guideline covers investigating and managing gastro-oesophageal reflux disease (GORD) and dyspepsia in people aged 18 and over. It aims to improve the treatment of GORD and dyspepsia by making detailed recommendations on Helicobacter pylori eradication, and specifying when to consider laparoscopic fundoplication and referral to specialist services.

    Clinical guideline
    Last updated
    18 October 2019
    View recommendations

    Sections for CG184

  42. MRI-based technologies for assessing non-alcoholic fatty liver disease (HTG655)

    Evidence-based recommendations on MRI-based technologies for assessing non-alcoholic fatty liver disease.

    HealthTech guidance
    Published
    12 January 2023
    View recommendations

    Sections for HTG655

  43. What is the prevalence and incidence of post-COVID-19 syndrome in patients who have received single, double, or boosted doses of the approved vaccinations in the UK? Does this vary across different population groups (for example in black, Asian and minority ethnic group communities)?

    Question What is the prevalence and incidence of post-COVID-19 syndrome in patients who have received single, double, or boosted doses...

    Research recommendation
    Published
    12 November 2021

  44. Evidence on the safety and efficacy of prostatic urethral temporary implant insertion for lower urinary tract symptoms caused by benign prostatic hyperplasia is limited in quantity and quality. Therefore, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Find out what special arrangements mean on the NICE interventional procedures guidance page.

    procedure.• Regularly review data on outcomes and safety for this procedure. Patient selection should be done by a team experienced in...

    Research recommendation
    Published
    30 September 2022

  45. Evidence on the efficacy and safety of neurostimulation of lumbar muscles for refractory non-specific chronic low back pain is limited in quantity and quality. Therefore, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Find out what special arrangements mean on the NICE interventional procedures guidance page.

    procedure.• Regularly review data on outcomes and safety for this procedure. Patient selection should be done by a multidisciplinary...

    Research recommendation
    Published
    30 September 2022

  46. Recognising dying:- What can multiprofessional teams do to reduce the impact of uncertainty of recognising when a person is entering the last days of life on clinical care, shared decision-making and communication with the dying person and those important to them?

    include quality of life, patient or carer satisfaction, changes to clinical care and identification and/or achievement of...

    Research recommendation
    Published
    27 January 2016

  47. The NICE public health guidance development process (third edition) (PMG5)

    This manual describes how public health guidance is produced, and explains the stages of guidance development, the different activities, roles and responsibilities of different groups of people involved at different stages

  48. Trabeculectomy with a biodegradable collagen matrix implant for glaucoma (IPG750)

    Evidence-based recommendations on trabeculectomy with a biodegradable collagen matrix implant for glaucoma. This involves cutting a small flap in the white of the eye and putting a patch over the flap to help healing and prevent scarring. Fluid slowly drains out of the flap and the patch dissolves over time. The aim is to reduce pressure in the eye and slow or stop damage to sight.

    Interventional procedures guidance
    Published
    17 January 2023
    View recommendations

    Sections for IPG750

  49. Routine antenatal anti-D prophylaxis for women who are rhesus D negative (TA156)

    Evidence-based recommendations on routine anti-D prophylaxis for women who are rhesus D negative.

    Technology appraisal guidance
    Published
    27 August 2008
    View recommendations

    Sections for TA156

  50. Mepolizumab for treating severe eosinophilic asthma (TA671)

    Evidence-based recommendations on mepolizumab (Nucala) for treating severe eosinophilic asthma in adults.

    Technology appraisal guidance
    Published
    3 February 2021
    View recommendations

    Sections for TA671