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Showing 3051 to 3100 of 3761 results for treatment

  1. FreeStyle Libre for glucose monitoring (MIB110)

    NICE has developed a medtech innovation briefing (MIB) on FreeStyle Libre for glucose monitoring .

    Medtech innovation briefing
    Last updated
    29 September 2017

  2. NICE encourages further research into the use of innovative technologies for the management of severe acute respiratory failure, and may review this guidance on publication of further evidence.

    hospitals in the control group and a single centre was used for the ECMO treatment group. Therefore this procedure should only be used...

    Research recommendation
    Published
    9 June 2015

  3. Effective proton pump inhibitor dosage for severe erosive reflux disease:- What is the clinical effectiveness of double-dose PPIs in people with severe erosive reflux disease (Los Angeles classification grade C/D or Savary–Miller grade 3/4): - to reduce severe oesophagitis - to control symptoms - as maintenance therapy?

    It would substantially improve people's quality of life if an optimal treatment regimen could be identified. Currently, there is a lack...

    Research recommendation
    Published
    9 June 2015

  4. Other specialist management:- What specialist management is effective for people whose symptoms do not respond to PPIs despite optimum primary care, or for people whose symptoms return after surgery?

    tricyclic antidepressants versus standard or full-dose PPI. The purpose of any treatment should focus on improving quality of life....

    Research recommendation
    Published
    9 June 2015

  5. Pain management for patients with an acute painful sickle cell episode:- For patients with an acute painful sickle cell episode, what are the effects of different opioid formulations, adjunct pain therapies and routes of administration on pain relief and acute sickle cell complications?

    opioid formulations, routes of administration and adjunct therapies in the treatment of an acute painful sickle cell episode. A series...

    Research recommendation
    Published
    9 June 2015

  6. Abatacept for the treatment of rheumatoid arthritis after the failure of conventional disease-modifying anti-rheumatic drugs (TA234)

    This guidance has been updated and replaced by NICE technology appraisal guidance 280.

    Withdrawn guidance

  7. Is the use of chlorhexidine body wash associated with increased antimicrobial resistance?

    An economic model based on UK data demonstrated that, compared with no treatment, using mupirocin with a chlorhexidine body wash before...

    Research recommendation
    Published
    16 August 2019

  8. Pembrolizumab for adjuvant treatment of locally advanced cutaneous squamous cell carcinoma after surgery and radiotherapy ID 6473

    In development Reference number: GID-TA11582 Expected publication date: TBC

    Technology appraisal guidance
    In development

  9. Cardiac rehabilitation:- Is an 8-week, comprehensive, multidisciplinary, cardiac rehabilitation service more clinically and cost effective for managing stable angina than current clinical practice?

    this is important:- Cardiac rehabilitation programmes are an established treatment strategy for certain heart conditions, such as for...

    Research recommendation
    Published
    9 June 2015

  10. The effect of drug therapy for concurrent conditions on melanoma survival: In people diagnosed with melanoma what is the effect of drug therapy to treat concurrent conditions on disease specific survival? This should be investigated in a national prospective cohort study. Secondary outcomes should include overall survival and quality of life.

    the risk of melanoma deaths with the benefits from the most effective treatment of the concurrent conditions. But there is currently no...

    Research recommendation
    Published
    4 August 2022

  11. Identifying infection in women with preterm prelabour rupture of membranes (P-PROM):- What is the diagnostic accuracy of serial C-reactive protein testing to identify chorioamnionitis in women with P-PROM?

    therapeutic strategies (including antibiotics and/or early birth). Effective treatment of infection is particularly important given that...

    Research recommendation
    Published
    11 December 2015

  12. Aside from mast cell tryptase, which other chemical inflammatory mediators offer potential as indicators of anaphylaxis?

    from guidance Anaphylaxis: assessment and referral after emergency treatment Number CG134 Date issued December 2011 Other

    Research recommendation
    Published
    26 October 2020

  13. Mediators of anaphylactic reactions:- Aside from mast cell tryptase, which other chemical inflammatory mediators offer potential as indicators of anaphylaxis?

    from guidance Anaphylaxis: assessment and referral after emergency treatment Number CG134 Date issued December 2011 Other

    Research recommendation
    Published
    9 June 2015

  14. Long-term effects of IVF with or without intracytoplasmic sperm injection in children:- What are the long-term (over 20 years) effects of IVF with or without intracytoplasmic sperm injection (ICSI) in children in the UK?

    details Comes from guidance Fertility problems: assessment and treatment Number CG156 Date issued February 2013 Other

    Research recommendation
    Published
    9 June 2015

  15. Neonatal parenteral nutrition (QS205)

    This quality standard covers parenteral nutrition (intravenous feeding) for babies born preterm, up to 28 days after their due birth date, and babies born at term, up to 28 days after their birth. It describes high-quality care in priority areas for improvement.

    Quality standard
    Published
    22 March 2022
    View quality statements

    Sections for QS205

  16. FebriDx for C-reactive protein and myxovirus resistance protein A testing (MIB224)

    NICE has developed a medtech innovation briefing (MIB) on FebriDx for C-reactive protein and myxovirus resistance protein A testing .

    Medtech innovation briefing
    Published
    26 August 2020

  17. Icare rebound tonometer to measure intraocular pressure (MIB57)

    NICE has developed a medtech innovation briefing (MIB) on the Icare rebound tonometer to measure intraocular pressure

    Medtech innovation briefing
    Published
    15 March 2016

  18. Active B12 assay for diagnosing vitamin B12 deficiency (MIB40)

    NICE has developed a medtech innovation briefing (MIB) on the Active-B12 assay for diagnosing vitamin B12 deficiency

    Medtech innovation briefing
    Published
    30 September 2015

  19. Does progesterone reduce the risk of preterm birth in women who have risk factors for preterm birth, but do not have a short cervix (cervical length of more than 25 mm)?

    for these women, and also whether measuring the cervical length to guide treatment is necessary. Source guidance details Comes from...

    Research recommendation
    Published
    25 October 2019

  20. Is primary radical cystectomy more effective than primary intravesical BCG (Bacille Calmette-Guérin) in high risk non-muscle-invasive bladder cancer, in terms of quality of life and cancer-specific outcomes?

    offset by continuing concern about cancer progression and morbidity from treatment. Primary cystectomy may improve survival; however, it...

    Research recommendation
    Published
    9 June 2015

  21. Is symptom-based review as effective as scheduled follow-up for people treated with radical cystectomy or radical radiotherapy for organ-confined, muscle-invasive bladder cancer? Outcomes of interest are overall survival, health-related quality of life, resource use and cost.

    cost. Any explanatory notes(if applicable) Standard care after treatment for organ-confined, muscle-invasive bladder cancer is scheduled...

    Research recommendation
    Published
    9 June 2015

  22. Oral health promotion advice:- For groups at high risk of poor oral health, how effective and cost effective is it to extend an existing appointment by a few minutes, or to offer separate sessions on oral health advice?

    give some advice about self-care during a patient's dental check-up or treatment. The economic modelling suggested it might be cost...

    Research recommendation
    Published
    28 January 2016

  23. Frequency of monitoring:- What is the long-term cost effectiveness, in terms of patient-relevant outcomes including bestcorrected visual acuity and quality of life, of different review frequencies/strategies for people at risk of progression to late AMD (wet active)?

    different stages of AMD, leading to uncertainty in how to correctly manage treatment for individuals or how to configure eye care...

    Research recommendation
    Published
    13 November 2018

  24. Does progesterone reduce the risk of preterm birth in women who have a short cervix (cervical length of 25 mm or less), but do not have other risk factors for preterm birth?

    for these women, and consequently whether measuring the cervix to guide treatment is necessary for women without other risk factors....

    Research recommendation
    Published
    25 October 2019

  25. Ultrasound in diagnosis:- What is the clinical and cost effectiveness of using ultrasound in addition to clinical assessment when there is uncertainty about the diagnosis in adults with suspected RA?

    diagnosis would otherwise be uncertain. Early diagnosis enables earlier treatment, providing an opportunity to improve the longer term...

    Research recommendation
    Published
    11 December 2018

  26. Pilon fractures: In adults with closed pilon fractures, what method of fixation provides the best clinical and cost effectiveness outcomes as assessed by function and incidence of major complications at 2 years (stratified for timing of definitive surgery early [under 36 hours] versus later [over 36 hours])?

    potential for life‑changing adverse consequences of both the injury and its treatment is known, but the best management strategy to...

    Research recommendation
    Published
    12 December 2022

  27. Midcarpal hemiarthroplasty for wrist arthritis (HTG529)

    Evidence-based recommendations on midcarpal hemiarthroplasty for wrist arthritis in adults. This involves using a metal implant to create an artificial wrist joint, to relieve pain and maintain movement.

    HealthTech guidance
    Published
    16 October 2019
    View recommendations

    Sections for HTG529

  28. In people with suspected TB, what is the relative clinical and cost effectiveness of universal andrisk-based use of rapid nucleic acid amplification tests?

    avoiding a large number of falsepositives, which leads to unnecessary treatment. This trade-off may lead to differences in the...

    Research recommendation
    Published
    8 November 2019

  29. Pilon fractures:- In adults with closed pilon fractures, what method of fixation provides the best clinical and cost effectiveness outcomes as assessed by function and incidence of major complications at 2 years (stratified for timing of definitive surgery early [under 36 hours] versus later [over 36 hours])?

    potential for life-changing adverse consequences of both the injury and its treatment is known, but the best management strategy to...

    Research recommendation
    Published
    21 March 2016

  30. Erlotinib in combination with bevacizumab for the maintenance treatment of advanced or metastatic non-small cell lung cancer [ID44]

    Discontinued Reference number: GID-TA11206

    Technology appraisal guidance
    Discontinued

  31. Nivolumab–relatlimab for adjuvant treatment of resected stage 3 or 4 melanoma in people 12 years and over [ID6475]

    In development Reference number: GID-TA11586 Expected publication date: TBC

    Technology appraisal guidance
    In development

  32. Further research in superior rectal artery embolisation for haemorrhoids should report details of patient selection, and follow-up efficacy (including symptom relief), need for subsequent treatments, quality of life and safety outcomes for at least 1 year.

    and follow-up efficacy (including symptom relief), need for subsequent treatments, quality of life and safety outcomes for at least 1...

    Research recommendation
    Published
    12 December 2018

  33. Pulmonary sarcoidosis: infliximab (ES2)

    Summary of the evidence on infliximab for treating pulmonary sarcoidosis to inform local NHS planning and decision-making

    Evidence summary
    Published
    20 December 2016

  34. Techniques for confirming a diagnosis in people with suspected atypical Spitzoid melanocytic lesions: In people with reported atypical Spitzoid lesions, how effective are fluorescence in situ hybridization (FISH), comparative genomic hybridization (CGH) and tests to detect driver mutations compared with histopathological examination alone in predicting disease specific survival? This should be investigated ina prospective diagnostic study. Secondary outcomes should include sensitivity, specificity, accuracy, positive predictive value, disease specific survival and progression free survival.

    changes in molecular pathways could predict outcome and inform individual treatment planning. Source guidance details Comes from...

    Research recommendation
    Published
    4 August 2022

  35. Evaluation of extensively used interventions:- Evaluate currently unevaluated but extensively used interventions for attachment difficulties.

    psychotherapy, and attachment aware schools program with an evidence-based treatment for attachment difficulties. The interventions...

    Research recommendation
    Published
    11 December 2015

  36. Compression as a management option:- What is the clinical and cost effectiveness of compression hosiery versus no compression for the management of symptomatic varicose veins?

    Why this is important:- Compression hosiery is widely used as first-line treatment for symptomatic varicose veins. In some areas of the...

    Research recommendation
    Published
    9 June 2015

  37. Leukocyte interleukin in combination for neoadjuvant treatment of resectable locally advanced squamous cell head and neck cancer [ID6390]

    In development Reference number: GID-TA11475 Expected publication date: TBC

    Technology appraisal guidance
    In development

  38. Paclitaxel, pegylated liposomal doxorubicin hydrochloride and topotecan for second-line or subsequent treatment of advanced ovarian cancer (TA91)

    This guidance has been updated and replaced by NICE technology appraisal guidance 389.

    Withdrawn guidance

  39. Consultation on changes to technology appraisals and highly specialised technologies

    patients by providing access to the most effective and cost-effective new treatments more quickly and will help the life sciences...

  40. Can rapid microbiological diagnosis of hospital-acquired pneumonia reduce the use of xtendedspectrum antibiotic therapy, without adversely affecting outcomes?

    Hospital-acquired infections can be caused by highly resistant pathogens that need treatment with extended-spectrum antibiotics (for...

    Research recommendation
    Published
    9 June 2015

  41. 1.1 Evidence on the safety of electrical stimulation to improve muscle strength in chronic respiratory conditions, chronic heart failure and chronic kidney disease shows no major safety concerns. For people who are having an acute exacerbation of their chronic condition and are unable to exercise, evidence of efficacy is adequate to support the use of this procedure provided that standard arrangements are in place for clinical governance, consent and audit.   Find out  what standard arrangements mean on the NICE website . For people who are able to exercise, evidence on efficacy is inadequate in quality. Therefore, this procedure should only be used in the context of research. Find out  what only in research means on the NICE website .

    These should report details of patient selection, and type and duration of treatment. Outcomes should include quality of life, social...

    Research recommendation
    Published
    10 August 2020

  42. Signs and symptoms that predict neutropenic sepsis in the community:- A prospective study should be carried out to determine which signs and symptoms experienced by patients in the community predict neutropenic sepsis and the outcomes of these episodes.

    service. Referral criteria that are too narrow will delay the emergency treatment of infection and may lead to death, increased need for...

    Research recommendation
    Published
    9 June 2015

  43. Topical therapy:- In people of all ages with psoriasis: 1. How should topical therapies be used to maintain disease control i) safely; ii) effectively and iii) what are the health economic implications? 2. What are the risks of 'real life' long term corticosteroid use, are there particular people at risk and what strategies can be used to modify or avoid risks?

    prescribed to virtually everyone with psoriasis, often as first line psoriasis treatment and they are also frequently used adjunctively...

    Research recommendation
    Published
    9 June 2015

  44. What is the clinical effectiveness and rate of adverse events of statin therapy using atorvastatin 20 mg per day compared with atorvastatin 40 mg per day and atorvastatin 80 mg per day in people without established CVD?

    QRISK2 calculator. However, this analysis looked at the effectiveness of treatment shown by 'high-intensity' statins as a group, as it...

    Research recommendation
    Published
    9 June 2015

  45. Hybrid closed loop systems for managing blood glucose levels in type 1 diabetes (TA943)

    Evidence-based recommendations on hybrid closed loop systems for managing blood glucose levels in type 1 diabetes.

    Technology appraisal guidance
    Published
    19 December 2023
    View recommendations

    Sections for TA943

  46. Dasatinib, high-dose imatinib and nilotinib for the treatment of imatinib-resistant chronic myeloid leukaemia (CML) (part review of NICE technology appraisal guidance 70), and dasatinib and nilotinib for people with CML for whom treatment with imatinib has failed because of intolerance (TA241)

    This guidance has been updated and replaced by NICE technology appraisal guidance 425.

    Withdrawn guidance

  47. Pregnancy and complex social factors: a model for service provision for pregnant women with complex social factors (CG110)

    This guideline covers antenatal care for all pregnant women with complex social factors (particularly alcohol or drug misuse, recent migrant or asylum seeker status, difficulty reading or speaking English, aged under 20, domestic abuse). It offers advice on improving access to care, maintaining contact with antenatal carers, and additional information and support for these women.

    Clinical guideline
    Published
    22 September 2010
    View recommendations

    Sections for CG110

  48. Preferred place of care and place of death:- When planning and managing end of life care, what factors help children and young people with life-limiting conditions and their parents or carers to decide where they would like end of life care to be provided and where they prefer to die?

    children and young people as well as their parents and carers (in particular, treatment of distressing symptoms) that may affect their...

    Research recommendation
    Published
    15 February 2017

  49. What is the safety and efficacy of botulinum toxin compared with (a) usual care, (b) antimuscarinics and (c) augmentation cystoplasty in people with primary cerebral conditions with lower urinary tract dysfunction?

    include heterogeneous groups of patients. Potential benefits of successful treatment in cerebral disease may include the avoidance of...

    Research recommendation
    Published
    9 June 2015

  50. Delirium in long-term care: How common is delirium and what are its adverse outcomes in people in long-term care?

    study would also inform cost-effectiveness analyses for the prevention and treatment of delirium. Source guidance details Comes from...

    Research recommendation
    Published
    3 February 2023