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  1. Current evidence on the safety and efficacy of implantation of a duodenal–jejunal bypass liner for managing type 2 diabetes is limited in quality and quantity. Therefore the procedure should only be used in the context of research.

    Recommendation ID IPG518/1 Question Current evidence on the safety and efficacy of implantation of a duodenal–jejunal bypass liner for

    Research recommendation
    Published
    9 June 2015

  2. Current evidence on the safety and efficacy of irreversible electroporation for treating liver metastases is inadequate in quantity and quality. Therefore, this procedure should only be used in the context of research. In particular, studies should report the effect of the procedure on local tumour control and patient survival.

    Recommendation ID IPG445/1 Question Current evidence on the safety and efficacy of irreversible electroporation for treating liver metastases

    Research recommendation
    Published
    9 June 2015

  3. Current evidence on the safety and efficacy of irreversible electroporation for treating primary lung cancer and metastases in the lung is inadequate in quantity and quality. Therefore, this procedure should only be used in the context of research. In particular, studies should report the effect of the procedure on local tumour control and patient survival.

    Recommendation ID IPG441/1 Question Current evidence on the safety and efficacy of irreversible electroporation for treating primary lung

    Research recommendation
    Published
    9 June 2015

  4. Current evidence on the safety and efficacy of irreversible electroporation for treating renal cancer is inadequate in quantity and quality. Therefore, this procedure should only be used in the context of research. In particular, studies should report the effect of the procedure on local tumour control and patient survival.

    Recommendation ID IPG443/1 Question Current evidence on the safety and efficacy of irreversible electroporation for treating renal cancer

    Research recommendation
    Published
    9 June 2015

  5. Current evidence on the safety and efficacy of radially emitting laser fibre treatment of an anal fistula is limited in quantity and quality. Therefore, although there are no major safety concerns, this procedure should only be used with special arrangements  for clinical governance, consent, and audit or research.

    Recommendation ID IPG644/1 Question Current evidence on the safety and efficacy of radially emitting laser fibre treatment of an anal fistula

    Research recommendation
    Published
    15 November 2019

  6. How can damp and mould in the home be prevented? How is damp and mould in the home best identified? How is damp and mould in the home best fixed? How can tenants be best made aware of whose responsibility it is to make any changes needed as a result of damp and mould in the home?

    Recommendation ID NG149/6 Question How can damp and mould in the home be prevented? How is damp and mould in the home best identified

    Research recommendation
    Published
    10 February 2020

  7. Cystourethrogram:- How accurate is the first CT scan with contrast (trauma scan) for detecting bladder injuries in people with suspected bladder injuries after a traumatic incident?

    Recommendation ID NG37/1 Question Cystourethrogram:- How accurate is the first CT scan with contrast (trauma scan) for detecting bladder

    Research recommendation
    Published
    21 March 2016

  8. Daily mouth care for residents:- Does the delivery of a daily mouth care regimen in care homes maintain or improve adult residents' oral health-related quality of life?

    Recommendation ID NG48/4 Question Daily mouth care for residents:- Does the delivery of a daily mouth care regimen in care homes maintain

    Research recommendation
    Published
    24 August 2016

  9. Further research should describe patient selection and clearly define the target area of the brain. Outcomes should include reduction in seizure frequency and improvement in the epilepsy seizure outcome scale, quality of life, reduction in concomitant medication and hospital admissions.

    Recommendation ID IPG678/1 Question Further research should describe patient selection and clearly define the target area of the brain

    Research recommendation
    Published
    26 October 2020

  10. Dementia care:- How effective and cost effective is intermediate care including reablement for supporting people living with dementia?

    Recommendation ID NG74/4 Question Dementia care:- How effective and cost effective is intermediate care including reablement for supporting

    Research recommendation
    Published
    15 October 2018

  11. Debridement:- What is the effect of enzymatic debridement of non-viable tissue compared with sharp debridement on the rate of healing of pressure ulcers in adults?

    Recommendation ID CG179/1 Question Debridement:- What is the effect of enzymatic debridement of non-viable tissue compared with sharp debridement

    Research recommendation
    Published
    9 June 2015

  12. Decision-making:- What interventions, systems and processes are effective and cost effective in changing health and social care practitioners' decision-making and ensuring appropriate antimicrobial stewardship?

    Recommendation ID Ng15/2 Question Decision-making:- What interventions, systems and processes are effective and cost effective in changing

    Research recommendation
    Published
    12 October 2015

  13. Designing systems for documenting drug allergy:- Which documentation strategies would be most clinically and cost effective to minimise the number of people who are re-exposed to drugs to which they have a suspected or confirmed allergy, looking in particular at: - electronic health records that include features specifically designed to record and alert clinicians to drug allergy information, compared with systems without such features and - different formats for patient-held, structured drug allergy documentation?

    Recommendation ID CG183/1 Question Designing systems for documenting drug allergy:- Which documentation strategies would be most clinically

    Research recommendation
    Published
    9 June 2015

  14. Decreasing pharmacological treatment:- In adults, young people and children with well-controlled asthma, what are the objective measurements and prognostic factors that indicate that a decrease in regular maintenance treatment is appropriate?

    Recommendation ID NG80/9 Question Decreasing pharmacological treatment:- In adults, young people and children with well-controlled asthma

    Research recommendation
    Published
    18 October 2018

  15. Attachment-focused interventions:- This research recommendation is composed of 2 parts.Develop attachment-focused interventions to treat attachment difficulties in children aged over 5 years and young people who have been adopted or are in the care system.Develop attachment-based interventions to promote secure attachment in children and young people who have been, or are at risk of being, maltreated.

    Recommendation ID NG26/2 Question Attachment-focused interventions:- This research recommendation is composed of 2 parts.Develop attachment-focused

    Research recommendation
    Published
    11 December 2015

  16. Dedicated transfer service:- Is it clinically and cost effective to provide a dedicated service to transfer patients with major trauma from the emergency department for ongoing care?

    Recommendation ID NG40/3 Question Dedicated transfer service:- Is it clinically and cost effective to provide a dedicated service to transfer

    Research recommendation
    Published
    4 April 2016

  17. Develop case identification tools for common mental health problems:- Develop or adapt reliable and valid tools for the case identification of common mental health problems in people with learning disabilities, for routine use in primary care, social care and education settings.

    Recommendation ID NG54/1 Question Develop case identification tools for common mental health problems:- Develop or adapt reliable and valid

    Research recommendation
    Published
    17 October 2016

  18. Developing a 'risk positive' approach in care homes:- What is the effectiveness and acceptability of different strategies to enable positive risk-taking in care homes?

    Recommendation ID NG22/4 Question Developing a 'risk positive' approach in care homes:- What is the effectiveness and acceptability of

    Research recommendation
    Published
    11 December 2015

  19. Epidurals:- What is the clinical and cost effectiveness of image-guided compared with non-image-guided epidural injections for people with acute sciatica?

    Recommendation ID NG59/4 Question Epidurals:- What is the clinical and cost effectiveness of image-guided compared with non-image-guided

    Research recommendation
    Published
    13 February 2017

  20. Epilepsy syndromes: What are the initial and add-on AEDs of choice in the treatment of the epilepsy syndromes with onset in childhood, for example, myoclonic-astatic epilepsy and Dravet syndrome?

    Recommendation ID CG137/2 Question Epilepsy syndromes: What are the initial and add-on AEDs of choice in the treatment of the epilepsy

    Research recommendation
    Published
    13 August 2021

  21. Evaluation frameworks and logic models:- Which evaluation frameworks and logic models can be used to evaluate the impact of community engagement on health and wellbeing?

    Recommendation ID NG44/2 Question Evaluation frameworks and logic models:- Which evaluation frameworks and logic models can be used to

    Research recommendation
    Published
    6 April 2016

  22. Epiretinal brachytherapy for wet age-related macular degeneration (AMD) should only be used in the context of research. Research studies should address whether epiretinal brachytherapy reduces the progression of wet AMD and whether it can reduce the number of injections of antivascular endothelial growth factor agents (anti-VEGF) required. Long-term outcomes should be reported.

    Recommendation ID IPG415/1 Question Epiretinal brachytherapy for wet age-related macular degeneration (AMD) should only be used in the

    Research recommendation
    Published
    9 June 2015

  23. Evaluation of extensively used interventions:- Evaluate currently unevaluated but extensively used interventions for attachment difficulties.

    Recommendation ID NG26/3 Question Evaluation of extensively used interventions:- Evaluate currently unevaluated but extensively used interventions

    Research recommendation
    Published
    11 December 2015

  24. Evidence on the progression of X-linked hypophosphataemia (XLH) over time and the long-term benefits of burosumab would also be valuable.

    Recommendation ID HST8/3 Question Evidence on the progression of X-linked hypophosphataemia (XLH) over time and the long-term benefits

    Research recommendation
    Published
    22 March 2019

  25. Further research should ideally be in the form of randomised controlled trials. Details of patient selection, the procedure and long-term outcomes should be reported.

    Recommendation ID IPG766 Question Further research should ideally be in the form of randomised controlled trials. Details of patient selection

    Research recommendation
    Published
    7 August 2023

  26. Evidence on the safety and efficacy of aortic remodelling hybrid stent insertion during surgical repair of an acute type A aortic dissection is limited in quantity and quality. Therefore, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Find out what special arrangements mean on the NICE interventional procedures guidance page.

    Recommendation ID IPG733/01 Question Evidence on the safety and efficacy of aortic remodelling hybrid stent insertion during surgical repair

    Research recommendation
    Published
    7 September 2022

  27. Evidence on the safety and efficacy of biodegradable spacer insertion to reduce rectal toxicity during radiotherapy for prostate cancer is limited in quality. Therefore, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Find out what special arrangements mean on the NICE interventional procedures guidance page.

    Recommendation ID IPG752/01 Question Evidence on the safety and efficacy of biodegradable spacer insertion to reduce rectal toxicity during

    Research recommendation
    Published
    9 March 2023

  28. Evidence on the safety and efficacy of intramedullary distraction for lower limb lengthening is limited in quantity and quality. Therefore, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Find out what special arrangements mean on the NICE interventional procedures guidance page. This guidance is not intended to cover this procedure for bilateral lower limb lengthening for people with short stature.

    Recommendation ID IPG718/01 Question Evidence on the safety and efficacy of intramedullary distraction for lower limb lengthening is limited

    Research recommendation
    Published
    8 April 2022

  29. Evidence on the efficacy and safety of neurostimulation of lumbar muscles for refractory non-specific chronic low back pain is limited in quantity and quality. Therefore, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Find out what special arrangements mean on the NICE interventional procedures guidance page.

    Recommendation ID IPG739/01 Question Evidence on the efficacy and safety of neurostimulation of lumbar muscles for refractory non-specific

    Research recommendation
    Published
    30 September 2022

  30. Evidence on the safety and efficacy of intramedullary distraction for upper limb lengthening is inadequate in quantity and quality. But because this is a rare condition with limited alternative treatments, the procedure can be considered as long as special arrangements for clinical governance, consent, and audit or research are in place. Find out what special arrangements mean on the NICE interventional procedures guidance page. Further research, which could be registry data, should report details of patient  selection, device selection, technique used, procedural outcomes, long-term  outcomes including quality of life, the need for repeat interventions or surgery and complication rates.

    Recommendation ID IPG722/01 Question Evidence on the safety and efficacy of intramedullary distraction for upper limb lengthening is inadequate

    Research recommendation
    Published
    11 May 2022

  31. Evidence on the safety and efficacy of daytime intraoral neuromuscular electrical tongue stimulation using a removable device for obstructive sleep apnoea is inadequate in quality and quantity. So, this procedure should be used only in research. Find out what only in research means on the NICE interventional procedures guidance page.

    Recommendation ID IPG760/1 Question Evidence on the safety and efficacy of daytime intraoral neuromuscular electrical tongue stimulation

    Research recommendation
    Published
    5 May 2023

  32. Evidence on the efficacy of bioresorbable stent implantation to treat coronary artery disease is inadequate. Evidence on its safety has shown an increased risk of serious complications in the longer term. This includes an increased risk of myocardial infarction and death with some types of bioresorbable stents. Therefore, this procedure should only be used in the context of research. Find out what only in research means on the NICE interventional procedures guidance page.

    Recommendation ID IPG732/01 Question Evidence on the efficacy of bioresorbable stent implantation to treat coronary artery disease is inadequate

    Research recommendation
    Published
    7 September 2022

  33. Evidence on the safety and efficacy of endobronchial nerve ablation for chronic obstructive pulmonary disease (COPD) is inadequate in quantity. Therefore, this procedure should only be used in the context of research. Find out what only in research means on the NICE interventional procedures guidance page. Further research should be randomised controlled trials comparing the procedure with sham treatment. It should report details of patient selection, and short and long-term functional outcomes including lung functional outcomes, quality of life and patient-reported outcomes, incidence of exacerbations and hospital admissions, and all adverse events.

    Recommendation ID IPG174/01 Question Evidence on the safety and efficacy of endobronchial nerve ablation for chronic obstructive pulmonary

    Research recommendation
    Published
    7 January 2022

  34. Evidence on the safety and efficacy of laparoscopic renal denervation for loin pain haematuria syndrome is inadequate in quality and quantity. Therefore, this procedure should only be used in the context of research. Find out what only in research means on the NICE interventional procedures guidance page. Further research should report details of patient selection, technique used and long-term follow-up outcomes

    Recommendation ID IPG709/01 Question Evidence on the safety and efficacy of laparoscopic renal denervation for loin pain haematuria syndrome

    Research recommendation
    Published
    5 November 2021

  35. Evidence on the efficacy of focal resurfacing implants to treat articular cartilage damage in the knee is limited in quality and quantity. Short-term evidence shows no major safety concerns, but long-term evidence on safety is limited in quality and quantity. Therefore, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Find out what special arrangements mean on the NICE interventional procedures guidance page.

    Recommendation ID IPG734/01 Question Evidence on the efficacy of focal resurfacing implants to treat articular cartilage damage in the

    Research recommendation
    Published
    7 September 2022

  36. Evidence on the safety and efficacy of lateral elbow resurfacing for arthritis is limited in quantity and quality. Therefore, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Find out what special arrangements mean on the NICE interventional procedures guidance page. Further research, which could include case series with long-term follow up, should report range of motion, patient-reported outcomes and complications.

    Recommendation ID IPG705/1 Question Evidence on the safety and efficacy of lateral elbow resurfacing for arthritis is limited in quantity

    Research recommendation
    Published
    30 September 2021

  37. Evidence on the safety and efficacy of inducing and maintaining normothermia using temperature modulation devices to improve outcomes after stroke or subarachnoid haemorrhage is inadequate in quality and quantity. Therefore, this procedure should only be used in the context of research. Find out what only in research means on the NICE interventional procedures guidance page.

    Recommendation ID IPG701/1 Question Evidence on the safety and efficacy of inducing and maintaining normothermia using temperature modulation

    Research recommendation
    Published
    13 August 2021

  38. Evidence on the safety and efficacy of percutaneous image-guided cryoablation of peripheral neuroma for chronic pain is inadequate in quality and quantity. Therefore, this procedure should only be used in thecontext of research. Find out what only in research means on the NICE interventional procedures guidance page.

    Recommendation ID IPG747/01 Question Evidence on the safety and efficacy of percutaneous image-guided cryoablation of peripheral neuroma

    Research recommendation
    Published
    3 February 2023

  39. Evidence on the safety and efficacy of percutaneous insertion of a cystic duct stent after cholecystostomy for acute calculous cholecystitis is inadequate in quality and quantity. But because patients would otherwise need permanent external drainage, the procedure can be considered for this condition, as long as special arrangements for clinical governance, consent, and audit or research are in place. Find out what special arrangements mean on the NICE interventional procedures guidance page.

    Recommendation ID IPG720/01 Question Evidence on the safety and efficacy of percutaneous insertion of a cystic duct stent after cholecystostomy

    Research recommendation
    Published
    8 April 2022

  40. Evidence on the safety and efficacy of percutaneous thoracic duct embolisation for persistent chyle leak is limited in quantity and quality. Therefore, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Find out what special arrangements mean on the NICE interventional procedures guidance page.

    Recommendation ID IPG755/1 Question Evidence on the safety and efficacy of percutaneous thoracic duct embolisation for persistent chyle

    Research recommendation
    Published
    5 May 2023

  41. Evidence on the safety and efficacy of permanent His-bundle pacemaker implantation for treating heart failure is inadequate in quality and quantity.Therefore, this procedure should only be used in the context of research. Find out what only in research means on the NICE interventional procedures guidance page.

    Recommendation ID IPG694/1 Question Evidence on the safety and efficacy of permanent His-bundle pacemaker implantation for treating heart

    Research recommendation
    Published
    10 August 2021

  42. Factors affecting participation and quality of life:- What are the key factors, including additional care and support, that influence participation and quality of life in people with neuropathic pain?

    Recommendation ID CG173/4 Question Factors affecting participation and quality of life:- What are the key factors, including additional

    Research recommendation
    Published
    9 June 2015

  43. Factors associated with sustained, high-quality residential care:- What factors (including service organisation and management, staff composition, training andsupervision, and the content of care and support) are associated with sustained high-quality residential care for people with a learning disability and behaviour that challenges?

    Recommendation ID NG11/4 Question Factors associated with sustained, high-quality residential care:- What factors (including service organisation

    Research recommendation
    Published
    5 October 2015

  44. Factors predicting outcomes for people with high-grade transformation of follicular lymphoma:- In people with high-grade transformation of follicular lymphoma, which biological and clinical factors predict good outcomes with immunochemotherapy alone?

    Recommendation ID NG52/2 Question Factors predicting outcomes for people with high-grade transformation of follicular lymphoma:- In people

    Research recommendation
    Published
    25 August 2016

  45. Factors that influence older people's mental wellbeing:- In the UK, which factors or processes in an intervention influence older people's mental wellbeing?How do these factors interact with one another and does the importance differ for different groups?

    Recommendation ID NG32/5 Question Factors that influence older people's mental wellbeing:- In the UK, which factors or processes in an

    Research recommendation
    Published
    25 January 2016

  46. What is the clinical and cost effectiveness, post-treatment and at longer-term follow‑up, of family therapy, psychodynamic psychotherapy and interpersonal psychotherapy for adolescents (IPT‑A) compared with each other and with individual CBT in young people aged 12 to 18 years with moderate to severe depression?

    Recommendation ID NG134/3 Question What is the clinical and cost effectiveness, post-treatment and at longer-term follow‑up, of family

    Research recommendation
    Published
    25 October 2019

  47. Feeding interventions for the management of neonatal weight loss:- What is the effectiveness of feeding interventions compared with usual care/advice for breastfedneonates (up to 28 days old) with weight loss of greater than 10%?

    Recommendation ID NG75/2 Question Feeding interventions for the management of neonatal weight loss:- What is the effectiveness of feeding

    Research recommendation
    Published
    15 October 2018

  48. Evidence on the safety and efficacy of fetoscopic prenatal repair of open neural tube defects in the fetus is inadequate in quantity and quality. Therefore, this procedure should only be used in the context of research. This could be in the form of randomised controlled trials or published registry data.

    Recommendation ID IPG668/1 Question Evidence on the safety and efficacy of fetoscopic prenatal repair of open neural tube defects in the

    Research recommendation
    Published
    10 February 2020

  49. For adults with fibromyalgia or persistent treatment-resistant neuropathic pain, what is the clinical and cost effectiveness of cannabidiol (CBD), containing no, or traces of, delta-9-tetrahydrocannabinol (THC), as an add-on to standard treatment?

    Recommendation ID NG144/1 Question For adults with fibromyalgia or persistent treatment-resistant neuropathic pain, what is the clinical

    Research recommendation
    Published
    10 February 2020

  50. In women with type 1 diabetes who are already pregnant, what is the most effective method of glucose monitoring to improve maternal and baby outcomes: continuous glucose monitoring flash glucose monitoring?

    Recommendation ID NG3/7 Question In women with type 1 diabetes who are already pregnant, what is the most effective method of glucose monitoring

    Research recommendation
    Published
    22 January 2021