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Area of interest

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Showing 2551 to 2600 of 3041 results for all

  1. Zolbetuximab with chemotherapy for untreated claudin-18.2-positive HER2-negative unresectable advanced gastric or gastro-oesophageal junction adenocarcinoma (TA1046)

    Evidence-based recommendations on zolbetuximab (Vyloy) with chemotherapy for untreated claudin-18.2-positive HER2-negative unresectable advanced gastric or gastro-oesophageal junction adenocarcinoma in adults.

    Technology appraisal guidance
    Published
    12 March 2025
    View recommendations

    Sections for TA1046

  2. Inflammatory bowel disease (QS81)

    This quality standard covers diagnosing and managing inflammatory bowel disease (Crohn’s disease and ulcerative colitis) in adults, young people and children. It describes high-quality care in priority areas for improvement.

    Quality standard
    Published
    26 February 2015
    View quality statements

    Sections for QS81

  3. 5-aminosalicylate (5-ASA) treatment:- Following successful medical induction of remission of Crohn's disease of the colon, is mesalazine more clinically and cost effective than no treatment?

    question is applicable to adults, young people and children, and trials in all are therefore required. A conventional...

    Research recommendation
    Published
    17 September 2020

  4. Reducing car ownership:- Does reducing car use or ownership change physical activity levels? Are effects maintained over time?

    asthe effects on different groups, and in different areas. For example not all areas have ready access to public transport; and for some...

    Research recommendation
    Published
    15 November 2018

  5. Predictors of acute physical risk:- What clinical and biochemical markers are the best predictors of acute physical risk for people with eating disorders?

    risk are used throughout this guideline. Despite their importance, almost all of the conventional risk frameworks are based on consensus...

    Research recommendation
    Published
    12 October 2018

  6. Pharmacological prevention: In people in hospital who are at high risk of delirium, which medication (atypical antipsychotics, typical antipsychotics, benzodiazepines or acetylcholinesterase inhibitors), compared with placebo or each other, is more clinically and cost effective in preventing the development of delirium?

    serious nature of delirium and its consequences makes it important to establish all methods of prevention. Pharmacological agents may be...

    Research recommendation
    Published
    3 February 2023

  7. Minimally invasive total hip replacement (IPG363)

    Evidence-based recommendations on minimally invasive total hip replacement. This involves replacing the damaged hip joint (the top part of the upper leg bone and the socket in the hip bone that it fits into) with an artificial one.

    Interventional procedures guidance
    Published
    27 October 2010
    View recommendations

    Sections for IPG363

  8. Therapeutic hypothermia with intracorporeal temperature monitoring for hypoxic perinatal brain injury (IPG347)

    Evidence-based recommendations on therapeutic hypothermia with intracorporeal temperature monitoring for hypoxic perinatal brain injury. This involves cooling either the baby's head or whole body to prevent brain damage.

    Interventional procedures guidance
    Published
    26 May 2010
    View recommendations

    Sections for IPG347

  9. Hand allotransplantation (IPG383)

    Evidence-based recommendations on hand transplant surgery (allotransplantation). This involves transplanting a hand from a recently deceased donor onto the amputated stump.

    Interventional procedures guidance
    Published
    23 March 2011
    View recommendations

    Sections for IPG383

  10. Placement of pectus bar for pectus excavatum (also known as MIRPE or the Nuss procedure) (IPG310)

    Evidence-based recommendations on placement of pectus bar for pectus excavatum (Nuss procedure). This involves placing one or two steel (pectus) bars under the breastbone with the aim of raising it and correcting the abnormal shape.

    Interventional procedures guidance
    Published
    26 August 2009
    View recommendations

    Sections for IPG310

  11. Endovascular stent-grafting of popliteal aneurysms (IPG390)

    Evidence-based recommendations on endovascular stent-grafting of popliteal aneurysms. This involves inserting a ‘stent-graft’ device through the femoral artery (in the groin) lining the inside of the aneurysm.

    Interventional procedures guidance
    Published
    27 April 2011
    View recommendations

    Sections for IPG390

  12. The evidence on the safety of transurethral laser ablation for recurrent non-muscle-invasive bladder cancer shows that there are no major safety concerns. However, current evidence on its efficacy is limited in quality and quantity. Therefore, this procedure should only be used with  special arrangements   for clinical governance, consent, and audit or research.

    for the public is recommended. Audit and review clinical outcomes of all patients having transurethral laser ablation for recurrent...

    Research recommendation
    Published
    15 November 2019

  13. What is the comparative effectiveness and cost effectiveness of exercise referral schemes compared with other interventions that aim to help people to become more physically active? Relative effectiveness and cost effectiveness should be compared in controlled trials.

    albeit below current UK physical activity guidelines rather than none at all, should be taken into account. (See the Department of...

    Research recommendation
    Published
    9 June 2015

  14. What factors encourage under-represented groups to participate in and complete an exercise referral scheme? What factors prevent these groups from participating? Under-represented groups include: people from black and minority ethnic groups, people with disabilities and those from lower socioeconomic groups.

    albeit below current UK physical activity guidelines rather than none at all, should be taken into account. (See the Department of...

    Research recommendation
    Published
    9 June 2015

  15. What factors encourage uptake of, and adherence to, an exercise referral scheme? Factors to consider include: design, content and delivery; referral mechanisms; choice of activity; qualifications and cost of instructors. Also identify any barriers preventing participation and factors that encourage it.

    albeit below current UK physical activity guidelines rather than none at all, should be taken into account. (See the Department of...

    Research recommendation
    Published
    9 June 2015

  16. Management of stable angina in people with evidence of ischaemia on non-invasive functional testing:- Do people with stable angina and evidence of reversible ischaemia on noninvasive functional testing who are on optimal drug treatment benefit from routine coronary angiography with a view to revascularisation?

    stable angina and myocardial ischaemia on noninvasive functional testing, with all-cause mortality and cardiovascular mortality as the...

    Research recommendation
    Published
    9 June 2015

  17. t:slim X2 insulin pump for managing blood glucose levels in type 1 diabetes (MIB227)

    NICE has developed a medtech innovation briefing (MIB) on t:slim X2 insulin pump for managing blood glucose levels in type 1 diabetes .

    Medtech innovation briefing
    Published
    22 September 2020

  18. Leadless cardiac pacemaker implantation for bradyarrhythmias (IPG626)

    Evidence-based recommendations on leadless cardiac pacemaker implantation for bradyarrhythmias in adults. This involves inserting a device into the heart that helps it beat at a normal rate.

    Interventional procedures guidance
    Published
    29 August 2018
    View recommendations

    Sections for IPG626

  19. Screening assessment tools:- Develop reliable and valid screening assessment tools for attachment and sensitivity that can be made available and used in routine health, social care and education settings.

    parents and foster or adoptive parents of children and young people across all groups (0–17 years).The tool must be readily available...

    Research recommendation
    Published
    11 December 2015

  20. Maternal request for caesarean birth: What support or psychological interventions would be appropriate for women who have a fear of vaginal childbirth and request a caesarean birth?

    lacking and could make a difference to women who are anxious or afraid. All of these interventions have different resource implications...

    Research recommendation
    Published
    24 April 2023

  21. Interventions to reduce the frequency and extent of moderate to severe behaviour that challenges in community settings:- Are interventions based on the science and practice of applied behaviour analysis or antipsychotic medication, or a combination of these, effective in reducing the frequency and severity of behaviour that challenges shown by adults with a learning disability?

    characterises the nature and function of the behaviour - assesses all coexisting problems that may contribute to the behaviour...

    Research recommendation
    Published
    5 October 2015

  22. Risk assessment:- What is the accuracy of individual risk assessment tools in predicting the risk of venousthromboembolism (VTE) and risk of bleeding in people admitted to hospital?

    applicable) Why this is important:- Risk assessment is a mandatory for all people admitted or having day procedures in hospital. Since...

    Research recommendation
    Published
    15 November 2018

  23. Assessment of disease severity and impact:- In children, young people and adults with psoriasis, can tools be developed and/or existing ones further refined and validated to: - assess disease severity and impact in both non-specialist and specialist healthcare settings, to facilitate assessment, appropriate referral, treatment planning and measurement of outcomes - measure burden and cumulative effect of disease activity, severity and impact for people with both psoriasis and psoriatic arthritis?

    well as extent and the impact of previous treatments. Tools should capture all aspects of impact on life including physical,...

    Research recommendation
    Published
    9 June 2015

  24. Botulinum toxin type A:- What is the clinical and cost effectiveness of botulinum toxin type A when used routinely or according to clinical need in children and young people who are at Gross Motor Function Classification System (GMFCS) level I, II or III?

    a strong recommendation to offer treatment with botulinum toxin type A to all children and young people who are at GMFCS level I, II or...

    Research recommendation
    Published
    9 June 2015

  25. Extended access to social care services:- What is the clinical and cost effectiveness of providing extended access to social care services, for example during early mornings and evenings, and 7 days a week?

    to social care differs throughout the country. Some areas have access to all socialcare services whereas others have very limited...

    Research recommendation
    Published
    15 November 2018

  26. Education and training programmes: self-management:- What is the effectiveness and cost effectiveness of education programmes to improve information and advice and to support self-management of chronic health conditions (for example, obesity, diabetes and cardiovascular disease) for people growing older with learning disabilities, and their family members and carers?

    medication management and have problems to access to healthcare more broadly, all of which can have costly consequences; some of those...

    Research recommendation
    Published
    29 November 2018

  27. The evidence on percutaneous insertion of a cerebral protection device to prevent cerebral embolism during TAVI raises no major safety concerns other than those associated with the TAVI procedure. However, the evidence on efficacy for preventing TAVI-related stroke is inconclusive. Therefore, this procedure should only be used with  special arrangements   for clinical governance, consent, and audit or research.

    use of NICE's information for the public is recommended. Details of all patients should be entered into the UK TAVI registry . Patient...

    Research recommendation
    Published
    15 November 2019

  28. Optimal interventional and conservative treatments at different stages of disease:- What is the optimal treatment (compression, surgery, endothermal ablation or foam sclerotherapy) for varicose veins at each of the CEAP stages, that is CEAP stages 2–3, CEAP stage 4 and CEAP stages 5–6?

    with varicose veins at different stages, may not be equally effective for all patients. A large-scale RCT that compares the 4 main...

    Research recommendation
    Published
    9 June 2015

  29. Etranacogene dezaparvovec for treating moderately severe or severe haemophilia B (TA989)

    Evidence-based recommendations on etranacogene dezaparvovec (Hemgenix) for treating moderately severe or severe haemophilia B in adults.

    Technology appraisal guidance
    Published
    24 July 2024

    Sections for TA989

  30. Alectinib for untreated ALK-positive advanced non-small-cell lung cancer (TA536)

    Evidence-based recommendations on alectinib (Alecensa) for untreated anaplastic lymphoma kinase (ALK)-positive advanced non-small-cell lung cancer in adults.

    Technology appraisal guidance
    Published
    8 August 2018

    Sections for TA536

  31. Enfortumab vedotin with pembrolizumab for untreated unresectable or metastatic urothelial cancer when platinum-based chemotherapy is suitable (TA1097)

    Evidence-based recommendations on enfortumab vedotin (Padcev) with pembrolizumab (Keytruda) for untreated unresectable or metastatic urothelial cancer in adults when platinum-based chemotherapy is suitable.

    Technology appraisal guidance
    Published
    11 September 2025

    Sections for TA1097

  32. Lung cancer: Treatment pathways

    pathways (linked below), or grouped together in a single interactive PDF of all treatment pathways for squamous and non-squamous...

  33. Hysteroscopy compared with ultrasound or empiric pharmacological treatment in the diagnosis and management of heavy menstrual bleeding (HMB): -Is initial testing using hysteroscopy more effective than testing with pelvic ultrasound or empiric pharmacological treatment in the diagnosis and management of HMB?

    absence of clinical trials, decision analytical economic models evaluating all possible outpatient testing algorithms have indicated...

    Research recommendation
    Published
    14 November 2018

  34. Endoscopic full thickness removal of non-lifting colonic polyps (IPG580)

    Evidence-based recommendations on endoscopic full thickness removal of non-lifting colonic polyps. This involves using a special device to remove the polyp and seal the bowel wall closed afterwards.

    Interventional procedures guidance
    Published
    24 May 2017
    View recommendations

    Sections for IPG580

  35. Acute coronary syndromes in adults (QS68)

    This quality standard covers diagnosing and managing acute coronary syndromes in adults (aged 18 and over). Acute coronary syndromes are medical emergencies that include myocardial infarction (heart attack) and unstable angina (unexpected, severe chest pain). It describes high-quality care in priority areas for improvement.

    Quality standard
    Last updated
    18 November 2020
    View quality statements

    Sections for QS68

  36. Meningitis (bacterial) and meningococcal disease (QS19)

    This quality standard covers recognising, diagnosing and managing bacterial meningitis and meningococcal disease in babies, children, young people and adults. It describes high-quality care in priority areas for improvement.

    Quality standard
    Last updated
    4 December 2024
    View quality statements

    Sections for QS19

  37. Chronic kidney disease in adults (QS5)

    This quality standard covers the assessment and management of chronic kidney disease in adults (aged 18 and over). It describes high-quality care in priority areas for improvement.

    Quality standard
    Last updated
    27 July 2017
    View quality statements

    Sections for QS5

  38. Vaccine uptake in under 19s (QS145)

    This quality standard covers increasing vaccine uptake among children and young people aged under 19 in groups and settings that have low immunisation coverage. It describes high-quality care in priority areas for improvement.

    Quality standard
    Last updated
    17 May 2022
    View quality statements

    Sections for QS145

  39. Evidence on the safety of the swallowable gastric balloon capsule for weight loss shows infrequent but potentially serious adverse events: For people who need to lose weight in the short term for medical reasons, the evidence of efficacy is adequate to support the use of this procedure provided that special arrangements are in place for clinical governance, consent and audit.  Find out  what special arrangements mean on the NICE interventional procedures guidance page . For people who are aiming for long-term weight loss, the evidence on efficacy is inadequate in quantity and quality, so the procedure should only be used in the context of research.   Find out  what only in research means on the NICE interventional procedures guidance page .

    any uncertainties about these. Audit and review clinical outcomes of all patients having the procedure. The main efficacy and safety...

    Research recommendation
    Published
    22 January 2021

  40. The role of parents in the treatment of children and young people with social anxiety disorder:- What is the best way of involving parents in the treatment of children and young people (at different stages of development) with social anxiety disorder?

    treatment of young socially anxious children. Furthermore, when considering all age groups, parental mental health difficulties and...

    Research recommendation
    Published
    9 June 2015

  41. Treatment of convulsive status epilepticus (that is, not just refractory): What is the most effective and safest AED to treat: established (usually lasting longer than 30 minutes) convulsive status epilepticus refractory convulsive status epilepticus?

    underlying cause of RCSE, its duration and management. The majority, if not all patients with RCSE are managed in an ICU. There are no...

    Research recommendation
    Published
    13 August 2021

  42. Staging investigations for CPG 3 prostate cancer: What is the diagnostic accuracy of staging investigations for CPG 3 prostate cancer?

    previous 'intermediate-risk' group now consists of some people in CPG 1, and all people in CPG 2 and CPG 3, and recommendations that...

    Research recommendation
    Published
    7 January 2022

  43. Current evidence on the safety of ultrasound-guided high‑intensity transcutaneous focused ultrasound for symptomatic uterine fibroids shows there are well-recognised complications including skin burns. The evidence on efficacy is limited in quality. Therefore, this procedure should only be used with  special arrangements   for clinical governance, consent, and audit or research.

    for the public is recommended. Audit and review clinical outcomes of all patients having ultrasound-guided high intensity transcutaneous...

    Research recommendation
    Published
    15 November 2019

  44. Electrochemotherapy for primary basal cell carcinoma and primary squamous cell carcinoma (IPG478)

    Evidence-based recommendations on electrochemotherapy for primary basal cell carcinoma and primary squamous cell carcinoma. This involves injecting a chemotherapy drug into the tumour and using electrical pulses to increase its effect.

    Interventional procedures guidance
    Published
    26 February 2014
    View recommendations

    Sections for IPG478

  45. HealthVCF for detecting vertebral compression fractures on CT scans (MIB267)

    NICE has developed a medtech innovation briefing (MIB) on HealthVCF for detecting vertebral compression fractures on CT scans .

    Medtech innovation briefing
    Published
    13 July 2021

  46. Setmelanotide for treating obesity and hyperphagia in Bardet-Biedl syndrome (HST31)

    Evidence-based recommendations on setmelanotide (Imcivree) for treating obesity and hyperphagia in Bardet-Biedl syndrome in people 6 years and over, only if they are between 6 and 17 years when treatment starts.

    Highly specialised technologies guidance
    Published
    22 May 2024
    View recommendations

    Sections for HST31

  47. Technology appraisal committees

    Membership details, terms of reference, future meeting dates and past meeting minutes for our 4 technology appraisal committees.

  48. Oral antibiotic challenge for diagnosing antibiotic allergy in children:- In children who have a suspected allergy to an antibiotic, is it clinically and cost effective to proceed directly (without prior skin or intradermal tests) to a diagnostic oral antibiotic challenge rather than referring them to specialist drug allergy services?

    to be safe, acceptable and cost effective, it could be rolled out across all centres that offer paediatric allergy services. This would...

    Research recommendation
    Published
    9 June 2015

  49. What is the clinical utility of bone turnover markers in the diagnosis and management of primary hyperparathyroidism?

    However, the committee were aware that vitamin D testing is not available to all primary care providers, and that waiting for vitamin D...

    Research recommendation
    Published
    25 October 2019

  50. Transcatheter aortic valve implantation (TAVI) for native aortic valve regurgitation (IPG805)

    Evidence-based recommendations on transcatheter aortic valve implantation (TAVI) for native aortic valve regurgitation. This involves implanting a replacement valve inside the faulty native valve.

    Interventional procedures guidance
    Published
    24 June 2025
    View recommendations

    Sections for IPG805