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Showing 2551 to 2600 of 2995 results for all

  1. HPV testing:- What is the comparative effectiveness of single-step laboratory diagnostic tests to identify human papillomavirus (HPV) against current diagnostic test algorithms and reference standards in people with cancer of the oropharynx?

    implication. Current methods use a 2-step procedure that is not widely available in all treatment centres. A single-step test is likely...

  2. Cannabidiol for treating seizures caused by tuberous sclerosis complex (TA873)

    Evidence-based recommendations on cannabidiol (Epidyolex) for treating seizures caused by tuberous sclerosis complex.

  3. Dupilumab for treating severe chronic rhinosinusitis with nasal polyps (TA1134)

    Evidence-based recommendations on dupilumab (Dupixent) for treating severe chronic rhinosinusitis with nasal polyps in adults.

  4. Epcoritamab for treating relapsed or refractory follicular lymphoma after 2 or more lines of systemic treatment (TA1139)

    Evidence-based recommendations on epcoritamab (Tepkinly) for treating relapsed or refractory follicular lymphoma after 2 or more lines of systemic treatment in adults.

  5. Transjugular intrahepatic portosystemic shunt:- What is the quality of life in people who have had a transjugular intrahepatic portosystemic shunt (TIPS)?

    veins in the stomach, oesophagus or intestines, ascites or hydrothorax – all of which will have had a detrimental effect on their...

  6. Treating small oesophageal varices:- Do non-selective beta-blockers improve survival and prevent first variceal bleeds in people with cirrhosis that is associated with small oesophageal varices?

    half of patients with cirrhosis have oesophageal varices, and one-third of all patients with varices will experience bleeding at some...

  7. PIUR tUS for abdominal aortic aneurysm surveillance and endovascular aneurysm repair endoleak detection (MIB200)

    NICE has developed a medtech innovation briefing (MIB) on PIUR tUS for abdominal aortic aneurysm surveillance and endovascular aneurysm repair endoleak detection .

  8. Noctura 400 Sleep Mask for diabetic retinopathy and diabetic macular oedema (MIB144)

    NICE has developed a medtech innovation briefing (MIB) on Noctura 400 Sleep Mask for diabetic retinopathy and diabetic macular oedema .

  9. Lung cancer: Treatment pathways

    pathways (linked below), or grouped together in a single interactive PDF of all treatment pathways for squamous and non-squamous...

  10. Key question: effective

    This resource is intended to demonstrate how our guidance can be used in the Care Quality Commission (CQC) assessment process.

  11. Does early review of service provision and referral to additional specialist palliative care services improve outcomes for adults with progressive non-cancer disease thought to be approaching the end of their life?

    patients are typically referred very late to specialist palliative care, if at all. Further research would compare outcomes for people...

  12. Current evidence on the safety and efficacy of electrical stimulation of the lower oesophageal sphincter for treating gastro-oesophageal reflux disease (GORD) is limited in quantity and quality. Therefore, this procedure should only be used in the context of research.

    for surgical treatment for GORD in the longer term (at least 2 years) and all complications should be reported. NICE may update the...

  13. Repositioning:- When repositioning a person who is at risk of developing a pressure ulcer, what is the most effective position – and optimum frequency of repositioning – to prevent a pressure ulcer developing?

    evidence on the most efficient position and frequency of repositioning for all age groups. Many studies include people who are on...

  14. Probiotic and prebiotic supplements:- What is the clinical and cost effectiveness of probiotics or prebiotics to treat NAFLD in adults, young people and children?

    the most common metabolic liver disease, occurring in approximately 30% of all adults, around 46% of obese people and around 53% of...

  15. Reasons for refusal for consent:- Why do families refuse to give permission for organ donation?

    The study could be, for example, a multi-centre observational study where all family members (those that did and those that did not give...

  16. Home-testing devices for diagnosing obstructive sleep apnoea hypopnoea syndrome (HTG735)

    Evidence-based recommendations on home-testing devices for diagnosing obstructive sleep apnoea hypopnoea syndrome.

  17. Prioritisation board decisions 2025

    Our centralised approach to prioritising our guidance topics ensures that we produce guidance that's relevant, timely, accessible, and has demonstrable impact.

  18. Alpha-Stim AID for anxiety disorders (HTG570)

    Evidence-based recommendations on Alpha-Stim AID for managing anxiety disorders.

  19. Support for black and minority ethnic groups:- How effective and cost effective are different approaches to supporting people from black and minority ethnic groups using intermediate care?

    planning and delivering intermediate care for minority groups. This includes all 4 service models of intermediate care. Qualitative data...

  20. Staff training:- What is the cost effectiveness of using a dementia-specific addition to the Care Certificate for community staff, including dementia-specific elements on managing anxiety, communication, nutritional status and personal care?

    However, it is not clear if it is effective to provide basic training to all staff who come into contact with people living with...

  21. What is the effectiveness and safety of standard-dose compared with intermediate-dose pharmacological venous thromboembolism (VTE) prophylaxis for people with COVID-19, with or without additional risk factors for VTE?

    anticoagulants vitamin K antagonists antiplatelets O:• incidence of VTE• mortality (all-cause, inpatient, COVID-19 related)• admission...

  22. Treosulfan with fludarabine for malignant disease before allogeneic stem cell transplant (TA640)

    Evidence-based recommendations on treosulfan (Trecondi) with fludarabine for conditioning treatment before allogeneic haematopoietic stem cell transplant for malignant diseases in people for whom a reduced intensity regimen would be suitable.

  23. Dapagliflozin in triple therapy for treating type 2 diabetes (TA418)

    Evidence-based recommendations on dapagliflozin (Forxiga) given with 2 other drugs for treating type 2 diabetes in adults.

  24. Upadacitinib for treating active ankylosing spondylitis (TA829)

    Evidence-based recommendations on upadacitinib (Rinvoq) for treating active ankylosing spondylitis that is not controlled well enough with conventional therapy in adults.

  25. Medication for promoting de-escalation:- Which medication is effective in promoting de-escalation in people who are identified as likely to demonstrate significant  violence?

    degree of sedation, acceptability of the medication and adverse effects, all recorded over a suitable timescale to match the...

  26. Psychological assessment:- What is the most effective measure of psychological functioning to use as a test for thresholds of concern in people with cystic fibrosis?

    most cost-effective service that can be provided. To prevent mental health problems, all people withcystic fibrosis would need to have...

  27. In people with suspected TB, what is the relative clinical and cost effectiveness of universal andrisk-based use of rapid nucleic acid amplification tests?

    with a possible diagnosis of TB. There is a trade-offbetween ensuring that all people with active TB are diagnosed and avoiding a large...

  28. Bladder EpiCheck for detecting bladder cancer recurrence (MIB293)

    NICE has developed a medtech innovation briefing (MIB) on Bladder EpiCheck for detecting bladder cancer recurrence .

  29. What is the most effective technological solution for minimising wrong implant selection during joint replacement surgery?

    other activity and formally inspect each implant component, would ensure that all components are compatible. The second stop moment...

  30. Unknown primary of presumed upper aerodigestive tract origin:- In people with CUADT of unknown primary, can radiotherapy target volumes be selected based on clinical and pathological factors?

    clinical teams will treat the neck disease alone and others will treat some or all potential primary sites with the radiotherapy with or...

  31. Constipation in children and young people (QS62)

    This quality standard covers the diagnosis and management of constipation of unknown cause in babies, children and young people (from birth to 18 years). It describes high-quality care in priority areas for improvement.

  32. Irritable bowel syndrome in adults (QS114)

    This quality standard covers diagnosing and managing irritable bowel syndrome in adults. It describes high-quality care in priority areas for improvement.

  33. Technology appraisal committee B members

    Find out more about the NICE technology appraisal advisory committee B members and their registered interests

  34. Technology appraisal committee B members

    Find out more about the NICE technology appraisal advisory committee B members and their registered interests

  35. What are the appropriate indications, effectiveness and safety of LDL apheresis in people with heterozygous FH?

    antisense oligonucleotides (ApoB). A national register should be established for all people with FH who are referred for and/or are...

  36. Use of technology in providing care- What are the views and experiences of people who use adult social care services on assistive technologies?

    example, integrated systems of sensors, alarms and remote monitoring. Across all population groups, there is a paucity of evidence about...

  37. Assessment tools for health promotion:- What are the most effective tools to determine the health promotion needs of people in prison?

    difficulties in accessing exercise programmes or information on sexual health. All of these may exacerbate existing health conditions or...

  38. Quantitative faecal immunochemical testing to guide colorectal cancer pathway referral in primary care (HTG690)

    Evidence-based recommendations on quantitative faecal immunochemical testing to guide colorectal cancer pathway referral in primary care.

  39. Rehabilitation: - What are the barriers to people with major trauma receiving early rehabilitation after rehabilitation assessment? What changes to services are needed to overcome these barriers?

    needs assessed, and that a rehabilitation prescription should be provided for all patients with rehabilitation needs. The rehabilitation...

  40. Pressure redistributing devices: Dopressure redistributing devices reduce the development of pressure ulcers for those who are at risk of developing a pressure ulcer?

    needed to identify what devices are beneficial for specific at-risk sites for all age groups. Source guidance details Comes from...

  41. How safe are drugs used to treat bipolar disorder in pregnancy and the postnatal period?

    effective for the acute treatment of bipolar disorder and for preventing relapse. All drugs used to treat mental health problems may...

  42. What is the best and most cost-effective management strategy for people whose first surgery for primary hyperparathyroidism is not successful?

    preoperative imaging is to help guide the surgical approach. It is not essential in all circumstances (for example, if a decision has...

  43. LIVERFASt for assessing and monitoring liver fibrosis, activity and steatosis (MIB317)

    NICE has developed a medtech innovation briefing (MIB) on LIVERFASt for assessing and monitoring liver fibrosis, activity and steatosis .