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Showing 2601 to 2650 of 3030 results for all

  1. How safe are drugs used to treat bipolar disorder in pregnancy and the postnatal period?

    effective for the acute treatment of bipolar disorder and for preventing relapse. All drugs used to treat mental health problems may...

    Research recommendation
    Published
    13 July 2017

  2. Short-term bridging treatment with glucocorticoids:- What is the clinical and cost effectiveness of short-term bridging treatment with glucocorticoids for adults with RA starting a new disease-modifying anti-rheumatic drug (DMARD), including the most effective dosing strategy and mode of administration?

    Any explanatory notes(if applicable) Why this is important:- All DMARDs have a slow onset of action. In some cases, response may not be...

    Research recommendation
    Published
    11 December 2018

  3. Alpha-Stim AID for anxiety disorders (HTG570)

    Evidence-based recommendations on Alpha-Stim AID for managing anxiety disorders.

    HealthTech guidance
    Published
    8 March 2021
    View recommendations

    Sections for HTG570

  4. Home-testing devices for diagnosing obstructive sleep apnoea hypopnoea syndrome (HTG735)

    Evidence-based recommendations on home-testing devices for diagnosing obstructive sleep apnoea hypopnoea syndrome.

    HealthTech guidance
    Published
    19 December 2024
    View recommendations

    Sections for HTG735

  5. Prioritisation board decisions 2025

    Our centralised approach to prioritising our guidance topics ensures that we produce guidance that's relevant, timely, accessible, and has demonstrable impact.

  6. Bladder EpiCheck for detecting bladder cancer recurrence (MIB293)

    NICE has developed a medtech innovation briefing (MIB) on Bladder EpiCheck for detecting bladder cancer recurrence .

    Medtech innovation briefing
    Published
    3 May 2022

  7. Recognition and early management of pain in children and young people with cerebral palsy:- Does use of pain assessment tools by parents or carers improve the recognition and early management of pain in children and young people with cerebral palsy in a community setting?

    pain and discomfort outside hospital is of clear importance to help with all aspects of quality of life, including learning, development...

    Research recommendation
    Published
    17 February 2017

  8. Co-producing research into the views and experiences of people who use services:- What approaches have been shown to work in supporting the co-production of research for the purposes of service improvement with people who use services?

    who useservices is a potential means of improving services. Co-producing all stages of the research process with people who use services...

    Research recommendation
    Published
    14 November 2018

  9. Risk tools to identify risk of developing COAG and risk of sight loss:- What is the predictive value of risk tools for identifying people in the community who are atincreased risk of developing chronic open angle glaucoma (COAG) and identifying people with COAG who are at increased risk of sight loss?

    and specificity of risk tools for developing COAG is of moderate-to-low quality, with all studies having a high or very high risk of...

    Research recommendation
    Published
    18 October 2018

  10. What structure and organisation of specialist autism teams are associated with improvements in care for autistic people?

    There is uncertainty about the precise nature of the population to be served (all autistic people or only those who have an IQ of 70 or...

    Research recommendation
    Published
    10 August 2021

  11. Measuring improvements in care home residents' oral health:- How can interventions to improve and maintain oral health and wellbeing, or to prevent dental disease, be measured using a patient-centred approach that can also be used to judge cost effectiveness?

    to determine cost effectiveness. These measures would capture the views of all residents living in care homes and could include: - how...

    Research recommendation
    Published
    24 August 2016

  12. Treosulfan with fludarabine for malignant disease before allogeneic stem cell transplant (TA640)

    Evidence-based recommendations on treosulfan (Trecondi) with fludarabine for conditioning treatment before allogeneic haematopoietic stem cell transplant for malignant diseases in people for whom a reduced intensity regimen would be suitable.

    Technology appraisal guidance
    Published
    5 August 2020
    View recommendations

    Sections for TA640

  13. Dapagliflozin in triple therapy for treating type 2 diabetes (TA418)

    Evidence-based recommendations on dapagliflozin (Forxiga) given with 2 other drugs for treating type 2 diabetes in adults.

    Technology appraisal guidance
    Published
    23 November 2016
    View recommendations

    Sections for TA418

  14. Upadacitinib for treating active ankylosing spondylitis (TA829)

    Evidence-based recommendations on upadacitinib (Rinvoq) for treating active ankylosing spondylitis that is not controlled well enough with conventional therapy in adults.

    Technology appraisal guidance
    Published
    30 September 2022
    View recommendations

    Sections for TA829

  15. Anti-reflux therapy as a treatment for idiopathic pulmonary fibrosis:- Is anti-reflux therapy an effective treatment for idiopathic pulmonary fibrosis?

    mortality (allcause and idiopathic pulmonary fibrosis-related); hospitalisation (all-cause, non-elective and idiopathic pulmonary...

    Research recommendation
    Published
    9 June 2015

  16. What are the clinical and cost effectiveness, and the safety, of specific antifungal treatments for treating suspected or confirmed COVID-19-associated pulmonary aspergillosis (CAPA), and the optimal treatment duration? When should treatment be started, stopped or modified?

    amphotericin B deoxycholate. C: Standard care (usually voriconazole) O:• all-cause mortality (at any time during treatment)• number of...

    Research recommendation
    Published
    9 March 2022

  17. What is the best and most cost-effective management strategy for people whose first surgery for primary hyperparathyroidism is not successful?

    preoperative imaging is to help guide the surgical approach. It is not essential in all circumstances (for example, if a decision has...

    Research recommendation
    Published
    25 October 2019

  18. Evidence on the safety and efficacy of artificial iris implant insertion for acquired aniridia is limited in quantity and quality. Therefore, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research.  Find out  what special arrangements mean on the NICE website .

    any uncertainties about these. Audit and review clinical outcomes of all patients having the procedure. NICE has identified relevant...

    Research recommendation
    Published
    10 August 2020

  19. Jejunostomy support after radical surgery:- What is the effectiveness of long-term jejunostomy support compared to intensive dietary counselling and support along with symptom management for people having radical surgery for oesophago-gastric cancer?

    and not using them routinely and others not placing jejunostomy tubes at all. Studies should aim to identify if jejunostomy placement...

    Research recommendation
    Published
    13 November 2018

  20. Technology appraisal committee B members

    Find out more about the NICE technology appraisal advisory committee B members and their registered interests

  21. Technology appraisal committee B members

    Find out more about the NICE technology appraisal advisory committee B members and their registered interests

  22. Reducing car ownership:- Does reducing car use or ownership change physical activity levels? Are effects maintained over time?

    asthe effects on different groups, and in different areas. For example not all areas have ready access to public transport; and for some...

    Research recommendation
    Published
    15 November 2018

  23. Predictors of acute physical risk:- What clinical and biochemical markers are the best predictors of acute physical risk for people with eating disorders?

    risk are used throughout this guideline. Despite their importance, almost all of the conventional risk frameworks are based on consensus...

    Research recommendation
    Published
    12 October 2018

  24. Pharmacological prevention: In people in hospital who are at high risk of delirium, which medication (atypical antipsychotics, typical antipsychotics, benzodiazepines or acetylcholinesterase inhibitors), compared with placebo or each other, is more clinically and cost effective in preventing the development of delirium?

    serious nature of delirium and its consequences makes it important to establish all methods of prevention. Pharmacological agents may be...

    Research recommendation
    Published
    3 February 2023

  25. 5-aminosalicylate (5-ASA) treatment:- Following successful medical induction of remission of Crohn's disease of the colon, is mesalazine more clinically and cost effective than no treatment?

    question is applicable to adults, young people and children, and trials in all are therefore required. A conventional...

    Research recommendation
    Published
    17 September 2020

  26. Constipation in children and young people (QS62)

    This quality standard covers the diagnosis and management of constipation of unknown cause in babies, children and young people (from birth to 18 years). It describes high-quality care in priority areas for improvement.

    Quality standard
    Published
    13 May 2014
    View quality statements

    Sections for QS62

  27. Irritable bowel syndrome in adults (QS114)

    This quality standard covers diagnosing and managing irritable bowel syndrome in adults. It describes high-quality care in priority areas for improvement.

    Quality standard
    Published
    11 February 2016
    View quality statements

    Sections for QS114

  28. The evidence on the safety of transurethral laser ablation for recurrent non-muscle-invasive bladder cancer shows that there are no major safety concerns. However, current evidence on its efficacy is limited in quality and quantity. Therefore, this procedure should only be used with  special arrangements   for clinical governance, consent, and audit or research.

    for the public is recommended. Audit and review clinical outcomes of all patients having transurethral laser ablation for recurrent...

    Research recommendation
    Published
    15 November 2019

  29. LIVERFASt for assessing and monitoring liver fibrosis, activity and steatosis (MIB317)

    NICE has developed a medtech innovation briefing (MIB) on LIVERFASt for assessing and monitoring liver fibrosis, activity and steatosis .

    Medtech innovation briefing
    Published
    21 February 2023

  30. Quantitative faecal immunochemical testing to guide colorectal cancer pathway referral in primary care (HTG690)

    Evidence-based recommendations on quantitative faecal immunochemical testing to guide colorectal cancer pathway referral in primary care.

    HealthTech guidance
    Published
    24 August 2023
    View recommendations

    Sections for HTG690

  31. What is the comparative effectiveness and cost effectiveness of exercise referral schemes compared with other interventions that aim to help people to become more physically active? Relative effectiveness and cost effectiveness should be compared in controlled trials.

    albeit below current UK physical activity guidelines rather than none at all, should be taken into account. (See the Department of...

    Research recommendation
    Published
    9 June 2015

  32. What factors encourage under-represented groups to participate in and complete an exercise referral scheme? What factors prevent these groups from participating? Under-represented groups include: people from black and minority ethnic groups, people with disabilities and those from lower socioeconomic groups.

    albeit below current UK physical activity guidelines rather than none at all, should be taken into account. (See the Department of...

    Research recommendation
    Published
    9 June 2015

  33. What factors encourage uptake of, and adherence to, an exercise referral scheme? Factors to consider include: design, content and delivery; referral mechanisms; choice of activity; qualifications and cost of instructors. Also identify any barriers preventing participation and factors that encourage it.

    albeit below current UK physical activity guidelines rather than none at all, should be taken into account. (See the Department of...

    Research recommendation
    Published
    9 June 2015

  34. Management of stable angina in people with evidence of ischaemia on non-invasive functional testing:- Do people with stable angina and evidence of reversible ischaemia on noninvasive functional testing who are on optimal drug treatment benefit from routine coronary angiography with a view to revascularisation?

    stable angina and myocardial ischaemia on noninvasive functional testing, with all-cause mortality and cardiovascular mortality as the...

    Research recommendation
    Published
    9 June 2015

  35. Schizophrenia: omega-3 fatty acid medicines (ESUOM19)

    Summary of the evidence on omega-3 fatty acid medicines for treating schizophrenia to inform local NHS planning and decision-making

    Evidence summary
    Published
    24 September 2013

  36. Screening assessment tools:- Develop reliable and valid screening assessment tools for attachment and sensitivity that can be made available and used in routine health, social care and education settings.

    parents and foster or adoptive parents of children and young people across all groups (0–17 years).The tool must be readily available...

    Research recommendation
    Published
    11 December 2015

  37. Maternal request for caesarean birth: What support or psychological interventions would be appropriate for women who have a fear of vaginal childbirth and request a caesarean birth?

    lacking and could make a difference to women who are anxious or afraid. All of these interventions have different resource implications...

    Research recommendation
    Published
    24 April 2023

  38. Interventions to reduce the frequency and extent of moderate to severe behaviour that challenges in community settings:- Are interventions based on the science and practice of applied behaviour analysis or antipsychotic medication, or a combination of these, effective in reducing the frequency and severity of behaviour that challenges shown by adults with a learning disability?

    characterises the nature and function of the behaviour - assesses all coexisting problems that may contribute to the behaviour...

    Research recommendation
    Published
    5 October 2015

  39. Risk assessment:- What is the accuracy of individual risk assessment tools in predicting the risk of venousthromboembolism (VTE) and risk of bleeding in people admitted to hospital?

    applicable) Why this is important:- Risk assessment is a mandatory for all people admitted or having day procedures in hospital. Since...

    Research recommendation
    Published
    15 November 2018

  40. Etanercept, infliximab and adalimumab for the treatment of psoriatic arthritis (TA199)

    Evidence-based recommendations on etanercept (Enbrel), infliximab (Remicade) and adalimumab (Humira) for treating active and progressive psoriatic arthritis in adults.

    Technology appraisal guidance
    Published
    25 August 2010
    View recommendations

    Sections for TA199

  41. Dostarlimab for previously treated advanced or recurrent endometrial cancer with high microsatellite instability or mismatch repair deficiency (TA779)

    Evidence-based recommendations on dostarlimab (Jemperli) for treating advanced or recurrent endometrial cancer with high microsatellite instability or mismatch repair deficiency in adults who have had platinum-based chemotherapy.

    Technology appraisal guidance
    Published
    16 March 2022
    View recommendations

    Sections for TA779

  42. Single-anastomosis duodeno-ileal bypass with sleeve gastrectomy for treating morbid obesity (HTG423)

    Evidence-based recommendations on single-anastomosis duodeno-ileal bypass with sleeve gastrectomy for treating morbid obesity. This involves reducing the size of the stomach and small intestine to reduce the amount of food absorbed.

    HealthTech guidance
    Published
    23 November 2016
    View recommendations

    Sections for HTG423

  43. Endocuff Vision for assisting visualisation during colonoscopy (HTG514)

    Evidence-based recommendations on Endocuff Vision for assisting visualisation during colonoscopy.

    HealthTech guidance
    Published
    7 June 2019
    View recommendations

    Sections for HTG514

  44. MiniMed 640G system with SmartGuard for managing blood glucose levels in people with type 1 diabetes (MIB51)

    NICE has developed a medtech innovation briefing (MIB) on MiniMed 640G system with SmartGuard for managing blood glucose levels in people with type 1 diabetes

    Medtech innovation briefing
    Published
    12 February 2016

  45. Assessment of disease severity and impact:- In children, young people and adults with psoriasis, can tools be developed and/or existing ones further refined and validated to: - assess disease severity and impact in both non-specialist and specialist healthcare settings, to facilitate assessment, appropriate referral, treatment planning and measurement of outcomes - measure burden and cumulative effect of disease activity, severity and impact for people with both psoriasis and psoriatic arthritis?

    well as extent and the impact of previous treatments. Tools should capture all aspects of impact on life including physical,...

    Research recommendation
    Published
    9 June 2015

  46. Botulinum toxin type A:- What is the clinical and cost effectiveness of botulinum toxin type A when used routinely or according to clinical need in children and young people who are at Gross Motor Function Classification System (GMFCS) level I, II or III?

    a strong recommendation to offer treatment with botulinum toxin type A to all children and young people who are at GMFCS level I, II or...

    Research recommendation
    Published
    9 June 2015

  47. Extended access to social care services:- What is the clinical and cost effectiveness of providing extended access to social care services, for example during early mornings and evenings, and 7 days a week?

    to social care differs throughout the country. Some areas have access to all socialcare services whereas others have very limited...

    Research recommendation
    Published
    15 November 2018

  48. Education and training programmes: self-management:- What is the effectiveness and cost effectiveness of education programmes to improve information and advice and to support self-management of chronic health conditions (for example, obesity, diabetes and cardiovascular disease) for people growing older with learning disabilities, and their family members and carers?

    medication management and have problems to access to healthcare more broadly, all of which can have costly consequences; some of those...

    Research recommendation
    Published
    29 November 2018

  49. The evidence on percutaneous insertion of a cerebral protection device to prevent cerebral embolism during TAVI raises no major safety concerns other than those associated with the TAVI procedure. However, the evidence on efficacy for preventing TAVI-related stroke is inconclusive. Therefore, this procedure should only be used with  special arrangements   for clinical governance, consent, and audit or research.

    use of NICE's information for the public is recommended. Details of all patients should be entered into the UK TAVI registry . Patient...

    Research recommendation
    Published
    15 November 2019

  50. Optimal interventional and conservative treatments at different stages of disease:- What is the optimal treatment (compression, surgery, endothermal ablation or foam sclerotherapy) for varicose veins at each of the CEAP stages, that is CEAP stages 2–3, CEAP stage 4 and CEAP stages 5–6?

    with varicose veins at different stages, may not be equally effective for all patients. A large-scale RCT that compares the 4 main...

    Research recommendation
    Published
    9 June 2015