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Showing 2601 to 2650 of 2995 results for all

  1. Risk tools to identify risk of developing COAG and risk of sight loss:- What is the predictive value of risk tools for identifying people in the community who are atincreased risk of developing chronic open angle glaucoma (COAG) and identifying people with COAG who are at increased risk of sight loss?

    and specificity of risk tools for developing COAG is of moderate-to-low quality, with all studies having a high or very high risk of...

    Research recommendation
    Published
    18 October 2018

  2. What structure and organisation of specialist autism teams are associated with improvements in care for autistic people?

    There is uncertainty about the precise nature of the population to be served (all autistic people or only those who have an IQ of 70 or...

    Research recommendation
    Published
    10 August 2021

  3. Measuring improvements in care home residents' oral health:- How can interventions to improve and maintain oral health and wellbeing, or to prevent dental disease, be measured using a patient-centred approach that can also be used to judge cost effectiveness?

    to determine cost effectiveness. These measures would capture the views of all residents living in care homes and could include: - how...

    Research recommendation
    Published
    24 August 2016

  4. Anti-reflux therapy as a treatment for idiopathic pulmonary fibrosis:- Is anti-reflux therapy an effective treatment for idiopathic pulmonary fibrosis?

    mortality (allcause and idiopathic pulmonary fibrosis-related); hospitalisation (all-cause, non-elective and idiopathic pulmonary...

    Research recommendation
    Published
    9 June 2015

  5. What are the clinical and cost effectiveness, and the safety, of specific antifungal treatments for treating suspected or confirmed COVID-19-associated pulmonary aspergillosis (CAPA), and the optimal treatment duration? When should treatment be started, stopped or modified?

    amphotericin B deoxycholate. C: Standard care (usually voriconazole) O:• all-cause mortality (at any time during treatment)• number of...

    Research recommendation
    Published
    9 March 2022

  6. Quantitative faecal immunochemical testing to guide colorectal cancer pathway referral in primary care (HTG690)

    Evidence-based recommendations on quantitative faecal immunochemical testing to guide colorectal cancer pathway referral in primary care.

    HealthTech guidance
    Published
    24 August 2023
    View recommendations

    Sections for HTG690

  7. LIVERFASt for assessing and monitoring liver fibrosis, activity and steatosis (MIB317)

    NICE has developed a medtech innovation briefing (MIB) on LIVERFASt for assessing and monitoring liver fibrosis, activity and steatosis .

    Medtech innovation briefing
    Published
    21 February 2023

  8. Evidence on the safety and efficacy of artificial iris implant insertion for acquired aniridia is limited in quantity and quality. Therefore, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research.  Find out  what special arrangements mean on the NICE website .

    any uncertainties about these. Audit and review clinical outcomes of all patients having the procedure. NICE has identified relevant...

    Research recommendation
    Published
    10 August 2020

  9. Jejunostomy support after radical surgery:- What is the effectiveness of long-term jejunostomy support compared to intensive dietary counselling and support along with symptom management for people having radical surgery for oesophago-gastric cancer?

    and not using them routinely and others not placing jejunostomy tubes at all. Studies should aim to identify if jejunostomy placement...

    Research recommendation
    Published
    13 November 2018

  10. Schizophrenia: omega-3 fatty acid medicines (ESUOM19)

    Summary of the evidence on omega-3 fatty acid medicines for treating schizophrenia to inform local NHS planning and decision-making

    Evidence summary
    Published
    24 September 2013

  11. Dostarlimab for previously treated advanced or recurrent endometrial cancer with high microsatellite instability or mismatch repair deficiency (TA779)

    Evidence-based recommendations on dostarlimab (Jemperli) for treating advanced or recurrent endometrial cancer with high microsatellite instability or mismatch repair deficiency in adults who have had platinum-based chemotherapy.

    Technology appraisal guidance
    Published
    16 March 2022
    View recommendations

    Sections for TA779

  12. Reducing car ownership:- Does reducing car use or ownership change physical activity levels? Are effects maintained over time?

    asthe effects on different groups, and in different areas. For example not all areas have ready access to public transport; and for some...

    Research recommendation
    Published
    15 November 2018

  13. Predictors of acute physical risk:- What clinical and biochemical markers are the best predictors of acute physical risk for people with eating disorders?

    risk are used throughout this guideline. Despite their importance, almost all of the conventional risk frameworks are based on consensus...

    Research recommendation
    Published
    12 October 2018

  14. Pharmacological prevention: In people in hospital who are at high risk of delirium, which medication (atypical antipsychotics, typical antipsychotics, benzodiazepines or acetylcholinesterase inhibitors), compared with placebo or each other, is more clinically and cost effective in preventing the development of delirium?

    serious nature of delirium and its consequences makes it important to establish all methods of prevention. Pharmacological agents may be...

    Research recommendation
    Published
    3 February 2023

  15. 5-aminosalicylate (5-ASA) treatment:- Following successful medical induction of remission of Crohn's disease of the colon, is mesalazine more clinically and cost effective than no treatment?

    question is applicable to adults, young people and children, and trials in all are therefore required. A conventional...

    Research recommendation
    Published
    17 September 2020

  16. Etanercept, infliximab and adalimumab for the treatment of psoriatic arthritis (TA199)

    Evidence-based recommendations on etanercept (Enbrel), infliximab (Remicade) and adalimumab (Humira) for treating active and progressive psoriatic arthritis in adults.

    Technology appraisal guidance
    Published
    25 August 2010
    View recommendations

    Sections for TA199

  17. The evidence on the safety of transurethral laser ablation for recurrent non-muscle-invasive bladder cancer shows that there are no major safety concerns. However, current evidence on its efficacy is limited in quality and quantity. Therefore, this procedure should only be used with  special arrangements   for clinical governance, consent, and audit or research.

    for the public is recommended. Audit and review clinical outcomes of all patients having transurethral laser ablation for recurrent...

    Research recommendation
    Published
    15 November 2019

  18. Endocuff Vision for assisting visualisation during colonoscopy (HTG514)

    Evidence-based recommendations on Endocuff Vision for assisting visualisation during colonoscopy.

    HealthTech guidance
    Published
    7 June 2019
    View recommendations

    Sections for HTG514

  19. Single-anastomosis duodeno-ileal bypass with sleeve gastrectomy for treating morbid obesity (HTG423)

    Evidence-based recommendations on single-anastomosis duodeno-ileal bypass with sleeve gastrectomy for treating morbid obesity. This involves reducing the size of the stomach and small intestine to reduce the amount of food absorbed.

    HealthTech guidance
    Published
    23 November 2016
    View recommendations

    Sections for HTG423

  20. What is the comparative effectiveness and cost effectiveness of exercise referral schemes compared with other interventions that aim to help people to become more physically active? Relative effectiveness and cost effectiveness should be compared in controlled trials.

    albeit below current UK physical activity guidelines rather than none at all, should be taken into account. (See the Department of...

    Research recommendation
    Published
    9 June 2015

  21. What factors encourage under-represented groups to participate in and complete an exercise referral scheme? What factors prevent these groups from participating? Under-represented groups include: people from black and minority ethnic groups, people with disabilities and those from lower socioeconomic groups.

    albeit below current UK physical activity guidelines rather than none at all, should be taken into account. (See the Department of...

    Research recommendation
    Published
    9 June 2015

  22. What factors encourage uptake of, and adherence to, an exercise referral scheme? Factors to consider include: design, content and delivery; referral mechanisms; choice of activity; qualifications and cost of instructors. Also identify any barriers preventing participation and factors that encourage it.

    albeit below current UK physical activity guidelines rather than none at all, should be taken into account. (See the Department of...

    Research recommendation
    Published
    9 June 2015

  23. Management of stable angina in people with evidence of ischaemia on non-invasive functional testing:- Do people with stable angina and evidence of reversible ischaemia on noninvasive functional testing who are on optimal drug treatment benefit from routine coronary angiography with a view to revascularisation?

    stable angina and myocardial ischaemia on noninvasive functional testing, with all-cause mortality and cardiovascular mortality as the...

    Research recommendation
    Published
    9 June 2015

  24. MiniMed 640G system with SmartGuard for managing blood glucose levels in people with type 1 diabetes (MIB51)

    NICE has developed a medtech innovation briefing (MIB) on MiniMed 640G system with SmartGuard for managing blood glucose levels in people with type 1 diabetes

    Medtech innovation briefing
    Published
    12 February 2016

  25. Renal and ureteric stones (QS195)

    This quality standard covers assessing and managing renal and ureteric stones in children, young people and adults. It describes high-quality care in priority areas for improvement.

    Quality standard
    Published
    29 July 2020
    View quality statements

    Sections for QS195

  26. Acute heart failure (QS103)

    This quality standard covers the care of adults (aged 18 and over) with suspected or confirmed acute heart failure. It describes high-quality care in priority areas for improvement.

    Quality standard
    Published
    3 December 2015
    View quality statements

    Sections for QS103

  27. Food allergy (QS118)

    This quality standard covers diagnosing, assessing and managing food allergy in children and young people (under 19) and adults. It describes high-quality care in priority areas for improvement.

    Quality standard
    Published
    24 March 2016
    View quality statements

    Sections for QS118

  28. Psoriasis (QS40)

    This quality standard covers assessing and managing psoriasis in adults, young people and children. It describes high-quality care in priority areas for improvement.

    Quality standard
    Published
    6 August 2013
    View quality statements

    Sections for QS40

  29. Screening assessment tools:- Develop reliable and valid screening assessment tools for attachment and sensitivity that can be made available and used in routine health, social care and education settings.

    parents and foster or adoptive parents of children and young people across all groups (0–17 years).The tool must be readily available...

    Research recommendation
    Published
    11 December 2015

  30. Maternal request for caesarean birth: What support or psychological interventions would be appropriate for women who have a fear of vaginal childbirth and request a caesarean birth?

    lacking and could make a difference to women who are anxious or afraid. All of these interventions have different resource implications...

    Research recommendation
    Published
    24 April 2023

  31. Interventions to reduce the frequency and extent of moderate to severe behaviour that challenges in community settings:- Are interventions based on the science and practice of applied behaviour analysis or antipsychotic medication, or a combination of these, effective in reducing the frequency and severity of behaviour that challenges shown by adults with a learning disability?

    characterises the nature and function of the behaviour - assesses all coexisting problems that may contribute to the behaviour...

    Research recommendation
    Published
    5 October 2015

  32. Risk assessment:- What is the accuracy of individual risk assessment tools in predicting the risk of venousthromboembolism (VTE) and risk of bleeding in people admitted to hospital?

    applicable) Why this is important:- Risk assessment is a mandatory for all people admitted or having day procedures in hospital. Since...

    Research recommendation
    Published
    15 November 2018

  33. Assessment of disease severity and impact:- In children, young people and adults with psoriasis, can tools be developed and/or existing ones further refined and validated to: - assess disease severity and impact in both non-specialist and specialist healthcare settings, to facilitate assessment, appropriate referral, treatment planning and measurement of outcomes - measure burden and cumulative effect of disease activity, severity and impact for people with both psoriasis and psoriatic arthritis?

    well as extent and the impact of previous treatments. Tools should capture all aspects of impact on life including physical,...

    Research recommendation
    Published
    9 June 2015

  34. Botulinum toxin type A:- What is the clinical and cost effectiveness of botulinum toxin type A when used routinely or according to clinical need in children and young people who are at Gross Motor Function Classification System (GMFCS) level I, II or III?

    a strong recommendation to offer treatment with botulinum toxin type A to all children and young people who are at GMFCS level I, II or...

    Research recommendation
    Published
    9 June 2015

  35. Extended access to social care services:- What is the clinical and cost effectiveness of providing extended access to social care services, for example during early mornings and evenings, and 7 days a week?

    to social care differs throughout the country. Some areas have access to all socialcare services whereas others have very limited...

    Research recommendation
    Published
    15 November 2018

  36. Education and training programmes: self-management:- What is the effectiveness and cost effectiveness of education programmes to improve information and advice and to support self-management of chronic health conditions (for example, obesity, diabetes and cardiovascular disease) for people growing older with learning disabilities, and their family members and carers?

    medication management and have problems to access to healthcare more broadly, all of which can have costly consequences; some of those...

    Research recommendation
    Published
    29 November 2018

  37. The evidence on percutaneous insertion of a cerebral protection device to prevent cerebral embolism during TAVI raises no major safety concerns other than those associated with the TAVI procedure. However, the evidence on efficacy for preventing TAVI-related stroke is inconclusive. Therefore, this procedure should only be used with  special arrangements   for clinical governance, consent, and audit or research.

    use of NICE's information for the public is recommended. Details of all patients should be entered into the UK TAVI registry . Patient...

    Research recommendation
    Published
    15 November 2019

  38. Optimal interventional and conservative treatments at different stages of disease:- What is the optimal treatment (compression, surgery, endothermal ablation or foam sclerotherapy) for varicose veins at each of the CEAP stages, that is CEAP stages 2–3, CEAP stage 4 and CEAP stages 5–6?

    with varicose veins at different stages, may not be equally effective for all patients. A large-scale RCT that compares the 4 main...

    Research recommendation
    Published
    9 June 2015

  39. Transvenous embolisation for spontaneous intracranial hypotension caused by a cerebrospinal fluid–venous fistula (HTG777)

    Evidence-based recommendations on transvenous embolisation for spontaneous intracranial hypotension caused by a cerebrospinal fluid–venous fistula. This involves inserting a catheter through the femoral vein and injecting embolisation liquid to seal the fistula.

    HealthTech guidance
    Published
    15 April 2026

    Sections for HTG777

  40. Darvadstrocel for treating complex perianal fistulas in Crohn's disease (TA556)

    Evidence-based recommendations on darvadstrocel (Alofisel) for previously treated complex perianal fistulas in adults with non-active or mildly active luminal Crohn’s disease.

    Technology appraisal guidance
    Published
    9 January 2019
    View recommendations

    Sections for TA556

  41. Zolbetuximab with chemotherapy for untreated claudin-18.2-positive HER2-negative unresectable advanced gastric or gastro-oesophageal junction adenocarcinoma (TA1046)

    Evidence-based recommendations on zolbetuximab (Vyloy) with chemotherapy for untreated claudin-18.2-positive HER2-negative unresectable advanced gastric or gastro-oesophageal junction adenocarcinoma in adults.

    Technology appraisal guidance
    Published
    12 March 2025
    View recommendations

    Sections for TA1046

  42. Hysteroscopy compared with ultrasound or empiric pharmacological treatment in the diagnosis and management of heavy menstrual bleeding (HMB): -Is initial testing using hysteroscopy more effective than testing with pelvic ultrasound or empiric pharmacological treatment in the diagnosis and management of HMB?

    absence of clinical trials, decision analytical economic models evaluating all possible outpatient testing algorithms have indicated...

    Research recommendation
    Published
    14 November 2018

  43. t:slim X2 insulin pump for managing blood glucose levels in type 1 diabetes (MIB227)

    NICE has developed a medtech innovation briefing (MIB) on t:slim X2 insulin pump for managing blood glucose levels in type 1 diabetes .

    Medtech innovation briefing
    Published
    22 September 2020

  44. Inflammatory bowel disease (QS81)

    This quality standard covers diagnosing and managing inflammatory bowel disease (Crohn’s disease and ulcerative colitis) in adults, young people and children. It describes high-quality care in priority areas for improvement.

    Quality standard
    Published
    26 February 2015
    View quality statements

    Sections for QS81

  45. Evidence on the safety of the swallowable gastric balloon capsule for weight loss shows infrequent but potentially serious adverse events: For people who need to lose weight in the short term for medical reasons, the evidence of efficacy is adequate to support the use of this procedure provided that special arrangements are in place for clinical governance, consent and audit.  Find out  what special arrangements mean on the NICE interventional procedures guidance page . For people who are aiming for long-term weight loss, the evidence on efficacy is inadequate in quantity and quality, so the procedure should only be used in the context of research.   Find out  what only in research means on the NICE interventional procedures guidance page .

    any uncertainties about these. Audit and review clinical outcomes of all patients having the procedure. The main efficacy and safety...

    Research recommendation
    Published
    22 January 2021

  46. The role of parents in the treatment of children and young people with social anxiety disorder:- What is the best way of involving parents in the treatment of children and young people (at different stages of development) with social anxiety disorder?

    treatment of young socially anxious children. Furthermore, when considering all age groups, parental mental health difficulties and...

    Research recommendation
    Published
    9 June 2015

  47. Treatment of convulsive status epilepticus (that is, not just refractory): What is the most effective and safest AED to treat: established (usually lasting longer than 30 minutes) convulsive status epilepticus refractory convulsive status epilepticus?

    underlying cause of RCSE, its duration and management. The majority, if not all patients with RCSE are managed in an ICU. There are no...

    Research recommendation
    Published
    13 August 2021

  48. Staging investigations for CPG 3 prostate cancer: What is the diagnostic accuracy of staging investigations for CPG 3 prostate cancer?

    previous 'intermediate-risk' group now consists of some people in CPG 1, and all people in CPG 2 and CPG 3, and recommendations that...

    Research recommendation
    Published
    7 January 2022

  49. Current evidence on the safety of ultrasound-guided high‑intensity transcutaneous focused ultrasound for symptomatic uterine fibroids shows there are well-recognised complications including skin burns. The evidence on efficacy is limited in quality. Therefore, this procedure should only be used with  special arrangements   for clinical governance, consent, and audit or research.

    for the public is recommended. Audit and review clinical outcomes of all patients having ultrasound-guided high intensity transcutaneous...

    Research recommendation
    Published
    15 November 2019

  50. Etranacogene dezaparvovec for treating moderately severe or severe haemophilia B (TA989)

    Evidence-based recommendations on etranacogene dezaparvovec (Hemgenix) for treating moderately severe or severe haemophilia B in adults.

    Technology appraisal guidance
    Published
    24 July 2024

    Sections for TA989