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  1. NICE encourages further research and data collection on endoscopic full thickness removal of non-lifting colonic polyps and may update the guidance on publication of further evidence. This should include safety and efficacy outcomes such as perforation, bleeding, the need for immediate re-intervention, inadequate resection and longer-term follow-up of patients found to have malignant disease.

    immediate re-intervention, inadequate resection and longer-term follow-up of patients found to have malignant disease. Any explanatory...

    Research recommendation
    Published
    12 October 2018

  2. Current evidence on the safety and efficacy of endovascular insertion of an intrasaccular wire-mesh blood-flow disruption device for intracranial aneurysms is adequate to support the use of this procedure provided that  standard arrangements   are in place for clinical governance, consent and audit.

    governance, consent and audit. Any explanatory notes(if applicable) Patient selection should be done by a multidisciplinary team, except...

    Research recommendation
    Published
    15 November 2019

  3. Long-term effect of very-low-calorie diets on people with a BMI of 40 kg/m2 or more: What are the long-term effects of using very-low-calorie diets (VLCDs) versus low-calorie diets (LCDs) on weight and quality of life in patients with a body mass index (BMI) of 40 kg/m2 or more, including the impact on weight cycling?

    (VLCDs) versus low-calorie diets (LCDs) on weight and quality of life in patients with a body mass index (BMI) of 40 kg/m2 or more,...

    Research recommendation
    Published
    30 September 2022

  4. NICE encourages further research into intravesical microwave hyperthermia and chemotherapy for non-muscle-invasive bladder cancer. Research should include randomised controlled trials, which stratify patients by risk and give adequate follow-up. They should report frequency of adverse events, patientreported outcome measures, overall and disease-free survival and quality of life.

    cancer. Research should include randomised controlled trials, which stratify patients by risk and give adequate follow-up. They should...

    Research recommendation
    Published
    12 December 2018

  5. NICE encourages further research into the efficacy of MRI-guided transcutaneous focused ultrasound for uterine fibroids. Research studies should report long-term outcomes, including the need for further treatment. Data on the incidence and outcomes of subsequent pregnancy in patients who choose this procedure because they wish to maintain or improve their fertility are particularly important.

    treatment. Data on the incidence and outcomes of subsequent pregnancy in patients who choose this procedure because they wish to...

    Research recommendation
    Published
    9 June 2015

  6. Evidence on the safety and efficacy of daytime intraoral neuromuscular electrical tongue stimulation using a removable device for obstructive sleep apnoea is inadequate in quality and quantity. So, this procedure should be used only in research. Find out what only in research means on the NICE interventional procedures guidance page.

    assess efficacy, safety and adherence. Research should report details of patient selection, duration of treatment and effect, effect on...

    Research recommendation
    Published
    5 May 2023

  7. Evidence on the efficacy of focal resurfacing implants to treat articular cartilage damage in the knee is limited in quality and quantity. Short-term evidence shows no major safety concerns, but long-term evidence on safety is limited in quality and quantity. Therefore, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Find out what special arrangements mean on the NICE interventional procedures guidance page.

    Any explanatory notes(if applicable) Further research should report patient selection, including the site and size of the cartilage...

    Research recommendation
    Published
    7 September 2022

  8. Evidence on the safety and efficacy of percutaneous image-guided cryoablation of peripheral neuroma for chronic pain is inadequate in quality and quantity. Therefore, this procedure should only be used in thecontext of research. Find out what only in research means on the NICE interventional procedures guidance page.

    in the form of randomised controlled trials and should report details of patient selection and the procedure, quality of life and pain...

    Research recommendation
    Published
    3 February 2023

  9. Evidence on the safety of transcranial magnetic stimulation for obsessive-compulsive disorder raises no major safety concerns. However, evidence on its efficacy is inadequate in quantity and quality. Therefore, this procedure should only be used in the context of research.  Find out  what only in research means on the NICE website .

    adequately powered, randomised controlled trials. It should report details of patient selection, including the use of concurrent...

    Research recommendation
    Published
    10 August 2020

  10. What are the clinically and cost-effective surgical approaches to managing complicated acute diverticulitis, including timing of surgery (elective or emergency)?

    This meant it was difficult to assess the true effect of interventions on patient outcomes. Therefore the committee decided not to make...

    Research recommendation
    Published
    10 February 2020

  11. NICE agreed that further research was needed because there is currently no clinical- or cost-effectiveness evidence evaluating the use of Holoclar in both eyes in bilateral patients. The committee was aware of the ongoing HOLOCORE trial which is recruiting both unilateral and bilateral patients, but only evaluates the success of a second transplant in 1 eye rather than transplant success in both eyes.

    cost-effectiveness evidence evaluating the use of Holoclar in both eyes in bilateral patients. The committee was aware of the ongoing...

    Research recommendation
    Published
    15 October 2018

  12. Holistic assessment in the community:- What is the clinical and cost effectiveness of a community holistic assessment and intervention for people living with high levels of multimorbidity?

    intervention in people with multimorbidity would be of value in defined patient groups in the community (for example, people in nursing...

    Research recommendation
    Published
    18 October 2016

  13. Hearing loss in adults: assessment and management (NG98)

    This guideline covers some aspects of assessing and managing hearing loss in primary, community and secondary care. It aims to improve the quality of life for adults with hearing loss by advising healthcare staff on assessing hearing difficulties, managing earwax and referring people for audiological or specialist assessment and management.

    NICE guideline
    Last updated
    2 October 2023
    View recommendations

    Sections for NG98

  14. Evidence on the safety of extracorporeal shockwave therapy for calcific tendinopathy in the shoulder shows no major safety concerns in the short term. Evidence on efficacy is inadequate. Therefore, this procedure should only be used in the context of research. Find out what only in research means on the NICE interventional procedures guidance page

    comparing the procedure with current best practice. It should report details of patient selection, including site and density of...

    Research recommendation
    Published
    12 December 2022

  15. Evidence on the safety and efficacy of aortic remodelling hybrid stent insertion during surgical repair of an acute type A aortic dissection is limited in quantity and quality. Therefore, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Find out what special arrangements mean on the NICE interventional procedures guidance page.

    controlled trials or analysis of registry data. It should include details of patient selection and report 30-day mortality, quality of...

    Research recommendation
    Published
    7 September 2022

  16. AMBLor for identifying low-risk non-ulcerated early-stage cutaneous melanomas (MIB294)

    NICE has developed a medtech innovation briefing (MIB) on AMBLor for identifying low-risk non-ulcerated early-stage cutaneous melanomas .

    Medtech innovation briefing
    Published
    5 May 2022

  17. The evidence on transvaginal laser therapy for stress urinary incontinence does not show any short-term safety concerns. Evidence on long-term safety andefficacy is inadequate in quality and quantity. Therefore, this procedure should only be used in the context of research. Find out what only in research means onthe NICE interventional procedures guidance page.

    efficacy outcomes, the type of laser and energy used, treatment protocols, and patient selection including age, menopausal status and...

    Research recommendation
    Published
    10 August 2021

  18. Imaging investigations for newly diagnosed myeloma:- What is the comparative effectiveness of whole-body MRI, fluorodeoxyglucose positron emission tomography CT (FDG PET-CT) and whole-body low-dose CT in detecting lesions that may determine the start of treatment for people with newly diagnosed myeloma?

    detection, sensitivity and specificity for myeloma-related bone disease, patient acceptability, incremental upstaging, radiation...

    Research recommendation
    Published
    5 April 2016

  19. Remdesivir and tixagevimab plus cilgavimab for treating COVID-19 (TA971)

    Evidence-based recommendations on remdesivir (Veklury) and tixagevimab plus cilgavimab (Evusheld) for treating COVID-19.

    Technology appraisal guidance
    Published
    8 May 2024
    View recommendations

    Sections for TA971

  20. Complications of IV fluid therapy:- What is the incidence of complications during, and as a consequence of, IV fluid therapy in children and young people?

    IV fluid therapy can lead to mortality and significant morbidity for the patient. This, in turn, represents a cost burden for the NHS in...

    Research recommendation
    Published
    28 January 2016

  21. Chronic wounds: advanced wound dressings and antimicrobial dressings (ESMPB2)

    Summary of the evidence on advanced wound dressings and antimicrobial dressings for managing chronic wounds to inform local NHS planning and decision-making

    Evidence summary
    Published
    30 March 2016

  22. Evidence on the safety and efficacy of biodegradable spacer insertion to reduce rectal toxicity during radiotherapy for prostate cancer is limited in quality. Therefore, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Find out what special arrangements mean on the NICE interventional procedures guidance page.

    including registry studies and real-world evidence. It should report details of patient selection, choice ofradiotherapy technique and...

    Research recommendation
    Published
    9 March 2023

  23. PICO negative pressure wound dressings for closed surgical incisions (HTG509)

    Evidence-based recommendations on PICO negative pressure wound dressings for closed surgical incisions.

    HealthTech guidance
    Last updated
    6 August 2019
    View recommendations

    Sections for HTG509

  24. VitalPAC for assessing vital signs of patients in hospital (MIB79)

    This advice has been updated and replaced by NICE medtech innovation briefing 205.

    Withdrawn advice

  25. Evidence on the efficacy of bioresorbable stent implantation to treat coronary artery disease is inadequate. Evidence on its safety has shown an increased risk of serious complications in the longer term. This includes an increased risk of myocardial infarction and death with some types of bioresorbable stents. Therefore, this procedure should only be used in the context of research. Find out what only in research means on the NICE interventional procedures guidance page.

    research should include randomised controlled trials reporting details of patient selection and choice of bioresorbable stent. It should...

    Research recommendation
    Published
    7 September 2022

  26. Is symptom-based review as effective as scheduled follow-up for people treated with radical cystectomy or radical radiotherapy for organ-confined, muscle-invasive bladder cancer? Outcomes of interest are overall survival, health-related quality of life, resource use and cost.

    out by the treating team. Although this can be reassuring for both the patient and the treating team, it is not known whether scheduled...

    Research recommendation
    Published
    9 June 2015

  27. Follow-up:- What is the optimal method, frequency and duration of follow-up for people who are disease-free after treatment for CUADT?

    on historical practice than evidence and are often disease- rather than patient-centred. Research to investigate how and when follow-up...

    Research recommendation
    Published
    6 April 2016

  28. Augmentative and alternative communication:- What is the current pattern of provision and use of augmentative and alternative communication (AAC) by people with motor neurone disease (MND) in England?

    with the collection and analysis of basic data. It will then progress to patient-related outcomes. Source guidance details Comes from...

    Research recommendation
    Published
    21 March 2016

  29. What are the possible outcomes for people who are critically ill and have COVID-19-associated pulmonary aspergillosis (CAPA)?

    intensive care)• long-term morbidity outcomes, functional measures and patient outcomes• results may be stratified (for example, disease...

    Research recommendation
    Published
    17 December 2021

  30. Psychological interventions to manage chronic headache disorders:- Does a psychological intervention such as cognitive behavioural therapy (CBT) improve headache outcomes and quality of life for people with chronic headache disorders?

    on headache alone, using appropriate headache outcomes such as change in patient-reported headache days and headache-specific quality of...

    Research recommendation
    Published
    9 June 2015

  31. Early mobilisation and optimum positioning of people with acute stroke: How safe and effective is very early mobilisation delivered by appropriately trained healthcare professionals after stroke?

    pneumonia. There could be benefits for motor and sensory recovery, and patient motivation. The research question to be addressed is...

    Research recommendation
    Published
    11 May 2022

  32. DOAC Dipstick for detecting direct oral anticoagulants (MIB248)

    NICE has developed a medtech innovation briefing (MIB) on DOAC Dipstick for detecting direct oral anticoagulants .

    Medtech innovation briefing
    Published
    2 February 2021

  33. Indicators and thresholds for referral for cataract surgery:- What is the association between preoperative vision- and health-related quality of life, and postoperative vision-related quality of life, health-related quality of life, and self-reported postoperative improvement?

    potential gains may be. Robust information around the link between preoperative patient characteristics and outcomes would be useful...

    Research recommendation
    Published
    6 November 2018

  34. Values of skin prick testing and specific IgE antibody testing and their predictive value:- Can skin prick testing and specific IgE antibody testing cut-off points be established to diagnose IgE-mediated food allergy in children and young people, and to predict the severity of reaction?

    reaction would therefore lead to huge cost savings in the NHS and would reduce patient risk. There are published data available from the...

    Research recommendation
    Published
    9 June 2015

  35. Assessment at home to improve hospital discharge success rates:- How effective are home assessment interventions and approaches designed to improve hospital discharge outcomes?

    needs perspective for different populations. In addition, information on patient- and cost-related outcomes is also needed. Source...

    Research recommendation
    Published
    29 January 2016

  36. Enteral nutrition support:- What specific clinical and non-clinical factors allow risk stratification when selecting which people with CUADT would benefit from short- or long-term enteral nutrition?

    meaningfully. These factors included restricted populations for tumour staging, patient demographics, treatment plan and intent,...

    Research recommendation
    Published
    6 April 2016

  37. Olaparib for treating BRCA mutation-positive HER2-negative advanced breast cancer after chemotherapy (TA1040)

    Evidence-based recommendations on olaparib (Lynparza) for BRCA mutation-positive HER2-negative advanced breast cancer after chemotherapy in adults.

    Technology appraisal guidance
    Published
    12 February 2025
    View recommendations

    Sections for TA1040

  38. Antimicrobial prescribing: delafloxacin for community-acquired pneumonia (ES37)

    Summary of the evidence on delafloxacin for community-acquired pneumonia in adults

    Evidence summary
    Published
    10 August 2021

  39. Complicated urinary tract infections: ceftolozane/tazobactam (ESNM74)

    Summary of the evidence on ceftolozane/tazobactam for treating complicated urinary tract infections to inform local NHS planning and decision-making

    Evidence summary
    Published
    9 June 2016

  40. Faltering growth: recognition and management of faltering growth in children (NG75)

    This guideline covers recognition, assessment and monitoring of faltering growth in infants and children. It includes a definition of growth thresholds for concern and identifying the risk factors for, and possible causes of, faltering growth. It also covers interventions, when to refer, service design, and information and support.

    NICE guideline
    Published
    27 September 2017
    View recommendations

    Sections for NG75

  41. NICE encourages further research into transcranial direct current stimulation (tDCS) for depression, which should document how patients were selected and any other treatments they were having. It should describe the precise method and regime used for administering tDCS. Outcome measures should include the duration of effect. NICE may update the guidance on publication of further evidence.

    direct current stimulation (tDCS) for depression, which should document how patients were selected and any other treatments they were...

    Research recommendation
    Published
    12 October 2015

  42. 1.1 Evidence on the safety of electrical stimulation to improve muscle strength in chronic respiratory conditions, chronic heart failure and chronic kidney disease shows no major safety concerns. For people who are having an acute exacerbation of their chronic condition and are unable to exercise, evidence of efficacy is adequate to support the use of this procedure provided that standard arrangements are in place for clinical governance, consent and audit.   Find out  what standard arrangements mean on the NICE website . For people who are able to exercise, evidence on efficacy is inadequate in quality. Therefore, this procedure should only be used in the context of research. Find out  what only in research means on the NICE website .

    appropriately controlled randomised trials. These should report details of patient selection, and type and duration of treatment....

    Research recommendation
    Published
    10 August 2020

  43. How cost effective are fluoride varnish programmes and tooth-brushing schemes?

    consider the long term impact of poor oral health. Research should include patient-reported outcome measures to assess health and...

    Research recommendation
    Published
    9 June 2015

  44. How can healthy habits that promote oral health be supported and encouraged in families with children at high risk of poor oral health?

    consider the long term impact of poor oral health. Research should include patient-reported outcome measures to assess health and...

    Research recommendation
    Published
    9 June 2015

  45. Developing NICE guidelines: the manual (PMG20)

    This manual explains the processes and methods used to develop and update NICE guidelines, the guidance that NICE develops covering topics across clinical care (in primary, secondary and community care settings), social care and public health. For more information on the other types of NICE guidance and advice (including technology appraisal guidance), see about NICE

  46. Educational intervention to improve healthcare professionals' awareness of spondyloarthritis:- What is the effectiveness and cost effectiveness of educational interventions for healthcare professionals in order to increase the number of prompt diagnoses of spondyloarthritis?

    between inflammatory and mechanical back pain) or characteristics of the patient populations (for example, that spondyloarthritis...

    Research recommendation
    Published
    4 May 2017

  47. Drug-eluting stents for treating coronary artery disease: late-stage assessment (HTG747)

    Late-stage assessment (LSA) guidance on drug-eluting stents for treating coronary artery disease.

    HealthTech guidance
    Published
    6 May 2025
    View recommendations

    Sections for HTG747

  48. Laboratory tests to diagnose initial and ongoing infection and determine re-infection in the different presentations of Lyme disease in the UK:- What is the most clinically and cost-effective serological antibody-based test, biomarker or other test for diagnosing Lyme disease in the UK at all stages, including re-infection?

    clinically and cost-effective diagnostic tests for Lyme disease will improve patient care and is a high priority. The clinical...

    Research recommendation
    Published
    27 November 2018

  49. What community-based interventions are effective and cost effective in improving dietary habits affecting the oral health of children and adults, and in particular those at high risk of poor oral health?

    consider the long term impact of poor oral health. Research should include patient-reported outcome measures to assess health and...

    Research recommendation
    Published
    9 June 2015

  50. What community-based interventions are effective and cost effective in improving oral health and reducing oral health inequalities among groups of adults at high risk of poor oral health?

    consider the long term impact of poor oral health. Research should include patient-reported outcome measures to assess health and...

    Research recommendation
    Published
    9 June 2015