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Showing 2651 to 2700 of 4091 results for patient

  1. Drug-eluting stents for treating coronary artery disease: late-stage assessment (HTG747)

    Late-stage assessment (LSA) guidance on drug-eluting stents for treating coronary artery disease.

    HealthTech guidance
    Published
    6 May 2025
    View recommendations

    Sections for HTG747

  2. Panitumumab in combination with chemotherapy for the treatment of metastatic colorectal cancer (terminated appraisal) (TA240)

    NICE is unable to recommend panitumumab with 5-fluorouracil, folinic acid and irinotecan (FOLFIRI) for previously treated metastatic colorectal cancer in adults. This is because Amgen did not provide an evidence submission.

    Technology appraisal guidance
    Last updated
    29 March 2017

    Sections for TA240

  3. Simple home test prevents thousands of unnecessary bowel cancer referrals

    A simple home test is sparing thousands of people from unnecessary hospital investigations for bowel cancer, while helping them get faster answers about whether they have the disease – with new data showing the impact of NICE's recommendation to use the test.

    News
    Last updated
    6 February 2026

  4. Crovalimab for treating paroxysmal nocturnal haemoglobinuria in people 12 years and over (TA1019)

    Evidence-based recommendations on crovalimab (Piasky) for paroxysmal nocturnal haemoglobinuria in people 12 years and over.

    Technology appraisal guidance
    Published
    20 November 2024
    View recommendations

    Sections for TA1019

  5. For people with severe and symptomatic tricuspid regurgitation, evidence on the efficacy of transcatheter tricuspid valve annuloplasty is limited in quantity and quality. Evidence on its safety shows there are serious but well-recognised complications. Therefore, for these people, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Find out what special arrangements mean on the NICE interventional procedures guidance page.

    explanatory notes(if applicable) Further research should include details of patient selection, including the type and severity of...

    Research recommendation
    Published
    4 August 2022

  6. Information needs for children and young people:- during their care pathway to diagnosis of food allergy:- What do children and young people with IgE-mediated food allergy and their parents or carers want to know during the process of diagnosis and how is this demand best met?

    Any explanatory notes(if applicable) Why this is important:- The patient journey to diagnosis, through testing, can last for several...

    Research recommendation
    Published
    9 June 2015

  7. Does a multidisciplinary team agreed approach to weaning from continuous positive airway pressure improve weaning times and result in stopping continuous positive airway pressure for people with COVID-19 and acute respiratory failure?

    weaning C: • standard care• different multidisciplinary team approaches O:• patient experience• symptom improvement• length of time to...

    Research recommendation
    Published
    12 November 2021

  8. Holistic assessment in the community:- What is the clinical and cost effectiveness of a community holistic assessment and intervention for people living with high levels of multimorbidity?

    intervention in people with multimorbidity would be of value in defined patient groups in the community (for example, people in nursing...

    Research recommendation
    Published
    18 October 2016

  9. Donor milk banks: service operation (CG93)

    This guideline covers how donor milk banks should recruit, screen and support women who donate breast milk. It also covers how milk banks should handle and process the breast milk they receive from donors. It aims to improve the safety of donor milk and operation of donor milk services.

    Clinical guideline
    Published
    24 February 2010
    View recommendations

    Sections for CG93

  10. NICE encourages further research into transcranial direct current stimulation (tDCS) for depression, which should document how patients were selected and any other treatments they were having. It should describe the precise method and regime used for administering tDCS. Outcome measures should include the duration of effect. NICE may update the guidance on publication of further evidence.

    direct current stimulation (tDCS) for depression, which should document how patients were selected and any other treatments they were...

    Research recommendation
    Published
    12 October 2015

  11. Causes of unwitnessed falls among older inpatients:- What are the causes of unwitnessed falls among older inpatients?

    unwitnessed. Although staff may deduce reasons for the fall and/or the patient (if able and if asked) may describe their own perception...

    Research recommendation
    Published
    9 June 2015

  12. Evidence on the safety of repetitive short-pulse transscleral cyclophotocoagulation for glaucoma shows no major safety concerns. Evidence on efficacy is inadequate in quality. Therefore, this procedure should only be used in the context of research. Find out what only in research means on the NICE website.

    comparing the procedure with standard care. It should report details of patient selection, particularly whether the glaucoma is...

    Research recommendation
    Published
    16 August 2021

  13. For people with severe and symptomatic tricuspid regurgitation, evidence on the efficacy of transcatheter tricuspid valve leaflet repair is limited in quantity and quality. Evidence on its safety shows there are serious but well-recognised complications. Therefore, for these people, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Find out what special arrangements mean on the NICE interventional procedures guidance page.

    explanatory notes(if applicable) Further research should include details of patient selection, including the type and severity of...

    Research recommendation
    Published
    5 August 2022

  14. For people with unfavourable aneurysm morphology needing an endovascular aortic aneurysm repair (EVAR) as a primary procedure, or for people with an existing EVAR who need a secondary procedure, evidence on the safety of using endoanchoring systems is adequate. Evidence on efficacy is limited in quantity and quality. Therefore, for these people, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Find out what special arrangements mean on the NICE interventional procedures guidance page.

    explanatory notes(if applicable) Further research should report details of patient selection and include longerterm outcomes. Source...

    Research recommendation
    Published
    1 June 2022

  15. Evidence on the safety and efficacy of supercapsular percutaneously assisted total hip arthroplasty for osteoarthritis is limited in quality and quantity. Therefore, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Find out what special arrangements mean on the NICE interventional procedures guidance page.

    standard approaches to total hip arthroplasty. It should report details of patient selection, short-term outcomes and long-term...

    Research recommendation
    Published
    1 June 2022

  16. Evidence on the safety of ab interno canaloplasty for open-angle glaucoma shows no major safety concerns. Evidence on the efficacy is limited in quality and quantity, particularly in the long term. Therefore, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Find out what special arrangements mean on the NICE interventional procedures guidance page.

    notes(if applicable) Further research should report: - details of patient selection, including concurrent procedures, severity of...

    Research recommendation
    Published
    12 December 2022

  17. Evidence on the safety and efficacy of percutaneous thoracic duct embolisation for persistent chyle leak is limited in quantity and quality. Therefore, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Find out what special arrangements mean on the NICE interventional procedures guidance page.

    embolisation for persistent chyle leak. Research should include details of patient selection, size and position of the leak, approaches...

    Research recommendation
    Published
    5 May 2023

  18. BladderScan BVI 9400 3D portable ultrasound scanner for measuring bladder volume (MIB50)

    NICE has developed a medtech innovation briefing (MIB) on the BladderScan BVI 9400 3D portable ultrasound scanner for measuring bladder volume

    Medtech innovation briefing
    Published
    22 January 2016

  19. Evidence on the safety of focal therapy using high-intensity focused ultrasound for localised prostate cancer is adequate, but evidence on its efficacy is limited. Therefore, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Find out what special arrangements mean on the NICE interventional procedures guidance page.

    include registry data or randomised trials. It should include details of patient selection, including size and classification of tumour,...

    Research recommendation
    Published
    5 May 2023

  20. Evidence on the safety and efficacy of YAG laser vitreolysis for symptomatic vitreous floaters is inadequate in quality and quantity. Therefore, this procedure should only be used in the context of research. Find out what only in research means on the NICE interventional procedures guidance page.

    powered randomised controlled trials. Research should report details of patient selection (including type, size and location of...

    Research recommendation
    Published
    7 November 2022

  21. Evidence on the safety and efficacy of permanent His-bundle pacemaker implantation for treating heart failure is inadequate in quality and quantity.Therefore, this procedure should only be used in the context of research. Find out what only in research means on the NICE interventional procedures guidance page.

    randomised controlled trials or registry data. It should report details of patient selection. Outcomes should include quality of life...

    Research recommendation
    Published
    10 August 2021

  22. Evidence on the safety of pressurised intraperitoneal aerosol chemotherapy for peritoneal carcinomatosis shows that this procedure can cause serious but well-recognised side effects. Evidence on its efficacy is inadequate in quality. Therefore, this procedure should only be used in the context of research. Find out what  only in research means on the NICE website .

    aerosol chemotherapy with standard care. Studies should report details of patient selection including type of tumour, the chemotherapy...

    Research recommendation
    Published
    22 January 2021

  23. Lisocabtagene maraleucel for treating relapsed or refractory large B-cell lymphoma after first-line chemoimmunotherapy when a stem cell transplant is suitable (TA1048)

    Evidence-based recommendations on lisocabtagene maraleucel (Breyanzi) for treating relapsed or refractory large B-cell lymphoma in adults after first-line chemoimmunotherapy when a stem cell transplant is suitable.

    Technology appraisal guidance
    Published
    26 March 2025
    View recommendations

    Sections for TA1048

  24. Current evidence on the safety and efficacy of endovascular insertion of an intrasaccular wire-mesh blood-flow disruption device for intracranial aneurysms is adequate to support the use of this procedure provided that  standard arrangements   are in place for clinical governance, consent and audit.

    governance, consent and audit. Any explanatory notes(if applicable) Patient selection should be done by a multidisciplinary team, except...

    Research recommendation
    Published
    15 November 2019

  25. The Versajet II hydrosurgery system for surgical debridement of acute and chronic wounds and burns (MIB1)

    NICE has developed a Medtech Innovation Briefing (MIB) on the Versajet II hydrosurgery system

    Medtech innovation briefing
    Published
    4 February 2014

  26. Evidence on the safety and efficacy of daytime intraoral neuromuscular electrical tongue stimulation using a removable device for obstructive sleep apnoea is inadequate in quality and quantity. So, this procedure should be used only in research. Find out what only in research means on the NICE interventional procedures guidance page.

    assess efficacy, safety and adherence. Research should report details of patient selection, duration of treatment and effect, effect on...

    Research recommendation
    Published
    5 May 2023

  27. Evidence on the efficacy of focal resurfacing implants to treat articular cartilage damage in the knee is limited in quality and quantity. Short-term evidence shows no major safety concerns, but long-term evidence on safety is limited in quality and quantity. Therefore, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Find out what special arrangements mean on the NICE interventional procedures guidance page.

    Any explanatory notes(if applicable) Further research should report patient selection, including the site and size of the cartilage...

    Research recommendation
    Published
    7 September 2022

  28. Evidence on the safety and efficacy of percutaneous image-guided cryoablation of peripheral neuroma for chronic pain is inadequate in quality and quantity. Therefore, this procedure should only be used in thecontext of research. Find out what only in research means on the NICE interventional procedures guidance page.

    in the form of randomised controlled trials and should report details of patient selection and the procedure, quality of life and pain...

    Research recommendation
    Published
    3 February 2023

  29. Evidence on the safety of transcranial magnetic stimulation for obsessive-compulsive disorder raises no major safety concerns. However, evidence on its efficacy is inadequate in quantity and quality. Therefore, this procedure should only be used in the context of research.  Find out  what only in research means on the NICE website .

    adequately powered, randomised controlled trials. It should report details of patient selection, including the use of concurrent...

    Research recommendation
    Published
    10 August 2020

  30. What are the clinically and cost-effective surgical approaches to managing complicated acute diverticulitis, including timing of surgery (elective or emergency)?

    This meant it was difficult to assess the true effect of interventions on patient outcomes. Therefore the committee decided not to make...

    Research recommendation
    Published
    10 February 2020

  31. Curos for preventing infections when using needleless connectors (HTG510)

    Evidence-based recommendations on Curos for preventing infections when using needleless connectors.

    HealthTech guidance
    Published
    9 May 2019
    View recommendations

    Sections for HTG510

  32. Evidence on the safety of extracorporeal shockwave therapy for calcific tendinopathy in the shoulder shows no major safety concerns in the short term. Evidence on efficacy is inadequate. Therefore, this procedure should only be used in the context of research. Find out what only in research means on the NICE interventional procedures guidance page

    comparing the procedure with current best practice. It should report details of patient selection, including site and density of...

    Research recommendation
    Published
    12 December 2022

  33. Evidence on the safety and efficacy of aortic remodelling hybrid stent insertion during surgical repair of an acute type A aortic dissection is limited in quantity and quality. Therefore, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Find out what special arrangements mean on the NICE interventional procedures guidance page.

    controlled trials or analysis of registry data. It should include details of patient selection and report 30-day mortality, quality of...

    Research recommendation
    Published
    7 September 2022

  34. Osteoporosis: assessing the risk of fragility fracture (CG146)

    This guideline covers assessing the risk of fragility fracture in people aged 18 and over with osteoporosis. It aims to provide guidance on the selection and use of risk assessment tools in the care of adults at risk of fragility fractures in all NHS settings.

    Clinical guideline
    Last updated
    7 February 2017
    View recommendations

    Sections for CG146

  35. Ectopic pregnancy and miscarriage: diagnosis and initial management (NG126)

    This guideline covers diagnosing and managing ectopic pregnancy and miscarriage in women with complications, such as pain and bleeding, in early pregnancy (that is, up to 13 completed weeks of pregnancy). It aims to improve how early pregnancy loss is diagnosed, and the support women are given, to limit the psychological impact of their loss.

    NICE guideline
    Last updated
    23 August 2023
    View recommendations

    Sections for NG126

  36. Antenatal and postnatal mental health: clinical management and service guidance (CG192)

    This guideline covers recognising, assessing and treating mental health problems in women who are planning to have a baby, are pregnant, or have had a baby or been pregnant in the past year. It covers depression, anxiety disorders, eating disorders, drug- and alcohol-use disorders and severe mental illness (such as psychosis, bipolar disorder and schizophrenia). It promotes early detection and good management of mental health problems to improve women’s quality of life during pregnancy and in the year after giving birth.

    Clinical guideline
    Last updated
    11 February 2020
    View recommendations

    Sections for CG192

  37. The evidence on transvaginal laser therapy for stress urinary incontinence does not show any short-term safety concerns. Evidence on long-term safety andefficacy is inadequate in quality and quantity. Therefore, this procedure should only be used in the context of research. Find out what only in research means onthe NICE interventional procedures guidance page.

    efficacy outcomes, the type of laser and energy used, treatment protocols, and patient selection including age, menopausal status and...

    Research recommendation
    Published
    10 August 2021

  38. Imaging investigations for newly diagnosed myeloma:- What is the comparative effectiveness of whole-body MRI, fluorodeoxyglucose positron emission tomography CT (FDG PET-CT) and whole-body low-dose CT in detecting lesions that may determine the start of treatment for people with newly diagnosed myeloma?

    detection, sensitivity and specificity for myeloma-related bone disease, patient acceptability, incremental upstaging, radiation...

    Research recommendation
    Published
    5 April 2016

  39. Complications of IV fluid therapy:- What is the incidence of complications during, and as a consequence of, IV fluid therapy in children and young people?

    IV fluid therapy can lead to mortality and significant morbidity for the patient. This, in turn, represents a cost burden for the NHS in...

    Research recommendation
    Published
    28 January 2016

  40. Terms and conditions

    decisions appropriate to the circumstances of the individual patient, in consultation with the patient and/or guardian or...

  41. Evidence on the safety and efficacy of biodegradable spacer insertion to reduce rectal toxicity during radiotherapy for prostate cancer is limited in quality. Therefore, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Find out what special arrangements mean on the NICE interventional procedures guidance page.

    including registry studies and real-world evidence. It should report details of patient selection, choice ofradiotherapy technique and...

    Research recommendation
    Published
    9 March 2023

  42. Ertugliflozin as monotherapy or with metformin for treating type 2 diabetes (TA572)

    Evidence-based recommendations on ertugliflozin (Steglatro) as monotherapy or with metformin for treating type 2 diabetes in adults.

    Technology appraisal guidance
    Published
    27 March 2019
    View recommendations

    Sections for TA572

  43. Rehabilitation for chronic neurological disorders including acquired brain injury (NG252)

    This guideline covers rehabilitation in all settings for children, young people and adults with a chronic neurological disorder, neurological impairment or disabling neurological symptoms due to acquired brain injury, acquired spinal cord injury, acquired peripheral nerve disorder, functional neurological disorder or progressive neurological disease.

    NICE guideline
    Published
    15 October 2025

    Sections for NG252

  44. Evidence on the efficacy of bioresorbable stent implantation to treat coronary artery disease is inadequate. Evidence on its safety has shown an increased risk of serious complications in the longer term. This includes an increased risk of myocardial infarction and death with some types of bioresorbable stents. Therefore, this procedure should only be used in the context of research. Find out what only in research means on the NICE interventional procedures guidance page.

    research should include randomised controlled trials reporting details of patient selection and choice of bioresorbable stent. It should...

    Research recommendation
    Published
    7 September 2022

  45. Augmentative and alternative communication:- What is the current pattern of provision and use of augmentative and alternative communication (AAC) by people with motor neurone disease (MND) in England?

    with the collection and analysis of basic data. It will then progress to patient-related outcomes. Source guidance details Comes from...

    Research recommendation
    Published
    21 March 2016

  46. Is symptom-based review as effective as scheduled follow-up for people treated with radical cystectomy or radical radiotherapy for organ-confined, muscle-invasive bladder cancer? Outcomes of interest are overall survival, health-related quality of life, resource use and cost.

    out by the treating team. Although this can be reassuring for both the patient and the treating team, it is not known whether scheduled...

    Research recommendation
    Published
    9 June 2015

  47. Follow-up:- What is the optimal method, frequency and duration of follow-up for people who are disease-free after treatment for CUADT?

    on historical practice than evidence and are often disease- rather than patient-centred. Research to investigate how and when follow-up...

    Research recommendation
    Published
    6 April 2016

  48. Psychological interventions to manage chronic headache disorders:- Does a psychological intervention such as cognitive behavioural therapy (CBT) improve headache outcomes and quality of life for people with chronic headache disorders?

    on headache alone, using appropriate headache outcomes such as change in patient-reported headache days and headache-specific quality of...

    Research recommendation
    Published
    9 June 2015

  49. Early mobilisation and optimum positioning of people with acute stroke: How safe and effective is very early mobilisation delivered by appropriately trained healthcare professionals after stroke?

    pneumonia. There could be benefits for motor and sensory recovery, and patient motivation. The research question to be addressed is...

    Research recommendation
    Published
    11 May 2022

  50. What are the possible outcomes for people who are critically ill and have COVID-19-associated pulmonary aspergillosis (CAPA)?

    intensive care)• long-term morbidity outcomes, functional measures and patient outcomes• results may be stratified (for example, disease...

    Research recommendation
    Published
    17 December 2021