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This guide describes the methods and processes, including expected timescales, that NICE follows when carrying out health technology evaluations. The methods and processes are designed to produce robust guidance for the NHS in an open, transparent and timely way, with appropriate contribution from stakeholders. Organisations invited to contribute to health technology evaluation development should read this manual in conjunction with the NICE health technology evaluation topic selection: the manual. All documents are available on the NICE website.

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This guideline covers managing ulcerative colitis in children, young people and adults. It aims to help professionals to provide consistent high-quality care and it highlights the importance of advice and support for people with ulcerative colitis.

Result type

NICE guideline

Published

3 May 2019

Guide to the processes of technology appraisal

This guideline covers the general principles for managing intravenous (IV) fluid therapy in hospital inpatients aged 16 and over with a range of conditions. It aims to help prescribers understand the optimal amount and composition of IV fluids to be administered and the best rate at which to give them, to improve fluid prescribing and outcomes among people in hospital. It does not cover pregnant women, and those with severe liver or renal disease, diabetes or burns.

Result type

Clinical guideline

Last updated

5 May 2017

The social care guidance manual

Summary of the evidence on ceftolozane/tazobactam for treating complicated intra-abdominal infections to inform local NHS planning and decision-making

Result type

Evidence summary

Published

9 June 2016

Summary of the evidence on idarucizumab for reversing the anticoagulant effect of dabigtatran to inform local NHS planning and decision-making

Result type

Evidence summary

Published

24 May 2016

Summary of the evidence on netupitant/palonosetron to prevent chemotherapy induced nausea and vomiting to inform local NHS planning and decision-making

Result type

Evidence summary

Published

1 March 2016

Interventional procedures programme manual

Summary of the evidence on eculizumab for treating C3 glomerulopathy in the native kidney inform local NHS planning and decision-making

Result type

Evidence summary

Published

22 December 2015

Summary of the evidence on insulin glargine biosimilar (Abasaglar) for type 1 and type 2 diabetes mellitus to inform local NHS planning and decision-making

Result type

Evidence summary

Published

2 December 2015

Healthy start vitamins: special report on cost effectiveness

Evidence-based recommendations on suture fixation of acute disruption of the distal tibiofibular syndesmosis. This involves threading a suture through a tunnel made in the bones (tibia and fibula) and tying the ends together to fix the joint.

Result type

Interventional procedures guidance

Published

26 June 2015

Summary of the evidence on eculizumab to prevent the recurrence of C3 glomerulopathy post-transplant to inform local NHS planning and decision-making

Result type

Evidence summary

Published

26 June 2015

Evidence-based recommendations on ultrasound enhanced catheter-directed thrombolysis for deep vein thrombosis. This involves using ultrasound waves and a drug to break up the clot.

Result type

Interventional procedures guidance

Published

26 June 2015

Evidence-based recommendations on ultrasound enhanced catheter-directed thrombolysis for pulmonary embolism. This involves using ultrasound waves and a drug to break up the clot.

Result type

Interventional procedures guidance

Published

26 June 2015

This quality standard covers reducing and preventing tobacco use in adults, young people and children. It includes interventions to discourage people from taking up smoking, tobacco control strategies and smokefree policies. It is particularly relevant to local authorities, schools and colleges, employers and NHS service providers. It describes high-quality care in priority areas for improvement.

Result type

Quality standard

Published

25 March 2015

Summary of the evidence on the risk of using broad-specturm antibiotics associated with clostridium difficile infection

Result type

Evidence summary

Published

17 March 2015

Summary of the evidence on rituximab for treating autoimmune haemolytic anaemia (AIHA) to inform local NHS planning and decision-making

Result type

Evidence summary

Published

10 February 2015

Interim methods guide for developing service guidance 2014

Summary of the evidence on rituximab subcutaneous injection for non-Hodgkin's lymphoma in adults to inform local NHS planning and decision-making

Result type

Evidence summary

Published

9 September 2014

Interim methods guide for developing good practice guidance

Evidence-based recommendations on extracorporeal membrane oxygenation (ECMO) for acute heart failure in adults. This involves using an artificial lung to oxygenate the blood outside the body.

Result type

Interventional procedures guidance

Published

27 March 2014

Evidence-based recommendations on insertion of a magnetic-bead band for faecal incontinence. This involves placing a ring of magnetic beads into a tunnel made around the anus to prevent incontinence.

Result type

Interventional procedures guidance

Published

27 March 2014

Evidence-based recommendations on electrochemotherapy for primary basal cell carcinoma and primary squamous cell carcinoma. This involves injecting a chemotherapy drug into the tumour and using electrical pulses to increase its effect.

Result type

Interventional procedures guidance

Published

26 February 2014

This guideline covers changing health-damaging behaviours among people aged 16 and over using interventions such as goals and planning, feedback and monitoring, and social support. It aims to help tackle a range of behaviours including alcohol misuse, poor eating patterns, lack of physical activity, unsafe sexual behaviour and smoking.

Result type

Public health guideline

Published

2 January 2014

Evidence-based recommendations on negative pressure wound therapy for the open abdomen. This involves using a small pump to remove infected material, stop fluid escaping and help the wound heal.

Result type

Interventional procedures guidance

Published

27 November 2013

Interim process and methods guide for the clinical guideline updates using standing committees pilot programme 2013

Interim clinical guideline surveillance process and methods guide 2013

Evidence-based recommendations on insertion of customised exposed titanium implants, without soft tissue cover, for complex orofacial reconstruction. This involves making the titanium implants specially to fit the person using a model of their face.

Result type

Interventional procedures guidance

Published

23 July 2013

Evidence-based recommendations on insertion of customised titanium implants, with soft tissue cover, for orofacial reconstruction. This involves inserting titanium implants to replace broken bones in the face as part of orofacial reconstruction.

Result type

Interventional procedures guidance

Last updated

1 July 2013

Evidence-based recommendations on insertion of endobronchial valves for treatment of persistent air leaks. This involves inserting valves into the airways to reduce or stop air leaks so the rest of the lung can function normally.

Result type

Interventional procedures guidance

Published

27 March 2013

Evidence-based recommendations on irreversible electroporation for treating primary lung cancer and metastases in the lung. This involves using electrical pulses to kill cancer cells.

Result type

Interventional procedures guidance

Published

23 February 2013

Evidence-based recommendations on irreversible electroporation (IRE) for treating renal cancer. This involves using electrical pulses to kill cancer cells, applied directly to the tumour through special needles.

Result type

Interventional procedures guidance

Published

23 February 2013

Evidence-based recommendations on irreversible electroporation for the treatment of liver metastases. This involves using very short electrical field pulses delivered over several minutes to destroy the tumour and a small surrounding tissue margin.

Result type

Interventional procedures guidance

Published

23 February 2013

Evidence-based recommendations on laparoscopic gastric plication for the treatment of morbid obesity. This involves folding the stomach in on itself and stitching it together to reduce its volume.

Result type

Interventional procedures guidance

Published

27 November 2012

The NICE public health guidance development process (third edition)

Methods for the development of NICE public health guidance (third edition)

Evidence summaries: unlicensed and off-label medicines – Interim process statement

Good practice guidance – Interim process statement

Evidence-based recommendations on endovascular stent insertion for intracranial atherosclerotic disease. This involves inflating a balloon catheter inserted into an artery in the arm or leg, and positioning a stent in the narrowing to maintain improved blood flow.

Result type

Interventional procedures guidance

Published

23 July 2012

Evidence summaries: new medicines – Interim process statement

Evidence-based recommendations on percutaneous balloon cryoablation for pulmonary vein isolation in atrial fibrillation. This involves using a probe attached to a balloon catheter to freeze tissue in one of the chambers on the left side of the heart.

Result type

Interventional procedures guidance

Published

27 May 2012

Evidence-based recommendations on focal therapy using cryoablation for localised stage prostate cancer. This involves using freezing (cryotherapy) needles to find and destroy only the cancerous part of the prostate.

Result type

Interventional procedures guidance

Published

26 April 2012