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  1. What is the relative effectiveness and cost effectiveness of different oral fluids and different oral fluid regimens, both with and without oral N-acetylcysteine, at preventing contrast-induced acute kidney injury?

    at particularly high risk and that oral hydration should be encouraged in all other adults at increased risk of contrast-induced acute...

  2. What interventions are effective and cost effective in supporting return to work after recurrent short-term sickness absence in the UK?

    they are properly implemented. The committee agreed that it is important for all sizes of organisation to clearly communicate policies...

  3. CaRi-Heart for predicting cardiac risk in suspected coronary artery disease: early value assessment (HTG663)

    Early value assessment (EVA) guidance on CaRi-Heart for predicting cardiac risk in suspected coronary artery disease.

  4. Hypertension in adults: diagnosis and management (NG136)

    This guideline covers identifying and treating primary hypertension (high blood pressure) in people aged 18 and over, including people with type 2 diabetes. It aims to reduce the risk of cardiovascular problems such as heart attacks and strokes by helping healthcare professionals to diagnose hypertension accurately and treat it effectively.

  5. Daratumumab in combination for untreated multiple myeloma when a stem cell transplant is suitable (TA763)

    Evidence-based recommendations on daratumumab (Darzalex) with bortezomib, thalidomide and dexamethasone for untreated multiple myeloma when a stem cell transplant is suitable.

  6. ClearWay RX for drug delivery to coronary artery thrombotic lesions (MIB55)

    NICE has developed a medtech innovation briefing (MIB) on ClearWay RX for drug delivery to coronary artery thrombotic lesions

  7. What are the most effective and cost-effective interventions to challenge stereotypes and change employers' and workforce attitudes towards older employees?

    attitudes and reducing stereotyping may result in people working for longer, with all the associated benefits for them and society....

  8. What is the best way of monitoring the local system for distributing vitamin D supplements?

    adherence or any unintentional consequences. The recommendations apply to all at-risk groups, but there is a particular need for...

  9. Needle-free arterial non-injectable connector (MIB85)

    NICE has developed a medtech innovation briefing (MIB) on the needle-free arterial non-injectable connector .

  10. U-Drain for people needing night drainage of urine or dialysis fluid (MIB95)

    NICE has developed a medtech innovation briefing (MIB) on U-Drain for people needing night drainage of urine or dialysis fluid .

  11. Pharmacological interventions – gabapentinoids and local anaesthetics for complex regional pain syndrome: What is the clinical and cost effectiveness of gabapentinoids or local anaesthetics for managing complex regional pain syndrome in people aged 16 years and over?

    guidance Chronic pain (primary and secondary) in over 16s: assessment of all chronic pain and management of chronic primary pain Number...

  12. Psychotherapy for chronic primary pain: What is the clinical and cost effectiveness of psychodynamic psychotherapy for managing chronic primary pain in people aged 16 years and over?

    guidance Chronic pain (primary and secondary) in over 16s: assessment of all chronic pain and management of chronic primary pain Number...

  13. Manual therapies for chronic primary pain: What is the clinical and cost effectiveness of manual therapy for managing chronic primary pain in people aged 16 years and over?

    guidance Chronic pain (primary and secondary) in over 16s: assessment of all chronic pain and management of chronic primary pain Number...

  14. Relaxation therapy for chronic primary pain: What is the clinical and cost effectiveness of relaxation therapies for managing chronic primary pain in people aged 16 years and over?

    guidance Chronic pain (primary and secondary) in over 16s: assessment of all chronic pain and management of chronic primary pain Number...

  15. Percutaneous closure of patent foramen ovale to prevent recurrent cerebral embolic events (HTG325)

    Evidence-based recommendations on percutaneous closure of the patent foramen ovale for the prevention of cerebral embolic stroke. This involves placing a small device into the heart to close the hole.

  16. What interventions are effective and cost effective at raising awareness of the health risks of damp and mould in the home?

    landlords, and those who regulate them.Similarly, the committee agreed that not all professionals who see people in their home know who...

  17. Dabrafenib with trametinib for adjuvant treatment of resected BRAF V600 mutation-positive melanoma (TA544)

    Evidence-based recommendations on dabrafenib (Tafinlar) with trametinib (Mekinist) for resected stage III, BRAF V600 mutation-positive melanoma in adults.

  18. Daratumumab with bortezomib and dexamethasone for previously treated multiple myeloma (TA897)

    Evidence-based recommendations on daratumumab (Darzalex) with bortezomib and dexamethasone for previously treated multiple myeloma in adults.

  19. Voclosporin with mycophenolate mofetil for treating lupus nephritis (TA882)

    Evidence-based recommendations on voclosporin (Lupkynis) with mycophenolate mofetil for treating lupus nephritis in adults.

  20. Cladribine for treating active relapsing forms of multiple sclerosis (TA1053)

    Evidence-based recommendations on cladribine (Mavenclad) for treating active relapsing forms of multiple sclerosis in adults.

  21. Palbociclib with an aromatase inhibitor for previously untreated, hormone receptor-positive, HER2-negative, locally advanced or metastatic breast cancer (TA495)

    Evidence-based recommendations on palbociclib (Ibrance) as initial endocrine-based therapy for hormone-receptor positive, human epidermal growth factor receptor 2 (HER2)-negative, locally advanced or metastatic (secondary) breast cancer in adults.

  22. Factors that may be barriers to successfully managing chronic pain, including chronic primary pain: What risk factors enable stratification of treatment for people aged 16 years and over with chronic pain?

    guidance Chronic pain (primary and secondary) in over 16s: assessment of all chronic pain and management of chronic primary pain Number...

  23. Transcranial magnetic stimulation for chronic primary pain: What is the clinical and cost effectiveness of transcranial magnetic stimulation for managing chronic primary pain in people aged 16 years and over?

    guidance Chronic pain (primary and secondary) in over 16s: assessment of all chronic pain and management of chronic primary pain Number...

  24. Psychological therapy – CBT for insomnia in chronic primary pain: What is the clinical and cost effectiveness of cognitive behavioural therapy (CBT) for insomnia or CBT for insomnia and pain for managing chronic primary pain in people aged 16 years and over?

    guidance Chronic pain (primary and secondary) in over 16s: assessment of all chronic pain and management of chronic primary pain Number...

  25. Repeat courses of acupuncture for chronic primary pain: What is the clinical and cost effectiveness of repeat courses of acupuncture or dry needling for managing chronic primary pain in people aged 16 years and over?

    guidance Chronic pain (primary and secondary) in over 16s: assessment of all chronic pain and management of chronic primary pain Number...

  26. Social interventions for chronic pain, including chronic primary pain: What is the clinical and cost effectiveness of social interventions aimed at improving the quality of life of people aged 16 years and over with chronic pain?

    guidance Chronic pain (primary and secondary) in over 16s: assessment of all chronic pain and management of chronic primary pain Number...

  27. Laser therapy for chronic primary pain: What is the clinical and cost effectiveness of laser therapy for managing chronic primary pain in people aged 16 years and over?

    guidance Chronic pain (primary and secondary) in over 16s: assessment of all chronic pain and management of chronic primary pain Number...

  28. Psychological therapy – mindfulness for chronic primary pain: What is the clinical and cost effectiveness of mindfulness therapy for managing chronic primary pain in people aged 16 years and over?

    guidance Chronic pain (primary and secondary) in over 16s: assessment of all chronic pain and management of chronic primary pain Number...

  29. How can a multiagency approach to improving awareness, availability and uptake of vitamin D supplements best be established, improved and sustained?

    adherence or any unintentional consequences. The recommendations apply to all at-risk groups, but there is a particular need for...

  30. Type 2 diabetes mellitus in adults: high-strength insulin glargine 300 units/ml (Toujeo) (ESNM65)

    Summary of the evidence on high-strength insulin glargine 300 units/ml (Toujeo) for type 2 diabetes mellitus to inform local NHS planning and decision-making

  31. Atrial fibrillation and heart valve disease: self-monitoring coagulation status using point-of-care coagulometers (the CoaguChek XS system) (HTG353)

    Evidence-based recommendations on the CoaguChek XS system for self-monitoring coagulation status in adults and children. The recommendations originally included the InRatio2 PT/INR, but this was withdrawn from the market in October 2016 and is not currently available.

  32. Community pharmacies: promoting health and wellbeing (QS196)

    This quality standard covers how community pharmacies can support the health and wellbeing of the local population. It describes high-quality care in priority areas for improvement.

  33. Spondyloarthritis (QS170)

    This quality standard covers diagnosing and managing spondyloarthritis in adults aged 16 and over. It describes high-quality care in priority areas for improvement.

  34. Flu vaccination: increasing uptake (QS190)

    This quality standard covers increasing the uptake of flu vaccination among people who are eligible. It describes high-quality care in priority areas for improvement.

  35. Ectopic pregnancy and miscarriage (QS69)

    This quality standard covers the diagnosis and initial management of ectopic pregnancy and miscarriage in women, trans men and non-binary people in their first trimester (up to 13 completed weeks of pregnancy). It includes assessment and diagnosis for people with suspected early pregnancy loss. It describes high-quality care in priority areas for improvement.

  36. What is the clinical and cost effectiveness of budesonide for treating COVID-19 in the community in adults, young people and children?

    I: Inhaled budesonide C: Inhaled placebo (to accommodate blinding) O:• All-cause mortality• Hospitalisation• Need for oxygen therapy...

  37. What is the clinical and cost effectiveness of preoperative optimisation clinics for older people?

    identified during the preoperative assessment. These clinics are not available in all areas and are expensive to establish. Although a...

  38. For people with iron-deficiency anaemia, how long before surgery should oral iron supplementation be started, and what is the clinical and cost effectiveness of daily oral iron compared with oral iron given on alternate days?

    identified during the preoperative assessment. These clinics are not available in all areas and are expensive to establish. Although a...

  39. What is the effectiveness and safety of a treatment dose with a low molecular weight heparin (LMWHs) compared with a standard prophylactic dose for venous thromboembolism (VTE) prophylaxis in young people under 18 years with COVID-19?

    LMWH C: standard prophylaxis with LMWH O:• incidence of VTE• mortality (all-cause, inpatient, COVID-19 related)• admission to critical...

  40. Point-of-care tests for urinary tract infections to improve antimicrobial prescribing: early value assessment (HTG674)

    Early value assessment (EVA) guidance on point-of-care tests for urinary tract infections to improve antimicrobial prescribing.

  41. Self-management:- Do structured psoriasis-focused self-management programmes improve patient confidence, wellbeing and disease control compared with standard care?

    Any explanatory notes(if applicable) Why this is important:- Virtually all patients self-manage their condition to a greater or lesser...

  42. Warming in patients with major trauma:- Is warming clinically and cost effective in patients with major trauma? If so, which groups of patients will benefit from warming and what is the best method of warming?

    is uncertainty about the clinical benefit of warming patients and whether all groups of patients would benefit from warming. In...

  43. Monitoring pulmonary disease:- Is lung clearance index a useful and cost-effective tool for the routine assessment and monitoring of changes in pulmonary status in people with cystic fibrosis?

    Assessing the severity of lung disease is difficult in younger children. Not all children under 5 years can do spirometry tests and they...

  44. What type of training and awareness-raising can improve how health and social care practitioners: - promote vitamin D supplements among at-risk groups - improve the local population's awareness of, and attitudes towards, vitamin D supplements - uptake of vitamin D supplements?

    adherence or any unintentional consequences. The recommendations apply to all at-risk groups, but there is a particular need for...

  45. Health Technology Assessment Innovation Laboratory (HTA Lab)

    NICE's HTA Lab enables us to develop creative solutions to complex problems in health technology assessment.

  46. What is the most clinical and cost-effective strategy, as identified by a consensus survey, for the perioperative management of anticoagulation treatment in people taking a vitamin K antagonist with a target international normalised ratio (INR) of more than 3 who need bridging therapy?

    identified during the preoperative assessment. These clinics are not available in all areas and are expensive to establish. Although a...

  47. Digitally enabled therapies for adults with depression: early value assessment (HTG675)

    Early value assessment (EVA) guidance on digitally enabled therapies for adults with depression.

  48. What is the effectiveness and safety of extended pharmacological venous thromboembolism (VTE) prophylaxis for people who have been discharged after treatment for COVID-19?

    extended pharmacological VTE prophylaxis O:• incidence of VTE• mortality (all-cause, inpatient, COVID-19 related)• serious adverse...

  49. Epilepsy syndromes: What are the initial and add-on AEDs of choice in the treatment of the epilepsy syndromes with onset in childhood, for example, myoclonic-astatic epilepsy and Dravet syndrome?

    attempt to obtain data on pharmaco-resistance the possibility of including all children with specific epilepsy syndromes for...

  50. Prevalence of risk factors for falling in older inpatients:- Which risk factors for falling that can be treated, improved or managed during the hospital stay are most prevalent in older patients who fall in inpatient settings in the UK?

    risk factors for falling in the inpatient setting, but these studies are not all relevant to a current UK hospital population....