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Showing 2551 to 2600 of 4138 results for patient

  1. Evidence on the safety and efficacy of permanent His-bundle pacemaker implantation for treating heart failure is inadequate in quality and quantity.Therefore, this procedure should only be used in the context of research. Find out what only in research means on the NICE interventional procedures guidance page.

    randomised controlled trials or registry data. It should report details of patient selection. Outcomes should include quality of life...

    Research recommendation
    Published
    10 August 2021

  2. Evidence on the safety of pressurised intraperitoneal aerosol chemotherapy for peritoneal carcinomatosis shows that this procedure can cause serious but well-recognised side effects. Evidence on its efficacy is inadequate in quality. Therefore, this procedure should only be used in the context of research. Find out what  only in research means on the NICE website .

    aerosol chemotherapy with standard care. Studies should report details of patient selection including type of tumour, the chemotherapy...

    Research recommendation
    Published
    22 January 2021

  3. Holistic assessment in the community:- What is the clinical and cost effectiveness of a community holistic assessment and intervention for people living with high levels of multimorbidity?

    intervention in people with multimorbidity would be of value in defined patient groups in the community (for example, people in nursing...

    Research recommendation
    Published
    18 October 2016

  4. NICE encourages further research into intravesical microwave hyperthermia and chemotherapy for non-muscle-invasive bladder cancer. Research should include randomised controlled trials, which stratify patients by risk and give adequate follow-up. They should report frequency of adverse events, patientreported outcome measures, overall and disease-free survival and quality of life.

    cancer. Research should include randomised controlled trials, which stratify patients by risk and give adequate follow-up. They should...

    Research recommendation
    Published
    12 December 2018

  5. NICE encourages further research into the efficacy of MRI-guided transcutaneous focused ultrasound for uterine fibroids. Research studies should report long-term outcomes, including the need for further treatment. Data on the incidence and outcomes of subsequent pregnancy in patients who choose this procedure because they wish to maintain or improve their fertility are particularly important.

    treatment. Data on the incidence and outcomes of subsequent pregnancy in patients who choose this procedure because they wish to...

    Research recommendation
    Published
    9 June 2015

  6. Research is recommended to address uncertainties in the potential benefits to patients and the NHS of using VibraTip. Research is needed into the diagnostic accuracy of VibraTip compared with the 10 g monofilament and calibrated tuning fork in the diagnosis of peripheral neuropathy in people with diabetes. This research should also address the assessment of vibration perception compared with touch sensation in this clinical context.

    Research is recommended to address uncertainties in the potential benefits to patients and the NHS of using VibraTip. Research is needed...

    Research recommendation
    Published
    9 June 2015

  7. Current evidence on the safety and efficacy of endovascular insertion of an intrasaccular wire-mesh blood-flow disruption device for intracranial aneurysms is adequate to support the use of this procedure provided that  standard arrangements   are in place for clinical governance, consent and audit.

    governance, consent and audit. Any explanatory notes(if applicable) Patient selection should be done by a multidisciplinary team, except...

    Research recommendation
    Published
    15 November 2019

  8. Long-term effect of very-low-calorie diets on people with a BMI of 40 kg/m2 or more: What are the long-term effects of using very-low-calorie diets (VLCDs) versus low-calorie diets (LCDs) on weight and quality of life in patients with a body mass index (BMI) of 40 kg/m2 or more, including the impact on weight cycling?

    (VLCDs) versus low-calorie diets (LCDs) on weight and quality of life in patients with a body mass index (BMI) of 40 kg/m2 or more,...

    Research recommendation
    Published
    30 September 2022

  9. NICE agreed that further research was needed because there is currently no clinical- or cost-effectiveness evidence evaluating the use of Holoclar in both eyes in bilateral patients. The committee was aware of the ongoing HOLOCORE trial which is recruiting both unilateral and bilateral patients, but only evaluates the success of a second transplant in 1 eye rather than transplant success in both eyes.

    cost-effectiveness evidence evaluating the use of Holoclar in both eyes in bilateral patients. The committee was aware of the ongoing...

    Research recommendation
    Published
    15 October 2018

  10. Evidence on the safety and efficacy of daytime intraoral neuromuscular electrical tongue stimulation using a removable device for obstructive sleep apnoea is inadequate in quality and quantity. So, this procedure should be used only in research. Find out what only in research means on the NICE interventional procedures guidance page.

    assess efficacy, safety and adherence. Research should report details of patient selection, duration of treatment and effect, effect on...

    Research recommendation
    Published
    5 May 2023

  11. Evidence on the efficacy of focal resurfacing implants to treat articular cartilage damage in the knee is limited in quality and quantity. Short-term evidence shows no major safety concerns, but long-term evidence on safety is limited in quality and quantity. Therefore, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Find out what special arrangements mean on the NICE interventional procedures guidance page.

    Any explanatory notes(if applicable) Further research should report patient selection, including the site and size of the cartilage...

    Research recommendation
    Published
    7 September 2022

  12. Evidence on the safety and efficacy of percutaneous image-guided cryoablation of peripheral neuroma for chronic pain is inadequate in quality and quantity. Therefore, this procedure should only be used in thecontext of research. Find out what only in research means on the NICE interventional procedures guidance page.

    in the form of randomised controlled trials and should report details of patient selection and the procedure, quality of life and pain...

    Research recommendation
    Published
    3 February 2023

  13. Evidence on the safety of transcranial magnetic stimulation for obsessive-compulsive disorder raises no major safety concerns. However, evidence on its efficacy is inadequate in quantity and quality. Therefore, this procedure should only be used in the context of research.  Find out  what only in research means on the NICE website .

    adequately powered, randomised controlled trials. It should report details of patient selection, including the use of concurrent...

    Research recommendation
    Published
    10 August 2020

  14. What are the clinically and cost-effective surgical approaches to managing complicated acute diverticulitis, including timing of surgery (elective or emergency)?

    This meant it was difficult to assess the true effect of interventions on patient outcomes. Therefore the committee decided not to make...

    Research recommendation
    Published
    10 February 2020

  15. Evidence on the safety of extracorporeal shockwave therapy for calcific tendinopathy in the shoulder shows no major safety concerns in the short term. Evidence on efficacy is inadequate. Therefore, this procedure should only be used in the context of research. Find out what only in research means on the NICE interventional procedures guidance page

    comparing the procedure with current best practice. It should report details of patient selection, including site and density of...

    Research recommendation
    Published
    12 December 2022

  16. Evidence on the safety and efficacy of aortic remodelling hybrid stent insertion during surgical repair of an acute type A aortic dissection is limited in quantity and quality. Therefore, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Find out what special arrangements mean on the NICE interventional procedures guidance page.

    controlled trials or analysis of registry data. It should include details of patient selection and report 30-day mortality, quality of...

    Research recommendation
    Published
    7 September 2022

  17. Naldemedine for treating opioid-induced constipation (TA651)

    Evidence-based recommendations on naldemedine (Rizmoic) for treating opioid-induced constipation in adults who have had laxative treatment.

    Technology appraisal guidance
    Published
    30 September 2020
    View recommendations

    Sections for TA651

  18. The evidence on transvaginal laser therapy for stress urinary incontinence does not show any short-term safety concerns. Evidence on long-term safety andefficacy is inadequate in quality and quantity. Therefore, this procedure should only be used in the context of research. Find out what only in research means onthe NICE interventional procedures guidance page.

    efficacy outcomes, the type of laser and energy used, treatment protocols, and patient selection including age, menopausal status and...

    Research recommendation
    Published
    10 August 2021

  19. Imaging investigations for newly diagnosed myeloma:- What is the comparative effectiveness of whole-body MRI, fluorodeoxyglucose positron emission tomography CT (FDG PET-CT) and whole-body low-dose CT in detecting lesions that may determine the start of treatment for people with newly diagnosed myeloma?

    detection, sensitivity and specificity for myeloma-related bone disease, patient acceptability, incremental upstaging, radiation...

    Research recommendation
    Published
    5 April 2016

  20. Complications of IV fluid therapy:- What is the incidence of complications during, and as a consequence of, IV fluid therapy in children and young people?

    IV fluid therapy can lead to mortality and significant morbidity for the patient. This, in turn, represents a cost burden for the NHS in...

    Research recommendation
    Published
    28 January 2016

  21. Long term real-world data is needed on AposHealth's clinical effectiveness and cost benefit

    health-related quality of life data may be collected using standardised patient-reported outcome measures, such as the EQ-5D. Source...

    Research recommendation
    Published
    5 May 2023

  22. Evidence on the safety and efficacy of biodegradable spacer insertion to reduce rectal toxicity during radiotherapy for prostate cancer is limited in quality. Therefore, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. Find out what special arrangements mean on the NICE interventional procedures guidance page.

    including registry studies and real-world evidence. It should report details of patient selection, choice ofradiotherapy technique and...

    Research recommendation
    Published
    9 March 2023

  23. Danicopan with ravulizumab or eculizumab for treating paroxysmal nocturnal haemoglobinuria (TA1010)

    Evidence-based recommendations on danicopan (Voydeya) with ravulizumab (Ultomiris) or eculizumab (Soliris) for paroxysmal nocturnal haemoglobinuria in adults with residual haemolytic anaemia.

    Technology appraisal guidance
    Published
    23 October 2024
    View recommendations

    Sections for TA1010

  24. VitalPAC for assessing vital signs of patients in hospital (MIB79)

    This advice has been updated and replaced by NICE medtech innovation briefing 205.

    Medtech innovation briefing
    Published
    14 September 2016

  25. Caesarean birth (NG192)

    This guideline covers when to offer and discuss caesarean birth, procedural aspects of the operation, and care after caesarean birth. It aims to improve the consistency and quality of care for women and pregnant people who are thinking about having a caesarean birth or have had a caesarean birth in the past and are now pregnant again.

    NICE guideline
    Last updated
    10 June 2025
    View recommendations

    Sections for NG192

  26. Evidence on the efficacy of bioresorbable stent implantation to treat coronary artery disease is inadequate. Evidence on its safety has shown an increased risk of serious complications in the longer term. This includes an increased risk of myocardial infarction and death with some types of bioresorbable stents. Therefore, this procedure should only be used in the context of research. Find out what only in research means on the NICE interventional procedures guidance page.

    research should include randomised controlled trials reporting details of patient selection and choice of bioresorbable stent. It should...

    Research recommendation
    Published
    7 September 2022

  27. The Versajet II hydrosurgery system for surgical debridement of acute and chronic wounds and burns (MIB1)

    NICE has developed a Medtech Innovation Briefing (MIB) on the Versajet II hydrosurgery system

    Medtech innovation briefing
    Published
    4 February 2014

  28. Is symptom-based review as effective as scheduled follow-up for people treated with radical cystectomy or radical radiotherapy for organ-confined, muscle-invasive bladder cancer? Outcomes of interest are overall survival, health-related quality of life, resource use and cost.

    out by the treating team. Although this can be reassuring for both the patient and the treating team, it is not known whether scheduled...

    Research recommendation
    Published
    9 June 2015

  29. Follow-up:- What is the optimal method, frequency and duration of follow-up for people who are disease-free after treatment for CUADT?

    on historical practice than evidence and are often disease- rather than patient-centred. Research to investigate how and when follow-up...

    Research recommendation
    Published
    6 April 2016

  30. Augmentative and alternative communication:- What is the current pattern of provision and use of augmentative and alternative communication (AAC) by people with motor neurone disease (MND) in England?

    with the collection and analysis of basic data. It will then progress to patient-related outcomes. Source guidance details Comes from...

    Research recommendation
    Published
    21 March 2016

  31. What are the possible outcomes for people who are critically ill and have COVID-19-associated pulmonary aspergillosis (CAPA)?

    intensive care)• long-term morbidity outcomes, functional measures and patient outcomes• results may be stratified (for example, disease...

    Research recommendation
    Published
    17 December 2021

  32. Psychological interventions to manage chronic headache disorders:- Does a psychological intervention such as cognitive behavioural therapy (CBT) improve headache outcomes and quality of life for people with chronic headache disorders?

    on headache alone, using appropriate headache outcomes such as change in patient-reported headache days and headache-specific quality of...

    Research recommendation
    Published
    9 June 2015

  33. Early mobilisation and optimum positioning of people with acute stroke: How safe and effective is very early mobilisation delivered by appropriately trained healthcare professionals after stroke?

    pneumonia. There could be benefits for motor and sensory recovery, and patient motivation. The research question to be addressed is...

    Research recommendation
    Published
    11 May 2022

  34. What is the most clinically and cost-effective timing and dose of a single administration of gabapentin to relieve pain in people undergoing surgery whose pain is expected to be moderate to severe?

    cannot take an oral opioid, the committee agreed that a choice of PCA (patient-controlled analgesia) or epidural should be offered...

    Research recommendation
    Published
    26 October 2020

  35. Indicators and thresholds for referral for cataract surgery:- What is the association between preoperative vision- and health-related quality of life, and postoperative vision-related quality of life, health-related quality of life, and self-reported postoperative improvement?

    potential gains may be. Robust information around the link between preoperative patient characteristics and outcomes would be useful...

    Research recommendation
    Published
    6 November 2018

  36. Values of skin prick testing and specific IgE antibody testing and their predictive value:- Can skin prick testing and specific IgE antibody testing cut-off points be established to diagnose IgE-mediated food allergy in children and young people, and to predict the severity of reaction?

    reaction would therefore lead to huge cost savings in the NHS and would reduce patient risk. There are published data available from the...

    Research recommendation
    Published
    9 June 2015

  37. Endovascular aneurysm sealing for abdominal aortic aneurysm (IPG547)

      March 2019: We have withdrawn the guidance because the CE mark for the Nellix Endovascular Aneurysm Sealing (EVAS) System has been withdrawn. Endologix is recalling unused stock. The MHRA recommends enhanced patient surveillance (see MDA/2019/002) because of a high risk of the graft failing beyond 2 years after implantation.

    Interventional procedures guidance
    Published
    24 February 2016

  38. Assessment at home to improve hospital discharge success rates:- How effective are home assessment interventions and approaches designed to improve hospital discharge outcomes?

    needs perspective for different populations. In addition, information on patient- and cost-related outcomes is also needed. Source...

    Research recommendation
    Published
    29 January 2016

  39. Enteral nutrition support:- What specific clinical and non-clinical factors allow risk stratification when selecting which people with CUADT would benefit from short- or long-term enteral nutrition?

    meaningfully. These factors included restricted populations for tumour staging, patient demographics, treatment plan and intent,...

    Research recommendation
    Published
    6 April 2016

  40. 1.1 Evidence on the safety of electrical stimulation to improve muscle strength in chronic respiratory conditions, chronic heart failure and chronic kidney disease shows no major safety concerns. For people who are having an acute exacerbation of their chronic condition and are unable to exercise, evidence of efficacy is adequate to support the use of this procedure provided that standard arrangements are in place for clinical governance, consent and audit.   Find out  what standard arrangements mean on the NICE website . For people who are able to exercise, evidence on efficacy is inadequate in quality. Therefore, this procedure should only be used in the context of research. Find out  what only in research means on the NICE website .

    appropriately controlled randomised trials. These should report details of patient selection, and type and duration of treatment....

    Research recommendation
    Published
    10 August 2020

  41. How cost effective are fluoride varnish programmes and tooth-brushing schemes?

    consider the long term impact of poor oral health. Research should include patient-reported outcome measures to assess health and...

    Research recommendation
    Published
    9 June 2015

  42. How can healthy habits that promote oral health be supported and encouraged in families with children at high risk of poor oral health?

    consider the long term impact of poor oral health. Research should include patient-reported outcome measures to assess health and...

    Research recommendation
    Published
    9 June 2015

  43. Natural Cycles for monitoring fertility (MIB244)

    NICE has developed a medtech innovation briefing (MIB) on Natural Cycles for monitoring fertility .

    Medtech innovation briefing
    Published
    19 January 2021

  44. Laboratory tests to diagnose initial and ongoing infection and determine re-infection in the different presentations of Lyme disease in the UK:- What is the most clinically and cost-effective serological antibody-based test, biomarker or other test for diagnosing Lyme disease in the UK at all stages, including re-infection?

    clinically and cost-effective diagnostic tests for Lyme disease will improve patient care and is a high priority. The clinical...

    Research recommendation
    Published
    27 November 2018

  45. Meningitis (bacterial) and meningococcal disease: recognition, diagnosis and management (NG240)

    This guideline covers recognising, diagnosing and managing bacterial meningitis and meningococcal disease in babies, children, young people and adults. It aims to reduce death and disability by helping healthcare professionals recognise meningitis and treat it quickly and effectively.

    NICE guideline
    Published
    19 March 2024
    View recommendations

    Sections for NG240

  46. NICE encourages further research into transcranial direct current stimulation (tDCS) for depression, which should document how patients were selected and any other treatments they were having. It should describe the precise method and regime used for administering tDCS. Outcome measures should include the duration of effect. NICE may update the guidance on publication of further evidence.

    direct current stimulation (tDCS) for depression, which should document how patients were selected and any other treatments they were...

    Research recommendation
    Published
    12 October 2015

  47. Educational intervention to improve healthcare professionals' awareness of spondyloarthritis:- What is the effectiveness and cost effectiveness of educational interventions for healthcare professionals in order to increase the number of prompt diagnoses of spondyloarthritis?

    between inflammatory and mechanical back pain) or characteristics of the patient populations (for example, that spondyloarthritis...

    Research recommendation
    Published
    4 May 2017

  48. Atopic eczema in under 12s: diagnosis and management (CG57)

    This guideline covers diagnosing and managing atopic eczema in children under 12. It aims to improve care for children with atopic eczema by making detailed recommendations on treatment and specialist referral. The guideline also explains how healthcare professionals should assess the effect eczema has on quality of life, in addition to its physical severity.

    Clinical guideline
    Last updated
    22 September 2025
    View recommendations

    Sections for CG57

  49. Optilume for anterior urethral strictures (MIB241)

    NICE has developed a medtech innovation briefing (MIB) on Optilume for anterior urethral strictures .

    Medtech innovation briefing
    Published
    5 January 2021

  50. What community-based interventions are effective and cost effective in improving dietary habits affecting the oral health of children and adults, and in particular those at high risk of poor oral health?

    consider the long term impact of poor oral health. Research should include patient-reported outcome measures to assess health and...

    Research recommendation
    Published
    9 June 2015