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Darvadstrocel for treating complex perianal fistulas in Crohn's disease (TA556)
Evidence-based recommendations on darvadstrocel (Alofisel) for previously treated complex perianal fistulas in adults with non-active or mildly active luminal Crohn’s disease.
Result type
Technology appraisal guidance
Published
9 January 2019
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Further research is recommended to resolve the uncertainties about the long-term clinical effectiveness of darvadstrocel compared with standard care. In particular, estimates of long-term remission rates (minimum of 2 years' follow-up) in Crohn's disease with perianal fistulas are needed.
resolve the uncertainties about the long-term clinical effectiveness of darvadstrocel compared with standard care. In particular,...
Result type
Research recommendation
Published
19 March 2019
The health-related quality-of-life evidence of patients with perianal fistulas is also lacking, therefore further research is recommended. Any research should measure the effect of treatment using preference-based measures (such as use of the EQ-5D questionnaire).
consultation did not clarify the uncertainties around the long-term benefits of darvadstrocel compared with placebo either, because the...
Result type
Research recommendation
Published
19 March 2019
Research recommendations
resolve the uncertainties about the long-term clinical effectiveness of darvadstrocel compared with standard care. In particular,...