5 Implementation


The Welsh ministers have issued directions to the NHS in Wales on implementing NICE technology appraisal guidance. When a NICE technology appraisal guidance recommends the use of a drug or treatment, or other technology, the NHS in Wales must usually provide funding and resources for it within 2 months of the first publication of the final draft guidance.


When NICE recommends a treatment 'as an option', the NHS must make sure it is available within the period set out in the paragraphs above. This means that, if a patient has previously treated anaplastic-lymphoma-kinase-positive advanced non-small-cell lung cancer and the doctor responsible for their care thinks that crizotinib is the right treatment, it should be available for use, in line with NICE's recommendations.


The Department of Health and Pfizer have agreed that crizotinib will be available to the NHS with a patient access scheme which makes it available with a discount. The size of the discount is commercial in confidence. It is the responsibility of the company to communicate details of the discount to the relevant NHS organisations. Any enquiries from NHS organisations about the patient access scheme should be directed to pfizerNICEaccount@pfizer.com.

  • National Institute for Health and Care Excellence (NICE)