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Renal cancer

Renal cancer overview Kidney conditions Patient experience in adult NHS services Your responsibility when using NICE advice Renal cancer About What is covered This interactive flowchart covers renal cancers. Updates Updates to this interactive

NICE Pathway Published December 2013 Last updated May 2017

Percutaneous radiofrequency ablation for renal cancer (IPG353)

Evidence-based recommendations on percutaneous radiofrequency ablation for treating renal (kidney) cancer

Interventional procedures guidance Published July 2010

Irreversible electroporation for treating renal cancer (IPG443)

Evidence-based recommendations on irreversible electroporation (IRE) for treating renal (kidney) cancer

Interventional procedures guidance Published February 2013

Laparoscopic cryotherapy for renal cancer (IPG405)

Evidence-based recommendations on laparoscopic cryotherapy (keyhole surgery to destroy cancer cells by freezing) for treating renal (kidney) cancer

Interventional procedures guidance Published August 2011

Percutaneous cryotherapy for renal cancer (IPG402)

Evidence-based recommendations on percutaneous cryotherapy for renal (kidney) cancer

Interventional procedures guidance Published July 2011

Percutaneous radiofrequency ablation of renal cancer (IPG91)

This guidance has been updated and replaced by percutaneous radiofrequency ablation for renal cancer

Interventional procedures guidance Published September 2004 Withdrawn

Collection and publication of data on the outcomes of percutaneous cryotherapy for renal cancer in the long term is encouraged. Further research should compare the long-term outcomes of cryotherapy with those of other treatments for renal cancer.

...outcomes of percutaneous cryotherapy for renal cancer in the long term is encouraged. Further...cryotherapy with those of other treatments for renal cancer. Any explanatory notes(if applicable...guidance Percutaneous cryotherapy for renal cancer Number IPG402 Date issued July 2011...

Research recommendation Published June 2015

Current evidence on the safety and efficacy of irreversible electroporation for treating renal cancer is inadequate in quantity and quality. Therefore, this procedure should only be used in the context of research. In particular, studies should report the effect of the procedure on local tumour control and patient survival.

...and efficacy of irreversible electroporation for treating renal cancer is inadequate in quantity and quality. Therefore, this...Comes from guidance Irreversible electroporation for treating renal cancer Number IPG443 Date issued February 2013 Other details Is...

Research recommendation Published June 2015

Nivolumab for previously treated advanced renal cell carcinoma (TA417)

Evidence-based recommendations on nivolumab (Opdivo) for previously treated advanced renal cell carcinoma (RCC/kidney cancer) in adults

Technology appraisal guidance Published November 2016

Axitinib for treating advanced renal cell carcinoma after failure of prior systemic treatment (TA333)

Evidence-based recommendations on axitinib (Inlyta) for treating advanced renal cell carcinoma (RCC) (kidney cancer) when prior systemic treatment has failed

Technology appraisal guidance Published February 2015

Everolimus for advanced renal cell carcinoma after previous treatment (TA432)

Evidence-based recommendations on everolimus (Afinitor) for advanced renal cell carcinoma (kidney cancer) after previous treatment

Technology appraisal guidance Published February 2017

New treatment recommended for kidney cancer

People with kidney cancer set to benefit from a new innovative immunotherapy, after NICE says it should be available on the NHS.

News Published October 2016

NICE approves kidney cancer drug for NHS use

Patients with advanced kidney cancer will have routine NHS access to the drug everolimus following recommendations by NICE, rather than apply to the Cancer Drugs Fund (CDF).

News Published January 2017

Sunitinib for the first-line treatment of advanced and/or metastatic renal cell carcinoma (TA169)

Evidence-based recommendations on sunitinib (Sutent) for the first-line treatment of advanced and/or metastatic renal cell carcinoma

Technology appraisal guidance Published March 2009

Pazopanib for the first-line treatment of advanced renal cell carcinoma (TA215)

Evidence-based recommendations on pazopanib (Votrient) for the first-line treatment of advanced renal cell carcinoma (RCC/kidney cancer)

Technology appraisal guidance Published February 2011 Last updated August 2013

Kidney conditions

This interactive flowchart covers kidney conditions, including pelviureteric junction obstruction, renal cysts and renal stones. It also includes links to the flowcharts on acute kidney injury, anaemia management in people with chronic kidney

NICE Pathway Published May 2015 Last updated June 2017

Chronic kidney disease in adults: assessment and management (CG182)

Evidence-based recommendations on the assessment and management of chronic kidney disease (CKD) in adults

Clinical guideline Published July 2014 Last updated January 2015

Proposed technology appraisals

...cell transplantation for haematological cancers Benralizumab for treating inadequately...gastric or gastro-oesophageal junction cancer Pembrolizumab for locally advanced or...gastric or gastro-oesophageal junction cancer Suggested remit To appraise the clinical...gastric or gastro-oesophageal junction cancer. Consultation on suggested remit, draft scope and...cell transplantation for haematological cancers Suggested remit To appraise the clinical...

Published June 2017

Haematological cancers: improving outcomes (NG47)

Evidence-based recommendations on integrated diagnostics reporting and improving services, staffing and care for people with haematological cancer

NICE guideline Published May 2016

Abiraterone for treating metastatic hormone-relapsed prostate cancer before chemotherapy is indicated (TA387)

Evidence-based recommendations on abiraterone (Zytiga) for treating metastatic hormone-relapsed prostate cancer before chemotherapy is indicated in adults.

Technology appraisal guidance Published April 2016 Last updated July 2016

Pemetrexed maintenance treatment for non-squamous non-small-cell lung cancer after pemetrexed and cisplatin (TA402)

Evidence-based recommendations on pemetrexed (Alimta) for locally advanced or metastatic non-squamous non-small-cell lung cancer in adults who have had..

Technology appraisal guidance Published August 2016

Cancer patients diagnosed quicker, thanks to NICE guidelines

The time taken to diagnose certain common cancers, from the point when a patient first reports a possible symptom to their GP, fell in adults by an average of five days, following the launch of NICE guidelines on cancer referral.

News Published February 2014

NICE says head and neck cancer drug is not cost effective

NICE has published draft guidance saying the cost of using nivolumab to treat head and neck cancer is too high for routine NHS use.

News Published April 2017

NICE says patients accessing more cancer drugs following price drops

Patients will have routine access to more cancer drugs as companies have dropped their prices as part of the reformed Cancer Drugs Fund (CDF) process.

News Published March 2017

Metastatic malignant disease of unknown primary origin

This interactive flowchart covers the diagnosis and management of metastatic malignant disease of unknown primary origin.Most patients with newly diagnosed cancer are found to have a clearly defined primary tumour after initial investigation and

NICE Pathway Published January 2013 Last updated March 2017

Irreversible electroporation for treating primary lung cancer and metastases in the lung (IPG441)

Evidence-based recommendations on irreversible electroporation (IRE) for treating primary lung cancer and metastases in the lung

Interventional procedures guidance Published February 2013

Irreversible electroporation for treating primary liver cancer (IPG444)

Evidence-based recommendations on irreversible electroporation (IRE) for treating primary liver cancer

Interventional procedures guidance Published February 2013

Preventing excess weight gain (NG7)

Evidence-based recommendations on maintaining a healthy weight and preventing excess weight gain among adults and children.

NICE guideline Published March 2015

Neutropenic sepsis: prevention and management in people with cancer (CG151)

Evidence-based recommendations on preventing and managing neutropenic sepsis in people with cancer who are having anticancer treatment

Clinical guideline Published September 2012

Topotecan for the treatment of recurrent and stage IVB cervical cancer (TA183)

Evidence-based recommendations on topotecan (Hycamtin) for treating recurrent stage IVB (stage 4B) cervical cancer (cancer of the cervix)

Technology appraisal guidance Published October 2009

Pemetrexed for the first-line treatment of non-small-cell lung cancer (TA181)

Evidence-based recommendations on pemetrexed disodium (Alimta) for the first-line treatment of non-small-cell lung cancer (NSCLC)

Technology appraisal guidance Published September 2009

Prostate cancer - intensity modulated radiotherapy [ID17]

In development [GID-TAG396] Expected publication date: TBC

Technology appraisal guidance In development

Acute kidney injury: prevention, detection and management (CG169)

Evidence-based recommendations on the prevention, detection and management of acute kidney injury (AKI)

Clinical guideline Published August 2013

Urogenital conditions

This interactive flowchart covers urogenital conditions, including gynaecological, male genital and urological conditions. It also includes links to interactive flowcharts on cervical cancer, heavy menstrual bleeding, ovarian cancer, prostate

NICE Pathway Published June 2015 Last updated May 2017

Cryotherapy for renal cancers (IPG207)

This guidance has been updated and replaced by laparoscopic cryotherapy for renal cancer

Interventional procedures guidance Published January 2007 Withdrawn

Laparoscopic nephrectomy (including nephroureterectomy) (IPG136)

Evidence-based recommendations on laparoscopic nephrectomy (including nephroureterectomy; keyhole surgery to remove a kidney)

Interventional procedures guidance Published August 2005

Machine perfusion systems and cold static storage of kidneys from deceased donors (TA165)

Evidence-based recommendations on machine perfusion systems and cold static storage of kidneys from deceased donors

Technology appraisal guidance Published January 2009

Cabozantinib for treating renal cell carcinoma [ID931]

In development [GID-TA10075] Expected publication date: 09 August 2017

Technology appraisal guidance In development

Tivozanib for treating renal cell carcinoma [ID591]

In development [GID-TA10123] Expected publication date: 27 December 2017

Technology appraisal guidance In development

Lenvatinib with everolimus for previously treated advanced renal cell carcinoma [ID1029]

In development [GID-TA10125] Expected publication date: 27 December 2017

Technology appraisal guidance In development

Axitinib, everolimus, sorafenib and sunitinib for treated advanced or metastatic renal cell carcinoma [ID897]

In development [GID-TAG526] Expected publication date: TBC

Technology appraisal guidance In development

Myeloma: diagnosis and management (NG35)

Evidence-based recommendations on the diagnosing and managing of myeloma in people aged 16 and over.

NICE guideline Published February 2016