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Showing 1 to 879 of 879

Published guidance, NICE advice and quality standards
TitleReference numberPublishedLast updated
Sebelipase alfa for treating lysosomal acid lipase deficiency that is not Wolman disease (terminated appraisal)TA961
Olaparib for maintenance treatment of BRCA mutation-positive advanced ovarian, fallopian tube or peritoneal cancer after response to first-line platinum-based chemotherapyTA962
Human alpha1-proteinase inhibitor for treating emphysema (terminated appraisal)TA965
Ritlecitinib for treating severe alopecia areata in people 12 years and overTA958
Daratumumab in combination for treating newly diagnosed systemic amyloid light-chain amyloidosisTA959
Satralizumab for preventing relapses in neuromyelitis optica spectrum disorders (terminated appraisal)TA960
Ovarian cancer: identifying and managing familial and genetic riskNG241
Momelotinib for treating myelofibrosis-related splenomegaly or symptomsTA957
Suspected sepsis: recognition, diagnosis and early managementNG51
Neonatal infection: antibiotics for prevention and treatmentNG195
Meningitis (bacterial) and meningococcal disease: recognition, diagnosis and managementNG240
Nirmatrelvir plus ritonavir, sotrovimab and tocilizumab for treating COVID-19TA878
Fluocinolone acetonide intravitreal implant for treating chronic diabetic macular oedemaTA953
Dupilumab for treating moderate to severe prurigo nodularisTA955
Etrasimod for treating moderately to severely active ulcerative colitis in people aged 16 and overTA956
Lung cancer: diagnosis and managementNG122
Epcoritamab for treating relapsed or refractory diffuse large B-cell lymphoma after 2 or more systemic treatmentsTA954
Vitamin B12 deficiency in over 16s: diagnosis and managementNG239
Endoscopic sleeve gastroplasty for obesityIPG783
Talazoparib for treating HER2-negative advanced breast cancer with germline BRCA mutationsTA952
TuberculosisNG33
Belumosudil for treating chronic graft-versus-host disease after 2 or more systemic treatments in people 12 years and overTA949
Nivolumab–relatlimab for untreated unresectable or metastatic melanoma in people 12 years and overTA950
Olaparib with abiraterone for untreated hormone-relapsed metastatic prostate cancerTA951
Loncastuximab tesirine for treating relapsed or refractory diffuse large B-cell lymphoma and high-grade B-cell lymphoma after 2 or more systemic treatmentsTA947
Ivosidenib for treating advanced cholangiocarcinoma with an IDH1 R132 mutation after 1 or more systemic treatmentsTA948
Treosulfan with fludarabine before allogeneic stem cell transplant for people aged 1 month to 17 years with non-malignant diseases (terminated appraisal)TA945
Caesarean birthNG192
Devices for remote monitoring of Parkinson's diseaseDG51
Pharyngeal electrical stimulation for neurogenic dysphagiaIPG781
Temperature control to improve neurological outcomes after cardiac arrestIPG782
Artificial intelligence (AI)-derived software to help clinical decision making in strokeDG57
Olaparib with bevacizumab for maintenance treatment of advanced high-grade epithelial ovarian, fallopian tube or primary peritoneal cancerTA946
Early and locally advanced breast cancer: diagnosis and managementNG101
Sebelipase alfa for treating Wolman diseaseHST30
Durvalumab with gemcitabine and cisplatin for treating unresectable or advanced biliary tract cancerTA944
Intravascular lithotripsy for calcified arteries in peripheral arterial diseaseIPG780
Bipolar disorder: assessment and managementCG185
Targeted-release budesonide for treating primary IgA nephropathyTA937
Ravulizumab for treating generalised myasthenia gravis (terminated appraisal)TA940
Ravulizumab for treating AQP4 antibody-positive neuromyelitis optica spectrum disorder (terminated appraisal)TA941
Empagliflozin for treating chronic kidney diseaseTA942
Hybrid closed loop systems for managing blood glucose levels in type 1 diabetesTA943
Risdiplam for treating spinal muscular atrophyTA755
Middle meningeal artery embolisation for chronic subdural haematomasIPG779
Cardiovascular disease: risk assessment and reduction, including lipid modificationNG238
Velmanase alfa for treating alpha-mannosidosisHST29
Pembrolizumab plus chemotherapy with or without bevacizumab for persistent, recurrent or metastatic cervical cancerTA939
Acne vulgaris: managementNG198
Dupilumab for treating eosinophilic oesophagitis in people 12 years and over (terminated appraisal)TA938
Secukinumab for treating moderate to severe hidradenitis suppurativaTA935
Idecabtagene vicleucel for treating relapsed and refractory multiple myeloma after 3 or more treatments (terminated appraisal)TA936
Percutaneous thrombectomy for intermediate-risk or high-risk pulmonary embolismIPG778
Tisagenlecleucel for treating relapsed or refractory diffuse large B-cell lymphoma after 2 or more systemic therapies (terminated appraisal)TA933
Foslevodopa–foscarbidopa for treating advanced Parkinson's with motor symptomsTA934
Decitabine–cedazuridine for untreated acute myeloid leukaemia when intensive chemotherapy is unsuitable (terminated appraisal)TA932
Percutaneous transarterial carotid artery stent placement for asymptomatic extracranial carotid stenosisIPG777
Zanubrutinib for treating chronic lymphocytic leukaemiaTA931
Transient loss of consciousness ('blackouts') in over 16sCG109
Hypertension in adults: diagnosis and managementNG136
Suspected acute respiratory infection in over 16s: assessment at first presentation and initial managementNG237
Biodegradable subacromial spacer insertion for rotator cuff tearsIPG775
Extracorporeal carbon dioxide removal for acute respiratory failureIPG776
Lutetium-177 vipivotide tetraxetan for treating PSMA-positive hormone-relapsed metastatic prostate cancer after 2 or more treatmentsTA930
Familial breast cancer: classification, care and managing breast cancer and related risks in people with a family history of breast cancerCG164
Empagliflozin for treating chronic heart failure with preserved or mildly reduced ejection fractionTA929
Cabozantinib for previously treated advanced differentiated thyroid cancer unsuitable for or refractory to radioactive iodineTA928
Jaundice in newborn babies under 28 daysCG98
Pneumonia in adults: diagnosis and managementCG191
Ranibizumab for treating diabetic macular oedemaTA274
Vaginal transluminal endoscopic hysterectomy and adnexal surgery for benign gynaecological conditionsIPG774
Daratumumab with lenalidomide and dexamethasone for untreated multiple myeloma when a stem cell transplant is unsuitableTA917
Tirzepatide for treating type 2 diabetesTA924
Mirikizumab for treating moderately to severely active ulcerative colitisTA925
Baricitinib for treating severe alopecia areataTA926
Tabelecleucel for treating post-transplant lymphoproliferative disorder caused by the Epstein-Barr virus (terminated appraisal)TA923
Percutaneous deep venous arterialisation for chronic limb-threatening ischaemiaIPG773
Stroke rehabilitation in adultsNG236
Rimegepant for treating migraineTA919
Tofacitinib for treating active ankylosing spondylitisTA920
Ruxolitinib for treating polycythaemia veraTA921
Daridorexant for treating long-term insomniaTA922
Glofitamab for treating relapsed or refractory diffuse large B-cell lymphoma after 2 or more systemic treatmentsTA927
Thyroid disease: assessment and managementNG145
Bimekizumab for treating axial spondyloarthritisTA918
Pegunigalsidase alfa for treating Fabry diseaseTA915
Bimekizumab for treating active psoriatic arthritisTA916
Urinary incontinence in neurological disease: assessment and managementCG148
Ovarian cancer: recognition and initial managementCG122
Suspected cancer: recognition and referralNG12
Suspected neurological conditions: recognition and referralNG127
Hearing loss in adults: assessment and managementNG98
Intrapartum careNG235
Acute kidney injury: prevention, detection and managementNG148
Removal, preservation and reimplantation of ovarian tissue for restoring fertility after gonadotoxic treatmentIPG772
Birch bark extract for treating epidermolysis bullosaHST28
Pembrolizumab for previously treated endometrial, biliary, colorectal, gastric or small intestine cancer with high microsatellite instability or mismatch repair deficiencyTA914
Transurethral water-jet ablation for lower urinary tract symptoms caused by benign prostatic hyperplasiaIPG770
Cryotherapy for chronic rhinitisIPG771
Cirrhosis in over 16s: assessment and managementNG50
Spinal metastases and metastatic spinal cord compressionNG234
Mavacamten for treating symptomatic obstructive hypertrophic cardiomyopathyTA913
Semaglutide for managing overweight and obesityTA875
Otitis media with effusion in under 12sNG233
Quantitative faecal immunochemical testing to guide colorectal cancer pathway referral in primary careDG56
Ectopic pregnancy and miscarriage: diagnosis and initial managementNG126
Cipaglucosidase alfa with miglustat for treating late-onset Pompe diseaseTA912
Aortic valve reconstruction with glutaraldehyde-treated autologous pericardium for aortic valve diseaseIPG769
Venous thromboembolic diseases: diagnosis, management and thrombophilia testingNG158
Obesity: identification, assessment and managementCG189
Afamelanotide for treating erythropoietic protoporphyriaHST27
Selpercatinib for untreated RET fusion-positive advanced non-small-cell lung cancerTA911
KardiaMobile for detecting atrial fibrillationMTG64
Semaglutide for managing overweight and obesity in young people aged 12 to 17 years (terminated appraisal)TA910
Lorlatinib for untreated ALK-positive advanced non-small-cell lung cancerTA909
AI-derived computer-aided detection (CAD) software for detecting and measuring lung nodules in CT scan imagesDG55
Irreversible electroporation for treating prostate cancerIPG768
Rimegepant for preventing migraineTA906
Olaparib for maintenance treatment of relapsed, platinum-sensitive ovarian, fallopian tube or peritoneal cancer after 2 or more courses of platinum-based chemotherapyTA908
Oesophago-gastric cancer: assessment and management in adultsNG83
Botulinum toxin type A injections into the urethral sphincter for idiopathic chronic non-obstructive urinary retentionIPG766
Radiofrequency denervation for osteoarthritic knee painIPG767
Deucravacitinib for treating moderate to severe plaque psoriasisTA907
Endoscopic ultrasound-guided gallbladder drainage for acute cholecystitis when surgery is not an optionIPG764
Minimally invasive fusionless posterior-approach surgery to correct idiopathic scoliosis in children and young peopleIPG765
Dapagliflozin for treating chronic heart failure with preserved or mildly reduced ejection fractionTA902
Darolutamide with androgen deprivation therapy and docetaxel for treating hormone-sensitive metastatic prostate cancerTA903
Pembrolizumab with lenvatinib for previously treated advanced or recurrent endometrial cancerTA904
Upadacitinib for previously treated moderately to severely active Crohn's diseaseTA905
Cemiplimab for treating recurrent or metastatic cervical cancer (terminated appraisal)TA901
Dabrafenib plus trametinib for treating BRAF V600 mutation-positive advanced non-small-cell lung cancerTA898
Tixagevimab plus cilgavimab for preventing COVID-19TA900
FibroScan for assessing liver fibrosis and cirrhosis outside secondary and specialist careDG48
Atopic eczema in under 12s: diagnosis and managementCG57
Axicabtagene ciloleucel for treating relapsed or refractory follicular lymphomaTA894
Axicabtagene ciloleucel for treating relapsed or refractory diffuse large B-cell lymphoma after first-line chemoimmunotherapyTA895
Bulevirtide for treating chronic hepatitis DTA896
Brexucabtagene autoleucel for treating relapsed or refractory B-cell acute lymphoblastic leukaemia in people 26 years and overTA893
Intraoperative electron beam radiotherapy for locally advanced and locally recurrent colorectal cancerIPG763
Daratumumab with bortezomib and dexamethasone for previously treated multiple myelomaTA897
Esketamine for treating major depressive disorder in adults at imminent risk of suicide (terminated appraisal)TA899
Transperineal biopsy for diagnosing prostate cancerDG54
Ibrutinib with venetoclax for untreated chronic lymphocytic leukaemiaTA891
Mosunetuzumab for treating relapsed or refractory follicular lymphomaTA892
Automated ankle brachial pressure index measurement devices to detect peripheral arterial disease in people with leg ulcersDG52
MRI fusion biopsy systems for diagnosing prostate cancerDG53
Intramuscular diaphragm stimulation for ventilator-dependent chronic respiratory failure from high spinal cord injuriesIPG762
Head injury: assessment and early managementNG232
Risankizumab for previously treated moderately to severely active Crohn's diseaseTA888
Ciltacabtagene autoleucel for treating relapsed or refractory multiple myeloma (terminated appraisal)TA889
Difelikefalin for treating pruritus in people having haemodialysisTA890
Diabetes (type 1 and type 2) in children and young people: diagnosis and managementNG18
Olaparib for adjuvant treatment of BRCA mutation-positive HER2-negative high-risk early breast cancer after chemotherapyTA886
Olaparib for previously treated BRCA mutation-positive hormone-relapsed metastatic prostate cancerTA887
Ripretinib for treating advanced gastrointestinal stromal tumour after 3 or more treatmentsTA881
Voclosporin with mycophenolate mofetil for treating lupus nephritisTA882
Tafasitamab with lenalidomide for treating relapsed or refractory diffuse large B-cell lymphomaTA883
Capmatinib for treating advanced non-small-cell lung cancer with MET exon 14 skipping (terminated appraisal)TA884
Metastatic malignant disease of unknown primary origin in adults: diagnosis and managementCG104
Tezepelumab for treating severe asthmaTA880
Lumasiran for treating primary hyperoxaluria type 1HST25
Onasemnogene abeparvovec for treating spinal muscular atrophyHST15
Eladocagene exuparvovec for treating aromatic L-amino acid decarboxylase deficiencyHST26
Onasemnogene abeparvovec for treating presymptomatic spinal muscular atrophyHST24
Daytime intraoral neuromuscular electrical tongue stimulation using a removable device for obstructive sleep apnoeaIPG760
Endoscopic ultrasound-guided biliary drainage for biliary obstructionIPG761
Hypertension in pregnancy: diagnosis and managementNG133
AposHealth for knee osteoarthritisMTG76
Trastuzumab deruxtecan for treating HER2-positive unresectable or metastatic gastric or gastro-oesophageal junction cancer after anti-HER2 treatment (terminated appraisal)TA879
Radiofrequency ablation as an adjunct to balloon kyphoplasty or percutaneous vertebroplasty for palliation of painful spinal metastasesIPG759
Percutaneous thoracic duct embolisation for persistent chyle leakIPG755
Focal therapy using high-intensity focused ultrasound for localised prostate cancerIPG756
Maximal cytoreductive surgery for advanced ovarian cancerIPG757
Radiofrequency ablation for palliation of painful spinal metastasesIPG758
UrgoStart for treating diabetic foot ulcers and leg ulcersMTG42
Finerenone for treating chronic kidney disease in type 2 diabetesTA877
Nivolumab with chemotherapy for neoadjuvant treatment of resectable non-small-cell lung cancerTA876
Asfotase alfa for treating paediatric-onset hypophosphatasiaHST23
Endoluminal gastroplication for gastro-oesophageal reflux diseaseIPG753
Percutaneous transluminal renal sympathetic denervation for resistant hypertensionIPG754
Eptinezumab for preventing migraineTA871
Cannabidiol for treating seizures caused by tuberous sclerosis complexTA873
Polatuzumab vedotin in combination for untreated diffuse large B-cell lymphomaTA874
Axicabtagene ciloleucel for treating diffuse large B-cell lymphoma and primary mediastinal large B-cell lymphoma after 2 or more systemic therapiesTA872
Ataluren for treating Duchenne muscular dystrophy with a nonsense mutation in the dystrophin geneHST22
Ixazomib with lenalidomide and dexamethasone for treating relapsed or refractory multiple myelomaTA870
Mitapivat for treating pyruvate kinase deficiency (terminated appraisal)TA867
Teclistamab for treating relapsed or refractory multiple myeloma after 3 or more therapies (terminated appraisal)TA869
Vutrisiran for treating hereditary transthyretin-related amyloidosisTA868
Barrett's oesophagus and stage 1 oesophageal adenocarcinoma: monitoring and managementNG231
Nivolumab with fluoropyrimidine- and platinum-based chemotherapy for untreated unresectable advanced, recurrent, or metastatic oesophageal squamous cell carcinomaTA865
Regorafenib for previously treated metastatic colorectal cancerTA866
Transvenous obliteration for gastric varicesIPG751
Biodegradable spacer insertion to reduce rectal toxicity during radiotherapy for prostate cancerIPG752
Upadacitinib for treating active non-radiographic axial spondyloarthritisTA861
Trastuzumab deruxtecan for treating HER2-positive unresectable or metastatic breast cancer after 1 or more anti-HER2 treatmentsTA862
Somatrogon for treating growth disturbance in children and young people aged 3 years and overTA863
Nintedanib for treating idiopathic pulmonary fibrosis when forced vital capacity is above 80% predictedTA864
Delirium: prevention, diagnosis and management in hospital and long-term careCG103
Maribavir for treating refractory cytomegalovirus infection after transplantTA860
Trabeculectomy with a biodegradable collagen matrix implant for glaucomaIPG750
Tobacco: preventing uptake, promoting quitting and treating dependenceNG209
Angiotensin II for treating vasosuppressor-resistant hypotension caused by septic or distributive shock (terminated appraisal)TA859
Disabled children and young people up to 25 with severe complex needs: integrated service delivery and organisation across health, social care and educationNG213
MRI-based technologies for assessing non-alcoholic fatty liver diseaseDG50
Laparoscopic insertion of a magnetic ring for gastro-oesophageal reflux diseaseIPG749
Transcutaneous electrical stimulation of the trigeminal nerve for ADHDIPG748
Nivolumab with platinum- and fluoropyrimidine-based chemotherapy for untreated HER2-negative advanced gastric, gastro-oesophageal junction or oesophageal adenocarcinomaTA857
Lenvatinib with pembrolizumab for untreated advanced renal cell carcinomaTA858
Hip fracture: managementCG124
Percutaneous image-guided cryoablation of peripheral neuroma for chronic painIPG747
Upadacitinib for treating moderately to severely active ulcerative colitisTA856
Thyroid cancer: assessment and managementNG230
Avatrombopag for treating primary chronic immune thrombocytopeniaTA853
Fetal monitoring in labourNG229
Cabozantinib for previously treated advanced hepatocellular carcinomaTA849
Amivantamab for treating EGFR exon 20 insertion mutation-positive advanced non-small-cell lung cancer after platinum-based chemotherapyTA850
Pembrolizumab for neoadjuvant and adjuvant treatment of triple-negative early or locally advanced breast cancerTA851
Trifluridine–tipiracil for treating metastatic gastric cancer or gastro-oesophageal junction adenocarcinoma after 2 or more treatmentsTA852
Esketamine nasal spray for treatment-resistant depressionTA854
Memokath 051 Ureter stent for ureteric obstructionMTG75
Cemiplimab for untreated PD-L1-positive advanced or metastatic non-small-cell lung cancer (terminated appraisal)TA848
Optilume for treating recurrent bulbar urethral stricturesMTG73
GreenLight XPS for treating benign prostatic hyperplasiaMTG74
Mepolizumab for treating eosinophilic granulomatosis with polyangiitis (terminated appraisal)TA845
Mepolizumab for treating severe hypereosinophilic syndrome (terminated appraisal)TA846
Mepolizumab for treating severe chronic rhinosinusitis with nasal polyps (terminated appraisal)TA847
Luspatercept for treating anaemia caused by myelodysplastic syndromes (terminated appraisal)TA844
Luspatercept for treating anaemia caused by beta-thalassaemia (terminated appraisal)TA843
Tunnelled peritoneal drainage catheter insertion for refractory ascites in cirrhosisIPG746
Fractures (complex): assessment and managementNG37
Subarachnoid haemorrhage caused by a ruptured aneurysm: diagnosis and managementNG228
Ab interno canaloplasty for open-angle glaucomaIPG745
Carfilzomib with daratumumab and dexamethasone for treating relapsed or refractory multiple myeloma (terminated appraisal)TA841
Tisagenlecleucel for treating follicular lymphoma after 2 or more therapies (terminated appraisal)TA842
Percutaneous ultrasound-guided microwave ablation for symptomatic benign thyroid nodulesIPG743
Ruxolitinib for treating acute graft versus host disease refractory to corticosteroids (terminated appraisal)TA839
Ruxolitinib for treating chronic graft versus host disease refractory to corticosteroids (terminated appraisal)TA840
Extracorporeal shockwave therapy for calcific tendinopathy in the shoulderIPG742
Advocacy services for adults with health and social care needsNG227
Slow-release potassium bicarbonate–potassium citrate for treating distal renal tubular acidosis (terminated appraisal)TA838
Transcutaneous electrical stimulation of the supraorbital nerve for treating and preventing migraineIPG740
YAG laser vitreolysis for symptomatic vitreous floatersIPG741
Pembrolizumab for adjuvant treatment of resected stage 2B or 2C melanomaTA837
Palbociclib with fulvestrant for treating hormone receptor-positive, HER2-negative advanced breast cancer after endocrine therapyTA836
Osteoarthritis in over 16s: diagnosis and managementNG226
Pembrolizumab for adjuvant treatment of renal cell carcinomaTA830
Relugolix–estradiol–norethisterone acetate for treating moderate to severe symptoms of uterine fibroidsTA832
Zanubrutinib for treating Waldenstrom's macroglobulinaemiaTA833
Fostamatinib for treating refractory chronic immune thrombocytopeniaTA835
SQ HDM SLIT for treating allergic rhinitis and allergic asthma caused by house dust mites (terminated appraisal)TA834
Magtrace and Sentimag system for locating sentinel lymph nodes for breast cancerMTG72
Oral azacitidine for maintenance treatment of acute myeloid leukaemia after induction therapyTA827
Ozanimod for treating moderately to severely active ulcerative colitisTA828
Upadacitinib for treating active ankylosing spondylitisTA829
Atezolizumab for adjuvant treatment of resected non-small-cell lung cancerTA823
Neurostimulation of lumbar muscles for refractory non-specific chronic low back painIPG739
Prostatic urethral temporary implant insertion for lower urinary tract symptoms caused by benign prostatic hyperplasiaIPG737
Removal, preservation and subsequent reimplantation of ovarian tissue to prevent symptoms from the menopauseIPG738
Neuropad for detecting preclinical diabetic peripheral neuropathyMTG38
Avacopan for treating severe active granulomatosis with polyangiitis or microscopic polyangiitisTA825
Vedolizumab for treating chronic refractory pouchitis after surgery for ulcerative colitis (terminated appraisal)TA826
Colorectal cancer prevention: colonoscopic surveillance in adults with ulcerative colitis, Crohn's disease or adenomasCG118
Melphalan for haematological diseases before allogeneic haematopoietic stem cell transplant (terminated appraisal)TA822
Dexamethasone intravitreal implant for treating diabetic macular oedemaTA824
Self-harm: assessment, management and preventing recurrenceNG225
Faecal microbiota transplant for recurrent Clostridioides difficile infectionMTG71
Brolucizumab for treating diabetic macular oedemaTA820
iFuse for treating chronic sacroiliac joint painMTG39
Focal resurfacing implants to treat articular cartilage damage in the kneeIPG734
Transcutaneous electrical neuromuscular stimulation for urinary incontinenceIPG735
Superficial venous arterialisation for chronic limb threatening ischaemiaIPG736
Avalglucosidase alfa for treating Pompe diseaseTA821
Type 1 diabetes in adults: diagnosis and managementNG17
Sacituzumab govitecan for treating unresectable triple-negative advanced breast cancer after 2 or more therapiesTA819
Nivolumab with ipilimumab for untreated unresectable malignant pleural mesotheliomaTA818
SecurAcath for securing percutaneous cathetersMTG34
Guselkumab for treating active psoriatic arthritis after inadequate response to DMARDsTA815
Alpelisib with fulvestrant for treating hormone receptor-positive, HER2-negative, PIK3CA-mutated advanced breast cancerTA816
Nivolumab for adjuvant treatment of invasive urothelial cancer at high risk of recurrenceTA817
Bioresorbable stent implantation to treat coronary artery diseaseIPG732
Aortic remodelling hybrid stent insertion during surgical repair of an acute type A aortic dissectionIPG733
Pralsetinib for treating RET fusion-positive advanced non-small-cell lung cancerTA812
Asciminib for treating chronic myeloid leukaemia after 2 or more tyrosine kinase inhibitorsTA813
Abrocitinib, tralokinumab or upadacitinib for treating moderate to severe atopic dermatitisTA814
PLGF-based testing to help diagnose suspected preterm pre-eclampsiaDG49
Transcatheter tricuspid valve annuloplasty for tricuspid regurgitationIPG730
Transcatheter tricuspid valve leaflet repair for tricuspid regurgitationIPG731
Melanoma: assessment and managementNG14
Urinary tract infection in under 16s: diagnosis and managementNG224
Duvelisib for treating relapsed or refractory chronic lymphocytic leukaemia after 2 or more treatments (terminated appraisal)TA811
Imlifidase for desensitisation treatment before kidney transplant in people with chronic kidney diseaseTA809
Abemaciclib with endocrine therapy for adjuvant treatment of hormone receptor-positive, HER2-negative, node-positive early breast cancer at high risk of recurrenceTA810
PeritX peritoneal catheter drainage system for vacuum-assisted drainage of treatment-resistant, recurrent malignant ascitesMTG9
Risankizumab for treating active psoriatic arthritis after inadequate response to DMARDsTA803
Icosapent ethyl with statin therapy for reducing the risk of cardiovascular events in people with raised triglyceridesTA805
Belimumab for treating lupus nephritis (terminated appraisal)TA806
Roxadustat for treating symptomatic anaemia in chronic kidney diseaseTA807
Fenfluramine for treating seizures associated with Dravet syndromeTA808
Setmelanotide for treating obesity caused by LEPR or POMC deficiencyHST21
Social, emotional and mental wellbeing in primary and secondary educationNG223
MiraQ for assessing graft flow during coronary artery bypass graft surgeryMTG8
Teduglutide for treating short bowel syndromeTA804
Vertebral body tethering for idiopathic scoliosis in children and young peopleIPG728
Nerve graft for corneal denervationIPG729
Depression in adults: treatment and managementNG222
Type 2 diabetes in adults: managementNG28
Faricimab for treating diabetic macular oedemaTA799
Faricimab for treating wet age-related macular degenerationTA800
Pembrolizumab plus chemotherapy for untreated, triple-negative, locally recurrent unresectable or metastatic breast cancerTA801
Cemiplimab for treating advanced cutaneous squamous cell carcinomaTA802
Multiple sclerosis in adults: managementNG220
Durvalumab for maintenance treatment of unresectable non-small-cell lung cancer after platinum-based chemoradiationTA798
Reducing sexually transmitted infectionsNG221
Venetoclax for treating chronic lymphocytic leukaemiaTA796
Enfortumab vedotin for previously treated locally advanced or metastatic urothelial cancer (terminated appraisal)TA797
Preterm labour and birthNG25
Gout: diagnosis and managementNG219
Anifrolumab for treating active autoantibody-positive systemic lupus erythematosus (terminated appraisal)TA793
Diroximel fumarate for treating relapsing–remitting multiple sclerosisTA794
Ibrutinib for treating Waldenstrom's macroglobulinaemiaTA795
Peristeen Plus transanal irrigation system for managing bowel dysfunctionMTG36
Thopaz+ portable digital system for managing chest drainsMTG37
Synthetic cartilage implant insertion for first metatarsophalangeal joint osteoarthritis (hallux rigidus)IPG727
Filgotinib for treating moderately to severely active ulcerative colitisTA792
Social work with adults experiencing complex needsNG216
Endoanchoring systems in endovascular aortic aneurysm repairIPG725
Supercapsular percutaneously assisted total hip arthroplasty for osteoarthritisIPG726
TYRX Absorbable Antibacterial Envelope for preventing infection from cardiac implantable electronic devices (terminated appraisal)TA790
Romosozumab for treating severe osteoporosisTA791
Sleepio to treat insomnia and insomnia symptomsMTG70
Personalised external aortic root support (PEARS) using mesh to prevent aortic root expansion and aortic dissection in people with Marfan syndromeIPG724
Tepotinib for treating advanced non-small-cell lung cancer with MET gene alterationsTA789
Vaccine uptake in the general populationNG218
Avelumab for maintenance treatment of locally advanced or metastatic urothelial cancer after platinum-based chemotherapyTA788
Selumetinib for treating symptomatic and inoperable plexiform neurofibromas associated with type 1 neurofibromatosis in children aged 3 and overHST20
Liposuction for chronic lymphoedemaIPG723
Epilepsies in children, young people and adultsNG217
Tucatinib with trastuzumab and capecitabine for treating HER2-positive advanced breast cancer after 2 or more anti-HER2 therapiesTA786
Venetoclax with low dose cytarabine for untreated acute myeloid leukaemia when intensive chemotherapy is unsuitableTA787
Elosulfase alfa for treating mucopolysaccharidosis type 4AHST19
Intramedullary distraction for upper limb lengtheningIPG722
Medicines associated with dependence or withdrawal symptoms: safe prescribing and withdrawal management for adultsNG215
Niraparib for maintenance treatment of relapsed, platinum-sensitive ovarian, fallopian tube and peritoneal cancerTA784
Nivolumab with cabozantinib for untreated advanced renal cell carcinoma (terminated appraisal)TA785
Stroke and transient ischaemic attack in over 16s: diagnosis and initial managementNG128
Daratumumab monotherapy for treating relapsed and refractory multiple myelomaTA783
myCOPD for managing chronic obstructive pulmonary diseaseMTG68
UroShield for preventing catheter-associated urinary tract infectionsMTG69
Freelite assays for diagnosing multiple myeloma and related conditions (terminated assessment)DG47
Sotorasib for previously treated KRAS G12C mutation-positive advanced non-small-cell lung cancerTA781
Tagraxofusp for treating blastic plasmacytoid dendritic cell neoplasm (terminated appraisal)TA782
Liposuction for chronic lipoedemaIPG721
Atidarsagene autotemcel for treating metachromatic leukodystrophyHST18
Nivolumab with ipilimumab for untreated advanced renal cell carcinomaTA780
Integrated health and social care for people experiencing homelessnessNG214
Dostarlimab for previously treated advanced or recurrent endometrial cancer with high microsatellite instability or mismatch repair deficiencyTA779
Otitis media (acute): antimicrobial prescribingNG91
Percutaneous insertion of a cystic duct stent after cholecystostomy for acute calculous cholecystitisIPG720
Lenalidomide for relapsed or refractory mantle cell lymphoma (terminated appraisal)TA774
Empagliflozin for treating chronic heart failure with reduced ejection fractionTA773
Dapagliflozin for treating chronic kidney diseaseTA775
Pitolisant hydrochloride for treating excessive daytime sleepiness caused by obstructive sleep apnoeaTA776
Solriamfetol for treating excessive daytime sleepiness caused by obstructive sleep apnoeaTA777
Pegcetacoplan for treating paroxysmal nocturnal haemoglobinuriaTA778
Prontosan for treating acute and chronic woundsMTG67
3C Patch for treating diabetic foot ulcersMTG66
Endoscopic full thickness removal of gastrointestinal stromal tumours of the stomachIPG717
Intramedullary distraction for lower limb lengtheningIPG718
Endoscopic balloon dilation for subglottic or tracheal stenosisIPG719
Mental wellbeing at workNG212
PredictSURE IBD and IBDX to guide treatment of Crohn's diseaseDG45
EarlyCDT Lung for assessing risk of lung cancer in solid lung nodulesDG46
Pembrolizumab for treating relapsed or refractory classical Hodgkin lymphoma after stem cell transplant or at least 2 previous therapiesTA772
Odevixibat for treating progressive familial intrahepatic cholestasisHST17
Pembrolizumab with carboplatin and paclitaxel for untreated metastatic squamous non-small-cell lung cancerTA770
Daratumumab with bortezomib, melphalan and prednisone for untreated multiple myeloma (terminated appraisal)TA771
Stereotactic radiosurgery for trigeminal neuralgiaIPG715
Microwave ablation for primary or metastatic cancer in the lungIPG716
Olaparib for treating BRCA mutation-positive HER2-negative metastatic breast cancer after chemotherapy (terminated appraisal)TA762
Daratumumab in combination for untreated multiple myeloma when a stem cell transplant is suitableTA763
Fremanezumab for preventing migraineTA764
Venetoclax with azacitidine for untreated acute myeloid leukaemia when intensive chemotherapy is unsuitableTA765
Pembrolizumab for adjuvant treatment of completely resected stage 3 melanomaTA766
Ponesimod for treating relapsing–remitting multiple sclerosisTA767
Upadacitinib for treating active psoriatic arthritis after inadequate response to DMARDsTA768
Palforzia for treating peanut allergy in children and young peopleTA769
Sedaconda ACD-S for sedation with volatile anaesthetics in intensive careMTG65
Glaucoma: diagnosis and managementNG81
Sodium zirconium cyclosilicate for treating hyperkalaemiaTA599
Osimertinib for adjuvant treatment of EGFR mutation-positive non-small-cell lung cancer after complete tumour resectionTA761
Rehabilitation after traumatic injuryNG211
Selpercatinib for previously treated RET fusion-positive advanced non-small-cell lung cancerTA760
Cabotegravir with rilpivirine for treating HIV-1TA757
Solriamfetol for treating excessive daytime sleepiness caused by narcolepsyTA758
Headaches in over 12s: diagnosis and managementCG150
Endo-SPONGE for treating low rectal anastomotic leakMTG63
Fedratinib for treating disease-related splenomegaly or symptoms in myelofibrosisTA756
Transanal total mesorectal excision for rectal cancerIPG713
Endobronchial nerve ablation for chronic obstructive pulmonary diseaseIPG714
Colorectal cancerNG151
Prostate cancer: diagnosis and managementNG131
Belimumab for treating active autoantibody-positive systemic lupus erythematosusTA752
Cenobamate for treating focal onset seizures in epilepsyTA753
Mogamulizumab for previously treated mycosis fungoides and Sézary syndromeTA754
ClearGuard HD antimicrobial barrier caps for preventing haemodialysis catheter-related bloodstream infectionsMTG62
Pelvic floor dysfunction: prevention and non-surgical managementNG210
Olaparib for maintenance treatment of BRCA mutation-positive metastatic pancreatic cancer after platinum-based chemotherapy (terminated appraisal)TA750
Dupilumab for treating severe asthma with type 2 inflammationTA751
Mexiletine for treating the symptoms of myotonia in non-dystrophic myotonic disordersTA748
Liraglutide for managing obesity in people aged 12 to 17 years (terminated appraisal)TA749
Synergo for non-muscle-invasive bladder cancerMTG61
Fever in under 5s: assessment and initial managementNG143
Givosiran for treating acute hepatic porphyriaHST16
Percutaneous implantation of pulmonary artery pressure sensors for monitoring treatment of chronic heart failureIPG711
Coronary sinus narrowing device implantation for refractory anginaIPG712
Chronic kidney disease: assessment and managementNG203
SeHCAT (tauroselcholic [75 selenium] acid) for diagnosing bile acid diarrhoeaDG44
Acute heart failure: diagnosis and managementCG187
Heart valve disease presenting in adults: investigation and managementNG208
Nivolumab for adjuvant treatment of resected oesophageal or gastro-oesophageal junction cancerTA746
Nintedanib for treating progressive fibrosing interstitial lung diseasesTA747
Upadacitinib for treating moderate rheumatoid arthritisTA744
NBTXR-3 for treating advanced soft tissue sarcoma (terminated appraisal)TA745
Inducing labourNG207
Selpercatinib for treating advanced thyroid cancer with RET alterationsTA742
Myalgic encephalomyelitis (or encephalopathy)/chronic fatigue syndrome: diagnosis and managementNG206
Apalutamide with androgen deprivation therapy for treating high-risk hormone-relapsed non-metastatic prostate cancerTA740
Apalutamide with androgen deprivation therapy for treating hormone-sensitive metastatic prostate cancerTA741
Genicular artery embolisation for pain from knee osteoarthritisIPG708
Laparoscopic renal denervation for loin pain haematuria syndromeIPG709
Percutaneous endovascular forearm arteriovenous fistula creation for haemodialysis accessIPG710
Atezolizumab for untreated PD-L1-positive advanced urothelial cancer when cisplatin is unsuitableTA739
Looked-after children and young peopleNG205
Tofacitinib for treating juvenile idiopathic arthritisTA735
Nivolumab for treating recurrent or metastatic squamous cell carcinoma of the head and neck after platinum-based chemotherapyTA736
Pembrolizumab with platinum- and fluoropyrimidine-based chemotherapy for untreated advanced oesophageal and gastro-oesophageal junction cancerTA737
Berotralstat for preventing recurrent attacks of hereditary angioedemaTA738
Secukinumab for treating moderate to severe plaque psoriasis in children and young peopleTA734
Baloxavir marboxil for treating acute uncomplicated influenza (terminated appraisal)TA732
Inclisiran for treating primary hypercholesterolaemia or mixed dyslipidaemiaTA733
DyeVert Systems for reducing the risk of acute kidney injury in coronary and peripheral angiographyMTG60
Avapritinib for treating unresectable or metastatic gastrointestinal stromal tumours (terminated appraisal)TA730
Vericiguat for treating chronic heart failure with reduced ejection fraction (terminated appraisal)TA731
Lateral elbow resurfacing for arthritisIPG705
Transapical transcatheter mitral valve-in-valve implantation for a failed surgically implanted mitral valve bioprosthesisIPG706
Transapical transcatheter mitral valve-in-ring implantation after failed annuloplasty for mitral valve repairIPG707
Daratumumab with pomalidomide and dexamethasone for treating relapsed or refractory multiple myeloma (terminated appraisal)TA726
Isatuximab with carfilzomib and dexamethasone for treating relapsed or refractory multiple myeloma (terminated appraisal)TA727
Midostaurin for treating advanced systemic mastocytosisTA728
Sapropterin for treating hyperphenylalaninaemia in phenylketonuriaTA729
Abemaciclib with fulvestrant for treating hormone receptor-positive, HER2-negative advanced breast cancer after endocrine therapyTA725
Nivolumab with ipilimumab and chemotherapy for untreated metastatic non-small-cell lung cancerTA724
Bimekizumab for treating moderate to severe plaque psoriasisTA723
Magnetic resonance therapy for knee osteoarthritisIPG702
Laparoscopic removal of uterine fibroids with power morcellationIPG703
Hysteroscopic mechanical tissue removal (hysteroscopic morcellation) for uterine fibroidsIPG704
Babies, children and young people's experience of healthcareNG204
Pemigatinib for treating relapsed or refractory advanced cholangiocarcinoma with FGFR2 fusion or rearrangementTA722
Obstructive sleep apnoea/hypopnoea syndrome and obesity hypoventilation syndrome in over 16sNG202
Continuous positive airway pressure for the treatment of obstructive sleep apnoea/hypopnoea syndromeTA139
Antenatal careNG201
Chlormethine gel for treating mycosis fungoides-type cutaneous T-cell lymphomaTA720
Abiraterone for treating newly diagnosed high-risk hormone-sensitive metastatic prostate cancerTA721
Bronchiolitis in children: diagnosis and managementNG9
Inducing and maintaining normothermia using temperature modulation devices to improve outcomes after stroke or subarachnoid haemorrhageIPG701
Nivolumab with ipilimumab for previously treated metastatic colorectal cancer with high microsatellite instability or mismatch repair deficiencyTA716
Clostridioides difficile infection: antimicrobial prescribingNG199
ENDURALIFE powered CRT-D devices for treating heart failureMTG33
Duvelisib for treating relapsed follicular lymphoma after 2 or more systemic therapies (terminated appraisal)TA717
Ixekizumab for treating axial spondyloarthritisTA718
Secukinumab for treating non-radiographic axial spondyloarthritisTA719
Dasatinib for treating Philadelphia-chromosome-positive acute lymphoblastic leukaemia (terminated appraisal)TA714
Adalimumab, etanercept, infliximab and abatacept for treating moderate rheumatoid arthritis after conventional DMARDs have failedTA715
Enzalutamide for treating hormone-sensitive metastatic prostate cancerTA712
Nivolumab for advanced non-squamous non-small-cell lung cancer after chemotherapyTA713
Apixaban for preventing stroke and systemic embolism in people with non-valvular atrial fibrillationTA275
Dabigatran etexilate for the prevention of stroke and systemic embolism in atrial fibrillationTA249
Rivaroxaban for the prevention of stroke and systemic embolism in people with atrial fibrillationTA256
Edoxaban for preventing stroke and systemic embolism in people with non-valvular atrial fibrillationTA355
Atrial fibrillation: diagnosis and managementNG196
Plus Sutures for preventing surgical site infectionMTG59
Laser lithotripsy for difficult-to-treat bile duct stonesIPG699
Percutaneous insertion of a closure device to repair a paravalvular leak around a replaced mitral or aortic valveIPG700
Budesonide orodispersible tablet for inducing remission of eosinophilic oesophagitisTA708
Pembrolizumab for untreated metastatic colorectal cancer with high microsatellite instability or mismatch repair deficiencyTA709
Ravulizumab for treating atypical haemolytic uraemic syndromeTA710
Patient experience in adult NHS services: improving the experience of care for people using adult NHS servicesCG138
Shared decision makingNG197
Nivolumab for previously treated unresectable advanced or recurrent oesophageal cancerTA707
Autism spectrum disorder in adults: diagnosis and managementCG142
Autism spectrum disorder in under 19s: support and managementCG170
Ozanimod for treating relapsing–remitting multiple sclerosisTA706
Atezolizumab monotherapy for untreated advanced non-small-cell lung cancerTA705
Electrohydraulic lithotripsy for difficult-to-treat bile duct stonesIPG698
Ex-situ machine perfusion for extracorporeal preservation of lungs (ex-vivo lung perfusion) for transplantIPG695
Transvaginal laser therapy for stress urinary incontinenceIPG696
Transvaginal laser therapy for urogenital atrophyIPG697
Ibrutinib with obinutuzumab for untreated chronic lymphocytic leukaemia and small lymphocytic lymphoma (terminated appraisal)TA702
Ibrutinib with rituximab for untreated chronic lymphocytic leukaemia (terminated appraisal)TA703
Trastuzumab deruxtecan for treating HER2-positive unresectable or metastatic breast cancer after 2 or more anti-HER2 therapiesTA704
Heavy menstrual bleeding: assessment and managementNG88
HeartFlow FFRCT for estimating fractional flow reserve from coronary CT angiographyMTG32
Parafricta Bootees and Undergarments to reduce skin breakdown in people with or at risk of pressure ulcersMTG20
Ravulizumab for treating paroxysmal nocturnal haemoglobinuriaTA698
Ofatumumab for treating relapsing multiple sclerosisTA699
Selinexor with low-dose dexamethasone for treating refractory multiple myeloma (terminated appraisal)TA700
Crisaborole for treating mild to moderate atopic dermatitis in people 2 years and older (terminated appraisal)TA701
Tafamidis for treating transthyretin amyloidosis with cardiomyopathyTA696
Andexanet alfa for reversing anticoagulation from apixaban or rivaroxabanTA697
Permanent His-bundle pacemaker implantation for treating heart failureIPG694
UroLift for treating lower urinary tract symptoms of benign prostatic hyperplasiaMTG58
Repetitive short-pulse transscleral cyclophotocoagulation for glaucomaIPG692
Deep brain stimulation for chronic, severe, treatment-resistant obsessive-compulsive disorder in adultsIPG693
Pembrolizumab for treating locally advanced or metastatic urothelial carcinoma after platinum-containing chemotherapyTA692
Bempedoic acid with ezetimibe for treating primary hypercholesterolaemia or mixed dyslipidaemiaTA694
Carfilzomib with dexamethasone and lenalidomide for previously treated multiple myelomaTA695
Melphalan chemosaturation with percutaneous hepatic artery perfusion and hepatic vein isolation for primary or metastatic cancer in the liverIPG691
Avelumab for treating metastatic Merkel cell carcinomaTA517
Acalabrutinib for treating chronic lymphocytic leukaemiaTA689
Avelumab for untreated metastatic Merkel cell carcinomaTA691
Postnatal careNG194
Chronic pain (primary and secondary) in over 16s: assessment of all chronic pain and management of chronic primary painNG193
Transcervical ultrasound-guided radiofrequency ablation for symptomatic uterine fibroidsIPG689
Extracorporeal whole liver perfusion for acute liver failureIPG690
Danis stent for acute oesophageal variceal bleedingMTG57
Anakinra for treating Still's diseaseTA685
Blinatumomab for previously treated Philadelphia-chromosome-positive acute lymphoblastic leukaemia (terminated appraisal)TA686
Ribociclib with fulvestrant for treating hormone receptor-positive, HER2-negative advanced breast cancer after endocrine therapyTA687
Selective internal radiation therapies for treating hepatocellular carcinomaTA688
Cannabis-based medicinal productsNG144
Asthma: diagnosis, monitoring and chronic asthma managementNG80
QAngio XA 3D QFR and CAAS vFFR imaging software for assessing coronary stenosis during invasive coronary angiographyDG43
Nivolumab for adjuvant treatment of completely resected melanoma with lymph node involvement or metastatic diseaseTA684
Erenumab for preventing migraineTA682
Pembrolizumab with pemetrexed and platinum chemotherapy for untreated, metastatic, non-squamous non-small-cell lung cancerTA683
Alpha-Stim AID for anxiety disordersMTG56
Free-functioning gracilis transfer to restore upper limb function in brachial plexus injuryIPG687
Cytoreduction surgery with hyperthermic intraoperative peritoneal chemotherapy for peritoneal carcinomatosisIPG688
Lenalidomide maintenance treatment after an autologous stem cell transplant for newly diagnosed multiple myelomaTA680
Baricitinib for treating moderate to severe atopic dermatitisTA681
Secondary bacterial infection of eczema and other common skin conditions: antimicrobial prescribingNG190
Safeguarding adults in care homesNG189
Metreleptin for treating lipodystrophyHST14
Filgotinib for treating moderate to severe rheumatoid arthritisTA676
Brexucabtagene autoleucel for treating relapsed or refractory mantle cell lymphomaTA677
Omalizumab for treating chronic rhinosinusitis with nasal polyps (terminated appraisal)TA678
Dapagliflozin for treating chronic heart failure with reduced ejection fractionTA679
Niraparib for maintenance treatment of advanced ovarian, fallopian tube and peritoneal cancer after response to first-line platinum-based chemotherapyTA673
Pembrolizumab for untreated PD-L1-positive, locally advanced or metastatic urothelial cancer when cisplatin is unsuitable (terminated appraisal)TA674
Vernakalant for the rapid conversion of recent onset atrial fibrillation to sinus rhythm (terminated appraisal)TA675
Trabectedin for the treatment of advanced soft tissue sarcomaTA185
Leukomed Sorbact for preventing surgical site infectionMTG55
Mepolizumab for treating severe eosinophilic asthmaTA671
Brolucizumab for treating wet age-related macular degenerationTA672
Brain tumours (primary) and brain metastases in over 16sNG99
Self-expanding implant insertion into the intersphincteric space for faecal incontinenceIPG685
Minimally invasive radical hysterectomy for early stage cervical cancerIPG686
The VAC Veraflo Therapy system for acute infected or chronic wounds that are failing to healMTG54
Brigatinib for ALK-positive advanced non-small-cell lung cancer that has not been previously treated with an ALK inhibitorTA670
The PLASMA system for transurethral resection and haemostasis of the prostateMTG53
Encorafenib plus cetuximab for previously treated BRAF V600E mutation-positive metastatic colorectal cancerTA668
PancreatitisNG104
Diabetes in pregnancy: management from preconception to the postnatal periodNG3
Eating disorders: recognition and treatmentNG69
Atezolizumab with bevacizumab for treating advanced or unresectable hepatocellular carcinomaTA666
Caplacizumab with plasma exchange and immunosuppression for treating acute acquired thrombotic thrombocytopenic purpuraTA667
Peripheral arterial disease: diagnosis and managementCG147
Low back pain and sciatica in over 16s: assessment and managementNG59
Venetoclax with obinutuzumab for untreated chronic lymphocytic leukaemiaTA663
Liraglutide for managing overweight and obesityTA664
Upadacitinib for treating severe rheumatoid arthritisTA665
Zio XT for detecting cardiac arrhythmiasMTG52
Darolutamide with androgen deprivation therapy for treating hormone-relapsed non-metastatic prostate cancerTA660
Pembrolizumab for untreated metastatic or unresectable recurrent head and neck squamous cell carcinomaTA661
Durvalumab in combination for untreated extensive-stage small-cell lung cancer (terminated appraisal)TA662
Swallowable gastric balloon capsule for weight lossIPG684
Acute coronary syndromesNG185
Drug-eluting stents for the treatment of coronary artery diseaseTA152
Guidance on the use of coronary artery stentsTA71
Siponimod for treating secondary progressive multiple sclerosisTA656
Carfilzomib for previously treated multiple myelomaTA657
Isatuximab with pomalidomide and dexamethasone for treating relapsed and refractory multiple myelomaTA658
Galcanezumab for preventing migraineTA659
Human and animal bites: antimicrobial prescribingNG184
Testing strategies for Lynch syndrome in people with endometrial cancerDG42
Pressurised intraperitoneal aerosol chemotherapy for peritoneal carcinomatosisIPG681
Balloon cryoablation for Barrett's oesophagusIPG682
Balloon cryoablation for squamous dysplasia of the oesophagusIPG683
Volanesorsen for treating familial chylomicronaemia syndromeHST13
Nivolumab for advanced squamous non-small-cell lung cancer after chemotherapyTA655
SEM Scanner 200 for preventing pressure ulcersMTG51
Osimertinib for treating EGFR T790M mutation-positive advanced non-small-cell lung cancerTA653
Osimertinib for untreated EGFR mutation-positive non-small-cell lung cancerTA654
Rheumatoid arthritis in adults: managementNG100
Behaviour change: digital and mobile health interventionsNG183
Pembrolizumab with axitinib for untreated advanced renal cell carcinomaTA650
Naldemedine for treating opioid-induced constipationTA651
Transcranial magnetic stimulation for auditory hallucinationsIPG680
Polatuzumab vedotin with rituximab and bendamustine for treating relapsed or refractory diffuse large B-cell lymphomaTA649
Neuropathic pain in adults: pharmacological management in non-specialist settingsCG173
Insect bites and stings: antimicrobial prescribingNG182
Dupilumab for treating chronic rhinosinusitis with nasal polyps (terminated appraisal)TA648
Axonics sacral neuromodulation system for treating refractory overactive bladderMTG50
Implantable cardiac monitors to detect atrial fibrillation after cryptogenic strokeDG41
Glasdegib with chemotherapy for untreated acute myeloid leukaemia (terminated appraisal)TA646
Eculizumab for treating relapsing neuromyelitis optica (terminated appraisal)TA647
Avelumab with axitinib for untreated advanced renal cell carcinomaTA645
High-sensitivity troponin tests for the early rule out of NSTEMIDG40
Anaphylaxis: assessment and referral after emergency treatmentCG134
Perioperative care in adultsNG180
Rehabilitation for adults with complex psychosisNG181
Surgical site infections: prevention and treatmentNG125
Deep brain stimulation for refractory epilepsy in adultsIPG678
Implanted vagus nerve stimulation for treatment-resistant depressionIPG679
Brentuximab vedotin in combination for untreated systemic anaplastic large cell lymphomaTA641
Gilteritinib for treating relapsed or refractory acute myeloid leukaemiaTA642
Entrectinib for treating ROS1-positive advanced non-small-cell lung cancerTA643
Entrectinib for treating NTRK fusion-positive solid tumoursTA644
Transcranial magnetic stimulation for obsessive-compulsive disorderIPG676
Electrical stimulation to improve muscle strength in chronic respiratory conditions, chronic heart failure and chronic kidney diseaseIPG677
Treosulfan with fludarabine for malignant disease before allogeneic stem cell transplantTA640
Artificial iris insertion for acquired aniridiaIPG674
Artificial iris insertion for congenital aniridiaIPG675
Atezolizumab with carboplatin and etoposide for untreated extensive-stage small-cell lung cancerTA638
Atezolizumab with nab-paclitaxel for untreated PD-L1-positive, locally advanced or metastatic, triple-negative breast cancerTA639
Daratumumab with lenalidomide and dexamethasone for untreated multiple myeloma (terminated appraisal)TA634
Ramucirumab with erlotinib for untreated EGFR-positive metastatic non-small-cell lung cancer (terminated appraisal)TA635
Eculizumab for treating refractory myasthenia gravis (terminated appraisal)TA636
Ranibizumab for treating diabetic retinopathy (terminated appraisal)TA637
Intravascular lithotripsy for calcified coronary arteries during percutaneous coronary interventionIPG673
Rezum for treating lower urinary tract symptoms secondary to benign prostatic hyperplasiaMTG49
Avatrombopag for treating thrombocytopenia in people with chronic liver disease needing a planned invasive procedureTA626
Tests to help assess risk of acute kidney injury for people being considered for critical care admission (ARCHITECT and Alinity i Urine NGAL assays, BioPorto NGAL test and NephroCheck test)DG39
Ustekinumab for treating moderately to severely active ulcerative colitisTA633
Generalised anxiety disorder and panic disorder in adults: managementCG113
Intravenous fluid therapy in children and young people in hospitalNG29
Trastuzumab emtansine for adjuvant treatment of HER2-positive early breast cancerTA632
Joint replacement (primary): hip, knee and shoulderNG157
Larotrectinib for treating NTRK fusion-positive solid tumoursTA630
Lorlatinib for previously treated ALK-positive advanced non-small-cell lung cancerTA628
Obinutuzumab with bendamustine for treating follicular lymphoma after rituximabTA629
PneuX to prevent ventilator-associated pneumoniaMTG48
Lenalidomide with rituximab for previously treated follicular lymphomaTA627
Abdominal aortic aneurysm: diagnosis and managementNG156
Alemtuzumab for treating highly active relapsing–remitting multiple sclerosisTA312
Tinnitus: assessment and managementNG155
Bilateral cervicosacropexy (CESA) or vaginosacropexy (VASA) using mesh for pelvic organ prolapseIPG669
Cyanoacrylate glue occlusion for varicose veinsIPG670
MRI-guided laser interstitial thermal therapy for drug-resistant epilepsyIPG671
Selective internal radiation therapy for unresectable colorectal metastases in the liverIPG672
Recombinant human parathyroid hormone for treating hypoparathyroidism (terminated appraisal)TA625
Impetigo: antimicrobial prescribingNG153
Neonatal parenteral nutritionNG154
SepsiTest assay for rapidly identifying bloodstream bacteria and fungiDG20
Peginterferon beta-1a for treating relapsing–remitting multiple sclerosisTA624
Patiromer for treating hyperkalaemiaTA623
Sotagliflozin with insulin for treating type 1 diabetesTA622
Antenatal and postnatal mental health: clinical management and service guidanceCG192
Episcissors-60 for mediolateral episiotomyMTG47
Leg ulcer infection: antimicrobial prescribingNG152
Fetoscopic prenatal repair for open neural tube defects in the fetusIPG667
Open prenatal repair for open neural tube defects in the fetusIPG668
Reducing the risk of transmission of Creutzfeldt–Jakob disease (CJD) from surgical instruments used for interventional procedures on high-risk tissuesIPG666
Supporting adult carersNG150
Virtual Touch Quantification to diagnose and monitor liver fibrosis in chronic hepatitis B and CMTG27
Atezolizumab with carboplatin and nab-paclitaxel for untreated advanced non-squamous non-small-cell lung cancer (terminated appraisal)TA618
Indoor air quality at homeNG149
Lusutrombopag for treating thrombocytopenia in people with chronic liver disease needing a planned invasive procedureTA617
Cladribine for treating relapsing–remitting multiple sclerosisTA616
Balloon dilation for chronic eustachian tube dysfunctionIPG665
Cannabidiol with clobazam for treating seizures associated with Dravet syndromeTA614
Cannabidiol with clobazam for treating seizures associated with Lennox–Gastaut syndromeTA615
Menopause: diagnosis and managementNG23
gammaCore for cluster headacheMTG46
Cerliponase alfa for treating neuronal ceroid lipofuscinosis type 2HST12
Irreversible electroporation for primary liver cancerIPG664
Diverticular disease: diagnosis and managementNG147
Workplace health: long-term sickness absence and capability to workNG146
Neratinib for extended adjuvant treatment of hormone receptor-positive, HER2-positive early stage breast cancer after adjuvant trastuzumabTA612
Point-of-care creatinine devices to assess kidney function before CT imaging with intravenous contrastDG37
Rapid tests for group A streptococcal infections in people with a sore throatDG38
Pentosan polysulfate sodium for treating bladder pain syndromeTA610
Rucaparib for maintenance treatment of relapsed platinum-sensitive ovarian, fallopian tube or peritoneal cancerTA611
Ibrutinib with rituximab for treating Waldenstrom's macroglobulinaemia (terminated appraisal)TA608
Ramucirumab for treating unresectable hepatocellular carcinoma after sorafenib (terminated appraisal)TA609
Gastro-oesophageal reflux disease and dyspepsia in adults: investigation and managementCG184
Rivaroxaban for preventing atherothrombotic events in people with coronary or peripheral artery diseaseTA607
Midcarpal hemiarthroplasty for wrist arthritisIPG663
End of life care for adults: service deliveryNG142
Lanadelumab for preventing recurrent attacks of hereditary angioedemaTA606
Diabetic foot problems: prevention and managementNG19
Voretigene neparvovec for treating inherited retinal dystrophies caused by RPE65 gene mutationsHST11
Gastro-oesophageal reflux disease in children and young people: diagnosis and managementNG1
Xeomin (botulinum neurotoxin type A) for treating chronic sialorrhoeaTA605
EXOGEN ultrasound bone healing system for long bone fractures with non-union or delayed healingMTG12
Familial hypercholesterolaemia: identification and managementCG71
Idelalisib for treating refractory follicular lymphomaTA604
Cellulitis and erysipelas: antimicrobial prescribingNG141
High-intensity focused ultrasound for glaucomaIPG661
Bioprosthetic plug insertion for anal fistulaIPG662
Abortion careNG140
Pomalidomide with bortezomib and dexamethasone for treating relapsed or refractory multiple myeloma (terminated appraisal)TA602
Lenalidomide with bortezomib and dexamethasone for untreated multiple myeloma (terminated appraisal)TA603
Tegaderm CHG securement dressing for vascular access sites in critically ill adultsMTG25
Pneumonia (community-acquired): antimicrobial prescribingNG138
Pneumonia (hospital-acquired): antimicrobial prescribingNG139
Attention deficit hyperactivity disorder: diagnosis and managementNG87
Implant insertion for prominent earsIPG660
Benralizumab for treating severe eosinophilic asthmaTA565
Risankizumab for treating moderate to severe plaque psoriasisTA596
Patisiran for treating hereditary transthyretin amyloidosisHST10
Endovascular insertion of an intrasaccular wire-mesh blood-flow disruption device for intracranial aneurysmsIPG658
Low-energy contact X-ray brachytherapy (the Papillon technique) for locally advanced rectal cancerIPG659
Brentuximab vedotin for untreated advanced Hodgkin lymphoma (terminated appraisal)TA594
Dacomitinib for untreated EGFR mutation-positive non-small-cell lung cancerTA595
Venous thromboembolism in over 16s: reducing the risk of hospital-acquired deep vein thrombosis or pulmonary embolismNG89
Alcohol interventions in secondary and further educationNG135
PICO negative pressure wound dressings for closed surgical incisionsMTG43
Fluocinolone acetonide intravitreal implant for treating recurrent non-infectious uveitisTA590
Letermovir for preventing cytomegalovirus disease after a stem cell transplantTA591
Chronic obstructive pulmonary disease in over 16s: diagnosis and managementNG115
End of life care for infants, children and young people with life-limiting conditions: planning and managementNG61
Transurethral laser ablation for recurrent non-muscle-invasive bladder cancerIPG656
Ultrasound-guided high-intensity transcutaneous focused ultrasound for symptomatic uterine fibroidsIPG657
Nusinersen for treating spinal muscular atrophyTA588
Blinatumomab for treating acute lymphoblastic leukaemia in remission with minimal residual disease activityTA589
Motor neurone disease: assessment and managementNG42
Therapeutic monitoring of TNF-alpha inhibitors in rheumatoid arthritisDG36
Bisphosphonates for treating osteoporosisTA464
Long-acting reversible contraceptionCG30
Cardiac contractility modulation device implantation for heart failureIPG655
Valve-in-valve TAVI for aortic bioprosthetic valve dysfunctionIPG653
Reinforcement of a permanent stoma with a synthetic or biological mesh to prevent a parastomal herniaIPG654
Lenalidomide for treating myelodysplastic syndromes associated with an isolated deletion 5q cytogenetic abnormalityTA322
Lenalidomide for the treatment of multiple myeloma in people who have received at least 2 prior therapiesTA171
Lenalidomide plus dexamethasone for multiple myeloma after 1 treatment with bortezomibTA586
Lenalidomide plus dexamethasone for previously untreated multiple myelomaTA587
Depression in children and young people: identification and managementNG134
Urinary incontinence and pelvic organ prolapse in women: managementNG123
Ambu aScope4 Broncho for use in unexpected difficult airwaysMTG14
Percutaneous insertion of a cerebral protection device to prevent cerebral embolism during TAVIIPG650
Percutaneous mechanical thrombectomy for acute deep vein thrombosis of the legIPG651
Bronchoscopic thermal vapour ablation for upper-lobe emphysemaIPG652
Ocrelizumab for treating primary progressive multiple sclerosisTA585
Endocuff Vision for assisting visualisation during colonoscopyMTG45
Ertugliflozin with metformin and a dipeptidyl peptidase-4 inhibitor for treating type 2 diabetesTA583
Atezolizumab in combination for treating metastatic non-squamous non-small-cell lung cancerTA584
The Sherlock 3CG Tip Confirmation System for placement of peripherally inserted central cathetersMTG24
Therapeutic hypothermia for acute ischaemic strokeIPG647
Collagen paste for closing an anal fistulaIPG648
Percutaneous mitral valve leaflet repair for mitral regurgitationIPG649
Hyperparathyroidism (primary): diagnosis, assessment and initial managementNG132
Inotersen for treating hereditary transthyretin amyloidosisHST9
Enzalutamide for hormone-relapsed non-metastatic prostate cancerTA580
Curos for preventing infections when using needleless connectorsMTG44
Lead-I ECG devices for detecting symptomatic atrial fibrillation using single time point testing in primary careDG35
Crohn's disease: managementNG129
Ulcerative colitis: managementNG130
Intrapartum care for women with existing medical conditions or obstetric complications and their babiesNG121
Brentuximab vedotin for treating CD30-positive cutaneous T-cell lymphomaTA577
Endoscopic ablation for an anal fistulaIPG645
Endoscopic ablation for a pilonidal sinusIPG646
Certolizumab pegol for treating moderate to severe plaque psoriasisTA574
Tildrakizumab for treating moderate to severe plaque psoriasisTA575
Bosutinib for untreated chronic myeloid leukaemia (terminated appraisal)TA576
Specialist neonatal respiratory care for babies born pretermNG124
Ertugliflozin as monotherapy or with metformin for treating type 2 diabetesTA572
The Debrisoft monofilament debridement pad for use in acute or chronic woundsMTG17
Brigatinib for treating ALK-positive advanced non-small-cell lung cancer after crizotinibTA571
Pembrolizumab for treating recurrent or metastatic squamous cell carcinoma of the head and neck after platinum-based chemotherapy (terminated appraisal)TA570
Pertuzumab for adjuvant treatment of HER2-positive early stage breast cancerTA569
Radially emitting laser fibre treatment of an anal fistulaIPG644
Abatacept for treating psoriatic arthritis after DMARDs (terminated appraisal)TA568
Cochlear implants for children and adults with severe to profound deafnessTA566
High-intensity focused ultrasound for symptomatic benign thyroid nodulesIPG643
Venetoclax with rituximab for previously treated chronic lymphocytic leukaemiaTA561
Encorafenib with binimetinib for unresectable or metastatic BRAF V600 mutation-positive melanomaTA562
Abemaciclib with an aromatase inhibitor for previously untreated, hormone receptor-positive, HER2-negative, locally advanced or metastatic breast cancerTA563
Barnett Continent Intestinal Reservoir (modified continent ileostomy) to restore continence after colon and rectum removalIPG642
Bevacizumab with carboplatin, gemcitabine and paclitaxel for treating the first recurrence of platinum-sensitive advanced ovarian cancer (terminated appraisal)TA560
Cough (acute): antimicrobial prescribingNG120
Electrically stimulated intravesical chemotherapy for non-muscle-invasive bladder cancerIPG638
Laparoscopic cerclage for cervical incompetence to prevent late miscarriage or preterm birthIPG639
Percutaneous venoplasty for chronic cerebrospinal venous insufficiency in multiple sclerosisIPG640
Senza spinal cord stimulation system for delivering HF10 therapy to treat chronic neuropathic painMTG41
Platelet-rich plasma injections for knee osteoarthritisIPG637
Ex-situ machine perfusion for extracorporeal preservation of livers for transplantationIPG636
Cerebral palsy in adultsNG119
Mepilex Border Heel and Sacrum dressings for preventing pressure ulcersMTG40
Pipeline Flex embolisation device with Shield Technology for the treatment of complex intracranial aneurysmsMTG10
Regorafenib for previously treated advanced hepatocellular carcinomaTA555
Darvadstrocel for treating complex perianal fistulas in Crohn's diseaseTA556
Renal and ureteric stones: assessment and managementNG118
Tisagenlecleucel for treating relapsed or refractory B-cell acute lymphoblastic leukaemia in people aged up to 25 yearsTA554
Tumour profiling tests to guide adjuvant chemotherapy decisions in early breast cancerDG34
Transcutaneous neuromuscular electrical stimulation for oropharyngeal dysphagia in adultsIPG634
Bronchial thermoplasty for severe asthmaIPG635
Lenvatinib for untreated advanced hepatocellular carcinomaTA551
Liposomal cytarabine–daunorubicin for untreated acute myeloid leukaemiaTA552
Bronchiectasis (non-cystic fibrosis), acute exacerbation: antimicrobial prescribingNG117
Vandetanib for treating medullary thyroid cancerTA550
Post-traumatic stress disorderNG116
Chronic obstructive pulmonary disease (acute exacerbation): antimicrobial prescribingNG114
Decitabine for untreated acute myeloid leukaemia (terminated appraisal)TA548
Denosumab for preventing skeletal-related events in multiple myeloma (terminated appraisal)TA549
Transcranial MRI-guided focused ultrasound thalamotomy for neuropathic painIPG632
Percutaneous insertion of a temporary heart pump for left ventricular haemodynamic support in high-risk percutaneous coronary interventionsIPG633
Tofacitinib for moderately to severely active ulcerative colitisTA547
Urinary tract infection (catheter-associated): antimicrobial prescribingNG113
Padeliporfin for untreated localised prostate cancerTA546
Subcutaneous automated low-flow pump implantation for refractory ascites caused by cirrhosisIPG631
Gemtuzumab ozogamicin for untreated acute myeloid leukaemiaTA545
Selective internal radiation therapy for unresectable primary intrahepatic cholangiocarcinomaIPG630
Urinary tract infection (lower): antimicrobial prescribingNG109
Prostatitis (acute): antimicrobial prescribingNG110
Pyelonephritis (acute): antimicrobial prescribingNG111
Urinary tract infection (recurrent): antimicrobial prescribingNG112
Eltrombopag for treating chronic immune thrombocytopeniaTA293
Romiplostim for the treatment of chronic immune thrombocytopeniaTA221
Myeloma: diagnosis and managementNG35
Lyme diseaseNG95
Dabrafenib with trametinib for adjuvant treatment of resected BRAF V600 mutation-positive melanomaTA544
Burosumab for treating X-linked hypophosphataemia in children and young peopleHST8
Renal replacement therapy and conservative managementNG107
Decision-making and mental capacityNG108
Cabozantinib for untreated advanced renal cell carcinomaTA542
Tofacitinib for treating active psoriatic arthritis after inadequate response to DMARDsTA543
E‑vita open plus for treating complex aneurysms and dissections of the thoracic aortaMTG16
Intravesical microwave hyperthermia and chemotherapy for non-muscle-invasive bladder cancerIPG628
Inotuzumab ozogamicin for treating relapsed or refractory B-cell acute lymphoblastic leukaemiaTA541
Chronic heart failure in adults: diagnosis and managementNG106
Preventing suicide in community and custodial settingsNG105
Pembrolizumab for treating relapsed or refractory classical Hodgkin lymphomaTA540
Leadless cardiac pacemaker implantation for bradyarrhythmiasIPG626
Superior rectal artery embolisation for haemorrhoidsIPG627
Lutetium (177Lu) oxodotreotide for treating unresectable or metastatic neuroendocrine tumoursTA539
Sutureless aortic valve replacement for aortic stenosisIPG624
Flu vaccination: increasing uptakeNG103
Dinutuximab beta for treating neuroblastomaTA538
Transurethral water vapour ablation for lower urinary tract symptoms caused by benign prostatic hyperplasiaIPG625
Lenvatinib and sorafenib for treating differentiated thyroid cancer after radioactive iodineTA535
Alectinib for untreated ALK-positive advanced non-small-cell lung cancerTA536
Ixekizumab for treating active psoriatic arthritis after inadequate response to DMARDsTA537
Community pharmacies: promoting health and wellbeingNG102
Dupilumab for treating moderate to severe atopic dermatitisTA534
Low-intensity pulsed ultrasound to promote healing of fresh fractures at low risk of non-healingIPG621
Low-intensity pulsed ultrasound to promote healing of fresh fractures at high risk of non-healingIPG622
Low-intensity pulsed ultrasound to promote healing of delayed-union and non-union fracturesIPG623
Superior capsular augmentation for massive rotator cuff tearsIPG619
Transaxial interbody lumbosacral fusion for severe chronic low back painIPG620
Ocrelizumab for treating relapsing–remitting multiple sclerosisTA533
Pembrolizumab for untreated PD-L1-positive metastatic non-small-cell lung cancerTA531
Biomarker tests to help diagnose preterm labour in women with intact membranesDG33
Crizotinib for treating ROS1-positive advanced non-small-cell lung cancerTA529
Nivolumab for treating locally advanced unresectable or metastatic urothelial cancer after platinum-containing chemotherapyTA530
Beta interferons and glatiramer acetate for treating multiple sclerosisTA527
Unilateral MRI-guided focused ultrasound thalamotomy for treatment-resistant essential tremorIPG617
Laparoscopic ventral mesh rectopexy for internal rectal prolapseIPG618
Dementia: assessment, management and support for people living with dementia and their carersNG97
Donepezil, galantamine, rivastigmine and memantine for the treatment of Alzheimer's diseaseTA217
Intranasal phototherapy for allergic rhinitisIPG616
Guselkumab for treating moderate to severe plaque psoriasisTA521
Midostaurin for untreated acute myeloid leukaemiaTA523
Brentuximab vedotin for treating CD30-positive Hodgkin lymphomaTA524
Atezolizumab for treating locally advanced or metastatic urothelial carcinoma after platinum-containing chemotherapyTA525
Arsenic trioxide for treating acute promyelocytic leukaemiaTA526
Cancer of the upper aerodigestive tract: assessment and management in people aged 16 and overNG36
Endoscopic bipolar radiofrequency ablation for treating biliary obstruction caused by cancerIPG614
Low-level laser therapy for preventing or treating oral mucositis caused by radiotherapy or chemotherapyIPG615
Atezolizumab for treating locally advanced or metastatic non-small-cell lung cancer after chemotherapyTA520
Percutaneous balloon valvuloplasty for fetal critical aortic stenosisIPG613
Adjunctive colposcopy technologies for assessing suspected cervical abnormalities: the DYSIS colposcope with DYSISmap and the ZedScan IDG32
Robot-assisted kidney transplantIPG609
Prostate artery embolisation for lower urinary tract symptoms caused by benign prostatic hyperplasiaIPG611
Microinvasive subconjunctival insertion of a trans-scleral gelatin stent for primary open-angle glaucomaIPG612
Nerve transfer to partially restore upper limb function in tetraplegiaIPG610
Tocilizumab for treating giant cell arteritisTA518
Care and support of people growing older with learning disabilitiesNG96

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