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Showing 1 to 1848 of 1848

Published guidance, NICE advice and quality standards
TitleReference numberPublishedLast updated
Melphalan flufenamide with dexamethasone for treating relapsed or refractory multiple myeloma (terminated appraisal)TA968
Pembrolizumab with gemcitabine and cisplatin for untreated advanced biliary tract cancer (terminated appraisal)TA966
Lymphovenous anastomosis during axillary or inguinal node dissection for preventing secondary lymphoedemaIPG785
Endometriosis: diagnosis and managementNG73
Cabozantinib with nivolumab for untreated advanced renal cell carcinomaTA964
Twin and triplet pregnancyNG137
Dostarlimab with platinum-based chemotherapy for treating advanced or recurrent endometrial cancer with high microsatellite instability or mismatch repair deficiencyTA963
Kurin Lock for blood culture collectionMTG77
GaitSmart rehabilitation exercise programme for gait and mobility issuesMTG78
Epidermal radiotherapy using rhenium-188 paste for non-melanoma skin cancerIPG784
Sebelipase alfa for treating lysosomal acid lipase deficiency that is not Wolman disease (terminated appraisal)TA961
Olaparib for maintenance treatment of BRCA mutation-positive advanced ovarian, fallopian tube or peritoneal cancer after response to first-line platinum-based chemotherapyTA962
Human alpha1-proteinase inhibitor for treating emphysema (terminated appraisal)TA965
Ritlecitinib for treating severe alopecia areata in people 12 years and overTA958
Daratumumab in combination for treating newly diagnosed systemic amyloid light-chain amyloidosisTA959
Satralizumab for preventing relapses in neuromyelitis optica spectrum disorders (terminated appraisal)TA960
Digital health technologies to help manage symptoms of psychosis and prevent relapse in adults and young people: early value assessmentHTE17
Ovarian cancer: identifying and managing familial and genetic riskNG241
Momelotinib for treating myelofibrosis-related splenomegaly or symptomsTA957
Suspected sepsis: recognition, diagnosis and early managementNG51
Neonatal infection: antibiotics for prevention and treatmentNG195
Meningitis (bacterial) and meningococcal disease: recognition, diagnosis and managementNG240
ProKnow cloud-based system for radiotherapy data storage, communication and management: early value assessmentHTE5
Fluocinolone acetonide intravitreal implant for treating chronic diabetic macular oedemaTA953
Dupilumab for treating moderate to severe prurigo nodularisTA955
Nirmatrelvir plus ritonavir, sotrovimab and tocilizumab for treating COVID-19TA878
COVID-19 rapid guideline: managing COVID-19NG191
Etrasimod for treating moderately to severely active ulcerative colitis in people aged 16 and overTA956
Lung cancer: diagnosis and managementNG122
Epcoritamab for treating relapsed or refractory diffuse large B-cell lymphoma after 2 or more systemic treatmentsTA954
Digital technologies for delivering multidisciplinary weight-management services: early value assessmentHTE14
Vitamin B12 deficiency in over 16s: diagnosis and managementNG239
Digital technologies for managing non-specific low back pain: early value assessmentHTE16
Endoscopic sleeve gastroplasty for obesityIPG783
Talazoparib for treating HER2-negative advanced breast cancer with germline BRCA mutationsTA952
TuberculosisNG33
Digitally enabled therapies for adults with depression: early value assessmentHTE8
Belumosudil for treating chronic graft-versus-host disease after 2 or more systemic treatments in people 12 years and overTA949
Nivolumab–relatlimab for untreated unresectable or metastatic melanoma in people 12 years and overTA950
Olaparib with abiraterone for untreated hormone-relapsed metastatic prostate cancerTA951
Loncastuximab tesirine for treating relapsed or refractory diffuse large B-cell lymphoma and high-grade B-cell lymphoma after 2 or more systemic treatmentsTA947
Ivosidenib for treating advanced cholangiocarcinoma with an IDH1 R132 mutation after 1 or more systemic treatmentsTA948
Treosulfan with fludarabine before allogeneic stem cell transplant for people aged 1 month to 17 years with non-malignant diseases (terminated appraisal)TA945
Caesarean birthNG192
Devices for remote monitoring of Parkinson's diseaseDG51
COVID-19 rapid guideline: managing the long-term effects of COVID-19NG188
Pharyngeal electrical stimulation for neurogenic dysphagiaIPG781
Temperature control to improve neurological outcomes after cardiac arrestIPG782
Artificial intelligence (AI)-derived software to help clinical decision making in strokeDG57
Olaparib with bevacizumab for maintenance treatment of advanced high-grade epithelial ovarian, fallopian tube or primary peritoneal cancerTA946
Early and locally advanced breast cancer: diagnosis and managementNG101
Sebelipase alfa for treating Wolman diseaseHST30
Durvalumab with gemcitabine and cisplatin for treating unresectable or advanced biliary tract cancerTA944
Intravascular lithotripsy for calcified arteries in peripheral arterial diseaseIPG780
Bipolar disorder: assessment and managementCG185
Targeted-release budesonide for treating primary IgA nephropathyTA937
Ravulizumab for treating generalised myasthenia gravis (terminated appraisal)TA940
Ravulizumab for treating AQP4 antibody-positive neuromyelitis optica spectrum disorder (terminated appraisal)TA941
Empagliflozin for treating chronic kidney diseaseTA942
Hybrid closed loop systems for managing blood glucose levels in type 1 diabetesTA943
Risdiplam for treating spinal muscular atrophyTA755
Digitally enabled therapies for adults with anxiety disorders: early value assessmentHTE9
Middle meningeal artery embolisation for chronic subdural haematomasIPG779
Cardiovascular disease: risk assessment and reduction, including lipid modificationNG238
Velmanase alfa for treating alpha-mannosidosisHST29
Pembrolizumab plus chemotherapy with or without bevacizumab for persistent, recurrent or metastatic cervical cancerTA939
Acne vulgaris: managementNG198
Dupilumab for treating eosinophilic oesophagitis in people 12 years and over (terminated appraisal)TA938
Secukinumab for treating moderate to severe hidradenitis suppurativaTA935
Idecabtagene vicleucel for treating relapsed and refractory multiple myeloma after 3 or more treatments (terminated appraisal)TA936
Percutaneous thrombectomy for intermediate-risk or high-risk pulmonary embolismIPG778
Tisagenlecleucel for treating relapsed or refractory diffuse large B-cell lymphoma after 2 or more systemic therapies (terminated appraisal)TA933
Foslevodopa–foscarbidopa for treating advanced Parkinson's with motor symptomsTA934
Decitabine–cedazuridine for untreated acute myeloid leukaemia when intensive chemotherapy is unsuitable (terminated appraisal)TA932
Percutaneous transarterial carotid artery stent placement for asymptomatic extracranial carotid stenosisIPG777
Zanubrutinib for treating chronic lymphocytic leukaemiaTA931
Transient loss of consciousness ('blackouts') in over 16sCG109
Hypertension in adults: diagnosis and managementNG136
Suspected acute respiratory infection in over 16s: assessment at first presentation and initial managementNG237
Virtual reality technologies for treating agoraphobia or agoraphobic avoidance: early value assessmentHTE15
Biodegradable subacromial spacer insertion for rotator cuff tearsIPG775
Extracorporeal carbon dioxide removal for acute respiratory failureIPG776
Lutetium-177 vipivotide tetraxetan for treating PSMA-positive hormone-relapsed metastatic prostate cancer after 2 or more treatmentsTA930
Familial breast cancer: classification, care and managing breast cancer and related risks in people with a family history of breast cancerCG164
Empagliflozin for treating chronic heart failure with preserved or mildly reduced ejection fractionTA929
Cabozantinib for previously treated advanced differentiated thyroid cancer unsuitable for or refractory to radioactive iodineTA928
Jaundice in newborn babies under 28 daysCG98
Pneumonia in adults: diagnosis and managementCG191
Ranibizumab for treating diabetic macular oedemaTA274
Vaginal transluminal endoscopic hysterectomy and adnexal surgery for benign gynaecological conditionsIPG774
Daratumumab with lenalidomide and dexamethasone for untreated multiple myeloma when a stem cell transplant is unsuitableTA917
Tirzepatide for treating type 2 diabetesTA924
Mirikizumab for treating moderately to severely active ulcerative colitisTA925
Baricitinib for treating severe alopecia areataTA926
Tabelecleucel for treating post-transplant lymphoproliferative disorder caused by the Epstein-Barr virus (terminated appraisal)TA923
Percutaneous deep venous arterialisation for chronic limb-threatening ischaemiaIPG773
Stroke rehabilitation in adultsNG236
Rimegepant for treating migraineTA919
Tofacitinib for treating active ankylosing spondylitisTA920
Ruxolitinib for treating polycythaemia veraTA921
Daridorexant for treating long-term insomniaTA922
Glofitamab for treating relapsed or refractory diffuse large B-cell lymphoma after 2 or more systemic treatmentsTA927
Virtual ward platform technologies for acute respiratory infectionsHTE13
Thyroid disease: assessment and managementNG145
Bimekizumab for treating axial spondyloarthritisTA918
Pegunigalsidase alfa for treating Fabry diseaseTA915
Bimekizumab for treating active psoriatic arthritisTA916
Urinary incontinence in neurological disease: assessment and managementCG148
Ovarian cancer: recognition and initial managementCG122
Suspected cancer: recognition and referralNG12
Suspected neurological conditions: recognition and referralNG127
Hearing loss in adults: assessment and managementNG98
Intrapartum careNG235
Artificial intelligence-derived software to analyse chest X-rays for suspected lung cancer in primary care referrals: early value assessmentHTE12
COVID-19 rapid guideline: haematopoietic stem cell transplantationNG164
Acute kidney injury: prevention, detection and managementNG148
Artificial intelligence technologies to aid contouring for radiotherapy treatment planning: early value assessmentHTE11
KardiaMobile 6L for measuring cardiac QT interval in adults having antipsychotic medicationHTE10
Removal, preservation and reimplantation of ovarian tissue for restoring fertility after gonadotoxic treatmentIPG772
Birch bark extract for treating epidermolysis bullosaHST28
Pembrolizumab for previously treated endometrial, biliary, colorectal, gastric or small intestine cancer with high microsatellite instability or mismatch repair deficiencyTA914
Transurethral water-jet ablation for lower urinary tract symptoms caused by benign prostatic hyperplasiaIPG770
Cryotherapy for chronic rhinitisIPG771
Cirrhosis in over 16s: assessment and managementNG50
Spinal metastases and metastatic spinal cord compressionNG234
Mavacamten for treating symptomatic obstructive hypertrophic cardiomyopathyTA913
Guided self-help digital cognitive behavioural therapy for children and young people with mild to moderate symptoms of anxiety or low mood: early value assessmentHTE3
Semaglutide for managing overweight and obesityTA875
Otitis media with effusion in under 12sNG233
Quantitative faecal immunochemical testing to guide colorectal cancer pathway referral in primary careDG56
Ectopic pregnancy and miscarriage: diagnosis and initial managementNG126
Cipaglucosidase alfa with miglustat for treating late-onset Pompe diseaseTA912
Genedrive MT-RNR1 ID Kit for detecting a genetic variant to guide antibiotic use and prevent hearing loss in babies: early value assessmentHTE6
Aortic valve reconstruction with glutaraldehyde-treated autologous pericardium for aortic valve diseaseIPG769
Venous thromboembolic diseases: diagnosis, management and thrombophilia testingNG158
Obesity: identification, assessment and managementCG189
Afamelanotide for treating erythropoietic protoporphyriaHST27
Selpercatinib for untreated RET fusion-positive advanced non-small-cell lung cancerTA911
KardiaMobile for detecting atrial fibrillationMTG64
Semaglutide for managing overweight and obesity in young people aged 12 to 17 years (terminated appraisal)TA910
Lorlatinib for untreated ALK-positive advanced non-small-cell lung cancerTA909
AI-derived computer-aided detection (CAD) software for detecting and measuring lung nodules in CT scan imagesDG55
Irreversible electroporation for treating prostate cancerIPG768
Rimegepant for preventing migraineTA906
Olaparib for maintenance treatment of relapsed, platinum-sensitive ovarian, fallopian tube or peritoneal cancer after 2 or more courses of platinum-based chemotherapyTA908
Oesophago-gastric cancer: assessment and management in adultsNG83
Botulinum toxin type A injections into the urethral sphincter for idiopathic chronic non-obstructive urinary retentionIPG766
Radiofrequency denervation for osteoarthritic knee painIPG767
Deucravacitinib for treating moderate to severe plaque psoriasisTA907
Endoscopic ultrasound-guided gallbladder drainage for acute cholecystitis when surgery is not an optionIPG764
Minimally invasive fusionless posterior-approach surgery to correct idiopathic scoliosis in children and young peopleIPG765
Dapagliflozin for treating chronic heart failure with preserved or mildly reduced ejection fractionTA902
Darolutamide with androgen deprivation therapy and docetaxel for treating hormone-sensitive metastatic prostate cancerTA903
Pembrolizumab with lenvatinib for previously treated advanced or recurrent endometrial cancerTA904
Upadacitinib for previously treated moderately to severely active Crohn's diseaseTA905
Cemiplimab for treating recurrent or metastatic cervical cancer (terminated appraisal)TA901
Dabrafenib plus trametinib for treating BRAF V600 mutation-positive advanced non-small-cell lung cancerTA898
Tixagevimab plus cilgavimab for preventing COVID-19TA900
FibroScan for assessing liver fibrosis and cirrhosis outside secondary and specialist careDG48
Atopic eczema in under 12s: diagnosis and managementCG57
Axicabtagene ciloleucel for treating relapsed or refractory follicular lymphomaTA894
Axicabtagene ciloleucel for treating relapsed or refractory diffuse large B-cell lymphoma after first-line chemoimmunotherapyTA895
Bulevirtide for treating chronic hepatitis DTA896
Brexucabtagene autoleucel for treating relapsed or refractory B-cell acute lymphoblastic leukaemia in people 26 years and overTA893
Intraoperative electron beam radiotherapy for locally advanced and locally recurrent colorectal cancerIPG763
Daratumumab with bortezomib and dexamethasone for previously treated multiple myelomaTA897
Esketamine for treating major depressive disorder in adults at imminent risk of suicide (terminated appraisal)TA899
Transperineal biopsy for diagnosing prostate cancerDG54
Ibrutinib with venetoclax for untreated chronic lymphocytic leukaemiaTA891
Mosunetuzumab for treating relapsed or refractory follicular lymphomaTA892
Automated ankle brachial pressure index measurement devices to detect peripheral arterial disease in people with leg ulcersDG52
MRI fusion biopsy systems for diagnosing prostate cancerDG53
Intramuscular diaphragm stimulation for ventilator-dependent chronic respiratory failure from high spinal cord injuriesIPG762
Head injury: assessment and early managementNG232
Risankizumab for previously treated moderately to severely active Crohn's diseaseTA888
Ciltacabtagene autoleucel for treating relapsed or refractory multiple myeloma (terminated appraisal)TA889
Difelikefalin for treating pruritus in people having haemodialysisTA890
Diabetes (type 1 and type 2) in children and young people: diagnosis and managementNG18
Olaparib for adjuvant treatment of BRCA mutation-positive HER2-negative high-risk early breast cancer after chemotherapyTA886
Olaparib for previously treated BRCA mutation-positive hormone-relapsed metastatic prostate cancerTA887
Point-of-care tests for urinary tract infections to improve antimicrobial prescribing: early value assessmentHTE7
Ripretinib for treating advanced gastrointestinal stromal tumour after 3 or more treatmentsTA881
Voclosporin with mycophenolate mofetil for treating lupus nephritisTA882
Tafasitamab with lenalidomide for treating relapsed or refractory diffuse large B-cell lymphomaTA883
Capmatinib for treating advanced non-small-cell lung cancer with MET exon 14 skipping (terminated appraisal)TA884
Metastatic malignant disease of unknown primary origin in adults: diagnosis and managementCG104
Tezepelumab for treating severe asthmaTA880
Lumasiran for treating primary hyperoxaluria type 1HST25
Onasemnogene abeparvovec for treating spinal muscular atrophyHST15
Eladocagene exuparvovec for treating aromatic L-amino acid decarboxylase deficiencyHST26
Onasemnogene abeparvovec for treating presymptomatic spinal muscular atrophyHST24
Daytime intraoral neuromuscular electrical tongue stimulation using a removable device for obstructive sleep apnoeaIPG760
Endoscopic ultrasound-guided biliary drainage for biliary obstructionIPG761
Hypertension in pregnancy: diagnosis and managementNG133
AposHealth for knee osteoarthritisMTG76
Trastuzumab deruxtecan for treating HER2-positive unresectable or metastatic gastric or gastro-oesophageal junction cancer after anti-HER2 treatment (terminated appraisal)TA879
Radiofrequency ablation as an adjunct to balloon kyphoplasty or percutaneous vertebroplasty for palliation of painful spinal metastasesIPG759
Percutaneous thoracic duct embolisation for persistent chyle leakIPG755
Focal therapy using high-intensity focused ultrasound for localised prostate cancerIPG756
Maximal cytoreductive surgery for advanced ovarian cancerIPG757
Radiofrequency ablation for palliation of painful spinal metastasesIPG758
UrgoStart for treating diabetic foot ulcers and leg ulcersMTG42
Finerenone for treating chronic kidney disease in type 2 diabetesTA877
Nivolumab with chemotherapy for neoadjuvant treatment of resectable non-small-cell lung cancerTA876
CaRi-Heart for predicting cardiac risk in suspected coronary artery disease: early value assessmentHTE4
Asfotase alfa for treating paediatric-onset hypophosphatasiaHST23
Endoluminal gastroplication for gastro-oesophageal reflux diseaseIPG753
Percutaneous transluminal renal sympathetic denervation for resistant hypertensionIPG754
Eptinezumab for preventing migraineTA871
Cannabidiol for treating seizures caused by tuberous sclerosis complexTA873
Polatuzumab vedotin in combination for untreated diffuse large B-cell lymphomaTA874
Axicabtagene ciloleucel for treating diffuse large B-cell lymphoma and primary mediastinal large B-cell lymphoma after 2 or more systemic therapiesTA872
Ataluren for treating Duchenne muscular dystrophy with a nonsense mutation in the dystrophin geneHST22
Ixazomib with lenalidomide and dexamethasone for treating relapsed or refractory multiple myelomaTA870
Mitapivat for treating pyruvate kinase deficiency (terminated appraisal)TA867
Teclistamab for treating relapsed or refractory multiple myeloma after 3 or more therapies (terminated appraisal)TA869
Vutrisiran for treating hereditary transthyretin-related amyloidosisTA868
Barrett's oesophagus and stage 1 oesophageal adenocarcinoma: monitoring and managementNG231
Nivolumab with fluoropyrimidine- and platinum-based chemotherapy for untreated unresectable advanced, recurrent, or metastatic oesophageal squamous cell carcinomaTA865
Regorafenib for previously treated metastatic colorectal cancerTA866
Transvenous obliteration for gastric varicesIPG751
Biodegradable spacer insertion to reduce rectal toxicity during radiotherapy for prostate cancerIPG752
Upadacitinib for treating active non-radiographic axial spondyloarthritisTA861
Trastuzumab deruxtecan for treating HER2-positive unresectable or metastatic breast cancer after 1 or more anti-HER2 treatmentsTA862
Somatrogon for treating growth disturbance in children and young people aged 3 years and overTA863
Nintedanib for treating idiopathic pulmonary fibrosis when forced vital capacity is above 80% predictedTA864
Delirium: prevention, diagnosis and management in hospital and long-term careCG103
Maribavir for treating refractory cytomegalovirus infection after transplantTA860
Trabeculectomy with a biodegradable collagen matrix implant for glaucomaIPG750
Tobacco: preventing uptake, promoting quitting and treating dependenceNG209
Angiotensin II for treating vasosuppressor-resistant hypotension caused by septic or distributive shock (terminated appraisal)TA859
Disabled children and young people up to 25 with severe complex needs: integrated service delivery and organisation across health, social care and educationNG213
MRI-based technologies for assessing non-alcoholic fatty liver diseaseDG50
Laparoscopic insertion of a magnetic ring for gastro-oesophageal reflux diseaseIPG749
Transcutaneous electrical stimulation of the trigeminal nerve for ADHDIPG748
Nivolumab with platinum- and fluoropyrimidine-based chemotherapy for untreated HER2-negative advanced gastric, gastro-oesophageal junction or oesophageal adenocarcinomaTA857
Lenvatinib with pembrolizumab for untreated advanced renal cell carcinomaTA858
Hip fracture: managementCG124
Percutaneous image-guided cryoablation of peripheral neuroma for chronic painIPG747
Upadacitinib for treating moderately to severely active ulcerative colitisTA856
Thyroid cancer: assessment and managementNG230
Avatrombopag for treating primary chronic immune thrombocytopeniaTA853
Fetal monitoring in labourNG229
Cabozantinib for previously treated advanced hepatocellular carcinomaTA849
Amivantamab for treating EGFR exon 20 insertion mutation-positive advanced non-small-cell lung cancer after platinum-based chemotherapyTA850
Pembrolizumab for neoadjuvant and adjuvant treatment of triple-negative early or locally advanced breast cancerTA851
Trifluridine–tipiracil for treating metastatic gastric cancer or gastro-oesophageal junction adenocarcinoma after 2 or more treatmentsTA852
Esketamine nasal spray for treatment-resistant depressionTA854
Memokath 051 Ureter stent for ureteric obstructionMTG75
Cemiplimab for untreated PD-L1-positive advanced or metastatic non-small-cell lung cancer (terminated appraisal)TA848
Optilume for treating recurrent bulbar urethral stricturesMTG73
GreenLight XPS for treating benign prostatic hyperplasiaMTG74
Mepolizumab for treating eosinophilic granulomatosis with polyangiitis (terminated appraisal)TA845
Mepolizumab for treating severe hypereosinophilic syndrome (terminated appraisal)TA846
Mepolizumab for treating severe chronic rhinosinusitis with nasal polyps (terminated appraisal)TA847
Luspatercept for treating anaemia caused by myelodysplastic syndromes (terminated appraisal)TA844
Luspatercept for treating anaemia caused by beta-thalassaemia (terminated appraisal)TA843
Tunnelled peritoneal drainage catheter insertion for refractory ascites in cirrhosisIPG746
Fractures (complex): assessment and managementNG37
Subarachnoid haemorrhage caused by a ruptured aneurysm: diagnosis and managementNG228
Ab interno canaloplasty for open-angle glaucomaIPG745
Carfilzomib with daratumumab and dexamethasone for treating relapsed or refractory multiple myeloma (terminated appraisal)TA841
Tisagenlecleucel for treating follicular lymphoma after 2 or more therapies (terminated appraisal)TA842
Percutaneous ultrasound-guided microwave ablation for symptomatic benign thyroid nodulesIPG743
Ruxolitinib for treating acute graft versus host disease refractory to corticosteroids (terminated appraisal)TA839
Ruxolitinib for treating chronic graft versus host disease refractory to corticosteroids (terminated appraisal)TA840
Extracorporeal shockwave therapy for calcific tendinopathy in the shoulderIPG742
Advocacy services for adults with health and social care needsNG227
Slow-release potassium bicarbonate–potassium citrate for treating distal renal tubular acidosis (terminated appraisal)TA838
Transcutaneous electrical stimulation of the supraorbital nerve for treating and preventing migraineIPG740
YAG laser vitreolysis for symptomatic vitreous floatersIPG741
Pembrolizumab for adjuvant treatment of resected stage 2B or 2C melanomaTA837
Palbociclib with fulvestrant for treating hormone receptor-positive, HER2-negative advanced breast cancer after endocrine therapyTA836
Osteoarthritis in over 16s: diagnosis and managementNG226
Pembrolizumab for adjuvant treatment of renal cell carcinomaTA830
Relugolix–estradiol–norethisterone acetate for treating moderate to severe symptoms of uterine fibroidsTA832
Zanubrutinib for treating Waldenstrom's macroglobulinaemiaTA833
Fostamatinib for treating refractory chronic immune thrombocytopeniaTA835
SQ HDM SLIT for treating allergic rhinitis and allergic asthma caused by house dust mites (terminated appraisal)TA834
Magtrace and Sentimag system for locating sentinel lymph nodes for breast cancerMTG72
Oral azacitidine for maintenance treatment of acute myeloid leukaemia after induction therapyTA827
Ozanimod for treating moderately to severely active ulcerative colitisTA828
Upadacitinib for treating active ankylosing spondylitisTA829
Atezolizumab for adjuvant treatment of resected non-small-cell lung cancerTA823
Neurostimulation of lumbar muscles for refractory non-specific chronic low back painIPG739
Prostatic urethral temporary implant insertion for lower urinary tract symptoms caused by benign prostatic hyperplasiaIPG737
Removal, preservation and subsequent reimplantation of ovarian tissue to prevent symptoms from the menopauseIPG738
Neuropad for detecting preclinical diabetic peripheral neuropathyMTG38
Avacopan for treating severe active granulomatosis with polyangiitis or microscopic polyangiitisTA825
Vedolizumab for treating chronic refractory pouchitis after surgery for ulcerative colitis (terminated appraisal)TA826
Colorectal cancer prevention: colonoscopic surveillance in adults with ulcerative colitis, Crohn's disease or adenomasCG118
Melphalan for haematological diseases before allogeneic haematopoietic stem cell transplant (terminated appraisal)TA822
Dexamethasone intravitreal implant for treating diabetic macular oedemaTA824
Self-harm: assessment, management and preventing recurrenceNG225
Faecal microbiota transplant for recurrent Clostridioides difficile infectionMTG71
Brolucizumab for treating diabetic macular oedemaTA820
iFuse for treating chronic sacroiliac joint painMTG39
Focal resurfacing implants to treat articular cartilage damage in the kneeIPG734
Transcutaneous electrical neuromuscular stimulation for urinary incontinenceIPG735
Superficial venous arterialisation for chronic limb threatening ischaemiaIPG736
Avalglucosidase alfa for treating Pompe diseaseTA821
Cefiderocol for treating severe drug-resistant gram-negative bacterial infectionsHTE2
Ceftazidime with avibactam for treating severe drug-resistant gram-negative bacterial infectionsHTE1
Type 1 diabetes in adults: diagnosis and managementNG17
Sacituzumab govitecan for treating unresectable triple-negative advanced breast cancer after 2 or more therapiesTA819
Nivolumab with ipilimumab for untreated unresectable malignant pleural mesotheliomaTA818
SecurAcath for securing percutaneous cathetersMTG34
Guselkumab for treating active psoriatic arthritis after inadequate response to DMARDsTA815
Alpelisib with fulvestrant for treating hormone receptor-positive, HER2-negative, PIK3CA-mutated advanced breast cancerTA816
Nivolumab for adjuvant treatment of invasive urothelial cancer at high risk of recurrenceTA817
Bioresorbable stent implantation to treat coronary artery diseaseIPG732
Aortic remodelling hybrid stent insertion during surgical repair of an acute type A aortic dissectionIPG733
Pralsetinib for treating RET fusion-positive advanced non-small-cell lung cancerTA812
Asciminib for treating chronic myeloid leukaemia after 2 or more tyrosine kinase inhibitorsTA813
Abrocitinib, tralokinumab or upadacitinib for treating moderate to severe atopic dermatitisTA814
PLGF-based testing to help diagnose suspected preterm pre-eclampsiaDG49
Transcatheter tricuspid valve annuloplasty for tricuspid regurgitationIPG730
Transcatheter tricuspid valve leaflet repair for tricuspid regurgitationIPG731
Melanoma: assessment and managementNG14
Urinary tract infection in under 16s: diagnosis and managementNG224
Duvelisib for treating relapsed or refractory chronic lymphocytic leukaemia after 2 or more treatments (terminated appraisal)TA811
Imlifidase for desensitisation treatment before kidney transplant in people with chronic kidney diseaseTA809
Abemaciclib with endocrine therapy for adjuvant treatment of hormone receptor-positive, HER2-negative, node-positive early breast cancer at high risk of recurrenceTA810
PeritX peritoneal catheter drainage system for vacuum-assisted drainage of treatment-resistant, recurrent malignant ascitesMTG9
Risankizumab for treating active psoriatic arthritis after inadequate response to DMARDsTA803
Icosapent ethyl with statin therapy for reducing the risk of cardiovascular events in people with raised triglyceridesTA805
Belimumab for treating lupus nephritis (terminated appraisal)TA806
Roxadustat for treating symptomatic anaemia in chronic kidney diseaseTA807
Fenfluramine for treating seizures associated with Dravet syndromeTA808
Setmelanotide for treating obesity caused by LEPR or POMC deficiencyHST21
Social, emotional and mental wellbeing in primary and secondary educationNG223
MiraQ for assessing graft flow during coronary artery bypass graft surgeryMTG8
Teduglutide for treating short bowel syndromeTA804
Vertebral body tethering for idiopathic scoliosis in children and young peopleIPG728
Nerve graft for corneal denervationIPG729
Depression in adults: treatment and managementNG222
Type 2 diabetes in adults: managementNG28
Faricimab for treating diabetic macular oedemaTA799
Faricimab for treating wet age-related macular degenerationTA800
Pembrolizumab plus chemotherapy for untreated, triple-negative, locally recurrent unresectable or metastatic breast cancerTA801
Cemiplimab for treating advanced cutaneous squamous cell carcinomaTA802
Multiple sclerosis in adults: managementNG220
Durvalumab for maintenance treatment of unresectable non-small-cell lung cancer after platinum-based chemoradiationTA798
Reducing sexually transmitted infectionsNG221
Venetoclax for treating chronic lymphocytic leukaemiaTA796
Enfortumab vedotin for previously treated locally advanced or metastatic urothelial cancer (terminated appraisal)TA797
Preterm labour and birthNG25
Gout: diagnosis and managementNG219
Anifrolumab for treating active autoantibody-positive systemic lupus erythematosus (terminated appraisal)TA793
Diroximel fumarate for treating relapsing–remitting multiple sclerosisTA794
Ibrutinib for treating Waldenstrom's macroglobulinaemiaTA795
Peristeen Plus transanal irrigation system for managing bowel dysfunctionMTG36
Thopaz+ portable digital system for managing chest drainsMTG37
Synthetic cartilage implant insertion for first metatarsophalangeal joint osteoarthritis (hallux rigidus)IPG727
Filgotinib for treating moderately to severely active ulcerative colitisTA792
Social work with adults experiencing complex needsNG216
Endoanchoring systems in endovascular aortic aneurysm repairIPG725
Supercapsular percutaneously assisted total hip arthroplasty for osteoarthritisIPG726
TYRX Absorbable Antibacterial Envelope for preventing infection from cardiac implantable electronic devices (terminated appraisal)TA790
Romosozumab for treating severe osteoporosisTA791
Sleepio to treat insomnia and insomnia symptomsMTG70
Personalised external aortic root support (PEARS) using mesh to prevent aortic root expansion and aortic dissection in people with Marfan syndromeIPG724
Tepotinib for treating advanced non-small-cell lung cancer with MET gene alterationsTA789
Vaccine uptake in the general populationNG218
Avelumab for maintenance treatment of locally advanced or metastatic urothelial cancer after platinum-based chemotherapyTA788
Selumetinib for treating symptomatic and inoperable plexiform neurofibromas associated with type 1 neurofibromatosis in children aged 3 and overHST20
Liposuction for chronic lymphoedemaIPG723
Epilepsies in children, young people and adultsNG217
Tucatinib with trastuzumab and capecitabine for treating HER2-positive advanced breast cancer after 2 or more anti-HER2 therapiesTA786
Venetoclax with low dose cytarabine for untreated acute myeloid leukaemia when intensive chemotherapy is unsuitableTA787
Elosulfase alfa for treating mucopolysaccharidosis type 4AHST19
Intramedullary distraction for upper limb lengtheningIPG722
Medicines associated with dependence or withdrawal symptoms: safe prescribing and withdrawal management for adultsNG215
Niraparib for maintenance treatment of relapsed, platinum-sensitive ovarian, fallopian tube and peritoneal cancerTA784
Nivolumab with cabozantinib for untreated advanced renal cell carcinoma (terminated appraisal)TA785
Stroke and transient ischaemic attack in over 16s: diagnosis and initial managementNG128
Daratumumab monotherapy for treating relapsed and refractory multiple myelomaTA783
myCOPD for managing chronic obstructive pulmonary diseaseMTG68
UroShield for preventing catheter-associated urinary tract infectionsMTG69
Freelite assays for diagnosing multiple myeloma and related conditions (terminated assessment)DG47
Sotorasib for previously treated KRAS G12C mutation-positive advanced non-small-cell lung cancerTA781
Tagraxofusp for treating blastic plasmacytoid dendritic cell neoplasm (terminated appraisal)TA782
Liposuction for chronic lipoedemaIPG721
Atidarsagene autotemcel for treating metachromatic leukodystrophyHST18
Nivolumab with ipilimumab for untreated advanced renal cell carcinomaTA780
Integrated health and social care for people experiencing homelessnessNG214
Dostarlimab for previously treated advanced or recurrent endometrial cancer with high microsatellite instability or mismatch repair deficiencyTA779
Otitis media (acute): antimicrobial prescribingNG91
Percutaneous insertion of a cystic duct stent after cholecystostomy for acute calculous cholecystitisIPG720
Lenalidomide for relapsed or refractory mantle cell lymphoma (terminated appraisal)TA774
Empagliflozin for treating chronic heart failure with reduced ejection fractionTA773
Dapagliflozin for treating chronic kidney diseaseTA775
Pitolisant hydrochloride for treating excessive daytime sleepiness caused by obstructive sleep apnoeaTA776
Solriamfetol for treating excessive daytime sleepiness caused by obstructive sleep apnoeaTA777
Pegcetacoplan for treating paroxysmal nocturnal haemoglobinuriaTA778
Prontosan for treating acute and chronic woundsMTG67
3C Patch for treating diabetic foot ulcersMTG66
Endoscopic full thickness removal of gastrointestinal stromal tumours of the stomachIPG717
Intramedullary distraction for lower limb lengtheningIPG718
Endoscopic balloon dilation for subglottic or tracheal stenosisIPG719
Mental wellbeing at workNG212
PredictSURE IBD and IBDX to guide treatment of Crohn's diseaseDG45
EarlyCDT Lung for assessing risk of lung cancer in solid lung nodulesDG46
Pembrolizumab for treating relapsed or refractory classical Hodgkin lymphoma after stem cell transplant or at least 2 previous therapiesTA772
Odevixibat for treating progressive familial intrahepatic cholestasisHST17
Pembrolizumab with carboplatin and paclitaxel for untreated metastatic squamous non-small-cell lung cancerTA770
Daratumumab with bortezomib, melphalan and prednisone for untreated multiple myeloma (terminated appraisal)TA771
Stereotactic radiosurgery for trigeminal neuralgiaIPG715
Microwave ablation for primary or metastatic cancer in the lungIPG716
Olaparib for treating BRCA mutation-positive HER2-negative metastatic breast cancer after chemotherapy (terminated appraisal)TA762
Daratumumab in combination for untreated multiple myeloma when a stem cell transplant is suitableTA763
Fremanezumab for preventing migraineTA764
Venetoclax with azacitidine for untreated acute myeloid leukaemia when intensive chemotherapy is unsuitableTA765
Pembrolizumab for adjuvant treatment of completely resected stage 3 melanomaTA766
Ponesimod for treating relapsing–remitting multiple sclerosisTA767
Upadacitinib for treating active psoriatic arthritis after inadequate response to DMARDsTA768
Palforzia for treating peanut allergy in children and young peopleTA769
Sedaconda ACD-S for sedation with volatile anaesthetics in intensive careMTG65
Glaucoma: diagnosis and managementNG81
Sodium zirconium cyclosilicate for treating hyperkalaemiaTA599
Osimertinib for adjuvant treatment of EGFR mutation-positive non-small-cell lung cancer after complete tumour resectionTA761
Rehabilitation after traumatic injuryNG211
Selpercatinib for previously treated RET fusion-positive advanced non-small-cell lung cancerTA760
Cabotegravir with rilpivirine for treating HIV-1TA757
Solriamfetol for treating excessive daytime sleepiness caused by narcolepsyTA758
Headaches in over 12s: diagnosis and managementCG150
Endo-SPONGE for treating low rectal anastomotic leakMTG63
Fedratinib for treating disease-related splenomegaly or symptoms in myelofibrosisTA756
Transanal total mesorectal excision for rectal cancerIPG713
Endobronchial nerve ablation for chronic obstructive pulmonary diseaseIPG714
Colorectal cancerNG151
Prostate cancer: diagnosis and managementNG131
Belimumab for treating active autoantibody-positive systemic lupus erythematosusTA752
Cenobamate for treating focal onset seizures in epilepsyTA753
Mogamulizumab for previously treated mycosis fungoides and Sézary syndromeTA754
ClearGuard HD antimicrobial barrier caps for preventing haemodialysis catheter-related bloodstream infectionsMTG62
Pelvic floor dysfunction: prevention and non-surgical managementNG210
Olaparib for maintenance treatment of BRCA mutation-positive metastatic pancreatic cancer after platinum-based chemotherapy (terminated appraisal)TA750
Dupilumab for treating severe asthma with type 2 inflammationTA751
Mexiletine for treating the symptoms of myotonia in non-dystrophic myotonic disordersTA748
Liraglutide for managing obesity in people aged 12 to 17 years (terminated appraisal)TA749
Synergo for non-muscle-invasive bladder cancerMTG61
Fever in under 5s: assessment and initial managementNG143
Givosiran for treating acute hepatic porphyriaHST16
Percutaneous implantation of pulmonary artery pressure sensors for monitoring treatment of chronic heart failureIPG711
Coronary sinus narrowing device implantation for refractory anginaIPG712
Chronic kidney disease: assessment and managementNG203
SeHCAT (tauroselcholic [75 selenium] acid) for diagnosing bile acid diarrhoeaDG44
Acute heart failure: diagnosis and managementCG187
Heart valve disease presenting in adults: investigation and managementNG208
Nivolumab for adjuvant treatment of resected oesophageal or gastro-oesophageal junction cancerTA746
Nintedanib for treating progressive fibrosing interstitial lung diseasesTA747
Upadacitinib for treating moderate rheumatoid arthritisTA744
NBTXR-3 for treating advanced soft tissue sarcoma (terminated appraisal)TA745
Inducing labourNG207
Selpercatinib for treating advanced thyroid cancer with RET alterationsTA742
Myalgic encephalomyelitis (or encephalopathy)/chronic fatigue syndrome: diagnosis and managementNG206
Apalutamide with androgen deprivation therapy for treating high-risk hormone-relapsed non-metastatic prostate cancerTA740
Apalutamide with androgen deprivation therapy for treating hormone-sensitive metastatic prostate cancerTA741
Genicular artery embolisation for pain from knee osteoarthritisIPG708
Laparoscopic renal denervation for loin pain haematuria syndromeIPG709
Percutaneous endovascular forearm arteriovenous fistula creation for haemodialysis accessIPG710
Atezolizumab for untreated PD-L1-positive advanced urothelial cancer when cisplatin is unsuitableTA739
Looked-after children and young peopleNG205
Tofacitinib for treating juvenile idiopathic arthritisTA735
Nivolumab for treating recurrent or metastatic squamous cell carcinoma of the head and neck after platinum-based chemotherapyTA736
Pembrolizumab with platinum- and fluoropyrimidine-based chemotherapy for untreated advanced oesophageal and gastro-oesophageal junction cancerTA737
Berotralstat for preventing recurrent attacks of hereditary angioedemaTA738
Secukinumab for treating moderate to severe plaque psoriasis in children and young peopleTA734
Baloxavir marboxil for treating acute uncomplicated influenza (terminated appraisal)TA732
Inclisiran for treating primary hypercholesterolaemia or mixed dyslipidaemiaTA733
DyeVert Systems for reducing the risk of acute kidney injury in coronary and peripheral angiographyMTG60
Avapritinib for treating unresectable or metastatic gastrointestinal stromal tumours (terminated appraisal)TA730
Vericiguat for treating chronic heart failure with reduced ejection fraction (terminated appraisal)TA731
Lateral elbow resurfacing for arthritisIPG705
Transapical transcatheter mitral valve-in-valve implantation for a failed surgically implanted mitral valve bioprosthesisIPG706
Transapical transcatheter mitral valve-in-ring implantation after failed annuloplasty for mitral valve repairIPG707
Daratumumab with pomalidomide and dexamethasone for treating relapsed or refractory multiple myeloma (terminated appraisal)TA726
Isatuximab with carfilzomib and dexamethasone for treating relapsed or refractory multiple myeloma (terminated appraisal)TA727
Midostaurin for treating advanced systemic mastocytosisTA728
Sapropterin for treating hyperphenylalaninaemia in phenylketonuriaTA729
Abemaciclib with fulvestrant for treating hormone receptor-positive, HER2-negative advanced breast cancer after endocrine therapyTA725
Nivolumab with ipilimumab and chemotherapy for untreated metastatic non-small-cell lung cancerTA724
Bimekizumab for treating moderate to severe plaque psoriasisTA723
Magnetic resonance therapy for knee osteoarthritisIPG702
Laparoscopic removal of uterine fibroids with power morcellationIPG703
Hysteroscopic mechanical tissue removal (hysteroscopic morcellation) for uterine fibroidsIPG704
Babies, children and young people's experience of healthcareNG204
Pemigatinib for treating relapsed or refractory advanced cholangiocarcinoma with FGFR2 fusion or rearrangementTA722
Obstructive sleep apnoea/hypopnoea syndrome and obesity hypoventilation syndrome in over 16sNG202
Continuous positive airway pressure for the treatment of obstructive sleep apnoea/hypopnoea syndromeTA139
Antenatal careNG201
Chlormethine gel for treating mycosis fungoides-type cutaneous T-cell lymphomaTA720
Abiraterone for treating newly diagnosed high-risk hormone-sensitive metastatic prostate cancerTA721
Bronchiolitis in children: diagnosis and managementNG9
Inducing and maintaining normothermia using temperature modulation devices to improve outcomes after stroke or subarachnoid haemorrhageIPG701
Nivolumab with ipilimumab for previously treated metastatic colorectal cancer with high microsatellite instability or mismatch repair deficiencyTA716
Clostridioides difficile infection: antimicrobial prescribingNG199
ENDURALIFE powered CRT-D devices for treating heart failureMTG33
Duvelisib for treating relapsed follicular lymphoma after 2 or more systemic therapies (terminated appraisal)TA717
Ixekizumab for treating axial spondyloarthritisTA718
Secukinumab for treating non-radiographic axial spondyloarthritisTA719
Dasatinib for treating Philadelphia-chromosome-positive acute lymphoblastic leukaemia (terminated appraisal)TA714
Adalimumab, etanercept, infliximab and abatacept for treating moderate rheumatoid arthritis after conventional DMARDs have failedTA715
Enzalutamide for treating hormone-sensitive metastatic prostate cancerTA712
Nivolumab for advanced non-squamous non-small-cell lung cancer after chemotherapyTA713
Apixaban for preventing stroke and systemic embolism in people with non-valvular atrial fibrillationTA275
Dabigatran etexilate for the prevention of stroke and systemic embolism in atrial fibrillationTA249
Rivaroxaban for the prevention of stroke and systemic embolism in people with atrial fibrillationTA256
Edoxaban for preventing stroke and systemic embolism in people with non-valvular atrial fibrillationTA355
Atrial fibrillation: diagnosis and managementNG196
Plus Sutures for preventing surgical site infectionMTG59
Laser lithotripsy for difficult-to-treat bile duct stonesIPG699
Percutaneous insertion of a closure device to repair a paravalvular leak around a replaced mitral or aortic valveIPG700
Budesonide orodispersible tablet for inducing remission of eosinophilic oesophagitisTA708
Pembrolizumab for untreated metastatic colorectal cancer with high microsatellite instability or mismatch repair deficiencyTA709
Ravulizumab for treating atypical haemolytic uraemic syndromeTA710
Patient experience in adult NHS services: improving the experience of care for people using adult NHS servicesCG138
Shared decision makingNG197
Nivolumab for previously treated unresectable advanced or recurrent oesophageal cancerTA707
Autism spectrum disorder in adults: diagnosis and managementCG142
Autism spectrum disorder in under 19s: support and managementCG170
Ozanimod for treating relapsing–remitting multiple sclerosisTA706
Atezolizumab monotherapy for untreated advanced non-small-cell lung cancerTA705
Electrohydraulic lithotripsy for difficult-to-treat bile duct stonesIPG698
Ex-situ machine perfusion for extracorporeal preservation of lungs (ex-vivo lung perfusion) for transplantIPG695
Transvaginal laser therapy for stress urinary incontinenceIPG696
Transvaginal laser therapy for urogenital atrophyIPG697
Ibrutinib with obinutuzumab for untreated chronic lymphocytic leukaemia and small lymphocytic lymphoma (terminated appraisal)TA702
Ibrutinib with rituximab for untreated chronic lymphocytic leukaemia (terminated appraisal)TA703
Trastuzumab deruxtecan for treating HER2-positive unresectable or metastatic breast cancer after 2 or more anti-HER2 therapiesTA704
Heavy menstrual bleeding: assessment and managementNG88
HeartFlow FFRCT for estimating fractional flow reserve from coronary CT angiographyMTG32
Parafricta Bootees and Undergarments to reduce skin breakdown in people with or at risk of pressure ulcersMTG20
Ravulizumab for treating paroxysmal nocturnal haemoglobinuriaTA698
Ofatumumab for treating relapsing multiple sclerosisTA699
Selinexor with low-dose dexamethasone for treating refractory multiple myeloma (terminated appraisal)TA700
Crisaborole for treating mild to moderate atopic dermatitis in people 2 years and older (terminated appraisal)TA701
Tafamidis for treating transthyretin amyloidosis with cardiomyopathyTA696
Andexanet alfa for reversing anticoagulation from apixaban or rivaroxabanTA697
Permanent His-bundle pacemaker implantation for treating heart failureIPG694
UroLift for treating lower urinary tract symptoms of benign prostatic hyperplasiaMTG58
Repetitive short-pulse transscleral cyclophotocoagulation for glaucomaIPG692
Deep brain stimulation for chronic, severe, treatment-resistant obsessive-compulsive disorder in adultsIPG693
Pembrolizumab for treating locally advanced or metastatic urothelial carcinoma after platinum-containing chemotherapyTA692
Bempedoic acid with ezetimibe for treating primary hypercholesterolaemia or mixed dyslipidaemiaTA694
Carfilzomib with dexamethasone and lenalidomide for previously treated multiple myelomaTA695
Melphalan chemosaturation with percutaneous hepatic artery perfusion and hepatic vein isolation for primary or metastatic cancer in the liverIPG691
Avelumab for treating metastatic Merkel cell carcinomaTA517
Acalabrutinib for treating chronic lymphocytic leukaemiaTA689
Avelumab for untreated metastatic Merkel cell carcinomaTA691
Postnatal careNG194
Chronic pain (primary and secondary) in over 16s: assessment of all chronic pain and management of chronic primary painNG193
Transcervical ultrasound-guided radiofrequency ablation for symptomatic uterine fibroidsIPG689
Extracorporeal whole liver perfusion for acute liver failureIPG690
Danis stent for acute oesophageal variceal bleedingMTG57
Anakinra for treating Still's diseaseTA685
Blinatumomab for previously treated Philadelphia-chromosome-positive acute lymphoblastic leukaemia (terminated appraisal)TA686
Ribociclib with fulvestrant for treating hormone receptor-positive, HER2-negative advanced breast cancer after endocrine therapyTA687
Selective internal radiation therapies for treating hepatocellular carcinomaTA688
Cannabis-based medicinal productsNG144
Asthma: diagnosis, monitoring and chronic asthma managementNG80
QAngio XA 3D QFR and CAAS vFFR imaging software for assessing coronary stenosis during invasive coronary angiographyDG43
Nivolumab for adjuvant treatment of completely resected melanoma with lymph node involvement or metastatic diseaseTA684
Erenumab for preventing migraineTA682
Pembrolizumab with pemetrexed and platinum chemotherapy for untreated, metastatic, non-squamous non-small-cell lung cancerTA683
Alpha-Stim AID for anxiety disordersMTG56
Free-functioning gracilis transfer to restore upper limb function in brachial plexus injuryIPG687
Cytoreduction surgery with hyperthermic intraoperative peritoneal chemotherapy for peritoneal carcinomatosisIPG688
Lenalidomide maintenance treatment after an autologous stem cell transplant for newly diagnosed multiple myelomaTA680
Baricitinib for treating moderate to severe atopic dermatitisTA681
Secondary bacterial infection of eczema and other common skin conditions: antimicrobial prescribingNG190
Safeguarding adults in care homesNG189
Metreleptin for treating lipodystrophyHST14
Filgotinib for treating moderate to severe rheumatoid arthritisTA676
Brexucabtagene autoleucel for treating relapsed or refractory mantle cell lymphomaTA677
Omalizumab for treating chronic rhinosinusitis with nasal polyps (terminated appraisal)TA678
Dapagliflozin for treating chronic heart failure with reduced ejection fractionTA679
Niraparib for maintenance treatment of advanced ovarian, fallopian tube and peritoneal cancer after response to first-line platinum-based chemotherapyTA673
Pembrolizumab for untreated PD-L1-positive, locally advanced or metastatic urothelial cancer when cisplatin is unsuitable (terminated appraisal)TA674
Vernakalant for the rapid conversion of recent onset atrial fibrillation to sinus rhythm (terminated appraisal)TA675
Trabectedin for the treatment of advanced soft tissue sarcomaTA185
Leukomed Sorbact for preventing surgical site infectionMTG55
Mepolizumab for treating severe eosinophilic asthmaTA671
Brolucizumab for treating wet age-related macular degenerationTA672
Brain tumours (primary) and brain metastases in over 16sNG99
Self-expanding implant insertion into the intersphincteric space for faecal incontinenceIPG685
Minimally invasive radical hysterectomy for early stage cervical cancerIPG686
The VAC Veraflo Therapy system for acute infected or chronic wounds that are failing to healMTG54
Brigatinib for ALK-positive advanced non-small-cell lung cancer that has not been previously treated with an ALK inhibitorTA670
The PLASMA system for transurethral resection and haemostasis of the prostateMTG53
Encorafenib plus cetuximab for previously treated BRAF V600E mutation-positive metastatic colorectal cancerTA668
PancreatitisNG104
Diabetes in pregnancy: management from preconception to the postnatal periodNG3
Eating disorders: recognition and treatmentNG69
Atezolizumab with bevacizumab for treating advanced or unresectable hepatocellular carcinomaTA666
Caplacizumab with plasma exchange and immunosuppression for treating acute acquired thrombotic thrombocytopenic purpuraTA667
Peripheral arterial disease: diagnosis and managementCG147
Low back pain and sciatica in over 16s: assessment and managementNG59
Venetoclax with obinutuzumab for untreated chronic lymphocytic leukaemiaTA663
Liraglutide for managing overweight and obesityTA664
Upadacitinib for treating severe rheumatoid arthritisTA665
Zio XT for detecting cardiac arrhythmiasMTG52
Darolutamide with androgen deprivation therapy for treating hormone-relapsed non-metastatic prostate cancerTA660
Pembrolizumab for untreated metastatic or unresectable recurrent head and neck squamous cell carcinomaTA661
Durvalumab in combination for untreated extensive-stage small-cell lung cancer (terminated appraisal)TA662
Swallowable gastric balloon capsule for weight lossIPG684
Acute coronary syndromesNG185
Drug-eluting stents for the treatment of coronary artery diseaseTA152
Guidance on the use of coronary artery stentsTA71
Siponimod for treating secondary progressive multiple sclerosisTA656
Carfilzomib for previously treated multiple myelomaTA657
Isatuximab with pomalidomide and dexamethasone for treating relapsed and refractory multiple myelomaTA658
Galcanezumab for preventing migraineTA659
Human and animal bites: antimicrobial prescribingNG184
Testing strategies for Lynch syndrome in people with endometrial cancerDG42
Pressurised intraperitoneal aerosol chemotherapy for peritoneal carcinomatosisIPG681
Balloon cryoablation for Barrett's oesophagusIPG682
Balloon cryoablation for squamous dysplasia of the oesophagusIPG683
Volanesorsen for treating familial chylomicronaemia syndromeHST13
Nivolumab for advanced squamous non-small-cell lung cancer after chemotherapyTA655
SEM Scanner 200 for preventing pressure ulcersMTG51
Osimertinib for treating EGFR T790M mutation-positive advanced non-small-cell lung cancerTA653
Osimertinib for untreated EGFR mutation-positive non-small-cell lung cancerTA654
Rheumatoid arthritis in adults: managementNG100
Behaviour change: digital and mobile health interventionsNG183
Pembrolizumab with axitinib for untreated advanced renal cell carcinomaTA650
Naldemedine for treating opioid-induced constipationTA651
Transcranial magnetic stimulation for auditory hallucinationsIPG680
Polatuzumab vedotin with rituximab and bendamustine for treating relapsed or refractory diffuse large B-cell lymphomaTA649
Neuropathic pain in adults: pharmacological management in non-specialist settingsCG173
Insect bites and stings: antimicrobial prescribingNG182
Dupilumab for treating chronic rhinosinusitis with nasal polyps (terminated appraisal)TA648
Axonics sacral neuromodulation system for treating refractory overactive bladderMTG50
Implantable cardiac monitors to detect atrial fibrillation after cryptogenic strokeDG41
Glasdegib with chemotherapy for untreated acute myeloid leukaemia (terminated appraisal)TA646
Eculizumab for treating relapsing neuromyelitis optica (terminated appraisal)TA647
Avelumab with axitinib for untreated advanced renal cell carcinomaTA645
High-sensitivity troponin tests for the early rule out of NSTEMIDG40
Anaphylaxis: assessment and referral after emergency treatmentCG134
Perioperative care in adultsNG180
Rehabilitation for adults with complex psychosisNG181
Surgical site infections: prevention and treatmentNG125
Deep brain stimulation for refractory epilepsy in adultsIPG678
Implanted vagus nerve stimulation for treatment-resistant depressionIPG679
Brentuximab vedotin in combination for untreated systemic anaplastic large cell lymphomaTA641
Gilteritinib for treating relapsed or refractory acute myeloid leukaemiaTA642
Entrectinib for treating ROS1-positive advanced non-small-cell lung cancerTA643
Entrectinib for treating NTRK fusion-positive solid tumoursTA644
Transcranial magnetic stimulation for obsessive-compulsive disorderIPG676
Electrical stimulation to improve muscle strength in chronic respiratory conditions, chronic heart failure and chronic kidney diseaseIPG677
Treosulfan with fludarabine for malignant disease before allogeneic stem cell transplantTA640
Artificial iris insertion for acquired aniridiaIPG674
Artificial iris insertion for congenital aniridiaIPG675
Atezolizumab with carboplatin and etoposide for untreated extensive-stage small-cell lung cancerTA638
Atezolizumab with nab-paclitaxel for untreated PD-L1-positive, locally advanced or metastatic, triple-negative breast cancerTA639
Daratumumab with lenalidomide and dexamethasone for untreated multiple myeloma (terminated appraisal)TA634
Ramucirumab with erlotinib for untreated EGFR-positive metastatic non-small-cell lung cancer (terminated appraisal)TA635
Eculizumab for treating refractory myasthenia gravis (terminated appraisal)TA636
Ranibizumab for treating diabetic retinopathy (terminated appraisal)TA637
Intravascular lithotripsy for calcified coronary arteries during percutaneous coronary interventionIPG673
Rezum for treating lower urinary tract symptoms secondary to benign prostatic hyperplasiaMTG49
Avatrombopag for treating thrombocytopenia in people with chronic liver disease needing a planned invasive procedureTA626
Tests to help assess risk of acute kidney injury for people being considered for critical care admission (ARCHITECT and Alinity i Urine NGAL assays, BioPorto NGAL test and NephroCheck test)DG39
Ustekinumab for treating moderately to severely active ulcerative colitisTA633
Generalised anxiety disorder and panic disorder in adults: managementCG113
Intravenous fluid therapy in children and young people in hospitalNG29
Trastuzumab emtansine for adjuvant treatment of HER2-positive early breast cancerTA632
Joint replacement (primary): hip, knee and shoulderNG157
Larotrectinib for treating NTRK fusion-positive solid tumoursTA630
Lorlatinib for previously treated ALK-positive advanced non-small-cell lung cancerTA628
Obinutuzumab with bendamustine for treating follicular lymphoma after rituximabTA629
PneuX to prevent ventilator-associated pneumoniaMTG48
Lenalidomide with rituximab for previously treated follicular lymphomaTA627
Abdominal aortic aneurysm: diagnosis and managementNG156
Alemtuzumab for treating highly active relapsing–remitting multiple sclerosisTA312
Tinnitus: assessment and managementNG155
Bilateral cervicosacropexy (CESA) or vaginosacropexy (VASA) using mesh for pelvic organ prolapseIPG669
Cyanoacrylate glue occlusion for varicose veinsIPG670
MRI-guided laser interstitial thermal therapy for drug-resistant epilepsyIPG671
Selective internal radiation therapy for unresectable colorectal metastases in the liverIPG672
Recombinant human parathyroid hormone for treating hypoparathyroidism (terminated appraisal)TA625
Impetigo: antimicrobial prescribingNG153
Neonatal parenteral nutritionNG154
SepsiTest assay for rapidly identifying bloodstream bacteria and fungiDG20
Peginterferon beta-1a for treating relapsing–remitting multiple sclerosisTA624
Patiromer for treating hyperkalaemiaTA623
Sotagliflozin with insulin for treating type 1 diabetesTA622
Antenatal and postnatal mental health: clinical management and service guidanceCG192
Episcissors-60 for mediolateral episiotomyMTG47
Leg ulcer infection: antimicrobial prescribingNG152
Fetoscopic prenatal repair for open neural tube defects in the fetusIPG667
Open prenatal repair for open neural tube defects in the fetusIPG668
Reducing the risk of transmission of Creutzfeldt–Jakob disease (CJD) from surgical instruments used for interventional procedures on high-risk tissuesIPG666
Supporting adult carersNG150
Virtual Touch Quantification to diagnose and monitor liver fibrosis in chronic hepatitis B and CMTG27
Atezolizumab with carboplatin and nab-paclitaxel for untreated advanced non-squamous non-small-cell lung cancer (terminated appraisal)TA618
Indoor air quality at homeNG149
Lusutrombopag for treating thrombocytopenia in people with chronic liver disease needing a planned invasive procedureTA617
Cladribine for treating relapsing–remitting multiple sclerosisTA616
Balloon dilation for chronic eustachian tube dysfunctionIPG665
Cannabidiol with clobazam for treating seizures associated with Dravet syndromeTA614
Cannabidiol with clobazam for treating seizures associated with Lennox–Gastaut syndromeTA615
Menopause: diagnosis and managementNG23
gammaCore for cluster headacheMTG46
Cerliponase alfa for treating neuronal ceroid lipofuscinosis type 2HST12
Irreversible electroporation for primary liver cancerIPG664
Diverticular disease: diagnosis and managementNG147
Workplace health: long-term sickness absence and capability to workNG146
Neratinib for extended adjuvant treatment of hormone receptor-positive, HER2-positive early stage breast cancer after adjuvant trastuzumabTA612
Point-of-care creatinine devices to assess kidney function before CT imaging with intravenous contrastDG37
Rapid tests for group A streptococcal infections in people with a sore throatDG38
Pentosan polysulfate sodium for treating bladder pain syndromeTA610
Rucaparib for maintenance treatment of relapsed platinum-sensitive ovarian, fallopian tube or peritoneal cancerTA611
Ibrutinib with rituximab for treating Waldenstrom's macroglobulinaemia (terminated appraisal)TA608
Ramucirumab for treating unresectable hepatocellular carcinoma after sorafenib (terminated appraisal)TA609
Gastro-oesophageal reflux disease and dyspepsia in adults: investigation and managementCG184
Rivaroxaban for preventing atherothrombotic events in people with coronary or peripheral artery diseaseTA607
Midcarpal hemiarthroplasty for wrist arthritisIPG663
End of life care for adults: service deliveryNG142
Lanadelumab for preventing recurrent attacks of hereditary angioedemaTA606
Diabetic foot problems: prevention and managementNG19
Voretigene neparvovec for treating inherited retinal dystrophies caused by RPE65 gene mutationsHST11
Gastro-oesophageal reflux disease in children and young people: diagnosis and managementNG1
Xeomin (botulinum neurotoxin type A) for treating chronic sialorrhoeaTA605
EXOGEN ultrasound bone healing system for long bone fractures with non-union or delayed healingMTG12
Familial hypercholesterolaemia: identification and managementCG71
Idelalisib for treating refractory follicular lymphomaTA604
Cellulitis and erysipelas: antimicrobial prescribingNG141
High-intensity focused ultrasound for glaucomaIPG661
Bioprosthetic plug insertion for anal fistulaIPG662
Abortion careNG140
Pomalidomide with bortezomib and dexamethasone for treating relapsed or refractory multiple myeloma (terminated appraisal)TA602
Lenalidomide with bortezomib and dexamethasone for untreated multiple myeloma (terminated appraisal)TA603
Tegaderm CHG securement dressing for vascular access sites in critically ill adultsMTG25
Pneumonia (community-acquired): antimicrobial prescribingNG138
Pneumonia (hospital-acquired): antimicrobial prescribingNG139
Attention deficit hyperactivity disorder: diagnosis and managementNG87
Implant insertion for prominent earsIPG660
Benralizumab for treating severe eosinophilic asthmaTA565
Risankizumab for treating moderate to severe plaque psoriasisTA596
Patisiran for treating hereditary transthyretin amyloidosisHST10
Endovascular insertion of an intrasaccular wire-mesh blood-flow disruption device for intracranial aneurysmsIPG658
Low-energy contact X-ray brachytherapy (the Papillon technique) for locally advanced rectal cancerIPG659
Brentuximab vedotin for untreated advanced Hodgkin lymphoma (terminated appraisal)TA594
Dacomitinib for untreated EGFR mutation-positive non-small-cell lung cancerTA595
Venous thromboembolism in over 16s: reducing the risk of hospital-acquired deep vein thrombosis or pulmonary embolismNG89
Alcohol interventions in secondary and further educationNG135
PICO negative pressure wound dressings for closed surgical incisionsMTG43
Fluocinolone acetonide intravitreal implant for treating recurrent non-infectious uveitisTA590
Letermovir for preventing cytomegalovirus disease after a stem cell transplantTA591
Chronic obstructive pulmonary disease in over 16s: diagnosis and managementNG115
End of life care for infants, children and young people with life-limiting conditions: planning and managementNG61
Transurethral laser ablation for recurrent non-muscle-invasive bladder cancerIPG656
Ultrasound-guided high-intensity transcutaneous focused ultrasound for symptomatic uterine fibroidsIPG657
Nusinersen for treating spinal muscular atrophyTA588
Blinatumomab for treating acute lymphoblastic leukaemia in remission with minimal residual disease activityTA589
Motor neurone disease: assessment and managementNG42
Therapeutic monitoring of TNF-alpha inhibitors in rheumatoid arthritisDG36
Bisphosphonates for treating osteoporosisTA464
Long-acting reversible contraceptionCG30
Cardiac contractility modulation device implantation for heart failureIPG655
Valve-in-valve TAVI for aortic bioprosthetic valve dysfunctionIPG653
Reinforcement of a permanent stoma with a synthetic or biological mesh to prevent a parastomal herniaIPG654
Lenalidomide for treating myelodysplastic syndromes associated with an isolated deletion 5q cytogenetic abnormalityTA322
Lenalidomide for the treatment of multiple myeloma in people who have received at least 2 prior therapiesTA171
Lenalidomide plus dexamethasone for multiple myeloma after 1 treatment with bortezomibTA586
Lenalidomide plus dexamethasone for previously untreated multiple myelomaTA587
Depression in children and young people: identification and managementNG134
Urinary incontinence and pelvic organ prolapse in women: managementNG123
Ambu aScope4 Broncho for use in unexpected difficult airwaysMTG14
Percutaneous insertion of a cerebral protection device to prevent cerebral embolism during TAVIIPG650
Percutaneous mechanical thrombectomy for acute deep vein thrombosis of the legIPG651
Bronchoscopic thermal vapour ablation for upper-lobe emphysemaIPG652
Ocrelizumab for treating primary progressive multiple sclerosisTA585
Endocuff Vision for assisting visualisation during colonoscopyMTG45
Ertugliflozin with metformin and a dipeptidyl peptidase-4 inhibitor for treating type 2 diabetesTA583
Atezolizumab in combination for treating metastatic non-squamous non-small-cell lung cancerTA584
The Sherlock 3CG Tip Confirmation System for placement of peripherally inserted central cathetersMTG24
Therapeutic hypothermia for acute ischaemic strokeIPG647
Collagen paste for closing an anal fistulaIPG648
Percutaneous mitral valve leaflet repair for mitral regurgitationIPG649
Hyperparathyroidism (primary): diagnosis, assessment and initial managementNG132
Inotersen for treating hereditary transthyretin amyloidosisHST9
Enzalutamide for hormone-relapsed non-metastatic prostate cancerTA580
Curos for preventing infections when using needleless connectorsMTG44
Lead-I ECG devices for detecting symptomatic atrial fibrillation using single time point testing in primary careDG35
Crohn's disease: managementNG129
Ulcerative colitis: managementNG130
Intrapartum care for women with existing medical conditions or obstetric complications and their babiesNG121
Brentuximab vedotin for treating CD30-positive cutaneous T-cell lymphomaTA577
Endoscopic ablation for an anal fistulaIPG645
Endoscopic ablation for a pilonidal sinusIPG646
Certolizumab pegol for treating moderate to severe plaque psoriasisTA574
Tildrakizumab for treating moderate to severe plaque psoriasisTA575
Bosutinib for untreated chronic myeloid leukaemia (terminated appraisal)TA576
Specialist neonatal respiratory care for babies born pretermNG124
Ertugliflozin as monotherapy or with metformin for treating type 2 diabetesTA572
The Debrisoft monofilament debridement pad for use in acute or chronic woundsMTG17
Brigatinib for treating ALK-positive advanced non-small-cell lung cancer after crizotinibTA571
Pembrolizumab for treating recurrent or metastatic squamous cell carcinoma of the head and neck after platinum-based chemotherapy (terminated appraisal)TA570
Pertuzumab for adjuvant treatment of HER2-positive early stage breast cancerTA569
Radially emitting laser fibre treatment of an anal fistulaIPG644
Abatacept for treating psoriatic arthritis after DMARDs (terminated appraisal)TA568
Cochlear implants for children and adults with severe to profound deafnessTA566
High-intensity focused ultrasound for symptomatic benign thyroid nodulesIPG643
Venetoclax with rituximab for previously treated chronic lymphocytic leukaemiaTA561
Encorafenib with binimetinib for unresectable or metastatic BRAF V600 mutation-positive melanomaTA562
Abemaciclib with an aromatase inhibitor for previously untreated, hormone receptor-positive, HER2-negative, locally advanced or metastatic breast cancerTA563
Barnett Continent Intestinal Reservoir (modified continent ileostomy) to restore continence after colon and rectum removalIPG642
Bevacizumab with carboplatin, gemcitabine and paclitaxel for treating the first recurrence of platinum-sensitive advanced ovarian cancer (terminated appraisal)TA560
Cough (acute): antimicrobial prescribingNG120
Electrically stimulated intravesical chemotherapy for non-muscle-invasive bladder cancerIPG638
Laparoscopic cerclage for cervical incompetence to prevent late miscarriage or preterm birthIPG639
Percutaneous venoplasty for chronic cerebrospinal venous insufficiency in multiple sclerosisIPG640
Senza spinal cord stimulation system for delivering HF10 therapy to treat chronic neuropathic painMTG41
Platelet-rich plasma injections for knee osteoarthritisIPG637
Ex-situ machine perfusion for extracorporeal preservation of livers for transplantationIPG636
Cerebral palsy in adultsNG119
Mepilex Border Heel and Sacrum dressings for preventing pressure ulcersMTG40
Pipeline Flex embolisation device with Shield Technology for the treatment of complex intracranial aneurysmsMTG10
Regorafenib for previously treated advanced hepatocellular carcinomaTA555
Darvadstrocel for treating complex perianal fistulas in Crohn's diseaseTA556
Renal and ureteric stones: assessment and managementNG118
Tisagenlecleucel for treating relapsed or refractory B-cell acute lymphoblastic leukaemia in people aged up to 25 yearsTA554
Tumour profiling tests to guide adjuvant chemotherapy decisions in early breast cancerDG34
Transcutaneous neuromuscular electrical stimulation for oropharyngeal dysphagia in adultsIPG634
Bronchial thermoplasty for severe asthmaIPG635
Lenvatinib for untreated advanced hepatocellular carcinomaTA551
Liposomal cytarabine–daunorubicin for untreated acute myeloid leukaemiaTA552
Bronchiectasis (non-cystic fibrosis), acute exacerbation: antimicrobial prescribingNG117
Vandetanib for treating medullary thyroid cancerTA550
Post-traumatic stress disorderNG116
Chronic obstructive pulmonary disease (acute exacerbation): antimicrobial prescribingNG114
Decitabine for untreated acute myeloid leukaemia (terminated appraisal)TA548
Denosumab for preventing skeletal-related events in multiple myeloma (terminated appraisal)TA549
Transcranial MRI-guided focused ultrasound thalamotomy for neuropathic painIPG632
Percutaneous insertion of a temporary heart pump for left ventricular haemodynamic support in high-risk percutaneous coronary interventionsIPG633
Tofacitinib for moderately to severely active ulcerative colitisTA547
Urinary tract infection (catheter-associated): antimicrobial prescribingNG113
Padeliporfin for untreated localised prostate cancerTA546
Subcutaneous automated low-flow pump implantation for refractory ascites caused by cirrhosisIPG631
Gemtuzumab ozogamicin for untreated acute myeloid leukaemiaTA545
Selective internal radiation therapy for unresectable primary intrahepatic cholangiocarcinomaIPG630
Urinary tract infection (lower): antimicrobial prescribingNG109
Prostatitis (acute): antimicrobial prescribingNG110
Pyelonephritis (acute): antimicrobial prescribingNG111
Urinary tract infection (recurrent): antimicrobial prescribingNG112
Eltrombopag for treating chronic immune thrombocytopeniaTA293
Romiplostim for the treatment of chronic immune thrombocytopeniaTA221
Myeloma: diagnosis and managementNG35
Lyme diseaseNG95
Dabrafenib with trametinib for adjuvant treatment of resected BRAF V600 mutation-positive melanomaTA544
Burosumab for treating X-linked hypophosphataemia in children and young peopleHST8
Renal replacement therapy and conservative managementNG107
Decision-making and mental capacityNG108
Cabozantinib for untreated advanced renal cell carcinomaTA542
Tofacitinib for treating active psoriatic arthritis after inadequate response to DMARDsTA543
E‑vita open plus for treating complex aneurysms and dissections of the thoracic aortaMTG16
Intravesical microwave hyperthermia and chemotherapy for non-muscle-invasive bladder cancerIPG628
Inotuzumab ozogamicin for treating relapsed or refractory B-cell acute lymphoblastic leukaemiaTA541
Chronic heart failure in adults: diagnosis and managementNG106
Preventing suicide in community and custodial settingsNG105
Pembrolizumab for treating relapsed or refractory classical Hodgkin lymphomaTA540
Leadless cardiac pacemaker implantation for bradyarrhythmiasIPG626
Superior rectal artery embolisation for haemorrhoidsIPG627
Lutetium (177Lu) oxodotreotide for treating unresectable or metastatic neuroendocrine tumoursTA539
Sutureless aortic valve replacement for aortic stenosisIPG624
Flu vaccination: increasing uptakeNG103
Dinutuximab beta for treating neuroblastomaTA538
Transurethral water vapour ablation for lower urinary tract symptoms caused by benign prostatic hyperplasiaIPG625
Lenvatinib and sorafenib for treating differentiated thyroid cancer after radioactive iodineTA535
Alectinib for untreated ALK-positive advanced non-small-cell lung cancerTA536
Ixekizumab for treating active psoriatic arthritis after inadequate response to DMARDsTA537
Community pharmacies: promoting health and wellbeingNG102
Dupilumab for treating moderate to severe atopic dermatitisTA534
Low-intensity pulsed ultrasound to promote healing of fresh fractures at low risk of non-healingIPG621
Low-intensity pulsed ultrasound to promote healing of fresh fractures at high risk of non-healingIPG622
Low-intensity pulsed ultrasound to promote healing of delayed-union and non-union fracturesIPG623
Superior capsular augmentation for massive rotator cuff tearsIPG619
Transaxial interbody lumbosacral fusion for severe chronic low back painIPG620
Ocrelizumab for treating relapsing–remitting multiple sclerosisTA533
Pembrolizumab for untreated PD-L1-positive metastatic non-small-cell lung cancerTA531
Biomarker tests to help diagnose preterm labour in women with intact membranesDG33
Crizotinib for treating ROS1-positive advanced non-small-cell lung cancerTA529
Nivolumab for treating locally advanced unresectable or metastatic urothelial cancer after platinum-containing chemotherapyTA530
Beta interferons and glatiramer acetate for treating multiple sclerosisTA527
Unilateral MRI-guided focused ultrasound thalamotomy for treatment-resistant essential tremorIPG617
Laparoscopic ventral mesh rectopexy for internal rectal prolapseIPG618
Dementia: assessment, management and support for people living with dementia and their carersNG97
Donepezil, galantamine, rivastigmine and memantine for the treatment of Alzheimer's diseaseTA217
Intranasal phototherapy for allergic rhinitisIPG616
Guselkumab for treating moderate to severe plaque psoriasisTA521
Midostaurin for untreated acute myeloid leukaemiaTA523
Brentuximab vedotin for treating CD30-positive Hodgkin lymphomaTA524
Atezolizumab for treating locally advanced or metastatic urothelial carcinoma after platinum-containing chemotherapyTA525
Arsenic trioxide for treating acute promyelocytic leukaemiaTA526
Cancer of the upper aerodigestive tract: assessment and management in people aged 16 and overNG36
Endoscopic bipolar radiofrequency ablation for treating biliary obstruction caused by cancerIPG614
Low-level laser therapy for preventing or treating oral mucositis caused by radiotherapy or chemotherapyIPG615
Atezolizumab for treating locally advanced or metastatic non-small-cell lung cancer after chemotherapyTA520
Percutaneous balloon valvuloplasty for fetal critical aortic stenosisIPG613
Adjunctive colposcopy technologies for assessing suspected cervical abnormalities: the DYSIS colposcope with DYSISmap and the ZedScan IDG32
Robot-assisted kidney transplantIPG609
Prostate artery embolisation for lower urinary tract symptoms caused by benign prostatic hyperplasiaIPG611
Microinvasive subconjunctival insertion of a trans-scleral gelatin stent for primary open-angle glaucomaIPG612
Nerve transfer to partially restore upper limb function in tetraplegiaIPG610
Tocilizumab for treating giant cell arteritisTA518
Care and support of people growing older with learning disabilitiesNG96
Learning disabilities and behaviour that challenges: service design and deliveryNG93
Emergency and acute medical care in over 16s: service delivery and organisationNG94
Eribulin for treating locally advanced or metastatic breast cancer after 1 chemotherapy regimenTA515
Cabozantinib for treating medullary thyroid cancerTA516
Physical activity and the environmentNG90
Brodalumab for treating moderate to severe plaque psoriasisTA511
Tivozanib for treating advanced renal cell carcinomaTA512
Obinutuzumab for untreated advanced follicular lymphomaTA513
Mosaicplasty for symptomatic articular cartilage defects of the kneeIPG607
Laparoscopic mesh pectopexy for apical prolapse of the uterus or vaginaIPG608
Autologous chondrocyte implantation using chondrosphere for treating symptomatic articular cartilage defects of the kneeTA508
Pertuzumab with trastuzumab and docetaxel for treating HER2-positive breast cancerTA509
Unilateral MRI-guided focused ultrasound thalamotomy for moderate to severe tremor in Parkinson's diseaseIPG606
Sofosbuvir–velpatasvir–voxilaprevir for treating chronic hepatitis CTA507
People's experience in adult social care services: improving the experience of care and support for people using adult social care servicesNG86
Aortic valve reconstruction with processed bovine pericardiumIPG604
Strimvelis for treating adenosine deaminase deficiency–severe combined immunodeficiencyHST7
Pancreatic cancer in adults: diagnosis and managementNG85
Raloxifene for the primary prevention of osteoporotic fragility fractures in postmenopausal womenTA160
Raloxifene and teriparatide for the secondary prevention of osteoporotic fragility fractures in postmenopausal womenTA161
Pirfenidone for treating idiopathic pulmonary fibrosisTA504
Intrabeam radiotherapy system for adjuvant treatment of early breast cancerTA501
Ibrutinib for treating relapsed or refractory mantle cell lymphomaTA502
Fulvestrant for untreated locally advanced or metastatic oestrogen-receptor positive breast cancerTA503
Sore throat (acute): antimicrobial prescribingNG84
Lenvatinib with everolimus for previously treated advanced renal cell carcinomaTA498
Glecaprevir–pibrentasvir for treating chronic hepatitis CTA499
Ceritinib for untreated ALK-positive non-small-cell lung cancerTA500
Age-related macular degenerationNG82
Golimumab for treating non-radiographic axial spondyloarthritisTA497
Autism spectrum disorder in under 19s: recognition, referral and diagnosisCG128
Endobronchial valve insertion to reduce lung volume in emphysemaIPG600
Transcutaneous microwave ablation for severe primary axillary hyperhidrosisIPG601
Artificial heart implantation as a bridge to transplantation for end-stage refractory biventricular heart failureIPG602
Subcutaneous implantable cardioverter defibrillator insertion for preventing sudden cardiac deathIPG603
Palbociclib with an aromatase inhibitor for previously untreated, hormone receptor-positive, HER2-negative, locally advanced or metastatic breast cancerTA495
Ribociclib with an aromatase inhibitor for previously untreated, hormone receptor-positive, HER2-negative, locally advanced or metastatic breast cancerTA496
Atrial fibrillation and heart valve disease: self-monitoring coagulation status using point-of-care coagulometers (the CoaguChek XS system)DG14
Transvaginal mesh repair of anterior or posterior vaginal wall prolapseIPG599
Naltrexone–bupropion for managing overweight and obesityTA494
Processed nerve allografts to repair peripheral nerve discontinuitiesIPG597
Hypoglossal nerve stimulation for moderate to severe obstructive sleep apnoeaIPG598
Vismodegib for treating basal cell carcinomaTA489
Trastuzumab emtansine for treating HER2-positive advanced breast cancer after trastuzumab and a taxaneTA458
Tests in secondary care to identify people at high risk of ovarian cancerDG31
Regorafenib for previously treated unresectable or metastatic gastrointestinal stromal tumoursTA488
Total distal radioulnar joint replacement for symptomatic joint instability or arthritisIPG595
Extracranial to intracranial bypass for intracranial atherosclerosisIPG596
Sarilumab for moderate to severe rheumatoid arthritisTA485
Aflibercept for treating choroidal neovascularisationTA486
Sinusitis (acute): antimicrobial prescribingNG79
Cataracts in adults: managementNG77
Cystic fibrosis: diagnosis and managementNG78
Hepatitis B (chronic): diagnosis and managementCG165
Tofacitinib for moderate to severe rheumatoid arthritisTA480
Immunosuppressive therapy for kidney transplant in adultsTA481
Immunosuppressive therapy for kidney transplant in children and young peopleTA482
Child maltreatment: when to suspect maltreatment in under 18sCG89
Child abuse and neglectNG76
Autologous chondrocyte implantation for treating symptomatic articular cartilage defects of the kneeTA477
Brentuximab vedotin for treating relapsed or refractory systemic anaplastic large cell lymphomaTA478
Reslizumab for treating severe eosinophilic asthmaTA479
Intramuscular diaphragm stimulation for ventilator-dependent chronic respiratory failure caused by motor neurone diseaseIPG593
Faltering growth: recognition and management of faltering growth in childrenNG75
Cetuximab and panitumumab for previously untreated metastatic colorectal cancerTA439
Intermediate care including reablementNG74
Type 2 diabetes: prevention in people at high riskPH38
Ab externo canaloplasty for primary open-angle glaucomaIPG591
High-intensity focused ultrasound for symptomatic breast fibroadenomaIPG592
Pembrolizumab for advanced melanoma not previously treated with ipilimumabTA366
Pembrolizumab for treating PD-L1-positive non-small-cell lung cancer after chemotherapyTA428
Pembrolizumab for treating advanced melanoma after disease progression with ipilimumabTA357
Fertility problems: assessment and treatmentCG156
Sorafenib for treating advanced hepatocellular carcinomaTA474
Dimethyl fumarate for treating moderate to severe plaque psoriasisTA475
Paclitaxel as albumin-bound nanoparticles with gemcitabine for untreated metastatic pancreatic cancerTA476
Psoriasis: assessment and managementCG153
Cetuximab for treating recurrent or metastatic squamous cell cancer of the head and neckTA473
Vitamin D: supplement use in specific population groupsPH56
Radiofrequency treatment for haemorrhoidsIPG589
Methylnaltrexone bromide for treating opioid-induced constipation (terminated appraisal)TA468
Idelalisib with ofatumumab for treating chronic lymphocytic leukaemia (terminated appraisal)TA469
Advanced breast cancer: diagnosis and treatmentCG81
Holoclar for treating limbal stem cell deficiency after eye burnsTA467
Pemetrexed for the maintenance treatment of non-small-cell lung cancerTA190
Developmental follow-up of children and young people born pretermNG72
Cabozantinib for previously treated advanced renal cell carcinomaTA463
Baricitinib for moderate to severe rheumatoid arthritisTA466
moorLDI2-BI: a laser doppler blood flow imager for burn wound assessmentMTG2
Nutrition support for adults: oral nutrition support, enteral tube feeding and parenteral nutritionCG32
Transcatheter aortic valve implantation for aortic stenosisIPG586
Adalimumab and dexamethasone for treating non-infectious uveitisTA460
Roflumilast for treating chronic obstructive pulmonary diseaseTA461
Nivolumab for treating relapsed or refractory classical Hodgkin lymphomaTA462
Parkinson's disease in adultsNG71
Constipation in children and young people: diagnosis and managementCG99
Adalimumab, etanercept and ustekinumab for treating plaque psoriasis in children and young peopleTA455
Ustekinumab for moderately to severely active Crohn's disease after previous treatmentTA456
New generation cardiac CT scanners (Aquilion ONE, Brilliance iCT, Discovery CT750 HD and Somatom Definition Flash) for cardiac imaging in people with suspected or known coronary artery disease in whom imaging is difficult with earlier generation CT scannersDG3
Ibrutinib for untreated chronic lymphocytic leukaemia without a 17p deletion or TP53 mutation (terminated appraisal)TA452
Bortezomib for treating multiple myeloma after second or subsequent relapse (terminated appraisal)TA453
Daratumumab with lenalidomide and dexamethasone for treating relapsed or refractory multiple myeloma (terminated appraisal)TA454
Air pollution: outdoor air quality and healthNG70
Eliglustat for treating type 1 Gaucher diseaseHST5
Infracoccygeal sacropexy using mesh to repair vaginal vault prolapseIPG581
Infracoccygeal sacropexy using mesh to repair uterine prolapseIPG582
Sacrocolpopexy using mesh to repair vaginal vault prolapseIPG583
Uterine suspension using mesh (including sacrohysteropexy) to repair uterine prolapseIPG584
Etelcalcetide for treating secondary hyperparathyroidismTA448
Everolimus and sunitinib for treating unresectable or metastatic neuroendocrine tumours in people with progressive diseaseTA449
Blinatumomab for previously treated Philadelphia-chromosome-negative acute lymphoblastic leukaemiaTA450
Ponatinib for treating chronic myeloid leukaemia and acute lymphoblastic leukaemiaTA451
Multiple frequency bioimpedance devices to guide fluid management in people with chronic kidney disease having dialysisDG29
Obesity: working with local communitiesPH42
Spondyloarthritis in over 16s: diagnosis and managementNG65
Endoscopic full thickness removal of non-lifting colonic polypsIPG580
Afatinib for treating advanced squamous non-small-cell lung cancer after platinum-based chemotherapy (terminated appraisal)TA444
Certolizumab pegol and secukinumab for treating active psoriatic arthritis after inadequate response to DMARDsTA445
Idiopathic pulmonary fibrosis in adults: diagnosis and managementCG163
Virtual chromoendoscopy to assess colorectal polyps during colonoscopyDG28
Intravenous fluid therapy in adults in hospitalCG174
Irreversible electroporation for treating pancreatic cancerIPG579
Pegylated liposomal irinotecan for treating pancreatic cancer after gemcitabineTA440
Ixekizumab for treating moderate to severe plaque psoriasisTA442
Obeticholic acid for treating primary biliary cholangitisTA443
Antisocial behaviour and conduct disorders in children and young people: recognition and managementCG158
Alcohol-use disorders: diagnosis and management of physical complicationsCG100
Sexually transmitted infections: condom distribution schemesNG68
Minimally invasive sacroiliac joint fusion surgery for chronic sacroiliac painIPG578
Irritable bowel syndrome in adults: diagnosis and managementCG61
Managing medicines for adults receiving social care in the communityNG67
Panitumumab in combination with chemotherapy for the treatment of metastatic colorectal cancer (terminated appraisal)TA240
Alectinib for previously treated anaplastic lymphoma kinase-positive advanced non-small-cell lung cancer (terminated appraisal)TA438
Patient group directionsMPG2
Extraurethral (non-circumferential) retropubic adjustable compression devices for stress urinary incontinence in womenIPG576
Sacrocolpopexy with hysterectomy using mesh to repair uterine prolapseIPG577
Bevacizumab for treating EGFR mutation-positive non-small-cell lung cancer (terminated appraisal)TA436
Ibrutinib with bendamustine and rituximab for treating relapsed or refractory chronic lymphocytic leukaemia after systemic therapy (terminated appraisal)TA437
Elotuzumab for previously treated multiple myeloma (terminated appraisal)TA434
Tenofovir alafenamide for treating chronic hepatitis B (terminated appraisal)TA435
Mental health of adults in contact with the criminal justice systemNG66
Ustekinumab for treating active psoriatic arthritisTA340
Ustekinumab for the treatment of adults with moderate to severe psoriasisTA180
Molecular testing strategies for Lynch syndrome in people with colorectal cancerDG27
Migalastat for treating Fabry diseaseHST4
Lateral interbody fusion in the lumbar spine for low back painIPG574
Trabecular stent bypass microsurgery for open-angle glaucomaIPG575
Drug misuse prevention: targeted interventionsNG64
Everolimus for advanced renal cell carcinoma after previous treatmentTA432
Apremilast for treating active psoriatic arthritisTA433
Healthcare-associated infections: prevention and control in primary and community careCG139
HumiGard for preventing inadvertent perioperative hypothermiaMTG31
Osteoporosis: assessing the risk of fragility fractureCG146
Cerebral palsy in under 25s: assessment and managementNG62
Antimicrobial stewardship: changing risk-related behaviours in the general populationNG63
Ibrutinib for previously treated chronic lymphocytic leukaemia and untreated chronic lymphocytic leukaemia with 17p deletion or TP53 mutationTA429
Sofosbuvir–velpatasvir for treating chronic hepatitis CTA430
Pomalidomide for multiple myeloma previously treated with lenalidomide and bortezomibTA427
Organ donation for transplantation: improving donor identification and consent rates for deceased organ donationCG135
Extracorporeal shockwave therapy for Achilles tendinopathyIPG571
Radiation therapy for early Dupuytren's diseaseIPG573
Everolimus with exemestane for treating advanced breast cancer after endocrine therapyTA421
Crizotinib for previously treated anaplastic lymphoma kinase-positive advanced non-small-cell lung cancerTA422
Eribulin for treating locally advanced or metastatic breast cancer after 2 or more chemotherapy regimensTA423
Pertuzumab for the neoadjuvant treatment of HER2-positive breast cancerTA424
Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemiaTA425
Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemiaTA426
Hypothermia: prevention and management in adults having surgeryCG65
Epiduroscopic lumbar discectomy through the sacral hiatus for sciaticaIPG570
Ticagrelor for preventing atherothrombotic events after myocardial infarctionTA420
XprESS multi sinus dilation system for treating chronic sinusitisMTG30
HIV testing: increasing uptake among people who may have undiagnosed HIVNG60
Recent-onset chest pain of suspected cardiac origin: assessment and diagnosisCG95
Coexisting severe mental illness and substance misuse: community health and social care servicesNG58
Spasticity in under 19s: managementCG145
Endoscopic transluminal pancreatic necrosectomyIPG567
Percutaneous insertion of craniocaudal expandable implants for vertebral compression fractureIPG568
Single-anastomosis duodeno-ileal bypass with sleeve gastrectomy for treating morbid obesityIPG569
Dapagliflozin in combination therapy for treating type 2 diabetesTA288
Nivolumab for previously treated advanced renal cell carcinomaTA417
Dapagliflozin in triple therapy for treating type 2 diabetesTA418
Apremilast for treating moderate to severe plaque psoriasisTA419
High-throughput non-invasive prenatal testing for fetal RHD genotypeDG25
Physical health of people in prisonNG57
Psychosis and schizophrenia in children and young people: recognition and managementCG155
Certolizumab pegol for treating rheumatoid arthritis after inadequate response to a TNF-alpha inhibitorTA415
Elbasvir–grazoprevir for treating chronic hepatitis CTA413
Cobimetinib in combination with vemurafenib for treating unresectable or metastatic BRAF V600 mutation-positive melanomaTA414
Single-incision short sling mesh insertion for stress urinary incontinence in womenIPG566
Miniature lens system implantation for advanced age-related macular degenerationIPG565
Necitumumab for untreated advanced or metastatic squamous non-small-cell lung cancerTA411
Radium-223 dichloride for treating hormone-relapsed prostate cancer with bone metastasesTA412
Crizotinib for untreated anaplastic lymphoma kinase-positive advanced non-small-cell lung cancerTA406
Secukinumab for active ankylosing spondylitis after treatment with non-steroidal anti-inflammatory drugs or TNF-alpha inhibitorsTA407
Pegaspargase for treating acute lymphoblastic leukaemiaTA408
Aflibercept for treating visual impairment caused by macular oedema after branch retinal vein occlusionTA409
Talimogene laherparepvec for treating unresectable metastatic melanomaTA410
Multimorbidity: clinical assessment and managementNG56
Harmful sexual behaviour among children and young peopleNG55
Mental health problems in people with learning disabilities: prevention, assessment and managementNG54
Transition between inpatient mental health settings and community or care home settingsNG53
Stable angina: managementCG126
Acute upper gastrointestinal bleeding in over 16s: managementCG141
Bosutinib for previously treated chronic myeloid leukaemiaTA401
Pemetrexed maintenance treatment for non-squamous non-small-cell lung cancer after pemetrexed and cisplatinTA402
Ramucirumab for previously treated locally advanced or metastatic non-small-cell lung cancerTA403
Degarelix for treating advanced hormone-dependent prostate cancerTA404
Trifluridine–tipiracil for previously treated metastatic colorectal cancerTA405
Cabazitaxel for hormone-relapsed metastatic prostate cancer treated with docetaxelTA391
Palliative care for adults: strong opioids for pain reliefCG140
Percutaneous endoscopic laser balloon pulmonary vein isolation for atrial fibrillationIPG563
Abiraterone for castration-resistant metastatic prostate cancer previously treated with a docetaxel-containing regimenTA259
Lumacaftor–ivacaftor for treating cystic fibrosis homozygous for the F508del mutationTA398
Azacitidine for treating acute myeloid leukaemia with more than 30% bone marrow blastsTA399
Nivolumab in combination with ipilimumab for treating advanced melanomaTA400
Abiraterone for treating metastatic hormone-relapsed prostate cancer before chemotherapy is indicatedTA387
Non-Hodgkin's lymphoma: diagnosis and managementNG52
Prophylaxis against infective endocarditis: antimicrobial prophylaxis against infective endocarditis in adults and children undergoing interventional proceduresCG64
Non-alcoholic fatty liver disease (NAFLD): assessment and managementNG49
Oral health for adults in care homesNG48
Microstructural scaffold (patch) insertion without autologous cell implantation for repairing symptomatic chondral knee defectsIPG560
Transcervical extracorporeal reverse flow neuroprotection for reducing the risk of stroke during carotid artery stentingIPG561
Ultrasound-guided percutaneous radiofrequency ablation for benign thyroid nodulesIPG562
Alirocumab for treating primary hypercholesterolaemia and mixed dyslipidaemiaTA393
Evolocumab for treating primary hypercholesterolaemia and mixed dyslipidaemiaTA394
Ceritinib for previously treated anaplastic lymphoma kinase positive non-small-cell lung cancerTA395
Trametinib in combination with dabrafenib for treating unresectable or metastatic melanomaTA396
Adalimumab for treating moderate to severe hidradenitis suppurativaTA392
Endovenous mechanochemical ablation for varicose veinsIPG557
Haematological cancers: improving outcomesNG47
Canagliflozin, dapagliflozin and empagliflozin as monotherapies for treating type 2 diabetesTA390
ImmunoCAP ISAC 112 for multiplex allergen testingDG24
Microwave ablation for treating liver metastasesIPG553
Balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertensionIPG554
Percutaneous interlaminar endoscopic lumbar discectomy for sciaticaIPG555
Percutaneous transforaminal endoscopic lumbar discectomy for sciaticaIPG556
Sacubitril valsartan for treating symptomatic chronic heart failure with reduced ejection fractionTA388
Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for treating recurrent ovarian cancerTA389
Controlled drugs: safe use and managementNG46
Routine preoperative tests for elective surgeryNG45
Workplace health: management practicesNG13
Corticosteroid-eluting bioabsorbable stent or spacer insertion during endoscopic sinus surgery to treat chronic rhinosinusitisIPG551
Transcutaneous stimulation of the cervical branch of the vagus nerve for cluster headache and migraineIPG552
Endoscopic carbon dioxide laser cricopharyngeal myotomy for relief of oropharyngeal dysphagiaIPG550
Ruxolitinib for treating disease-related splenomegaly or symptoms in adults with myelofibrosisTA386
Community engagement: improving health and wellbeing and reducing health inequalitiesNG44
Guidance on the use of temozolomide for the treatment of recurrent malignant glioma (brain cancer)TA23
Spectra Optia for automatic red blood cell exchange in people with sickle cell diseaseMTG28
Angioplasty and stenting to treat peripheral arterial disease causing refractory erectile dysfunctionIPG546
Mechanical clot retrieval for treating acute ischaemic strokeIPG548
Normothermic extracorporeal preservation of hearts for transplantation following donation after brainstem deathIPG549
Ezetimibe for treating primary heterozygous-familial and non-familial hypercholesterolaemiaTA385
Transition from children's to adults' services for young people using health or social care servicesNG43
Nivolumab for treating advanced (unresectable or metastatic) melanomaTA384
Therapeutic monitoring of TNF-alpha inhibitors in Crohn's disease (LISA-TRACKER ELISA kits, IDKmonitor ELISA kits, and Promonitor ELISA kits)DG22
Fractures (non-complex): assessment and managementNG38
Major trauma: assessment and initial managementNG39
Major trauma: service deliveryNG40
Spinal injury: assessment and initial managementNG41
Skin cancer preventionPH32
Sunlight exposure: risks and benefitsNG34
TNF-alpha inhibitors for ankylosing spondylitis and non-radiographic axial spondyloarthritisTA383
Percutaneous coblation of the intervertebral disc for low back pain and sciaticaIPG543
Percutaneous electrothermal treatment of the intervertebral disc annulus for low back pain and sciaticaIPG544
Percutaneous intradiscal radiofrequency treatment of the intervertebral disc nucleus for low back painIPG545
Enzalutamide for treating metastatic hormone-relapsed prostate cancer before chemotherapy is indicatedTA377
Ramucirumab for treating advanced gastric cancer or gastro–oesophageal junction adenocarcinoma previously treated with chemotherapyTA378
Nintedanib for treating idiopathic pulmonary fibrosisTA379
Panobinostat for treating multiple myeloma after at least 2 previous treatmentsTA380
Eltrombopag for treating severe aplastic anaemia refractory to immunosuppressive therapy (terminated appraisal)TA382
Adalimumab, etanercept, infliximab, certolizumab pegol, golimumab, tocilizumab and abatacept for rheumatoid arthritis not previously treated with DMARDs or after conventional DMARDs only have failedTA375
Guidance on the use of imatinib for chronic myeloid leukaemiaTA70
Older people: independence and mental wellbeingNG32
Repetitive transcranial magnetic stimulation for depressionIPG542
Joint distraction for ankle osteoarthritisIPG538
Radiofrequency ablation for symptomatic interdigital (Morton's) neuromaIPG539
Electrical stimulation of the lower oesophageal sphincter for treating gastro-oesophageal reflux diseaseIPG540
Insertion of a subretinal prosthesis system for retinitis pigmentosaIPG537
Care of dying adults in the last days of lifeNG31
Ciclosporin for treating dry eye disease that has not improved despite treatment with artificial tearsTA369
Bortezomib for previously untreated mantle cell lymphomaTA370
Abatacept, adalimumab, etanercept and tocilizumab for treating juvenile idiopathic arthritisTA373
Erlotinib and gefitinib for treating non-small-cell lung cancer that has progressed after prior chemotherapyTA374
Oral health promotion: general dental practiceNG30
Transition between inpatient hospital settings and community or care home settings for adults with social care needsNG27
Implantation of a corneal graft–keratoprosthesis for severe corneal opacity in wet blinking eyesIPG534
Living-donor liver transplantationIPG535
Sacral nerve stimulation for idiopathic chronic non-obstructive urinary retentionIPG536
Children's attachment: attachment in children and young people who are adopted from care, in care or at high risk of going into careNG26
Ombitasvir–paritaprevir–ritonavir with or without dasabuvir for treating chronic hepatitis CTA365
Vortioxetine for treating major depressive episodesTA367
Ledipasvir–sofosbuvir for treating chronic hepatitis CTA363
Blood transfusionNG24
VivaScope 1500 and 3000 imaging systems for detecting skin cancer lesionsDG19
Older people with social care needs and multiple long-term conditionsNG22
Implanting a baroreceptor stimulation device for resistant hypertensionIPG533
Developing and updating local formulariesMPG1
Tolvaptan for treating autosomal dominant polycystic kidney diseaseTA358
Idelalisib for treating chronic lymphocytic leukaemiaTA359
Paclitaxel as albumin-bound nanoparticles with carboplatin for untreated non-small-cell lung cancer (terminated appraisal)TA362
Dementia, disability and frailty in later life – mid-life approaches to delay or prevent onsetNG16
Procalcitonin testing for diagnosing and monitoring sepsis (ADVIA Centaur BRAHMS PCT assay, BRAHMS PCT Sensitive Kryptor assay, Elecsys BRAHMS PCT assay, LIAISON BRAHMS PCT assay and VIDAS BRAHMS PCT assay)DG18
Low energy contact X-ray brachytherapy (the Papillon technique) for early stage rectal cancerIPG532
Home care: delivering personal care and practical support to older people living in their own homesNG21
Coeliac disease: recognition, assessment and managementNG20
Preoperative high dose rate brachytherapy for rectal cancerIPG531
Transcranial direct current stimulation (tDCS) for depressionIPG530
Vedolizumab for treating moderately to severely active Crohn's disease after prior therapyTA352
Bevacizumab for treating relapsed, platinum‑resistant epithelial ovarian, fallopian tube or primary peritoneal cancer (terminated appraisal)TA353
Edoxaban for treating and for preventing deep vein thrombosis and pulmonary embolismTA354
Antimicrobial stewardship: systems and processes for effective antimicrobial medicine useNG15
Insertion of a double balloon catheter for induction of labour in pregnant women without previous caesarean sectionIPG528
Joint distraction for knee osteoarthritis without alignment correctionIPG529
Naloxegol for treating opioid‑induced constipationTA345
Aflibercept for treating diabetic macular oedemaTA346
Nintedanib for previously treated locally advanced, metastatic, or locally recurrent non‑small‑cell lung cancerTA347
Everolimus for preventing organ rejection in liver transplantationTA348
Secukinumab for treating moderate to severe plaque psoriasisTA350
Cangrelor for reducing atherothrombotic events in people undergoing percutaneous coronary intervention or awaiting surgery requiring interruption of anti‑platelet therapy (terminated appraisal)TA351
Suture fixation of acute disruption of the distal tibiofibular syndesmosisIPG521
Ultrasound‑enhanced, catheter‑directed thrombolysis for deep vein thrombosisIPG523
Ultrasound‑enhanced, catheter‑directed thrombolysis for pulmonary embolismIPG524
Electrotherapy for the treatment of haemorrhoidsIPG525
Implantation of a sphenopalatine ganglion stimulation device for chronic cluster headacheIPG527
Insertion of an epiretinal prosthesis for retinitis pigmentosaIPG519
Radiofrequency ablation for gastric antral vascular ectasiaIPG520
Omalizumab for previously treated chronic spontaneous urticariaTA339
Vedolizumab for treating moderately to severely active ulcerative colitisTA342
Apixaban for the treatment and secondary prevention of deep vein thrombosis and/or pulmonary embolismTA341
Lower urinary tract symptoms in men: managementCG97
Obinutuzumab in combination with chlorambucil for untreated chronic lymphocytic leukaemiaTA343
Challenging behaviour and learning disabilities: prevention and interventions for people with learning disabilities whose behaviour challengesNG11
Violence and aggression: short-term management in mental health, health and community settingsNG10
Insertion of a balloon device to disimpact an engaged fetal head before an emergency caesarean sectionIPG515
Implantation of a left ventricular assist device for destination therapy in people ineligible for heart transplantationIPG516
Insertion of endobronchial nitinol coils to improve lung function in emphysemaIPG517
Implantation of a duodenal–jejunal bypass liner for managing type 2 diabetesIPG518
Rivaroxaban for preventing adverse outcomes after acute management of acute coronary syndromeTA335
Empagliflozin in combination therapy for treating type 2 diabetesTA336
Rifaximin for preventing episodes of overt hepatic encephalopathyTA337
Obesity preventionCG43
Preventing excess weight gainNG7
Excess winter deaths and illness and the health risks associated with cold homesNG6
Medicines optimisation: the safe and effective use of medicines to enable the best possible outcomesNG5
VibraTip for testing vibration perception to detect diabetic peripheral neuropathyMTG22
Safe midwifery staffing for maternity settingsNG4
Bladder cancer: diagnosis and managementNG2
Infliximab, adalimumab and golimumab for treating moderately to severely active ulcerative colitis after the failure of conventional therapyTA329
Sofosbuvir for treating chronic hepatitis CTA330
Axitinib for treating advanced renal cell carcinoma after failure of prior systemic treatmentTA333
Regorafenib for metastatic colorectal cancer after treatment for metastatic disease (terminated appraisal)TA334
Flexible endoscopic treatment of a pharyngeal pouchIPG513
Eculizumab for treating atypical haemolytic uraemic syndromeHST1
Implantation of a shock or load absorber for mild to moderate symptomatic medial knee osteoarthritisIPG512
Open reduction of slipped capital femoral epiphysisIPG511
Hysteroscopic metroplasty of a uterine septum for primary infertilityIPG509
Hysteroscopic metroplasty of a uterine septum for recurrent miscarriageIPG510
Vemurafenib for treating locally advanced or metastatic BRAF V600 mutation‑positive malignant melanomaTA269
Single‑incision laparoscopic cholecystectomyIPG508
Dabigatran etexilate for the treatment and secondary prevention of deep vein thrombosis and/or pulmonary embolismTA327
Fluorouracil chemotherapy: The My5‑FU assay for guiding dose adjustmentDG16
Telemetric adjustable pulmonary artery banding for pulmonary hypertension in infants with congenital heart defectsIPG505
Insertion of an annular disc implant at lumbar discectomyIPG506
Insertion of a collagen plug to close an abdominal wall enterocutaneous fistulaIPG507
Erythropoiesis‑stimulating agents (epoetin and darbepoetin) for treating anaemia in people with cancer having chemotherapyTA323
Dual‑chamber pacemakers for symptomatic bradycardia due to sick sinus syndrome without atrioventricular blockTA324
Nalmefene for reducing alcohol consumption in people with alcohol dependenceTA325
Imatinib for the adjuvant treatment of gastrointestinal stromal tumoursTA326
The ReCell Spray‑On Skin system for treating skin loss, scarring and depigmentation after burn injuryMTG21
Maternal and child nutritionPH11
Dual‑chamber pacemakers for symptomatic bradycardia due to sick sinus syndrome and/or atrioventricular blockTA88
Gallstone disease: diagnosis and managementCG188
Oral health: local authorities and partnersPH55
Dabrafenib for treating unresectable or metastatic BRAF V600 mutation‑positive melanomaTA321
Combined endoscopic and laparoscopic removal of colonic polypsIPG503
Physical activity: exercise referral schemesPH54
Drug allergy: diagnosis and managementCG183
Total prosthetic replacement of the temporomandibular jointIPG500
Dimethyl fumarate for treating relapsing‑remitting multiple sclerosisTA320
Minimally invasive video-assisted thyroidectomyIPG499
Minimally invasive video‑assisted parathyroidectomyIPG501
Assessing motility of the gastrointestinal tract using a wireless capsuleIPG502
Detecting, managing and monitoring haemostasis: viscoelastometric point‑of‑care testing (ROTEM, TEG and Sonoclot systems)DG13
Endoscopic radiofrequency ablation for Barrett's oesophagus with low‑grade dysplasia or no dysplasiaIPG496
Endoscopic radiofrequency ablation for squamous dysplasia of the oesophagusIPG497
Powered microdebrider turbinoplasty for inferior turbinate hypertrophyIPG498
Enzalutamide for metastatic hormone‑relapsed prostate cancer previously treated with a docetaxel‑containing regimenTA316
Prasugrel with percutaneous coronary intervention for treating acute coronary syndromesTA317
Ipilimumab for previously untreated advanced (unresectable or metastatic) melanomaTA319
Safe staffing for nursing in adult inpatient wards in acute hospitalsSG1
Endoscopic saphenous vein harvest for coronary artery bypass graftingIPG494
Radiofrequency tissue reduction for turbinate hypertrophyIPG495
The geko device for reducing the risk of venous thromboembolismMTG19
Implantable cardioverter defibrillators and cardiac resynchronisation therapy for arrhythmias and heart failureTA314
Canagliflozin in combination therapy for treating type 2 diabetesTA315
Teriflunomide for treating relapsing–remitting multiple sclerosisTA303
Gastroelectrical stimulation for gastroparesisIPG489
Weight management: lifestyle services for overweight or obese adultsPH53
Endoscopic thoracic sympathectomy for primary hyperhidrosis of the upper limbIPG487
Arthroscopic radiofrequency chondroplasty for discrete chondral defects of the kneeIPG493
Pressure ulcers: prevention and managementCG179
Afatinib for treating epidermal growth factor receptor mutation-positive locally advanced or metastatic non-small-cell lung cancerTA310
Bortezomib for induction therapy in multiple myeloma before high-dose chemotherapy and autologous stem cell transplantationTA311
Measuring fractional exhaled nitric oxide concentration in asthma: NIOX MINO, NIOX VERO and NObreathDG12
Extracorporeal membrane oxygenation (ECMO) for acute heart failure in adultsIPG482
Insertion of a magnetic bead band for faecal incontinenceIPG483
Transoral carbon dioxide laser surgery for primary treatment of oropharyngeal malignancyIPG484
Faecal microbiota transplant for recurrent Clostridium difficile infectionIPG485
Contraceptive services for under 25sPH51
Needle and syringe programmesPH52
Rituximab in combination with glucocorticoids for treating anti-neutrophil cytoplasmic antibody-associated vasculitisTA308
Aflibercept in combination with irinotecan and fluorouracil-based therapy for treating metastatic colorectal cancer that has progressed following prior oxaliplatin-based chemotherapyTA307
Managing medicines in care homesSC1
Psychosis and schizophrenia in adults: prevention and managementCG178
Electrochemotherapy for primary basal cell carcinoma and primary squamous cell carcinomaIPG478
Domestic violence and abuse: multi-agency workingPH50
Total hip replacement and resurfacing arthroplasty for end-stage arthritis of the hipTA304
Aflibercept for treating visual impairment caused by macular oedema secondary to central retinal vein occlusionTA305
Pixantrone monotherapy for treating multiply relapsed or refractory aggressive non-Hodgkin's B‑cell lymphomaTA306
Optical coherence tomography to guide percutaneous coronary interventionIPG481
Endoscopic thoracic sympathectomy for primary facial blushingIPG480
Insertion of prostatic urethral lift implants to treat lower urinary tract symptoms secondary to benign prostatic hyperplasiaIPG475
Transcranial magnetic stimulation for treating and preventing migraineIPG477
Arthroscopic trochleoplasty for patellar instabilityIPG474
Radiofrequency ablation of the soft palate for snoringIPG476
Behaviour change: individual approachesPH49
Percutaneous closure of patent foramen ovale to prevent recurrent cerebral embolic eventsIPG472
Uterine artery embolisation for treating adenomyosisIPG473
Negative pressure wound therapy for the open abdomenIPG467
Phrenic nerve transfer in brachial plexus injuryIPG468
Implantation of a duodenal–jejunal bypass sleeve for managing obesityIPG471
Ranibizumab for treating choroidal neovascularisation associated with pathological myopiaTA298
Peginterferon alfa and ribavirin for treating chronic hepatitis C in children and young peopleTA300
Canakinumab for treating systemic juvenile idiopathic arthritis (terminated appraisal)TA302
Peginterferon alfa and ribavirin for the treatment of mild chronic hepatitis CTA106
Interferon alfa (pegylated and non-pegylated) and ribavirin for the treatment of chronic hepatitis CTA75
Weight management: lifestyle services for overweight or obese children and young peoplePH47
Faecal calprotectin diagnostic tests for inflammatory diseases of the bowelDG11
Photochemical corneal collagen cross‑linkage using riboflavin and ultraviolet A for keratoconus and keratectasiaIPG466
Endoscopic radiofrequency ablation for gastro-oesophageal reflux diseaseIPG461
Translaryngeal tracheostomyIPG462
EGFR‑TK mutation testing in adults with locally advanced or metastatic non-small-cell lung cancerDG9
Intraoperative tests (RD‑100i OSNA system and Metasin test) for detecting sentinel lymph node metastases in breast cancerDG8
Pazopanib for the first-line treatment of advanced renal cell carcinomaTA215
Varicose veins: diagnosis and managementCG168
Aripiprazole for treating moderate to severe manic episodes in adolescents with bipolar I disorderTA292
Aflibercept solution for injection for treating wet age‑related macular degenerationTA294
Insertion of customised exposed titanium implants, without soft tissue cover, for complex orofacial reconstructionIPG457
Selective internal radiation therapy for primary hepatocellular carcinomaIPG460
Insertion of customised titanium implants, with soft tissue cover, for orofacial reconstructionIPG449
Rivaroxaban for treating pulmonary embolism and preventing recurrent venous thromboembolismTA287
Mirabegron for treating symptoms of overactive bladderTA290
Falls in older people: assessing risk and preventionCG161
Physical activity: brief advice for adults in primary carePH44
Social anxiety disorder: recognition, assessment and treatmentCG159
Ranibizumab for treating visual impairment caused by macular oedema secondary to retinal vein occlusionTA283
Bevacizumab in combination with paclitaxel and carboplatin for first-line treatment of advanced ovarian cancerTA284
Bevacizumab in combination with gemcitabine and carboplatin for treating the first recurrence of platinum-sensitive advanced ovarian cancerTA285
Loxapine inhalation for treating acute agitation and disturbed behaviours associated with schizophrenia and bipolar disorder (terminated appraisal)TA286
Occipital nerve stimulation for intractable chronic migraineIPG452
Corneal inlay implantation for correction of presbyopiaIPG455
Omalizumab for treating severe persistent allergic asthmaTA278
Percutaneous vertebroplasty and percutaneous balloon kyphoplasty for treating osteoporotic vertebral compression fracturesTA279
Antisocial personality disorder: prevention and managementCG77
Electrochemotherapy for metastases in the skin from tumours of non-skin origin and melanomaIPG446
Insertion of endobronchial valves for persistent air leaksIPG448
Percutaneous electrical nerve stimulation for refractory neuropathic painIPG450
Peripheral nerve-field stimulation for chronic low back painIPG451
Colistimethate sodium and tobramycin dry powders for inhalation for treating pseudomonas lung infection in cystic fibrosisTA276
Methylnaltrexone for treating opioid-induced bowel dysfunction in people with advanced illness receiving palliative care (terminated appraisal)TA277
Hepatitis B and C testing: people at risk of infectionPH43
Irreversible electroporation for treating primary lung cancer and metastases in the lungIPG441
Irreversible electroporation for treating renal cancerIPG443
Irreversible electroporation for treating liver metastasesIPG445
Ultrasound-guided foam sclerotherapy for varicose veinsIPG440
Percutaneous pulmonary valve implantation for right ventricular outflow tract dysfunctionIPG436
Autologous blood injection for plantar fasciitisIPG437
Autologous blood injection for tendinopathyIPG438
Deep dermal injection of non-absorbable gel polymer for HIV-related lipoatrophyIPG439
Vinflunine for the treatment of advanced or metastatic transitional cell carcinoma of the urothelial tractTA272
Tadalafil for the treatment of symptoms associated with benign prostatic hyperplasia (terminated appraisal)TA273
Ipilimumab for previously treated advanced (unresectable or metastatic) melanomaTA268
Decitabine for the treatment of acute myeloid leukaemia (terminated appraisal)TA270
Dronedarone for the treatment of non-permanent atrial fibrillationTA197
Physical activity: walking and cyclingPH41
Mannitol dry powder for inhalation for treating cystic fibrosisTA266
Ivabradine for treating chronic heart failureTA267
Laparoscopic gastric plication for the treatment of severe obesityIPG432
Percutaneous laser atherectomy as an adjunct to balloon angioplasty (with or without stenting) for peripheral arterial diseaseIPG433
Radiofrequency cold ablation for respiratory papillomatosisIPG434
Depth of anaesthesia monitors – Bispectral Index (BIS), E-Entropy and Narcotrend-Compact MDG6
Social and emotional wellbeing: early yearsPH40
Denosumab for the prevention of skeletal-related events in adults with bone metastases from solid tumoursTA265
Alteplase for treating acute ischaemic strokeTA264
Neutropenic sepsis: prevention and management in people with cancerCG151
SonoVue (sulphur hexafluoride microbubbles) – contrast agent for contrast-enhanced ultrasound imaging of the liverDG5
Mega Soft Patient Return Electrode for use during monopolar electrosurgeryMTG11
Bevacizumab in combination with capecitabine for the first-line treatment of metastatic breast cancerTA263
Rivaroxaban for the treatment of deep vein thrombosis and prevention of recurrent deep vein thrombosis and pulmonary embolismTA261
Endovascular stent insertion for intracranial atherosclerotic diseaseIPG429
Partial replacement of the meniscus of the knee using a biodegradable scaffoldIPG430
Sickle cell disease: managing acute painful episodes in hospitalCG143
Lapatinib or trastuzumab in combination with an aromatase inhibitor for the first-line treatment of metastatic hormone-receptor-positive breast cancer that overexpresses HER2TA257
Erlotinib for the first-line treatment of locally advanced or metastatic EGFR-TK mutation-positive non-small-cell lung cancerTA258
Botulinum toxin type A for the prevention of headaches in adults with chronic migraineTA260
Percutaneous balloon cryoablation for pulmonary vein isolation in atrial fibrillationIPG427
Ranibizumab and pegaptanib for the treatment of age-related macular degenerationTA155
Focal therapy using cryoablation for localised prostate cancerIPG423
Micropressure therapy for refractory Ménière's diseaseIPG426
Fingolimod for the treatment of highly active relapsing–remitting multiple sclerosisTA254
Incisionless otoplastyIPG422
Pharmalgen for the treatment of bee and wasp venom allergyTA246
Tocilizumab for the treatment of rheumatoid arthritisTA247
Cetuximab, bevacizumab and panitumumab for the treatment of metastatic colorectal cancer after first-line chemotherapy: Cetuximab (monotherapy or combination chemotherapy), bevacizumab (in combination with non-oxaliplatin chemotherapy) and panitumumab (monotherapy) for the treatment of metastatic colorectal cancer after first-line chemotherapyTA242
Rituximab for the first-line treatment of stage III-IV follicular lymphomaTA243
Apixaban for the prevention of venous thromboembolism after total hip or knee replacement in adultsTA245
Breast reconstruction using lipomodelling after breast cancer treatmentIPG417
Bevacizumab and cetuximab for the treatment of metastatic colorectal cancerTA118
Epiretinal brachytherapy for wet age-related macular degenerationIPG415
Service user experience in adult mental health: improving the experience of care for people using adult NHS mental health servicesCG136
Tocilizumab for the treatment of systemic juvenile idiopathic arthritisTA238
Fulvestrant for the treatment of locally advanced or metastatic breast cancerTA239
Drainage, irrigation and fibrinolytic therapy (DRIFT) for post-haemorrhagic hydrocephalus in preterm infantsIPG412
Magnetic resonance image-guided transcutaneous focused ultrasound for uterine fibroidsIPG413
Single-port laparoscopic nephrectomyIPG414
Healthcare-associated infections: prevention and controlPH36
The EOS 2D/3D imaging systemDG1
Ticagrelor for the treatment of acute coronary syndromesTA236
Mifamurtide for the treatment of osteosarcomaTA235
Arthroscopic femoro–acetabular surgery for hip impingement syndromeIPG408
Minimally invasive oesophagectomyIPG407
Laparoscopic cryotherapy for renal cancerIPG405
Percutaneous cryotherapy for renal cancerIPG402
Open femoro–acetabular surgery for hip impingement syndromeIPG403
Bortezomib and thalidomide for the first‑line treatment of multiple myelomaTA228
Dexamethasone intravitreal implant for the treatment of macular oedema secondary to retinal vein occlusionTA229
Agomelatine for the treatment of major depressive episodes (terminated appraisal)TA231
Ambulight PDT for the treatment of non-melanoma skin cancerMTG6
The MIST Therapy system for the promotion of wound healingMTG5
Myocardial perfusion scintigraphy for the diagnosis and management of angina and myocardial infarctionTA73
Erlotinib monotherapy for maintenance treatment of non-small-cell lung cancerTA227
Endoscopic radical inguinal lymphadenectomyIPG398
Thoracoscopic exclusion of the left atrial appendage (with or without surgical ablation) for non-valvular atrial fibrillation for the prevention of thromboembolismIPG400
Golimumab for the treatment of rheumatoid arthritis after the failure of previous disease-modifying anti-rheumatic drugsTA225
Rituximab for the first-line maintenance treatment of follicular non-Hodgkin's lymphomaTA226
Common mental health problems: identification and pathways to careCG123
Endoscopic radiofrequency therapy of the anal sphincter for faecal incontinenceIPG393
Percutaneous tibial nerve stimulation for faecal incontinenceIPG395
Trabeculotomy ab interno for open angle glaucomaIPG397
Cilostazol, naftidrofuryl oxalate, pentoxifylline and inositol nicotinate for the treatment of intermittent claudication in people with peripheral arterial diseaseTA223
Type 2 diabetes prevention: population and community-level interventionsPH35
Carotid artery stent placement for symptomatic extracranial carotid stenosisIPG389
Endovascular stent-grafting of popliteal aneurysmsIPG390
Extracorporeal membrane oxygenation for severe acute respiratory failure in adultsIPG391
Stent insertion for bleeding oesophageal varicesIPG392
Golimumab for the treatment of psoriatic arthritisTA220
Coexisting severe mental illness (psychosis) and substance misuse: assessment and management in healthcare settingsCG120
Hand allotransplantationIPG383
Percutaneous retroperitoneal endoscopic necrosectomyIPG384
Laser correction of refractive error following non-refractive ophthalmic surgeryIPG385
Deep brain stimulation for intractable trigeminal autonomic cephalalgiasIPG381
Deep brain stimulation for refractory chronic pain syndromes (excluding headache)IPG382
Azacitidine for the treatment of myelodysplastic syndromes, chronic myelomonocytic leukaemia and acute myeloid leukaemiaTA218
Alcohol-use disorders: diagnosis, assessment and management of harmful drinking (high-risk drinking) and alcohol dependenceCG115
Food allergy in under 19s: assessment and diagnosisCG116
Percutaneous atherectomy of femoropopliteal arterial lesions with plaque excision devicesIPG380
Bevacizumab in combination with a taxane for the first-line treatment of metastatic breast cancerTA214
Bendamustine for the first-line treatment of chronic lymphocytic leukaemiaTA216
Extracorporeal shockwave therapy for refractory greater trochanteric pain syndromeIPG376
Off-pump coronary artery bypass graftingIPG377
Percutaneous laser coronary angioplastyIPG378
Aripiprazole for the treatment of schizophrenia in people aged 15 to 17 yearsTA213
Thoracoscopic repair of congenital diaphragmatic hernia in neonatesIPG379
Distal iliotibial band lengthening for refractory greater trochanteric pain syndromeIPG375
Sedation in under 19s: using sedation for diagnostic and therapeutic proceduresCG112
Cryotherapy for the treatment of liver metastasesIPG369
Percutaneous closure of patent foramen ovale for recurrent migraineIPG370
Percutaneous closure of patent foramen ovale for the secondary prevention of recurrent paradoxical embolism in diversIPG371
Percutaneous radiofrequency ablation for primary or secondary lung cancersIPG372
Selective dorsal rhizotomy for spasticity in cerebral palsyIPG373
Clopidogrel and modified-release dipyridamole for the prevention of occlusive vascular eventsTA210
Prucalopride for the treatment of chronic constipation in womenTA211
Bevacizumab in combination with oxaliplatin and either fluorouracil plus folinic acid or capecitabine for the treatment of metastatic colorectal cancerTA212
Interspinous distraction procedures for lumbar spinal stenosis causing neurogenic claudicationIPG365
Non-rigid stabilisation techniques for the treatment of low back painIPG366
Uterine artery embolisation for fibroidsIPG367
Unintentional injuries: prevention strategies for under 15sPH29
Unintentional injuries in the home: interventions for under 15sPH30
Unintentional injuries on the road: interventions for under 15sPH31
Trastuzumab for the treatment of HER2-positive metastatic gastric cancerTA208
Imatinib for the treatment of unresectable and/or metastatic gastrointestinal stromal tumoursTA209
Imatinib for the treatment of unresectable and/or metastatic gastro-intestinal stromal tumoursTA86
Bedwetting in under 19sCG111
Endoscopic mucosal resection and endoscopic submucosal dissection of non-ampullary duodenal lesionsIPG359
Endoscopic submucosal dissection of gastric lesionsIPG360
Insertion of metal rib reinforcements to stabilise a flail chest wallIPG361
Percutaneous posterior tibial nerve stimulation for overactive bladder syndromeIPG362
Minimally invasive total hip replacementIPG363
Transperineal template biopsy and mapping of the prostateIPG364
Denosumab for the prevention of osteoporotic fractures in postmenopausal womenTA204
Bendamustine for the treatment of indolent (low grade) non-Hodgkin's lymphoma that is refractory to rituximab (terminated appraisal)TA206
Temsirolimus for the treatment of relapsed or refractory mantle cell lymphoma (terminated appraisal)TA207
Pregnancy and complex social factors: a model for service provision for pregnant women with complex social factorsCG110
Endoscopic submucosal dissection of oesophageal dysplasia and neoplasiaIPG355
Laparoscopic hysterectomy (including laparoscopic total hysterectomy and laparoscopically assisted vaginal hysterectomy) for endometrial cancerIPG356
Percutaneous intradiscal laser ablation in the lumbar spineIPG357
Phototherapeutic laser keratectomy for corneal surface irregularitiesIPG358
Peginterferon alfa and ribavirin for the treatment of chronic hepatitis CTA200
Adalimumab, etanercept, infliximab, rituximab and abatacept for the treatment of rheumatoid arthritis after the failure of a TNF inhibitorTA195
Etanercept, infliximab and adalimumab for the treatment of psoriatic arthritisTA199
Percutaneous mitral valve annuloplastyIPG352
Percutaneous radiofrequency ablation for renal cancerIPG353
Shoulder resurfacing arthroplastyIPG354
Weight management before, during and after pregnancyPH27
Rituximab for the treatment of relapsed or refractory chronic lymphocytic leukaemiaTA193
Capecitabine for the treatment of advanced gastric cancerTA191
Gefitinib for the first-line treatment of locally advanced or metastatic non-small-cell lung cancerTA192
Stapled transanal rectal resection for obstructed defaecation syndromeIPG351
Percutaneous occlusion of the left atrial appendage in non-valvular atrial fibrillation for the prevention of thromboembolismIPG349
Photodynamic therapy for Barrett's oesophagusIPG350
Cardiovascular disease preventionPH25
Alcohol-use disorders: preventionPH24
Epithelial radiofrequency ablation for Barrett's oesophagusIPG344
Mini-incision surgery for total knee replacementIPG345
Therapeutic hypothermia with intracorporeal temperature monitoring for hypoxic perinatal brain injuryIPG347
Human growth hormone (somatropin) for the treatment of growth failure in childrenTA188
Improving outcomes for people with skin tumours including melanomaCSG8
Limited macular translocation for wet age-related macular degenerationIPG339
Macular translocation with 360° retinotomy for wet age-related macular degenerationIPG340
Prosthetic intervertebral disc replacement in the cervical spineIPG341
Haemorrhoidal artery ligationIPG342
Infliximab and adalimumab for the treatment of Crohn's diseaseTA187
Arteriovenous crossing sheathotomy for branch retinal vein occlusionIPG334
Endoscopic submucosal dissection of lower gastrointestinal lesionsIPG335
Transcatheter endovascular closure of perimembranous ventricular septal defectIPG336
Endobronchial ultrasound-guided transbronchial biopsy for peripheral lung lesionsIPG337
Guidance on the use of glycoprotein IIb/IIIa inhibitors in the treatment of acute coronary syndromesTA47
Donor milk banks: service operationCG93
Surgical correction of hallux valgus using minimal access techniquesIPG332
Therapeutic endoscopic division of epidural adhesionsIPG333
Radiofrequency ablation for colorectal liver metastasesIPG327
Suction diathermy adenoidectomyIPG328
Balloon catheter insertion for Bartholin's cyst or abscessIPG323
Electrocautery cutting balloon treatment for pelviureteric junction obstructionIPG324
Endopyelotomy for pelviureteric junction obstructionIPG325
Laparoscopic augmentation cystoplasty (including clam cystoplasty)IPG326
Topotecan for the treatment of relapsed small-cell lung cancerTA184
Depression in adults with a chronic physical health problem: recognition and managementCG91
Topotecan for the treatment of recurrent and stage IVB cervical cancerTA183
Guidance on the use of electroconvulsive therapyTA59
Extracorporeal albumin dialysis for acute liver failureIPG316
Individually magnetic resonance imaging-designed unicompartmental interpositional implant insertion for osteoarthritis of the kneeIPG317
Sunitinib for the treatment of gastrointestinal stromal tumoursTA179
Pemetrexed for the first-line treatment of non-small-cell lung cancerTA181
Placement of pectus bar for pectus excavatum (also known as MIRPE or the Nuss procedure)IPG310
Extracorporeal shockwave therapy for refractory plantar fasciitisIPG311
Extracorporeal shockwave therapy for refractory tennis elbowIPG313
Alitretinoin for the treatment of severe chronic hand eczemaTA177
Bevacizumab (first-line), sorafenib (first- and second-line), sunitinib (second-line) and temsirolimus (first-line) for the treatment of advanced and/or metastatic renal cell carcinomaTA178
Prosthetic intervertebral disc replacement in the lumbar spineIPG306
Image-guided radiofrequency excision biopsy of breast lesionsIPG308
Sinus tarsi implant insertion for mobile flatfootIPG305
Tenofovir disoproxil for the treatment of chronic hepatitis BTA173
Rituximab for the first-line treatment of chronic lymphocytic leukaemiaTA174
Percutaneous endoscopic laser cervical discectomyIPG303
Corneal endothelial transplantationIPG304
Tenotomy of horizontal eye muscles for nystagmus (with reattachment at their original insertions)IPG299
Transmyocardial laser revascularisation for refractory angina pectorisIPG301
Percutaneous laser revascularisation for refractory angina pectorisIPG302
Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and managementCG84
Combined bony and soft tissue reconstruction for hip joint stabilisation in proximal focal femoral deficiency (PFFD)IPG297
Ex-vivo hepatic resection and reimplantation for liver cancerIPG298
Endoscopic mastectomy and endoscopic wide local excision for breast cancerIPG296
Rivaroxaban for the prevention of venous thromboembolism after total hip or total knee replacement in adultsTA170
Percutaneous (non-thoracoscopic) epicardial catheter radiofrequency ablation for atrial fibrillationIPG294
Percutaneous (non-thoracoscopic) epicardial catheter radiofrequency ablation for ventricular tachycardiaIPG295
Rehabilitation after critical illness in adultsCG83
Photodynamic therapy for brain tumoursIPG290
Implantation of an opaque intraocular lens for intractable double visionIPG293
Sunitinib for the first-line treatment of advanced and/or metastatic renal cell carcinomaTA169
Extracorporeal photopheresis for Crohn's diseaseIPG288
Intraocular lens insertion for correction of refractive error, with preservation of the natural lensIPG289
Laparoscopic cystectomyIPG287
Amantadine, oseltamivir and zanamivir for the treatment of influenzaTA168
Medicines adherence: involving patients in decisions about prescribed medicines and supporting adherenceCG76
Borderline personality disorder: recognition and managementCG78
Functional electrical stimulation for drop foot of central neurological originIPG278
Ultrasound-guided regional nerve blockIPG285
Thoracoscopic epicardial radiofrequency ablation for atrial fibrillationIPG286
Physical activity for children and young peoplePH17
Machine perfusion systems and cold static storage of kidneys from deceased donorsTA165
Infliximab for acute exacerbations of ulcerative colitisTA163
Laparoscopic prostatectomy for benign prostatic obstructionIPG275
Transabdominal artificial bowel sphincter implantation for faecal incontinenceIPG276
Mental wellbeing in over 65s: occupational therapy and physical activity interventionsPH16
Spinal cord stimulation for chronic pain of neuropathic or ischaemic originTA159
Balloon catheter dilation of paranasal sinus ostia for chronic sinusitisIPG273
Autologous pancreatic islet cell transplantation for improved glycaemic control after pancreatectomyIPG274
Cardiovascular disease: identifying and supporting people most at risk of dying earlyPH15
Dabigatran etexilate for the prevention of venous thromboembolism after hip or knee replacement surgery in adultsTA157
Oseltamivir, amantadine (review) and zanamivir for the prophylaxis of influenzaTA158
Total wrist replacementIPG271
Routine antenatal anti-D prophylaxis for women who are rhesus D negativeTA156
Entecavir for the treatment of chronic hepatitis BTA153
Telbivudine for the treatment of chronic hepatitis BTA154
Brachytherapy as the sole method of adjuvant radiotherapy for breast cancer after local excisionIPG268
Laparoscopic gastrectomy for cancerIPG269
Direct skeletal fixation of limb or digit prostheses using intraosseous transcutaneous implantsIPG270
Continuous subcutaneous insulin infusion for the treatment of diabetes mellitusTA151
Lumbar infusion test for the investigation of normal pressure hydrocephalusIPG263
Implantation of multifocal (non-accommodative) intraocular lenses during cataract surgeryIPG264
Bevacizumab for the treatment of non-small-cell lung cancer (terminated appraisal)TA148
Carmustine implants for the treatment of recurrent glioblastoma multiforme (terminated appraisal)TA149
Cetuximab for the treatment of locally advanced squamous cell cancer of the head and neckTA145
Adalimumab for the treatment of adults with psoriasisTA146
Endoaortic balloon occlusion for cardiac surgeryIPG261
Physical activity in the workplacePH13
Intraoperative red blood cell salvage during radical prostatectomy or radical cystectomyIPG258
Interstitial photodynamic therapy for malignant parotid tumoursIPG259
Allogeneic pancreatic islet cell transplantation for type 1 diabetes mellitusIPG257
Intraoperative nerve monitoring during thyroid surgeryIPG255
Inhaled corticosteroids for the treatment of chronic asthma in adults and in children aged 12 years and overTA138
Laser-assisted cerebral vascular anastomosis without temporary arterial occlusionIPG252
Laparoscopic mobilisation of the greater omentum for breast reconstructionIPG253
Endobronchial ultrasound-guided transbronchial needle aspiration for mediastinal massesIPG254
Structural neuroimaging in first-episode psychosisTA136
Rituximab for the treatment of relapsed or refractory stage III or IV follicular non-Hodgkin's lymphomaTA137
Ultrasound-guided catheterisation of the epidural spaceIPG249
Infliximab for the treatment of adults with psoriasisTA134
Pemetrexed for the treatment of malignant pleural mesotheliomaTA135
Thoracoscopically assisted mitral valve surgeryIPG245
Hybrid procedure for interim management of hypoplastic left heart syndrome in neonatesIPG246
Thoracoscopic excision of mediastinal parathyroid tumoursIPG247
Thoracoscopic aortopexy for severe primary tracheomalaciaIPG243
Grenz rays therapy for inflammatory skin conditionsIPG236
Mini/micro screw implantation for orthodontic anchorageIPG238
Laparoscopic techniques for hysterectomyIPG239
Soft-palate implants for simple snoringIPG240
Soft-palate implants for obstructive sleep apnoeaIPG241
Inhaled corticosteroids for the treatment of chronic asthma in children under the age of 12 yearsTA131
Laparoscopic uterine nerve ablation (LUNA) for chronic pelvic painIPG234
Behaviour change: general approachesPH6
Bortezomib monotherapy for relapsed multiple myelomaTA129
Serial transverse enteroplasty procedure (STEP) for bowel lengthening in parenteral nutrition-dependent childrenIPG232
Stapled haemorrhoidopexy for the treatment of haemorrhoidsTA128
Laparoscopic repair of abdominal aortic aneurysmIPG229
Arthroscopic knee washout, with or without debridement, for the treatment of osteoarthritisIPG230
Pemetrexed for the treatment of non-small-cell lung cancerTA124
Natalizumab for the treatment of adults with highly active relapsing–remitting multiple sclerosisTA127
Therapeutic percutaneous image-guided aspiration of spinal cystsIPG223
Acutely ill adults in hospital: recognising and responding to deteriorationCG50
Drug misuse in over 16s: opioid detoxificationCG52
Drug misuse in over 16s: psychosocial interventionsCG51
Laparoscopic deroofing of simple renal cystsIPG226
Corneal implants for keratoconusIPG227
Corneal implants for the correction of refractive errorIPG225
Varenicline for smoking cessationTA123
Faecal incontinence in adults: managementCG49
Endoscopic augmentation of the lower oesophageal sphincter using hydrogel implants for the treatment of gastro-oesophageal reflux diseaseIPG222
Carmustine implants and temozolomide for the treatment of newly diagnosed high-grade gliomaTA121
Therapeutic sialendoscopyIPG218
Lower limb deep vein valve reconstruction for chronic deep venous incompetenceIPG219
Tissue-cultured limbal stem cell allograft transplantation for regrowth of corneal epitheliumIPG216
Laparoscopic nephrolithotomy and pyelolithotomyIPG212
Microwave ablation of hepatocellular carcinomaIPG214
Radiofrequency-assisted liver resectionIPG211
Laparoscopic insertion of peritoneal dialysis catheterIPG208
Implantation of accommodating intraocular lenses for cataractIPG209
Injectable bulking agents for faecal incontinenceIPG210
Fludarabine monotherapy for the first-line treatment of chronic lymphocytic leukaemiaTA119
Laparoscopic distal pancreatectomyIPG204
Fetal cystoscopy for the diagnosis and treatment of lower urinary outflow tract obstructionIPG205
Palliative photodynamic therapy for advanced oesophageal cancerIPG206
Cinacalcet for the treatment of secondary hyperparathyroidism in patients with end-stage renal disease on maintenance dialysis therapyTA117
Methadone and buprenorphine for the management of opioid dependenceTA114
Naltrexone for the management of opioid dependenceTA115
Gemcitabine for the treatment of metastatic breast cancerTA116
Intrauterine laser ablation of placental vessels for the treatment of twin-to-twin transfusion syndromeIPG198
Septostomy with or without amnioreduction for the treatment of twin-to-twin transfusion syndromeIPG199
Photodynamic therapy for early-stage oesophageal cancerIPG200
Fetal vesico–amniotic shunt for lower urinary tract outflow obstructionIPG202
Therapeutic amnioinfusion for oligohydramnios during pregnancy (excluding labour)IPG192
Laparoscopic radical prostatectomyIPG193
Insertion of pleuro–amniotic shunt for fetal pleural effusionIPG190
Deep brain stimulation for tremor and dystonia (excluding Parkinson's disease)IPG188
Laparoscopic surgery for colorectal cancerTA105
High-intensity focused ultrasound for atrial fibrillation in association with other cardiac surgeryIPG184
Tonsillectomy using laserIPG186
Catheterless oesophageal pH monitoringIPG187
Etanercept and efalizumab for the treatment of adults with psoriasisTA103
Improving outcomes for people with brain and other central nervous system tumoursCSG10
Percutaneous cementoplasty for palliative treatment of bony malignanciesIPG179
Percutaneous laser therapy for fetal tumoursIPG180
Short-term circulatory support with left ventricular assist devices as a bridge to cardiac transplantation or recoveryIPG177
Tonsillectomy using ultrasonic scalpelIPG178
Docetaxel for the treatment of hormone-refractory metastatic prostate cancerTA101
Living-donor lung transplantation for end-stage lung diseaseIPG170
Laparoscopic helium plasma coagulation for the treatment of endometriosisIPG171
High dose rate brachytherapy in combination with external-beam radiotherapy for localised prostate cancerIPG174
Percutaneous fetal balloon valvuloplasty for pulmonary atresia with intact ventricular septumIPG176
Percutaneous radiofrequency ablation for atrial fibrillationIPG168
Balloon kyphoplasty for vertebral compression fracturesIPG166
Retrograde urethral sphincterometryIPG167
Capecitabine and oxaliplatin in the adjuvant treatment of stage III (Dukes' C) colon cancerTA100
Laparoscopic retroperitoneal lymph node dissection for testicular cancerIPG158
Stimulated graciloplasty for faecal incontinenceIPG159
High dose rate brachytherapy for carcinoma of the cervixIPG160
Percutaneous endoscopic colostomyIPG161
Stent-graft placement in abdominal aortic aneurysmIPG163
Photorefractive (laser) surgery for the correction of refractive errorsIPG164
Endometrial cryotherapy for menorrhagiaIPG157
Improving outcomes for people with sarcomaCSG9
Photodynamic therapy for non-melanoma skin tumours (including premalignant and primary non-metastatic skin lesions)IPG155
Image-guided vacuum-assisted excision biopsy of benign breast lesionsIPG156
Adefovir dipivoxil and peginterferon alfa-2a for the treatment of chronic hepatitis BTA96
Laparoscopic partial nephrectomyIPG151
Foker technique for long-gap oesophageal atresiaIPG153
Retrobulbar irradiation for thyroid eye diseaseIPG148
Division of ankyloglossia (tongue-tie) for breastfeedingIPG149
Electrosurgery (diathermy and coblation) for tonsillectomyIPG150
Direct C1 lateral mass screw for cervical spine stabilisationIPG146
Endoscopic axillary lymph node retrieval for breast cancerIPG147
Obsessive-compulsive disorder and body dysmorphic disorder: treatmentCG31
Metatarsophalangeal joint replacement of the halluxIPG140
Automated percutaneous mechanical lumbar discectomyIPG141
Cryotherapy for malignant endobronchial obstructionIPG142
Intraoperative blood cell salvage in obstetricsIPG144
Photodynamic therapy for localised inoperable endobronchial cancerIPG137
Cryotherapy as a primary treatment for prostate cancerIPG145
Intramural urethral bulking procedures for stress urinary incontinence in womenIPG138
Improving outcomes in children and young people with cancerCSG7
Laparoscopic nephrectomy (including nephroureterectomy)IPG136
Low dose rate brachytherapy for localised prostate cancerIPG132
Photodynamic therapy for bile duct cancerIPG134
Laparoscopic liver resectionIPG135
HealOzone for the treatment of tooth decay (occlusal pit and fissure caries and root caries)TA92
Leukapheresis for inflammatory bowel diseaseIPG126
Collagen injection for vocal cord augmentationIPG130
Endovascular stent–graft placement in thoracic aortic aneurysms and dissectionsIPG127
Interstitial laser therapy for fibroadenomas of the breastIPG131
Totally endoscopic robotically assisted coronary artery bypass graftingIPG128
Computed tomographic colonography (virtual colonoscopy)IPG129
Radiofrequency ablation for atrial fibrillation in association with other cardiac surgeryIPG121
Microwave ablation for atrial fibrillation in association with other cardiac surgeryIPG122
Cryoablation for atrial fibrillation in association with other cardiac surgeryIPG123
Cryotherapy for recurrent prostate cancerIPG119
Guidance on the use of paclitaxel in the treatment of ovarian cancerTA55
High-intensity focused ultrasound for prostate cancerIPG118
Artificial metacarpophalangeal and interphalangeal joint replacement for end-stage arthritisIPG110
Artificial trapeziometacarpal joint replacement for end-stage osteoarthritisIPG111
Endoscopic dacryocystorhinostomyIPG113
Lung volume reduction surgery for advanced emphysemaIPG114
Coil embolisation of ruptured intracranial aneurysmsIPG106
Auditory brain stem implantsIPG108
Coil embolisation of unruptured intracranial aneurysmsIPG105
Wireless capsule endoscopy for investigation of the small bowelIPG101
Improving outcomes in head and neck cancersCSG6
Sacral nerve stimulation for faecal incontinenceIPG99
Dental checks: intervals between oral health reviewsCG19
Radiofrequency valvotomy for pulmonary atresiaIPG95
Endovascular closure of atrial septal defectIPG96
Endovascular closure of patent ductus arteriosusIPG97
Intraoperative fluorescence angiography for the evaluation of coronary artery bypass graft patencyIPG98
Interstitial laser therapy for breast cancerIPG89
Intralesional photocoagulation of subcutaneous congenital vascular disordersIPG90
Laparoscopic surgery for inguinal hernia repairTA83
Selective peripheral denervation for cervical dystoniaIPG80
Supraorbital minicraniotomy for intracranial aneurysmIPG84
Endovascular atrial septostomyIPG86
Photodynamic therapy for advanced bronchial carcinomaIPG87
Tacrolimus and pimecrolimus for atopic eczemaTA82
Frequency of application of topical corticosteroids for atopic eczemaTA81
Balloon dilatation of systemic to pulmonary arterial shunts in childrenIPG77
Balloon valvuloplasty for aortic valve stenosis in adults and childrenIPG78
Balloon dilatation with or without stenting for pulmonary artery or non-valvar right ventricular outflow tract obstruction in childrenIPG76
Scleral expansion surgery for presbyopiaIPG70
Balloon angioplasty of pulmonary vein stenosis in infantsIPG75
Stent placement for vena caval obstructionIPG79
Balloon angioplasty with or without stenting for coarctation or recoarctation of the aorta in adults and childrenIPG74
Fallopian tube recanalisation by guidewireIPG71
Insertion of hydrogel keratoprosthesisIPG69
Lumbar subcutaneous shuntIPG68
Balloon dilatation of pulmonary valve stenosisIPG67
Artificial anal sphincter implantationIPG66
Subthalamotomy for Parkinson's diseaseIPG65
Sacral nerve stimulation for urge incontinence and urgency-frequencyIPG64
Falloposcopy with coaxial catheterIPG62
Laser sheath removal of pacing leadsIPG63
Thrombin injections for pseudoaneurysmsIPG60
Laparoscopic live donor simple nephrectomyIPG57
Transpupillary thermotherapy for age-related macular degenerationIPG58
Subfascial endoscopic perforator vein surgeryIPG59
Percutaneous endoscopic laser thoracic discectomyIPG61
Complete cytoreduction for pseudomyxoma peritonei (Sugarbaker technique)IPG56
Endoscopic injection of bulking agents for gastro-oesophageal reflux diseaseIPG55
Guidance on the use of zaleplon, zolpidem and zopiclone for the short-term management of insomniaTA77
Fluid-filled thermal balloon and microwave endometrial ablation techniques for heavy menstrual bleedingTA78
Improving supportive and palliative care for adults with cancerCSG4
Photodynamic endometrial ablationIPG47
Vagus nerve stimulation for refractory epilepsy in childrenIPG50
Radiotherapy for age-related macular degenerationIPG49
Laparoscopic pyeloplastyIPG46
Computed tomography-guided thermocoagulation of osteoid osteomaIPG53
Endovenous laser treatment of the long saphenous veinIPG52
Cyanoacrylate instillation for occlusion of parotid sinusesIPG42
Partial left ventriculectomy (the Batista procedure)IPG41
Non-surgical reduction of the myocardial septumIPG40
Needle fasciotomy for Dupuytren's contractureIPG43
Transilluminated powered phlebectomy for varicose veinsIPG37
Extracorporeal membrane oxygenation (ECMO) in postneonatal childrenIPG38
Pre-hospital initiation of fluid replacement therapy in traumaTA74
Circular stapled haemorrhoidectomyIPG34
Endoscopic laser foraminoplastyIPG31
Laparo-endogastric surgeryIPG25
Extracorporeal shockwave therapy for Peyronie's diseaseIPG29
Endoscopic transsphenoidal pituitary adenoma resectionIPG32
Magnetic resonance (MR) image-guided percutaneous laser ablation of uterine fibroidsIPG30
Holmium laser prostatectomyIPG17
Bone-anchored cystourethropexyIPG18
Deep brain stimulation for Parkinson's diseaseIPG19
Endoscopic stapling of pharyngeal pouchIPG22
Laparoscopic laser myomectomyIPG23
Transurethral electrovaporisation of the prostateIPG14
Guidance on the use of liquid-based cytology for cervical screeningTA69
Percutaneous vertebroplastyIPG12
Radiofrequency ablation of varicose veinsIPG8
Human growth hormone (somatropin) in adults with growth hormone deficiencyTA64
Radiofrequency ablation of hepatocellular carcinomaIPG2
Guidance on the use of capecitabine and tegafur with uracil for metastatic colorectal cancerTA61
Guidance on the use of drugs for early thrombolysis in the treatment of acute myocardial infarctionTA52
Guidance on the use of ultrasound locating devices for placing central venous cathetersTA49
Improving outcomes in urological cancersCSG2
Improving outcomes in breast cancerCSG1
Inhaler devices for routine treatment of chronic asthma in older children (aged 5–15 years)TA38
Guidance on the use of trastuzumab for the treatment of advanced breast cancerTA34
Guidance on the use of fludarabine for B-cell chronic lymphocytic leukaemiaTA29
Guidance on the use of riluzole (Rilutek) for the treatment of motor neurone diseaseTA20
Guidance on the use of inhaler systems (devices) in children under the age of 5 years with chronic asthmaTA10
Guidance on the extraction of wisdom teethTA1

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