Status In progress
Process MTA
Topic area
  • Cancer
  • Therapeutic procedures

Provisional Schedule

Closing date for invited submissions / evidence submission: 6 January 2014
1st appraisal committee meeting: 24 June 2014
2nd appraisal committee meeting: 27 August 2014
3rd appraisal committee meeting: 26 August 2015

Project Team

Project lead Thomas Feist

Email enquiries


Key events during the development of the guidance:

Date Update
08 December 2017 Appeal
08 December 2017 Appeal
01 September 2017 - 15 September 2017 Final appraisal determination: 1
09 March 2017 Committee meeting: 5
01 February 2017 - 01 March 2017 Appraisal consultation: 2
23 December 2016 As you are aware, the appraisal committee met in closed session at its November meeting to discuss this topic, with the intention of producing a consultation document. We now expect to be able to release this document in January, a little later than originally planned. As a consequence, the full public meeting to develop the final guidance for Intrabeam has been moved to 09 March 2017. We appreciate that the timeline for this appraisal has now been extended several times. We hope this is the final change, and we fully expect to produce final guidance after that meeting.
15 November 2016 Committee meeting: 4
06 November 2015 The Committee decided that further work by the Institute would be required before it could issue a recommendation to the NHS. The Committee appreciated the advantages of Intrabeam, especially for people who are keen to avoid having external beam radiotherapy, but was also concerned about the remaining uncertainties in the evidence, and the difficulties these present for both patients and clinicians in making an informed choice about the best treatment. The technology appraisals team is exploring options for evidence development that could be used to support the use of Intrabeam intraoperative radiotherapy in the NHS. Consequently the timeline for the development of the provisional guidance has been extended.
September 2014 Following its discussion of Intrabeam radiotherapy for treating early breast cancer on 27th August, the Appraisal Committee wishes to request further information from the TARGIT-A clinical trial investigators. Please refer to the document Breast cancer (early) - intrabeam radiotherapy system: Request for further information, under project documents

For further information on how we develop guidance, please see our page about NICE technology appraisal guidance