Suggested remit: To appraise the clinical and cost effectiveness of durvalumab with tremelimumab within its marketing authorisation for untreated advanced or unresectable hepatocellular carcinoma in adults.
 
Status In progress
Technology type Medicine
Decision Selected
Process STA Standard
ID number 2725

Provisional Schedule

Committee meeting 14 January 2025
Expected publication 26 March 2025

Project Team

Project lead Kate Moore

Email enquiries

External Assessment Group Warwick Evidence, Warwick Medical School, University of Warwick

Stakeholders

Companies sponsors AstraZeneca (durvalumab, tremelimumab)
Others Department of Health and Social Care
  NHS England
Patient carer groups Addenbrookes Liver Transplant Association
  Black Health Agency for Equality
  British Liver Trust
  Cancer Black Care
  Cancer Equality
  Cancer 52
  GUTS UK
  Haemochromatosis UK
  Helen Rollason Cancer Charity
  Independent Cancer Patients’ Voice
  Liver4Life
  Macmillan Cancer Support
  Maggie’s Centres
  Marie Curie
  Pelican Cancer Foundation
  South Asian Health Foundation
  Specialised Healthcare Alliance
  Tenovus Cancer Care
  The Hepatitis C Trust
Professional groups Association of Anaesthetists of Great Britain & Ireland
  Association of Cancer Physicians
  Association of Surgeons of Great Britain & Ireland
  British Association of the Study of the Liver (BASL) / HCC UK
  British Geriatrics Society
  British Institute of Radiologists
  British Oncology Pharmacy Association
  British Psychosocial Oncology Society
  British Society of Gastroenterology
  Cancer Research UK
  Hepatitis Nurse Specialist Forum
  Royal College of Anaesthetists
  Royal College of General Practitioners
  Royal College of Nursing
  Royal College of Pathologists
  Royal College of Physicians
  Royal College of Radiologists
  Royal College of Surgeons
  Royal Pharmaceutical Society
  Royal Society of Medicine
  Society and College of Radiologists
  UK Clinical Pharmacy Association
  UK Oncology Nursing Society
Associated guideline groups NICE - National Guideline Alliance (cancer, mental health, and women and children’s health)
Associated public health groups Public Health Wales
  UK Health Security Agency
Comparator companies Bayer (sorafenib)
  Boston Scientific (TheraSphere)
  Celltrion Healthcare (bevacizumab)
  Dr. Reddy’s Laboratories (bevacizumab)
  Eisai (lenvatinib)
  Organon Pharma (bevacizumab)
  Pfizer (bevacizumab)
  Roche (atezolizumab, bevacizumab)
  Sandoz (sorafenib)
  Sirtex (SIR-Spheres)
  Terumo Europe (QuirumSpheres)
  Thornton and Ross (bevacizumab, sorafenib)
  Zentiva (bevacizumab, sorafenib)
Evidence review group National Institute for Health Research Health Technology Assessment Programme (NETSCC)
  Warwick Evidence
General commentators All Wales Therapeutics and Toxicology Centre
  Allied Health Professionals Federation
  Board of Community Health Councils in Wales
  British National Formulary
  Care Quality Commission
  Department of Health, Social Services and Public Safety for Northern Ireland
  Healthcare Improvement Scotland
  Medicines and Healthcare products Regulatory Agency
  National Association of Primary Care
  National Pharmacy Association
  NHS Confederation
  Scottish Medicines Consortium
  Welsh Government
  Welsh Health Specialised Services Committee
Relevant research groups Cochrane Hepato-biliary Group
  Cochrane Infectious Diseases Group
  Cochrane UK
  Foundation for Liver Research
  Genomics England
  Institute of Cancer Research
  MRC Clinical Trials Unit
  National Institute for Health Research

Timeline

Key events during the development of the guidance:

Date Update
11 June 2024 Invitation to participate
08 April 2024 - 06 May 2024 Consultation on suggested remit, draft scope and provisional stakeholder list of consultees and commentators: 2725
28 March 2024 In progress. Please note that following on from advice received from the company this topic has now been scheduled back into the work programme. We now anticipate that the appraisal will begin during mid-June 2024 when we will write to you about how you can get involved.
22 November 2023 Suspended. The company has informed NICE that it will not provide an evidence submission for this appraisal at this time. Therefore, we are suspending the appraisal while we consider the next steps.
10 January 2020 In progress. Referred October 28 2019

For further information on our processes and methods, please see our CHTE processes and methods manual