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Appendix C: Risks of hyperstimulation associated with different pharmacological methods of inducing labour
Appendix C: Risks of hyperstimulation associated with different pharmacological methods of inducing labour
|
Preparation (dose or type) |
Risk of hyperstimulation with fetal heart rate changes compared to placebo in women with a Bishop score of 6 or less (OR, 95% Credible Interval) |
|---|---|
|
Oral misoprostol (under 50 micrograms) |
1.54 (0.32 to 7.60) |
|
Titrated oral (low dose) misoprostol |
1.96 (0.65 to 8.12) |
|
Vaginal dinoprostone tablet |
2.22 (0.59 to 6.03) |
|
Oral misoprostol (50 micrograms or more) |
3.09 (1.10 to 9.19) |
|
Vaginal dinoprostone gel |
3.45 (1.24 to 10.53) |
|
Vaginal misoprostol (under 50 micrograms) |
4.12 (1.57 to 11.60) |
|
Vaginal dinoprostone pessary (slow release) |
4.98 (1.82, 15.01) |
|
Vaginal misoprostol (50 micrograms or more) |
5.92 (2.26, 16.81) |
|
Buccal/sublingual misoprostol |
7.07 (2.22, 24.45) |
For sources of data and more complete information on risks of hyperstimulation, see evidence review B.
ISBN: 978-1-4731-4327-2
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